JPS54157820A - Preparation of multi-layered suppository base - Google Patents

Preparation of multi-layered suppository base

Info

Publication number
JPS54157820A
JPS54157820A JP6528978A JP6528978A JPS54157820A JP S54157820 A JPS54157820 A JP S54157820A JP 6528978 A JP6528978 A JP 6528978A JP 6528978 A JP6528978 A JP 6528978A JP S54157820 A JPS54157820 A JP S54157820A
Authority
JP
Japan
Prior art keywords
active agent
molten
water
surface active
base
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP6528978A
Other languages
Japanese (ja)
Other versions
JPS5632289B2 (en
Inventor
Takahiro Yabuuchi
Tsunetoshi Hino
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Research Institute for Production Development
Zaidan Hojin Seisan Kaihatsu Kenkyusho
Original Assignee
Research Institute for Production Development
Zaidan Hojin Seisan Kaihatsu Kenkyusho
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Research Institute for Production Development, Zaidan Hojin Seisan Kaihatsu Kenkyusho filed Critical Research Institute for Production Development
Priority to JP6528978A priority Critical patent/JPS54157820A/en
Publication of JPS54157820A publication Critical patent/JPS54157820A/en
Publication of JPS5632289B2 publication Critical patent/JPS5632289B2/ja
Granted legal-status Critical Current

Links

Landscapes

  • Medicinal Preparation (AREA)

Abstract

PURPOSE: To prepare a rapid- and long-acting double-layered suppository, in a simple process, by pouring a molten water-soluble base and a molten oleagenous base successively into a mold of the suppository, wherein at least one of the bases contains a surface active agent as a binding component, and solidifying the melt.
CONSTITUTION: A water-soluble base such as macrogol, etc., is molten, and mixed with an effective drug component, a surface active agent which acts as a binder between two layers, pref. a nonionic surface active agent such as polyethylene glycol monostearate, etc., and if necessary, colorants, preservatives, etc. The mixture is poured into a mold of suppository. An oleaginous base prepared by the process similar to the above, is poured into the mold containing the water-soluble base, while the surface of the water-soluble base is still molten or at least semi- solid, and cooled below the melting points of the bases. One of the bases is not necessarily added with the surface active agent.
COPYRIGHT: (C)1979,JPO&Japio
JP6528978A 1978-05-30 1978-05-30 Preparation of multi-layered suppository base Granted JPS54157820A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP6528978A JPS54157820A (en) 1978-05-30 1978-05-30 Preparation of multi-layered suppository base

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP6528978A JPS54157820A (en) 1978-05-30 1978-05-30 Preparation of multi-layered suppository base

Publications (2)

Publication Number Publication Date
JPS54157820A true JPS54157820A (en) 1979-12-13
JPS5632289B2 JPS5632289B2 (en) 1981-07-27

Family

ID=13282616

Family Applications (1)

Application Number Title Priority Date Filing Date
JP6528978A Granted JPS54157820A (en) 1978-05-30 1978-05-30 Preparation of multi-layered suppository base

Country Status (1)

Country Link
JP (1) JPS54157820A (en)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4462984A (en) * 1979-10-26 1984-07-31 Nippon Oil And Fats Company, Ltd. Suppository base composition
US4784855A (en) * 1986-06-16 1988-11-15 Otsuka Pharmaceutical Co., Ltd. Pharmaceutical compositions and suppository
CN103285002A (en) * 2013-04-25 2013-09-11 烟台绿叶动物保健品有限公司 Compound norfloxacin double-layered suppository for animals, and preparation method thereof

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6384691U (en) * 1986-11-18 1988-06-03
JPS63107098U (en) * 1986-12-26 1988-07-11

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3122475A (en) * 1960-02-25 1964-02-25 Schaeppi Ag Dr Circulatory adjuvant shell elements for cardiac glycoside suppository cores
JPS50157518A (en) * 1974-06-11 1975-12-19

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3122475A (en) * 1960-02-25 1964-02-25 Schaeppi Ag Dr Circulatory adjuvant shell elements for cardiac glycoside suppository cores
JPS50157518A (en) * 1974-06-11 1975-12-19

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4462984A (en) * 1979-10-26 1984-07-31 Nippon Oil And Fats Company, Ltd. Suppository base composition
US4784855A (en) * 1986-06-16 1988-11-15 Otsuka Pharmaceutical Co., Ltd. Pharmaceutical compositions and suppository
CN103285002A (en) * 2013-04-25 2013-09-11 烟台绿叶动物保健品有限公司 Compound norfloxacin double-layered suppository for animals, and preparation method thereof

Also Published As

Publication number Publication date
JPS5632289B2 (en) 1981-07-27

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