JPS58192853A - Novel biphenyl ether and preparation thereof - Google Patents

Novel biphenyl ether and preparation thereof

Info

Publication number
JPS58192853A
JPS58192853A JP7559882A JP7559882A JPS58192853A JP S58192853 A JPS58192853 A JP S58192853A JP 7559882 A JP7559882 A JP 7559882A JP 7559882 A JP7559882 A JP 7559882A JP S58192853 A JPS58192853 A JP S58192853A
Authority
JP
Japan
Prior art keywords
formula
compound expressed
reaction
biphenyl ether
substituted
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP7559882A
Other languages
Japanese (ja)
Inventor
Akira Inoue
Hideji Itokawa
Seiji Kosemura
Noboru Mori
Kenji Naito
Nobuaki Serizawa
Toru Sonobe
Original Assignee
Toubishi Yakuhin Kogyo Kk
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Toubishi Yakuhin Kogyo Kk filed Critical Toubishi Yakuhin Kogyo Kk
Priority to JP7559882A priority Critical patent/JPS58192853A/en
Publication of JPS58192853A publication Critical patent/JPS58192853A/en
Pending legal-status Critical Current

Links

Abstract

NEW MATERIAL:A compound expressed by formula I (R' is phenyl in which the p-position is substituted by at least one alkyl or substituted alkyl group; R" is H or protected or unprotected amino; R''' is H or ester residue).
EXAMPLE: 2-( p-Methyl-phenoxy)-4-[2'( S)-( N-benzyloxcarbonyl-N-methylamino)-2'- methoxycarbonyl-ethyl]phenol.
USE: A synthetic intermediate for TPC compounds.
PROCESS: An epoxide compound expressed by formula II or III is reacted with a phenolic compound expressed by the formula R'-OH or a salt thereof or further acylated to give a reaction product, which is then reduced to afford the compound expressed by formula I . The reduction reaction is easily carried out in the presence of a reducing agent, e.g. zinc/acetic acid, to convert the reaction product into the biphenyl ether compound expressed by formula I .
COPYRIGHT: (C)1983,JPO&Japio
JP7559882A 1982-05-06 1982-05-06 Novel biphenyl ether and preparation thereof Pending JPS58192853A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP7559882A JPS58192853A (en) 1982-05-06 1982-05-06 Novel biphenyl ether and preparation thereof

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP7559882A JPS58192853A (en) 1982-05-06 1982-05-06 Novel biphenyl ether and preparation thereof

Publications (1)

Publication Number Publication Date
JPS58192853A true JPS58192853A (en) 1983-11-10

Family

ID=13580794

Family Applications (1)

Application Number Title Priority Date Filing Date
JP7559882A Pending JPS58192853A (en) 1982-05-06 1982-05-06 Novel biphenyl ether and preparation thereof

Country Status (1)

Country Link
JP (1) JPS58192853A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5948442A (en) * 1982-09-11 1984-03-19 Toubishi Yakuhin Kogyo Kk Novel biphenyl ether and its preparation

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS50151838A (en) * 1974-05-16 1975-12-06
JPS5283814A (en) * 1976-01-01 1977-07-13 Takeda Chem Ind Ltd 2-halogeno-3-substituted-propionic acids
JPS5283812A (en) * 1976-01-01 1977-07-13 Takeda Chem Ind Ltd Alpha-halogenocarboxylic acids

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS50151838A (en) * 1974-05-16 1975-12-06
JPS5283814A (en) * 1976-01-01 1977-07-13 Takeda Chem Ind Ltd 2-halogeno-3-substituted-propionic acids
JPS5283812A (en) * 1976-01-01 1977-07-13 Takeda Chem Ind Ltd Alpha-halogenocarboxylic acids

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5948442A (en) * 1982-09-11 1984-03-19 Toubishi Yakuhin Kogyo Kk Novel biphenyl ether and its preparation
JPH0254331B2 (en) * 1982-09-11 1990-11-21 Tobishi Pharmaceutical Co

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