JPS5527153A - Production of 3,5-dimethyl-4-lower alkoxycarbonyl phthailc anhydride - Google Patents

Production of 3,5-dimethyl-4-lower alkoxycarbonyl phthailc anhydride

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Publication number
JPS5527153A
JPS5527153A JP10007078A JP10007078A JPS5527153A JP S5527153 A JPS5527153 A JP S5527153A JP 10007078 A JP10007078 A JP 10007078A JP 10007078 A JP10007078 A JP 10007078A JP S5527153 A JPS5527153 A JP S5527153A
Authority
JP
Japan
Prior art keywords
formula
anhydride
lower alkyl
acid
acid anhydride
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP10007078A
Other languages
Japanese (ja)
Other versions
JPS5934190B2 (en
Inventor
Taichi Koshigoe
Masao Takei
Tadashi Fujii
Rinzo Nishizawa
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Nippon Kayaku Co Ltd
Original Assignee
Nippon Kayaku Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nippon Kayaku Co Ltd filed Critical Nippon Kayaku Co Ltd
Priority to JP10007078A priority Critical patent/JPS5934190B2/en
Publication of JPS5527153A publication Critical patent/JPS5527153A/en
Publication of JPS5934190B2 publication Critical patent/JPS5934190B2/en
Expired legal-status Critical Current

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Abstract

PURPOSE: An acid anhydride is made to react with a lower alkyl ester of isodehydroacetic acid to give title compound useful as an synthetic intermediate of phthalazone derivatives used as a drug for cerebral thrombosis and hemorrhage because of its activity of inhibiting blood platelet coagulation.
CONSTITUTION: The reaction between an acid anhydride of formula I (A is a group of formula II or III; X is halogen) and a lower alkyl ester of isodehydroacetic acid of formula IV (R is lower alkyl of 1W6 carbon atoms) is effected at 50W 250°C to give title compound of formula V with high safety in one stage process. The process is unnecessary for using toxic and decomposable substances that have been used in the conventional processes and consists of reduced steps. The acid anhydride is, e.g., a monohalide of maleic anhydride.
COPYRIGHT: (C)1980,JPO&Japio
JP10007078A 1978-08-18 1978-08-18 Method for producing 3,5↓-dimethyl↓-4↓-lower alkoxycarbonyl phthalic anhydride Expired JPS5934190B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP10007078A JPS5934190B2 (en) 1978-08-18 1978-08-18 Method for producing 3,5↓-dimethyl↓-4↓-lower alkoxycarbonyl phthalic anhydride

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP10007078A JPS5934190B2 (en) 1978-08-18 1978-08-18 Method for producing 3,5↓-dimethyl↓-4↓-lower alkoxycarbonyl phthalic anhydride

Publications (2)

Publication Number Publication Date
JPS5527153A true JPS5527153A (en) 1980-02-27
JPS5934190B2 JPS5934190B2 (en) 1984-08-21

Family

ID=14264192

Family Applications (1)

Application Number Title Priority Date Filing Date
JP10007078A Expired JPS5934190B2 (en) 1978-08-18 1978-08-18 Method for producing 3,5↓-dimethyl↓-4↓-lower alkoxycarbonyl phthalic anhydride

Country Status (1)

Country Link
JP (1) JPS5934190B2 (en)

Also Published As

Publication number Publication date
JPS5934190B2 (en) 1984-08-21

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