JPS54157820A - Preparation of multi-layered suppository base - Google Patents
Preparation of multi-layered suppository baseInfo
- Publication number
- JPS54157820A JPS54157820A JP6528978A JP6528978A JPS54157820A JP S54157820 A JPS54157820 A JP S54157820A JP 6528978 A JP6528978 A JP 6528978A JP 6528978 A JP6528978 A JP 6528978A JP S54157820 A JPS54157820 A JP S54157820A
- Authority
- JP
- Japan
- Prior art keywords
- active agent
- molten
- water
- surface active
- base
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Medicinal Preparation (AREA)
Abstract
PURPOSE: To prepare a rapid- and long-acting double-layered suppository, in a simple process, by pouring a molten water-soluble base and a molten oleagenous base successively into a mold of the suppository, wherein at least one of the bases contains a surface active agent as a binding component, and solidifying the melt.
CONSTITUTION: A water-soluble base such as macrogol, etc., is molten, and mixed with an effective drug component, a surface active agent which acts as a binder between two layers, pref. a nonionic surface active agent such as polyethylene glycol monostearate, etc., and if necessary, colorants, preservatives, etc. The mixture is poured into a mold of suppository. An oleaginous base prepared by the process similar to the above, is poured into the mold containing the water-soluble base, while the surface of the water-soluble base is still molten or at least semi- solid, and cooled below the melting points of the bases. One of the bases is not necessarily added with the surface active agent.
COPYRIGHT: (C)1979,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP6528978A JPS54157820A (en) | 1978-05-30 | 1978-05-30 | Preparation of multi-layered suppository base |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP6528978A JPS54157820A (en) | 1978-05-30 | 1978-05-30 | Preparation of multi-layered suppository base |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS54157820A true JPS54157820A (en) | 1979-12-13 |
JPS5632289B2 JPS5632289B2 (en) | 1981-07-27 |
Family
ID=13282616
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP6528978A Granted JPS54157820A (en) | 1978-05-30 | 1978-05-30 | Preparation of multi-layered suppository base |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS54157820A (en) |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4462984A (en) * | 1979-10-26 | 1984-07-31 | Nippon Oil And Fats Company, Ltd. | Suppository base composition |
US4784855A (en) * | 1986-06-16 | 1988-11-15 | Otsuka Pharmaceutical Co., Ltd. | Pharmaceutical compositions and suppository |
CN103285002A (en) * | 2013-04-25 | 2013-09-11 | 烟台绿叶动物保健品有限公司 | Compound norfloxacin double-layered suppository for animals, and preparation method thereof |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS6384691U (en) * | 1986-11-18 | 1988-06-03 | ||
JPS63107098U (en) * | 1986-12-26 | 1988-07-11 |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3122475A (en) * | 1960-02-25 | 1964-02-25 | Schaeppi Ag Dr | Circulatory adjuvant shell elements for cardiac glycoside suppository cores |
JPS50157518A (en) * | 1974-06-11 | 1975-12-19 |
-
1978
- 1978-05-30 JP JP6528978A patent/JPS54157820A/en active Granted
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3122475A (en) * | 1960-02-25 | 1964-02-25 | Schaeppi Ag Dr | Circulatory adjuvant shell elements for cardiac glycoside suppository cores |
JPS50157518A (en) * | 1974-06-11 | 1975-12-19 |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4462984A (en) * | 1979-10-26 | 1984-07-31 | Nippon Oil And Fats Company, Ltd. | Suppository base composition |
US4784855A (en) * | 1986-06-16 | 1988-11-15 | Otsuka Pharmaceutical Co., Ltd. | Pharmaceutical compositions and suppository |
CN103285002A (en) * | 2013-04-25 | 2013-09-11 | 烟台绿叶动物保健品有限公司 | Compound norfloxacin double-layered suppository for animals, and preparation method thereof |
Also Published As
Publication number | Publication date |
---|---|
JPS5632289B2 (en) | 1981-07-27 |
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