JPS58201791A - Hematoporphyrin derivative - Google Patents

Hematoporphyrin derivative

Info

Publication number
JPS58201791A
JPS58201791A JP8465382A JP8465382A JPS58201791A JP S58201791 A JPS58201791 A JP S58201791A JP 8465382 A JP8465382 A JP 8465382A JP 8465382 A JP8465382 A JP 8465382A JP S58201791 A JPS58201791 A JP S58201791A
Authority
JP
Japan
Prior art keywords
ch
compound
etc
hp
antitumor
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP8465382A
Inventor
Tetsuo Kato
Hisashi Mori
Etsuko Sato
Toshio Suzuki
Katsuo Unno
Original Assignee
Tetsuo Kato
Toshio Suzuki
Katsuo Unno
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Tetsuo Kato, Toshio Suzuki, Katsuo Unno filed Critical Tetsuo Kato
Priority to JP8465382A priority Critical patent/JPS58201791A/en
Publication of JPS58201791A publication Critical patent/JPS58201791A/en
Application status is Pending legal-status Critical

Links

Abstract

NEW MATERIAL:A compound shown by the formula I [Me is methyl; R1 and R2 are CH(OH)Me, CH(OAc)Me, CH=CH2, CO(CH2)2COOH, or CH(OSi)Me; Z1 and Z2 are -NH-R', or -O-R' (R' antitumor compound residue containing amino or OH)].
EXAMPLE: Hematoporphyrin(Hp)-diAc-dimitomycin C(MMC).
USE: An antitumor agent. Having selective orienting properties for tumor cell.
PROCESS: If necessary, carboxyl group of Hp or a carboxyl group-containing Hp derivative [e.g., compound shown by the formula II (A1 and A2 are as shown for R1 and R2)] is activated with an activator (e.g., 4-dimethylaminopyridine, etc.), and this compound is condensed through dehydration with an amino group or hydroxyl group-containing antitumor compound (e.g., MMC, etc.) in the presence of a condensation agent such as dicyclohexylcarbodiimide, etc.
COPYRIGHT: (C)1983,JPO&Japio
JP8465382A 1982-05-19 1982-05-19 Hematoporphyrin derivative Pending JPS58201791A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP8465382A JPS58201791A (en) 1982-05-19 1982-05-19 Hematoporphyrin derivative

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP8465382A JPS58201791A (en) 1982-05-19 1982-05-19 Hematoporphyrin derivative

Publications (1)

Publication Number Publication Date
JPS58201791A true JPS58201791A (en) 1983-11-24

Family

ID=13836669

Family Applications (1)

Application Number Title Priority Date Filing Date
JP8465382A Pending JPS58201791A (en) 1982-05-19 1982-05-19 Hematoporphyrin derivative

Country Status (1)

Country Link
JP (1) JPS58201791A (en)

Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6183186A (en) * 1984-07-18 1986-04-26 Nippon Petrochem Co Ltd Novel tetrapyrrole medical composition
JPS61186385A (en) * 1985-02-13 1986-08-20 Sato Yakugaku Kenkyusho:Kk Deuteroporphyrin derivative and its salt
JPS625985A (en) * 1985-04-30 1987-01-12 Nippon Petrochem Co Ltd Novel tetrapyrrole compound
JPS625924A (en) * 1985-04-30 1987-01-12 Nippon Petrochem Co Ltd Pharmaceutical composition containing novel tetrapyrrolepolyaminomonocarboxylic acid
JPS62167783A (en) * 1986-01-17 1987-07-24 Hamari Yakuhin Kogyo Kk Porphyrin derivative
JPS62205082A (en) * 1986-03-03 1987-09-09 Hamari Yakuhin Kogyo Kk Porphyrin derivative
JPS63154689A (en) * 1986-12-18 1988-06-27 Mihama Hisaharu Modified porphyrin and antitumor agent
JPH02138280A (en) * 1988-07-14 1990-05-28 Toyo Hatsuka Kogyo Kk Porphyrin derivative
WO1999004817A1 (en) * 1997-07-25 1999-02-04 Brigham & Women's Hospital, Inc. Chemotherapy synergistic agent

Cited By (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6183186A (en) * 1984-07-18 1986-04-26 Nippon Petrochem Co Ltd Novel tetrapyrrole medical composition
JPS61129163A (en) * 1984-07-18 1986-06-17 Nippon Petrochem Co Ltd Novel tetrapyrrole compound
JPS61186385A (en) * 1985-02-13 1986-08-20 Sato Yakugaku Kenkyusho:Kk Deuteroporphyrin derivative and its salt
JPS625985A (en) * 1985-04-30 1987-01-12 Nippon Petrochem Co Ltd Novel tetrapyrrole compound
JPS625924A (en) * 1985-04-30 1987-01-12 Nippon Petrochem Co Ltd Pharmaceutical composition containing novel tetrapyrrolepolyaminomonocarboxylic acid
JPS62167783A (en) * 1986-01-17 1987-07-24 Hamari Yakuhin Kogyo Kk Porphyrin derivative
JPS62205082A (en) * 1986-03-03 1987-09-09 Hamari Yakuhin Kogyo Kk Porphyrin derivative
JPS63154689A (en) * 1986-12-18 1988-06-27 Mihama Hisaharu Modified porphyrin and antitumor agent
JPH02138280A (en) * 1988-07-14 1990-05-28 Toyo Hatsuka Kogyo Kk Porphyrin derivative
WO1999004817A1 (en) * 1997-07-25 1999-02-04 Brigham & Women's Hospital, Inc. Chemotherapy synergistic agent

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