JPS5690036A - Cyclohexylidene acetic acid derivative and its preparation - Google Patents

Cyclohexylidene acetic acid derivative and its preparation

Info

Publication number
JPS5690036A
JPS5690036A JP16683779A JP16683779A JPS5690036A JP S5690036 A JPS5690036 A JP S5690036A JP 16683779 A JP16683779 A JP 16683779A JP 16683779 A JP16683779 A JP 16683779A JP S5690036 A JPS5690036 A JP S5690036A
Authority
JP
Japan
Prior art keywords
compound
formula
preparation
react
acetic acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP16683779A
Other languages
Japanese (ja)
Inventor
Kiyohide Matsui
Etsuko Kasai
Akemi Tanaka
Akira Negishi
Sei Kondo
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sagami Chemical Research Institute
Original Assignee
Sagami Chemical Research Institute
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sagami Chemical Research Institute filed Critical Sagami Chemical Research Institute
Priority to JP16683779A priority Critical patent/JPS5690036A/en
Publication of JPS5690036A publication Critical patent/JPS5690036A/en
Pending legal-status Critical Current

Links

Classifications

    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

NEW MATERIAL:The titled compound of formula I (Ar is aryl; R1 is H or lower alkyl; R2 is H or alkyl).
EXAMPLE: Ethyl α-(3-benzoylcyclohexylidene)propionate.
USE: Intermediates for the preparation of ketoprofen having lenitive and anti-inflammatory activities. Ketoprofen or its analogs are prepared in high yield in a short process.
PROCESS: A compound of formula II [R4 is disubstituted amino, group of OR5 or SR6; (R5 is protecting group of OH; R6 is protecting group of thiol)] is made to react with 2-cyclohexenone in the presence of a basic catalyst (e.g. NaOH, KOH etc.) and then hydrolyzed to give a compound of formula III. The compound obtained is made to react with a compound of formula IV (R3 is lower alkyl) in the presence of a base to afford a compound of formula V, which is then made to react with a compound of CuX2 (X is halogen) to give the titled compound of formula I.
COPYRIGHT: (C)1981,JPO&Japio
JP16683779A 1979-12-24 1979-12-24 Cyclohexylidene acetic acid derivative and its preparation Pending JPS5690036A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP16683779A JPS5690036A (en) 1979-12-24 1979-12-24 Cyclohexylidene acetic acid derivative and its preparation

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP16683779A JPS5690036A (en) 1979-12-24 1979-12-24 Cyclohexylidene acetic acid derivative and its preparation

Publications (1)

Publication Number Publication Date
JPS5690036A true JPS5690036A (en) 1981-07-21

Family

ID=15838568

Family Applications (1)

Application Number Title Priority Date Filing Date
JP16683779A Pending JPS5690036A (en) 1979-12-24 1979-12-24 Cyclohexylidene acetic acid derivative and its preparation

Country Status (1)

Country Link
JP (1) JPS5690036A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2014024755A (en) * 2012-07-24 2014-02-06 Daikin Ind Ltd PRODUCTION METHOD OF α-FLUOROACRYLATE ESTER

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2014024755A (en) * 2012-07-24 2014-02-06 Daikin Ind Ltd PRODUCTION METHOD OF α-FLUOROACRYLATE ESTER

Similar Documents

Publication Publication Date Title
JPS5587771A (en) 1-phenylisoquinoline derivative
JPS5690031A (en) Preparation of aromatic aldehyde
IE36116B1 (en) Furylmethyl morphinane derivatives and pharmaceutical compositions containing them
JPS5690036A (en) Cyclohexylidene acetic acid derivative and its preparation
JPS5524116A (en) Preparation of o-(2, 6-dichloroanilino)-phenylacetic acid
JPS5690035A (en) Cyclohexylidene acetic acid derivative
JPS5655355A (en) Preparation of alkylenediamine derivative
JPS5517324A (en) Preparation of thiophosphoric acid ester
JPS5798232A (en) 1-(6-methoxy-2-naphthyl)-2-oxy-1-alkanone acetal
JPS56125333A (en) Phenylacetic acid derivative and its preparation
JPS57192342A (en) Isoprenylamine derivative
JPS5629542A (en) Preparation of phenylacetic acid derivative
JPS5325551A (en) Intermediates for preparing oxacephalosporins
JPS57126427A (en) Preparation of 1-substituted-azulene derivative
JPS5463024A (en) 3-(n-formyl-n-hydroxyamino)-2(r)-hydroxypropyl-phosphonic acid, its preparation, and its use
JPS572257A (en) Preparation of 4-hydroxybenzylnitrile derivative
JPS56164144A (en) Preparation of novel aryloxyacid derivative
JPS54125633A (en) 4-chloro-3,5-diaminophenyl acetate, its preparation, and hardeners for preparing polyurethane elastomers
JPS57192343A (en) Isoprenylamine derivative
JPS5436226A (en) Preparation of derivative of phenyl acetic acid
JPS5239648A (en) Aprocess for preparing p-cyanobenzoic acid amide from terephthalonitril e
JPS5564596A (en) Preparation of alkylmethyl-3-dialkoxy-propylphosphinate
JPS56147787A (en) Preparation of theobromine derivative
JPS57188549A (en) Preparation of 2-aminobutyric acid derivative
JPS5490158A (en) Novel benzoylphenoxyacetic acid derivatives