JPS58189118A - Pernasal administration pharmaceutical - Google Patents

Pernasal administration pharmaceutical

Info

Publication number
JPS58189118A
JPS58189118A JP7373182A JP7373182A JPS58189118A JP S58189118 A JPS58189118 A JP S58189118A JP 7373182 A JP7373182 A JP 7373182A JP 7373182 A JP7373182 A JP 7373182A JP S58189118 A JPS58189118 A JP S58189118A
Authority
JP
Grant status
Application
Patent type
Prior art keywords
polypeptide
cyclodextrin
pharmaceutical
administration
digestive tract
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
JP7373182A
Other versions
JPH0219092B2 (en )
Inventor
Shinichiro Hirai
Hiroaki Okada
Koji Yashiki
Original Assignee
Takeda Chem Ind Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date

Links

Abstract

PURPOSE: The titled pharmaceutical, containing a polypeptide having the physiological activity and a cyclodextrin, and having improved absorptivity of the polypeptide and high safety without a pain in administration.
CONSTITUTION: A pernasal administration pharmaceutical containing a polypeptide having the phyiological activity, e.g. L-pyroglutamyl-L-histidyl-L-prolinamide (thyrotropin-releasing hormone) and a cyclodextrin (e.g. α-cyclodextrin). The polypeptide has a powerful hydrophilicity and low oil-water distribution coefficent and is not easily absorbed through the digestive tract due to the hydrolysis by enzymes in the wall of the digestive tract. The incorporation of the cyclodextrin increases the absorption of the polypeptide, and the pharmaceutical is highly safe in administration many times due to no taste, smell, toxicity nor irritation to the membranes.
COPYRIGHT: (C)1983,JPO&Japio
JP7373182A 1982-04-30 1982-04-30 Expired - Fee Related JPH0219092B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP7373182A JPH0219092B2 (en) 1982-04-30 1982-04-30

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
JP7373182A JPH0219092B2 (en) 1982-04-30 1982-04-30
EP19830302118 EP0094157B1 (en) 1982-04-30 1983-04-14 Pharmaceutical composition and its use
DE19833372705 DE3372705D1 (en) 1982-04-30 1983-04-14 Pharmaceutical composition and its use
US06487836 US4659696A (en) 1982-04-30 1983-04-22 Pharmaceutical composition and its nasal or vaginal use
CA 427018 CA1218606A (en) 1982-04-30 1983-04-29 Pharmaceutical composition and its nasal or vaginal use

Publications (2)

Publication Number Publication Date
JPS58189118A true true JPS58189118A (en) 1983-11-04
JPH0219092B2 JPH0219092B2 (en) 1990-04-27

Family

ID=13526667

Family Applications (1)

Application Number Title Priority Date Filing Date
JP7373182A Expired - Fee Related JPH0219092B2 (en) 1982-04-30 1982-04-30

Country Status (1)

Country Link
JP (1) JPH0219092B2 (en)

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5989619A (en) * 1982-10-05 1984-05-23 Sandoz Ag Calcitonin composition and use
JPS6357528A (en) * 1986-08-18 1988-03-12 Sandoz Ag Novel medicine
JPH01500116A (en) * 1986-04-18 1989-01-19
JPH01132532A (en) * 1987-10-15 1989-05-25 Syntex Usa Inc Nosal administration of powder-form polypeptides
US4985242A (en) * 1985-02-25 1991-01-15 Teljin Limited Intranasally applicable powdery pharmaceutical composition
WO1997006813A1 (en) * 1995-08-15 1997-02-27 Asahi Kasei Kogyo Kabushiki Kaisha Mucosal preparation containing physiologically active peptide

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0545521U (en) * 1991-11-20 1993-06-18 日本精機株式会社 Lighting device for a display plate
EP0709099A3 (en) 1994-09-28 1996-07-24 Senju Pharma Co An aqueous nasal suspension comprising cyclodextrin

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5989619A (en) * 1982-10-05 1984-05-23 Sandoz Ag Calcitonin composition and use
JPH0354647B2 (en) * 1982-10-05 1991-08-20
US4985242A (en) * 1985-02-25 1991-01-15 Teljin Limited Intranasally applicable powdery pharmaceutical composition
JPH01500116A (en) * 1986-04-18 1989-01-19
JPS6357528A (en) * 1986-08-18 1988-03-12 Sandoz Ag Novel medicine
JPH01132532A (en) * 1987-10-15 1989-05-25 Syntex Usa Inc Nosal administration of powder-form polypeptides
WO1997006813A1 (en) * 1995-08-15 1997-02-27 Asahi Kasei Kogyo Kabushiki Kaisha Mucosal preparation containing physiologically active peptide

Also Published As

Publication number Publication date Type
JPH0219092B2 (en) 1990-04-27 grant

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Legal Events

Date Code Title Description
LAPS Cancellation because of no payment of annual fees