JPS5549353A - Preparation of indole - Google Patents
Preparation of indoleInfo
- Publication number
- JPS5549353A JPS5549353A JP12250278A JP12250278A JPS5549353A JP S5549353 A JPS5549353 A JP S5549353A JP 12250278 A JP12250278 A JP 12250278A JP 12250278 A JP12250278 A JP 12250278A JP S5549353 A JPS5549353 A JP S5549353A
- Authority
- JP
- Japan
- Prior art keywords
- sodium
- formula
- indole
- ring closure
- amide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Indole Compounds (AREA)
Abstract
PURPOSE: To obtain a specific indole for perfumes, while recovering and reusing the by-product amine readily, by ring closure of an easily synthesized N,N'-diarylformamidine with sodium (aryl)amide.
CONSTITUTION: An easily synthesized formamidine of formula I: (R, R1, R2, and R3 are H or 1W6C alkyl group; R4 is H or CH2R) is subjected to ring closure with sodium amide and/or sodium-arylamide of formula II in the presence or absence of an inert solvent to give an indole substituted by alkyl groups at the 3- to 7-positions of formula III. The raw material can be readily obtained by heating a mixture of an arylamine formic acid in the presence of a catalytic amount of boric acid in high yield. The by-product amine can be easily recovered and reused. Distillation of the reaction product permits a high purity ≥99.
USE: An intermediate for the synthesis of varoius organic compounds.
COPYRIGHT: (C)1980,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP12250278A JPS5549353A (en) | 1978-10-06 | 1978-10-06 | Preparation of indole |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP12250278A JPS5549353A (en) | 1978-10-06 | 1978-10-06 | Preparation of indole |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS5549353A true JPS5549353A (en) | 1980-04-09 |
JPS638104B2 JPS638104B2 (en) | 1988-02-19 |
Family
ID=14837424
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP12250278A Granted JPS5549353A (en) | 1978-10-06 | 1978-10-06 | Preparation of indole |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS5549353A (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5879977A (en) * | 1981-11-06 | 1983-05-13 | Nippon Kayaku Co Ltd | Preparation of indole |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH01293214A (en) * | 1988-05-20 | 1989-11-27 | Kayaba Ind Co Ltd | Attitude control device |
JPH0740214U (en) * | 1993-12-27 | 1995-07-18 | 勉 中山 | Attitude control device for automobile |
-
1978
- 1978-10-06 JP JP12250278A patent/JPS5549353A/en active Granted
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5879977A (en) * | 1981-11-06 | 1983-05-13 | Nippon Kayaku Co Ltd | Preparation of indole |
JPH0138105B2 (en) * | 1981-11-06 | 1989-08-11 | Nippon Kayaku Kk |
Also Published As
Publication number | Publication date |
---|---|
JPS638104B2 (en) | 1988-02-19 |
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