JPS5527153A - Production of 3,5-dimethyl-4-lower alkoxycarbonyl phthailc anhydride - Google Patents
Production of 3,5-dimethyl-4-lower alkoxycarbonyl phthailc anhydrideInfo
- Publication number
- JPS5527153A JPS5527153A JP10007078A JP10007078A JPS5527153A JP S5527153 A JPS5527153 A JP S5527153A JP 10007078 A JP10007078 A JP 10007078A JP 10007078 A JP10007078 A JP 10007078A JP S5527153 A JPS5527153 A JP S5527153A
- Authority
- JP
- Japan
- Prior art keywords
- formula
- anhydride
- lower alkyl
- acid
- acid anhydride
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Furan Compounds (AREA)
Abstract
PURPOSE: An acid anhydride is made to react with a lower alkyl ester of isodehydroacetic acid to give title compound useful as an synthetic intermediate of phthalazone derivatives used as a drug for cerebral thrombosis and hemorrhage because of its activity of inhibiting blood platelet coagulation.
CONSTITUTION: The reaction between an acid anhydride of formula I (A is a group of formula II or III; X is halogen) and a lower alkyl ester of isodehydroacetic acid of formula IV (R is lower alkyl of 1W6 carbon atoms) is effected at 50W 250°C to give title compound of formula V with high safety in one stage process. The process is unnecessary for using toxic and decomposable substances that have been used in the conventional processes and consists of reduced steps. The acid anhydride is, e.g., a monohalide of maleic anhydride.
COPYRIGHT: (C)1980,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP10007078A JPS5934190B2 (en) | 1978-08-18 | 1978-08-18 | Method for producing 3,5↓-dimethyl↓-4↓-lower alkoxycarbonyl phthalic anhydride |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP10007078A JPS5934190B2 (en) | 1978-08-18 | 1978-08-18 | Method for producing 3,5↓-dimethyl↓-4↓-lower alkoxycarbonyl phthalic anhydride |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS5527153A true JPS5527153A (en) | 1980-02-27 |
JPS5934190B2 JPS5934190B2 (en) | 1984-08-21 |
Family
ID=14264192
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP10007078A Expired JPS5934190B2 (en) | 1978-08-18 | 1978-08-18 | Method for producing 3,5↓-dimethyl↓-4↓-lower alkoxycarbonyl phthalic anhydride |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS5934190B2 (en) |
-
1978
- 1978-08-18 JP JP10007078A patent/JPS5934190B2/en not_active Expired
Also Published As
Publication number | Publication date |
---|---|
JPS5934190B2 (en) | 1984-08-21 |
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