JPS57122798A - Production of 3 beta, 7 beta-dihydroxy- delta 5-steroid - Google Patents

Production of 3 beta, 7 beta-dihydroxy- delta 5-steroid

Info

Publication number
JPS57122798A
JPS57122798A JP56174650A JP17465081A JPS57122798A JP S57122798 A JPS57122798 A JP S57122798A JP 56174650 A JP56174650 A JP 56174650A JP 17465081 A JP17465081 A JP 17465081A JP S57122798 A JPS57122798 A JP S57122798A
Authority
JP
Japan
Prior art keywords
beta
steroid
delta
dihydroxy
image
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP56174650A
Other languages
English (en)
Japanese (ja)
Other versions
JPH0121759B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html
Inventor
Petsuoruto Kaaru
Buiihieruto Rudorufu
Raurento Henrii
Nikishiyu Kurausu
Bitoraa Deiitaa
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer Pharma AG
Original Assignee
Schering AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering AG filed Critical Schering AG
Publication of JPS57122798A publication Critical patent/JPS57122798A/ja
Publication of JPH0121759B2 publication Critical patent/JPH0121759B2/ja
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P33/00—Preparation of steroids
    • C12P33/06—Hydroxylating
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J53/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by condensation with a carbocyclic rings or by formation of an additional ring by means of a direct link between two ring carbon atoms, including carboxyclic rings fused to the cyclopenta(a)hydrophenanthrene skeleton are included in this class
    • C07J53/002—Carbocyclic rings fused
    • C07J53/004—3 membered carbocyclic rings
    • C07J53/008—3 membered carbocyclic rings in position 15/16
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0005—Oxygen-containing hetero ring
    • C07J71/001—Oxiranes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Microbiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Steroid Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
JP56174650A 1980-11-03 1981-11-02 Production of 3 beta, 7 beta-dihydroxy- delta 5-steroid Granted JPS57122798A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19803042136 DE3042136A1 (de) 1980-11-03 1980-11-03 Verfahren zur herstellung von 3 (beta), 7 (beta) -dihydroxy- (delta) (pfeil hoch)5(pfeil hoch) -steroiden

Publications (2)

Publication Number Publication Date
JPS57122798A true JPS57122798A (en) 1982-07-30
JPH0121759B2 JPH0121759B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 1989-04-24

Family

ID=6116255

Family Applications (1)

Application Number Title Priority Date Filing Date
JP56174650A Granted JPS57122798A (en) 1980-11-03 1981-11-02 Production of 3 beta, 7 beta-dihydroxy- delta 5-steroid

Country Status (6)

Country Link
US (2) US4416985A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
EP (1) EP0051143B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
JP (1) JPS57122798A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
AT (1) ATE8274T1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
DE (2) DE3042136A1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
DK (1) DK157892C (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2008522962A (ja) * 2004-12-06 2008-07-03 インダストリアレ チミカ ソシエタ ア レスポンサビリタ リミタータ ドロスピレノンの調製方法

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0075189B1 (en) * 1981-09-21 1985-08-28 Schering Aktiengesellschaft 3-beta,7-beta,15-alpha-trihydroxy-5-androsten-17-one, its 3,15-dipivalate, and its preparation
KR0147376B1 (ko) * 1988-07-07 1998-08-17 오노 알버어스 개질된 폴리페닐렌 에테르의 제조 방법 및 비닐 치환 방향족의 개질된 고온 경질 중합체 내에서의 이의 사용 방법
US5219951A (en) * 1988-07-07 1993-06-15 Shell Internationale Research Maatschappij B.V. Process for preparation of modified polyphenylene ether or related polymers and the use thereof in modified high temperature rigid polymer of vinyl substituted aromatics
US5215894A (en) * 1992-02-25 1993-06-01 Merck & Co., Inc. Biological process for producing 17β-N-monosubstituted carbamoyl-11-oxo-4-aza-5-α-androst-3-one testosterone-5-α reductase inhibitors
DE19633685C1 (de) * 1996-08-12 1997-10-09 Schering Ag Verfahren zur Herstellung von Drospirenon (6beta,7beta;15 beta,16beta-Dimethyl-en-3-oxo-17alpha-pregn-4-en-21,17-carbolacton, DRSP) sowie 7alpha-(3-Hydroxy-1-propyl)-6beta,7beta;15beta, 16beta-dimethylen-5beta-androstan-3beta,5,17beta-triol (ZK 92836) und 6beta,7beta;15beta,16beta-dimethylen-5beta-hydroxy-3-oxo-17alpha-androstan-21,17-carbolacton (90965) als Zwischenprodukte des Verfahrens
US20070066579A1 (en) * 2002-08-16 2007-03-22 White Michael J 5-androsten-3beta-ol steroid intermediates and processs for their preparation
AU2003285485A1 (en) * 2002-08-16 2004-03-03 Pharmacia & Upjohn Company Llc 5 ANDROSTEN-3Beta-OL STEROID INTERMEDIATES AND PROCESSES FOR THEIR PREPARATION
HUP0402465A2 (en) * 2004-11-30 2006-07-28 Richter Gedeon Vegyeszet Industrial process for preparing 17-hydroxy-6-betha, 7-betha, 15-betha, 16-betha-bis-methylene-3-oxo-17-alpha-pregn-4-ene-21-carboxylic acid gamma lacton and the main intermediates of the process
HUP0402466A2 (en) * 2004-11-30 2006-07-28 Richter Gedeon Vegyeszet Industrial process for preparing 17-hydroxy-6-betha, 7-betha, 15-betha, 16-betha-bis-methylene-3-oxo-17-alpha-pregn-4-ene-21-carboxylic acid gamma lacton and the main, intermediates of the process
NZ565247A (en) 2005-07-21 2011-02-25 Bayer Schering Pharma Ag Process for the production drospirenone utilising the metal-free oxidation of 17-(3-hydroxypropyl)-3,17-dihydroxyandrostanes with TEMPO
EP1746101B2 (de) 2005-07-21 2014-05-14 Bayer Pharma Aktiengesellschaft Verfahren zur Herstellung von 3-Oxo-pregn-4-en-21,17-carbolactonen durch die metallfreie Oxidation von 17-(3-hydroxypropyl)-3,17-dihydroxyandrostanen
US20090023914A1 (en) * 2007-05-01 2009-01-22 Alessandro Pontiroli Process for preparing drospirenone and intermediate thereof
DE102007030596B3 (de) * 2007-06-28 2009-03-12 Bayer Schering Pharma Aktiengesellschaft Verfahren zur Herstellung von 17-(3-Hydroxypropyl)-17-hydroxysteroiden
ATE491717T1 (de) 2007-07-26 2011-01-15 Newchem S P A Herstellungsverfahren für drospirenon
CN101570775B (zh) * 2008-05-04 2012-03-21 上海医药工业研究院 微生物转化法制备3β,7β-二羟基-15β,16β-亚甲基-5-雄烯-17-酮的方法
ES2432063T3 (es) * 2009-06-16 2013-11-29 Crystal Pharma, S.A.U. Procedimiento para la obtención de 17-espirolactonas en esteroides
EP2415778B1 (en) 2010-08-03 2013-05-15 Newchem S.p.A. Methods for the preparation of Drospirenone and intermediates thereof
WO2012107513A1 (en) 2011-02-10 2012-08-16 Crystal Pharma, S.A.U. Process for obtaining drospirenone
ES2630331T3 (es) 2013-04-12 2017-08-21 Industriale Chimica S.R.L. Proceso para la preparación de drospirenona
WO2014174338A1 (en) 2013-04-22 2014-10-30 Industriale Chimica S.R.L. Process for preparing an intermediate useful in the production of drospirenone
CN109824751B (zh) * 2019-04-08 2021-11-26 郑州大学 一种15β，16β-环丙烷化制备屈螺酮关键中间体的方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3429778A (en) * 1967-08-24 1969-02-25 Squibb & Sons Inc Synthesis of steroids
NL7701384A (nl) * 1977-02-10 1978-08-14 Akzo Nv Werkwijze voor het bereiden van nieuwe steroiden van de oestraanreeks.
US4267117A (en) * 1978-06-19 1981-05-12 The Upjohn Company Compounds and process
US4336332A (en) 1979-02-20 1982-06-22 Hoffmann-La Roche, Inc. Process for the manufacture of hydroxylated steroids
EP0075189B1 (en) * 1981-09-21 1985-08-28 Schering Aktiengesellschaft 3-beta,7-beta,15-alpha-trihydroxy-5-androsten-17-one, its 3,15-dipivalate, and its preparation
US4470981A (en) * 1982-12-20 1984-09-11 Hesse Robert H Chemical compounds

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2008522962A (ja) * 2004-12-06 2008-07-03 インダストリアレ チミカ ソシエタ ア レスポンサビリタ リミタータ ドロスピレノンの調製方法

Also Published As

Publication number Publication date
EP0051143B1 (de) 1984-07-04
DK157892C (da) 1990-08-06
US4614616A (en) 1986-09-30
DE3164576D1 (en) 1984-08-09
EP0051143A1 (de) 1982-05-12
ATE8274T1 (de) 1984-07-15
DK157892B (da) 1990-02-26
DE3042136A1 (de) 1982-06-09
JPH0121759B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 1989-04-24
DK484781A (da) 1982-05-04
US4416985A (en) 1983-11-22

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