JPS55118489A - Heterocyclic ring condensed naphthyridine derivative - Google Patents
Heterocyclic ring condensed naphthyridine derivativeInfo
- Publication number
- JPS55118489A JPS55118489A JP2651879A JP2651879A JPS55118489A JP S55118489 A JPS55118489 A JP S55118489A JP 2651879 A JP2651879 A JP 2651879A JP 2651879 A JP2651879 A JP 2651879A JP S55118489 A JPS55118489 A JP S55118489A
- Authority
- JP
- Japan
- Prior art keywords
- compound
- formula
- derivative
- heterocyclic ring
- ring condensed
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
NEW MATERIAL:A heterocyclic ring condensed naphthyridine derivative of formula I (X is O or S; R is lower alkyl group), and its salt.
EXAMPLE: 8-Ethyl-5,8-dihydro-5-oxofuro[2,3-b]1,8-naphthyridine-6-carboxylic acid.
USE: Antibacterials effective against Gram-positive and Gram-negative bacteria.
PROCESS: A compound of formula II (R' is R) is alkylated to form a compound of formula III (R" is R), which is converted into an 6-NH2 derivative, which is led to an 7-OH derivative via the 6-CN and 6-CHO derivatives. The resulting 7-OH derivative is reacted with a bromomalonic ester to form a compound of formula VIII a compound of formula IX. The compound thus obtained is decarboxylated partly by heating in a solvent, e.g. quinoline, in the presence of copper powder to afford the compound of formula Ia.
COPYRIGHT: (C)1980,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2651879A JPS55118489A (en) | 1979-03-07 | 1979-03-07 | Heterocyclic ring condensed naphthyridine derivative |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2651879A JPS55118489A (en) | 1979-03-07 | 1979-03-07 | Heterocyclic ring condensed naphthyridine derivative |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS55118489A true JPS55118489A (en) | 1980-09-11 |
JPS6237637B2 JPS6237637B2 (en) | 1987-08-13 |
Family
ID=12195690
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2651879A Granted JPS55118489A (en) | 1979-03-07 | 1979-03-07 | Heterocyclic ring condensed naphthyridine derivative |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS55118489A (en) |
-
1979
- 1979-03-07 JP JP2651879A patent/JPS55118489A/en active Granted
Also Published As
Publication number | Publication date |
---|---|
JPS6237637B2 (en) | 1987-08-13 |
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