JPS588079A - ピリミドン誘導体 - Google Patents

ピリミドン誘導体

Info

Publication number
JPS588079A
JPS588079A JP57110567A JP11056782A JPS588079A JP S588079 A JPS588079 A JP S588079A JP 57110567 A JP57110567 A JP 57110567A JP 11056782 A JP11056782 A JP 11056782A JP S588079 A JPS588079 A JP S588079A
Authority
JP
Japan
Prior art keywords
pyridyl
methyl
formula
oxo
hydroxymethyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP57110567A
Other languages
English (en)
Japanese (ja)
Other versions
JPS6328424B2 (forum.php
Inventor
ジヨ−ジ・シドニイ・サツチ
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Smith Kline and French Laboratories Ltd
Original Assignee
Smith Kline and French Laboratories Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smith Kline and French Laboratories Ltd filed Critical Smith Kline and French Laboratories Ltd
Publication of JPS588079A publication Critical patent/JPS588079A/ja
Publication of JPS6328424B2 publication Critical patent/JPS6328424B2/ja
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/73—Unsubstituted amino or imino radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/04—Drugs for disorders of the respiratory system for throat disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/16—Otologicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/61—Halogen atoms or nitro radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
    • C07D213/63—One oxygen atom
    • C07D213/65—One oxygen atom attached in position 3 or 5
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Otolaryngology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Luminescent Compositions (AREA)
  • Treating Waste Gases (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Diaphragms For Electromechanical Transducers (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Compounds Of Unknown Constitution (AREA)
  • Steroid Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
JP57110567A 1981-06-27 1982-06-26 ピリミドン誘導体 Granted JPS588079A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB8119906 1981-06-27
GB8119906 1981-06-27

Publications (2)

Publication Number Publication Date
JPS588079A true JPS588079A (ja) 1983-01-18
JPS6328424B2 JPS6328424B2 (forum.php) 1988-06-08

Family

ID=10522859

Family Applications (4)

Application Number Title Priority Date Filing Date
JP57110567A Granted JPS588079A (ja) 1981-06-27 1982-06-26 ピリミドン誘導体
JP57110568A Granted JPS588080A (ja) 1981-06-27 1982-06-26 ピリミドン誘導体
JP61093194A Pending JPS61233670A (ja) 1981-06-27 1986-04-21 置換ピリジン化合物
JP61093193A Granted JPS61233616A (ja) 1981-06-27 1986-04-21 ヒスタミンｈ↓１‐拮抗剤組成物

Family Applications After (3)

Application Number Title Priority Date Filing Date
JP57110568A Granted JPS588080A (ja) 1981-06-27 1982-06-26 ピリミドン誘導体
JP61093194A Pending JPS61233670A (ja) 1981-06-27 1986-04-21 置換ピリジン化合物
JP61093193A Granted JPS61233616A (ja) 1981-06-27 1986-04-21 ヒスタミンｈ↓１‐拮抗剤組成物

Country Status (27)

Country Link
US (4) US4486434A (forum.php)
EP (2) EP0068833B1 (forum.php)
JP (4) JPS588079A (forum.php)
KR (1) KR880001475B1 (forum.php)
AT (2) ATE21900T1 (forum.php)
AU (2) AU8535282A (forum.php)
BG (1) BG38163A3 (forum.php)
CS (1) CS241036B2 (forum.php)
DD (1) DD202291A5 (forum.php)
DE (2) DE3273019D1 (forum.php)
DK (2) DK287082A (forum.php)
ES (1) ES513469A0 (forum.php)
FI (1) FI822281A7 (forum.php)
GR (2) GR74926B (forum.php)
HU (1) HU190396B (forum.php)
IE (1) IE53348B1 (forum.php)
IL (1) IL66125A (forum.php)
JO (1) JO1185B1 (forum.php)
NO (1) NO822120L (forum.php)
NZ (1) NZ201077A (forum.php)
PH (1) PH19680A (forum.php)
PL (3) PL138524B1 (forum.php)
PT (1) PT75074B (forum.php)
SU (1) SU1232145A3 (forum.php)
YU (1) YU138982A (forum.php)
ZA (2) ZA824537B (forum.php)
ZW (1) ZW13082A1 (forum.php)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6376200A (ja) * 1986-09-19 1988-04-06 Hitachi Ltd 半導体集積回路

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IN151188B (forum.php) * 1978-02-13 1983-03-05 Smith Kline French Lab
US4808589A (en) * 1982-02-20 1989-02-28 Smith Kline & French Laboratories Limited Pyrimidone derivatives
DE3376422D1 (en) * 1982-03-25 1988-06-01 Smith Kline French Lab Process for preparing 3,5-disubstituted 2-pyridylalkyl amines
GR78463B (forum.php) * 1982-03-25 1984-09-27 Smith Kline French Lab
PT77287B (en) * 1982-10-01 1986-02-04 Smith Kline French Lab Compound
GB8319874D0 (en) * 1983-07-23 1983-08-24 Smith Kline French Lab Compounds
CA1286297C (en) * 1985-06-13 1991-07-16 George S. Sach Pyridine derivatives
GB8601816D0 (en) * 1986-01-25 1986-02-26 Smith Kline French Lab Pyridine derivatives
GB8610867D0 (en) * 1986-05-02 1986-06-11 Smith Kline French Lab 3-hydroxypyridines
EP0364584A4 (en) * 1988-04-27 1990-12-05 Kievsky Nauchno-Issledovatelsky Institut Farmakologii I Toxikologii Antidote for organic phosphorus compound poisoning
US5216170A (en) * 1989-01-26 1993-06-01 Bayer Aktiengesellschaft (2-aminopropyl) pyridines useful as intermediates
KR100498005B1 (ko) * 2002-07-26 2005-07-01 주식회사 소하드 기능성 액상비료 및 그 제조방법
EP1572752B1 (en) * 2002-12-20 2014-08-13 ExxonMobil Chemical Patents Inc. Polymerization processes
US7443103B2 (en) * 2005-06-24 2008-10-28 General Electric Company High pressure lamp with lamp flicker suppression and lamp voltage control
EP2303857A1 (en) * 2008-07-10 2011-04-06 Novartis AG Cyclic sulfones with aminobenzyl substitution useful as bace inhibitors

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5246087A (en) * 1975-10-02 1977-04-12 Smith Kline French Lab Heterocyclic compound
JPS5283388A (en) * 1975-12-29 1977-07-12 Smith Kline French Lab Heterocyclic compounds
JPS54157584A (en) * 1978-05-30 1979-12-12 Smith Kline French Lab Nitro compound*its manufacture and medical composition containing it
JPS55145683A (en) * 1979-04-26 1980-11-13 Smith Kline French Lab Pyrimidone derivative

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4154834A (en) * 1975-12-29 1979-05-15 Smith Kline & French Laboratories Limited Substituted isocytosines having histamine H2 -antagonist activity
US4216318A (en) * 1975-12-29 1980-08-05 Smith Kline & French Laboratories Limited Heterocyclic alkyl 4-pyrimidones
US4227000A (en) * 1978-04-11 1980-10-07 Smith Kline & French Laboratories Limited Intermediates in the process for making histamine antagonists
US4255428A (en) * 1979-03-24 1981-03-10 Smith Kline & French Laboratories Limited 5-(Hydroxypyridylalkyl)-4-pyrimidones
JPS55133379A (en) * 1979-04-05 1980-10-17 Smith Kline French Lab Pyrimidone compound
EP0017680B1 (en) * 1979-04-11 1982-04-21 Smith Kline & French Laboratories Limited Pyrimidone derivatives, process for preparing them and pharmaceutical compositions containing them

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5246087A (en) * 1975-10-02 1977-04-12 Smith Kline French Lab Heterocyclic compound
JPS5283388A (en) * 1975-12-29 1977-07-12 Smith Kline French Lab Heterocyclic compounds
JPS54157584A (en) * 1978-05-30 1979-12-12 Smith Kline French Lab Nitro compound*its manufacture and medical composition containing it
JPS55145683A (en) * 1979-04-26 1980-11-13 Smith Kline French Lab Pyrimidone derivative

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6376200A (ja) * 1986-09-19 1988-04-06 Hitachi Ltd 半導体集積回路

Also Published As

Publication number Publication date
CS480082A2 (en) 1985-06-13
US4584381A (en) 1986-04-22
IE53348B1 (en) 1988-10-26
BG38163A3 (bg) 1985-10-15
ATE21900T1 (de) 1986-09-15
IE821533L (en) 1982-12-27
AU551066B2 (en) 1986-04-17
JPH0244812B2 (forum.php) 1990-10-05
DE3273019D1 (en) 1986-10-09
NZ201077A (en) 1985-09-13
IL66125A0 (en) 1982-09-30
AU8535182A (en) 1983-01-06
JPS6328424B2 (forum.php) 1988-06-08
PT75074B (en) 1986-02-26
EP0068834A2 (en) 1983-01-05
EP0068834A3 (en) 1983-04-06
EP0068833B1 (en) 1986-10-15
JO1185B1 (en) 1983-11-30
JPS61233670A (ja) 1986-10-17
PT75074A (en) 1982-07-01
JPS61233616A (ja) 1986-10-17
US4486434A (en) 1984-12-04
PL237110A1 (en) 1983-06-20
ES8305755A1 (es) 1983-05-01
ZW13082A1 (en) 1982-09-29
GR74926B (forum.php) 1984-07-12
SU1232145A3 (ru) 1986-05-15
CS241036B2 (en) 1986-03-13
US4535163A (en) 1985-08-13
HU190396B (en) 1986-08-28
EP0068834B1 (en) 1986-09-03
PL137600B1 (en) 1986-07-31
AU8535282A (en) 1983-01-06
DD202291A5 (de) 1983-09-07
FI822281A0 (fi) 1982-06-24
PL138524B1 (en) 1986-09-30
FI822281L (fi) 1982-12-28
JPH0345073B2 (forum.php) 1991-07-09
YU138982A (en) 1985-03-20
PH19680A (en) 1986-06-13
PL240628A1 (en) 1983-10-10
JPS588080A (ja) 1983-01-18
FI822281A7 (fi) 1982-12-28
KR840000533A (ko) 1984-02-25
US4444772A (en) 1984-04-24
ES513469A0 (es) 1983-05-01
DE3273782D1 (en) 1986-11-20
DK286982A (da) 1982-12-28
NO822120L (no) 1982-12-28
ZA824537B (en) 1983-05-25
KR880001475B1 (ko) 1988-08-13
PL137627B1 (en) 1986-07-31
ZA824580B (en) 1983-05-25
EP0068833A3 (en) 1983-03-30
ATE22891T1 (de) 1986-11-15
GR74925B (forum.php) 1984-07-12
EP0068833A2 (en) 1983-01-05
IL66125A (en) 1986-01-31
DK287082A (da) 1982-12-28

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