JPS58128322A - 制癌剤 - Google Patents
制癌剤Info
- Publication number
- JPS58128322A JPS58128322A JP57011116A JP1111682A JPS58128322A JP S58128322 A JPS58128322 A JP S58128322A JP 57011116 A JP57011116 A JP 57011116A JP 1111682 A JP1111682 A JP 1111682A JP S58128322 A JPS58128322 A JP S58128322A
- Authority
- JP
- Japan
- Prior art keywords
- glycoprotein
- chlorella
- separated
- carcinostatic agent
- molecular weight
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 230000003327 cancerostatic effect Effects 0.000 title abstract 3
- 241000195649 Chlorella <Chlorellales> Species 0.000 claims abstract description 15
- 102000003886 Glycoproteins Human genes 0.000 claims abstract description 10
- 108090000288 Glycoproteins Proteins 0.000 claims abstract description 10
- 108090000623 proteins and genes Proteins 0.000 claims abstract description 6
- 102000004169 proteins and genes Human genes 0.000 claims abstract description 6
- 235000016425 Arthrospira platensis Nutrition 0.000 claims abstract description 4
- 240000002900 Arthrospira platensis Species 0.000 claims abstract description 4
- 229940082787 spirulina Drugs 0.000 claims abstract description 4
- 210000004027 cell Anatomy 0.000 abstract description 7
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 abstract description 6
- 239000012528 membrane Substances 0.000 abstract description 6
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 abstract description 4
- 230000000694 effects Effects 0.000 abstract description 4
- 238000000338 in vitro Methods 0.000 abstract description 4
- 210000004881 tumor cell Anatomy 0.000 abstract description 4
- 230000000259 anti-tumor effect Effects 0.000 abstract description 3
- 239000003795 chemical substances by application Substances 0.000 abstract description 3
- 238000001727 in vivo Methods 0.000 abstract description 3
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 abstract description 2
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 abstract description 2
- 239000001569 carbon dioxide Substances 0.000 abstract description 2
- 229910002092 carbon dioxide Inorganic materials 0.000 abstract description 2
- 238000004440 column chromatography Methods 0.000 abstract description 2
- 239000008103 glucose Substances 0.000 abstract description 2
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 abstract 1
- 241000195628 Chlorophyta Species 0.000 abstract 1
- 241000195663 Scenedesmus Species 0.000 abstract 1
- 239000004480 active ingredient Substances 0.000 abstract 1
- 229910052799 carbon Inorganic materials 0.000 abstract 1
- 229930182470 glycoside Natural products 0.000 abstract 1
- 150000002338 glycosides Chemical class 0.000 abstract 1
- 239000000126 substance Substances 0.000 description 15
- 241000699670 Mus sp. Species 0.000 description 14
- 150000001408 amides Chemical class 0.000 description 8
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 8
- 239000000843 powder Substances 0.000 description 7
- 238000010521 absorption reaction Methods 0.000 description 6
- 239000002246 antineoplastic agent Substances 0.000 description 6
- 238000000034 method Methods 0.000 description 5
- 238000012360 testing method Methods 0.000 description 5
- XKRFYHLGVUSROY-UHFFFAOYSA-N Argon Chemical compound [Ar] XKRFYHLGVUSROY-UHFFFAOYSA-N 0.000 description 4
- BVKZGUZCCUSVTD-UHFFFAOYSA-L Carbonate Chemical compound [O-]C([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-L 0.000 description 4
- 241000195493 Cryptophyta Species 0.000 description 4
- 238000005452 bending Methods 0.000 description 4
- 241000894007 species Species 0.000 description 4
- 208000028018 Lymphocytic leukaemia Diseases 0.000 description 3
- 241000283973 Oryctolagus cuniculus Species 0.000 description 3
- 125000000539 amino acid group Chemical group 0.000 description 3
- 150000001413 amino acids Chemical class 0.000 description 3
- 230000001093 anti-cancer Effects 0.000 description 3
- 239000000872 buffer Substances 0.000 description 3
- 239000000470 constituent Substances 0.000 description 3
- 238000007796 conventional method Methods 0.000 description 3
- 238000001962 electrophoresis Methods 0.000 description 3
- 208000003747 lymphoid leukemia Diseases 0.000 description 3
- 239000002609 medium Substances 0.000 description 3
- 210000004379 membrane Anatomy 0.000 description 3
- 239000000203 mixture Substances 0.000 description 3
- 239000000047 product Substances 0.000 description 3
- 230000004083 survival effect Effects 0.000 description 3
- 229920001817 Agar Polymers 0.000 description 2
- 101100005765 Arabidopsis thaliana CDF1 gene Proteins 0.000 description 2
- 101100007579 Arabidopsis thaliana CPP1 gene Proteins 0.000 description 2
- YZCKVEUIGOORGS-OUBTZVSYSA-N Deuterium Chemical compound [2H] YZCKVEUIGOORGS-OUBTZVSYSA-N 0.000 description 2
- XLYOFNOQVPJJNP-ZSJDYOACSA-N Heavy water Chemical compound [2H]O[2H] XLYOFNOQVPJJNP-ZSJDYOACSA-N 0.000 description 2
- 241000699666 Mus <mouse, genus> Species 0.000 description 2
- 238000001069 Raman spectroscopy Methods 0.000 description 2
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 2
- 239000002253 acid Substances 0.000 description 2
- 239000008272 agar Substances 0.000 description 2
- 229910052786 argon Inorganic materials 0.000 description 2
- 238000006243 chemical reaction Methods 0.000 description 2
- 229910052805 deuterium Inorganic materials 0.000 description 2
- 238000000605 extraction Methods 0.000 description 2
- 235000013305 food Nutrition 0.000 description 2
- 230000002401 inhibitory effect Effects 0.000 description 2
- 238000005259 measurement Methods 0.000 description 2
- 150000003214 pyranose derivatives Chemical class 0.000 description 2
- 239000002994 raw material Substances 0.000 description 2
- 230000000241 respiratory effect Effects 0.000 description 2
- 239000000243 solution Substances 0.000 description 2
- 238000004114 suspension culture Methods 0.000 description 2
- 238000002054 transplantation Methods 0.000 description 2
- 210000003462 vein Anatomy 0.000 description 2
- FYGDTMLNYKFZSV-URKRLVJHSA-N (2s,3r,4s,5s,6r)-2-[(2r,4r,5r,6s)-4,5-dihydroxy-2-(hydroxymethyl)-6-[(2r,4r,5r,6s)-4,5,6-trihydroxy-2-(hydroxymethyl)oxan-3-yl]oxyoxan-3-yl]oxy-6-(hydroxymethyl)oxane-3,4,5-triol Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC1[C@@H](CO)O[C@@H](OC2[C@H](O[C@H](O)[C@H](O)[C@H]2O)CO)[C@H](O)[C@H]1O FYGDTMLNYKFZSV-URKRLVJHSA-N 0.000 description 1
- 229920000310 Alpha glucan Polymers 0.000 description 1
- -1 Amino Acid Residues Amino acid Chemical class 0.000 description 1
- 229920002498 Beta-glucan Polymers 0.000 description 1
- GUBGYTABKSRVRQ-WFVLMXAXSA-N DEAE-cellulose Chemical compound OC1C(O)C(O)C(CO)O[C@H]1O[C@@H]1C(CO)OC(O)C(O)C1O GUBGYTABKSRVRQ-WFVLMXAXSA-N 0.000 description 1
- 229920001503 Glucan Polymers 0.000 description 1
- 241001529936 Murinae Species 0.000 description 1
- 229930182555 Penicillin Natural products 0.000 description 1
- JGSARLDLIJGVTE-MBNYWOFBSA-N Penicillin G Chemical compound N([C@H]1[C@H]2SC([C@@H](N2C1=O)C(O)=O)(C)C)C(=O)CC1=CC=CC=C1 JGSARLDLIJGVTE-MBNYWOFBSA-N 0.000 description 1
- 239000012980 RPMI-1640 medium Substances 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 230000000996 additive effect Effects 0.000 description 1
- 239000003513 alkali Substances 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 229940041181 antineoplastic drug Drugs 0.000 description 1
- 239000007853 buffer solution Substances 0.000 description 1
- 239000003560 cancer drug Substances 0.000 description 1
- 230000022534 cell killing Effects 0.000 description 1
- 239000001913 cellulose Substances 0.000 description 1
- 229920002678 cellulose Polymers 0.000 description 1
- 229940044683 chemotherapy drug Drugs 0.000 description 1
- 238000001142 circular dichroism spectrum Methods 0.000 description 1
- 238000010367 cloning Methods 0.000 description 1
- 230000015271 coagulation Effects 0.000 description 1
- 238000005345 coagulation Methods 0.000 description 1
- 239000012141 concentrate Substances 0.000 description 1
- 239000013078 crystal Substances 0.000 description 1
- 238000012136 culture method Methods 0.000 description 1
- 230000002354 daily effect Effects 0.000 description 1
- 238000000502 dialysis Methods 0.000 description 1
- 239000006185 dispersion Substances 0.000 description 1
- 239000012153 distilled water Substances 0.000 description 1
- 238000010828 elution Methods 0.000 description 1
- 230000003203 everyday effect Effects 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 210000003918 fraction a Anatomy 0.000 description 1
- 238000005194 fractionation Methods 0.000 description 1
- 238000004108 freeze drying Methods 0.000 description 1
- 230000002949 hemolytic effect Effects 0.000 description 1
- 230000001900 immune effect Effects 0.000 description 1
- 238000000760 immunoelectrophoresis Methods 0.000 description 1
- 230000003308 immunostimulating effect Effects 0.000 description 1
- 238000002513 implantation Methods 0.000 description 1
- 238000012844 infrared spectroscopy analysis Methods 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 230000001404 mediated effect Effects 0.000 description 1
- 230000003287 optical effect Effects 0.000 description 1
- 238000004816 paper chromatography Methods 0.000 description 1
- 229940049954 penicillin Drugs 0.000 description 1
- 210000004303 peritoneum Anatomy 0.000 description 1
- 239000008363 phosphate buffer Substances 0.000 description 1
- 238000002264 polyacrylamide gel electrophoresis Methods 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 230000035755 proliferation Effects 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 238000004062 sedimentation Methods 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 238000004611 spectroscopical analysis Methods 0.000 description 1
- 238000001694 spray drying Methods 0.000 description 1
- 238000010561 standard procedure Methods 0.000 description 1
- QAOWNCQODCNURD-UHFFFAOYSA-N sulfuric acid Substances OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 description 1
- 239000006228 supernatant Substances 0.000 description 1
- 230000002747 voluntary effect Effects 0.000 description 1
- 238000003809 water extraction Methods 0.000 description 1
Landscapes
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Plant Substances (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP57011116A JPS58128322A (ja) | 1982-01-27 | 1982-01-27 | 制癌剤 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP57011116A JPS58128322A (ja) | 1982-01-27 | 1982-01-27 | 制癌剤 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS58128322A true JPS58128322A (ja) | 1983-07-30 |
| JPS6330286B2 JPS6330286B2 (enrdf_load_stackoverflow) | 1988-06-17 |
Family
ID=11769033
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP57011116A Granted JPS58128322A (ja) | 1982-01-27 | 1982-01-27 | 制癌剤 |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS58128322A (enrdf_load_stackoverflow) |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0209078A3 (en) * | 1985-07-16 | 1988-04-27 | Chlorella Industry Co., Ltd | Anticancer agent |
| JPS63239231A (ja) * | 1987-03-27 | 1988-10-05 | Kurorera Kogyo Kk | 分化誘導剤 |
| US6893642B1 (en) * | 1999-07-19 | 2005-05-17 | Qing Qi | Algae protein polysaccharide extraction and use thereof |
| JP2008255057A (ja) * | 2007-04-05 | 2008-10-23 | Noda Shokukin Kogyo Kk | 抗癌剤、抗癌剤の製造方法、及び飲食品 |
| JP2011522911A (ja) * | 2008-05-06 | 2011-08-04 | オーシャン ニュートリッション カナダ リミテッド | 免疫調節特性を有するクロレラ抽出物から得られる組成物 |
-
1982
- 1982-01-27 JP JP57011116A patent/JPS58128322A/ja active Granted
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0209078A3 (en) * | 1985-07-16 | 1988-04-27 | Chlorella Industry Co., Ltd | Anticancer agent |
| US4822612A (en) * | 1985-07-16 | 1989-04-18 | Chlorella Industry Co., Ltd. | Anticancer agent |
| JPS63239231A (ja) * | 1987-03-27 | 1988-10-05 | Kurorera Kogyo Kk | 分化誘導剤 |
| US6893642B1 (en) * | 1999-07-19 | 2005-05-17 | Qing Qi | Algae protein polysaccharide extraction and use thereof |
| JP2008255057A (ja) * | 2007-04-05 | 2008-10-23 | Noda Shokukin Kogyo Kk | 抗癌剤、抗癌剤の製造方法、及び飲食品 |
| JP2011522911A (ja) * | 2008-05-06 | 2011-08-04 | オーシャン ニュートリッション カナダ リミテッド | 免疫調節特性を有するクロレラ抽出物から得られる組成物 |
Also Published As
| Publication number | Publication date |
|---|---|
| JPS6330286B2 (enrdf_load_stackoverflow) | 1988-06-17 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US4699787A (en) | Nitrogen-containing polysaccharide | |
| JPS6219528A (ja) | 制癌剤 | |
| JPS5896025A (ja) | 新規生理活性物質ｃｈ−１およびその製造法 | |
| CN108546306A (zh) | 一种蛹虫草培养基多糖及其分离纯化方法和用途 | |
| JPS58128322A (ja) | 制癌剤 | |
| JPH0920672A (ja) | 抗アレルギー物質、その製造方法、抗アレルギー剤及び機能性食品 | |
| JP4081663B2 (ja) | Ａｎｔｒｏｄｉａｃａｍｐｈｏｒａｔａの培養物の製造方法およびそれによって得られるプロダクト | |
| CN114686542B (zh) | 一种低分子量牛樟芝胞外多糖及其制备和应用 | |
| EP0286869B1 (de) | Verfahren zur Herstellung von Zellwandkomponenten aus Halobakterien und deren Verwendung als Arzneimittel | |
| EP0132981A2 (en) | Hypotriglyceridemically active polysaccharides | |
| CN108503724A (zh) | 蛹虫草培养基多糖及其分离纯化方法和应用 | |
| JPH0413684A (ja) | リグニン配糖体およびその用途 | |
| JPS6328888B2 (enrdf_load_stackoverflow) | ||
| US3905870A (en) | Purification of kallikrein | |
| JPH0721003B2 (ja) | 多糖体およびその製造方法 | |
| Hakomori et al. | Fractionation of compound lipids by dialysation in an organic solvent against an organic solvent | |
| JPH03205402A (ja) | リグニン配糖体およびその用途 | |
| CN111960932B (zh) | 二氯雷琐酚类化合物及其制备方法和医药用途 | |
| CN117088991B (zh) | 一种粗毛纤孔菌多糖及其制备方法和在制备免疫调节药物中的应用 | |
| CN113116758B (zh) | 一种灵芝提取液的制备方法 | |
| US3718741A (en) | N-1 and N-2 FRACTIONS OF NEOCARZIONSTATIN | |
| Saim et al. | Low molecular weight immunosuppressive factors found in elevated amounts in cancer ascitic fluids of mice 1. Isolation, identification and immunosuppressive effects of uric acid and uracil | |
| JP2961431B2 (ja) | 新規生理活性物質およびその製造方法 | |
| JPH09241172A (ja) | 生理活性剤 | |
| JPS6169728A (ja) | 制癌剤 |