JPS5145651B1 - - Google Patents
Info
- Publication number
- JPS5145651B1 JPS5145651B1 JP41035355A JP3535566A JPS5145651B1 JP S5145651 B1 JPS5145651 B1 JP S5145651B1 JP 41035355 A JP41035355 A JP 41035355A JP 3535566 A JP3535566 A JP 3535566A JP S5145651 B1 JPS5145651 B1 JP S5145651B1
- Authority
- JP
- Japan
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
- C07D295/125—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
- C07D295/13—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/14—Antitussive agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C233/12—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by halogen atoms or by nitro or nitroso groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Anesthesiology (AREA)
- Pain & Pain Management (AREA)
- Pulmonology (AREA)
- Dermatology (AREA)
- Hospice & Palliative Care (AREA)
- Otolaryngology (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR869010A FR1313758A (fr) | 1961-07-25 | 1961-07-25 | Nouveaux benzamides substitués et leur procédé de préparation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JPS5145651B1 true JPS5145651B1 (US20030204162A1-20031030-M00001.png) | 1976-12-04 |
Family
ID=8760052
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP41035355A Pending JPS5145651B1 (US20030204162A1-20031030-M00001.png) | 1961-07-25 | 1966-06-01 | |
| JP45099379A Pending JPS5216104B1 (US20030204162A1-20031030-M00001.png) | 1961-07-25 | 1970-11-11 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP45099379A Pending JPS5216104B1 (US20030204162A1-20031030-M00001.png) | 1961-07-25 | 1970-11-11 |
Country Status (11)
Families Citing this family (54)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL281394A (US20030204162A1-20031030-M00001.png) * | 1961-07-25 | |||
| GB1019781A (US20030204162A1-20031030-M00001.png) * | 1963-03-05 | |||
| FR1407055A (fr) * | 1963-03-05 | 1965-07-30 | Ile De France | Nouveau procédé de préparation de benzamides substitués |
| US3342826A (en) * | 1964-01-13 | 1967-09-19 | Ile De France | Heterocyclic aminoalkyl benzamides |
| US3885033A (en) * | 1967-04-03 | 1975-05-20 | Ile De France | Method of anesthetizing a mammal by administration of a substituted 2-arylalkyloxy benzamide |
| US3509166A (en) * | 1968-01-15 | 1970-04-28 | American Cyanamid Co | Tetrahydro-pyridine derivatives of benzamide |
| JPS4940459B1 (US20030204162A1-20031030-M00001.png) * | 1970-12-21 | 1974-11-02 | ||
| GB1399632A (en) * | 1972-07-13 | 1975-07-02 | Leo Pharm Prod Ltd | Sulphamoyl-benzoic acids |
| CA1082181A (en) * | 1976-06-03 | 1980-07-22 | Eric A. Watts | Benzamide derivatives |
| US4255580A (en) * | 1976-08-04 | 1981-03-10 | Siociete D'etudes Scientifiques Et Industrielles De L'ile-De-France | Substituted 2,3-alkylene bis (oxy) benzamides and derivatives |
| US4140769A (en) | 1976-12-23 | 1979-02-20 | Miles Laboratories, Inc. | 3-Substituted salicylamides |
| US4109005A (en) * | 1977-05-11 | 1978-08-22 | A. H. Robins Company, Inc. | Method of increasing rate of gastric emptying with pyrrolidinylbenzamides |
| JPS54130599A (en) * | 1978-03-31 | 1979-10-09 | Taisho Pharmaceut Co Ltd | Furoindole derivative |
| JPS54148743A (en) * | 1978-05-12 | 1979-11-21 | Asahi Chem Ind Co Ltd | Production of methoclopramide |
| JPS6058224B2 (ja) * | 1978-07-31 | 1985-12-19 | 旭化成株式会社 | メトクロプラミドの製造方法 |
| FR2446274A1 (fr) * | 1979-01-15 | 1980-08-08 | Delalande Sa | Nouveaux derives de salicylamide, leur procede de preparation et leur application en therapeutique |
| US4301159A (en) * | 1980-06-20 | 1981-11-17 | Shionogi & Co., Ltd. | N-(Diethylaminoethyl)-2-alkoxy-benzamide derivatives |
| US4440941A (en) * | 1980-12-22 | 1984-04-03 | Usv Pharmaceutical Corporation | Aroyl-aminoacids, amides and esters thereof |
| US4536386B1 (en) * | 1981-01-26 | 1995-03-07 | Robins Co Inc A H | Method of controlling emesis caused by cisplatin in cancer chemotherapy |
| US4666911A (en) * | 1981-07-14 | 1987-05-19 | Taiho Pharmaceutical Company Limited | Allophanoylpiperazine compound and analgesic composition containing same as active ingredient |
| JPS59186969A (ja) * | 1983-04-08 | 1984-10-23 | Yoshitomi Pharmaceut Ind Ltd | ベンゾフラン−およびベンゾピランカルボキサミド誘導体 |
| US4501749A (en) * | 1983-10-31 | 1985-02-26 | Merck & Co., Inc. | Peripherally selective dopamine antagonists in the treatment of ocular hypertension |
| FR2557110B1 (fr) * | 1983-12-23 | 1989-11-24 | Sandoz Sa | Nouveaux derives d'amines cycliques, leur preparation et leur utilisation comme medicaments |
| US4808624A (en) * | 1984-06-28 | 1989-02-28 | Bristol-Myers Company | Pharmacologically active substituted benzamides |
| US5011992A (en) * | 1984-06-28 | 1991-04-30 | Bristol-Myers Squibb Company | Pharmacologically active substituted benzamides |
| US4772630A (en) * | 1984-11-23 | 1988-09-20 | Ciba-Geigy Corp. | Benzamides and their salts |
| US4772459A (en) * | 1986-09-09 | 1988-09-20 | Erbamont, Inc. | Method for controlling emesis caused by chemotherapeutic agents and antiemetic agents useful therein |
| GB8708833D0 (en) * | 1987-04-13 | 1987-05-20 | Lilly S A E | Organic compounds |
| IT1216120B (it) * | 1988-03-17 | 1990-02-22 | Poli Ind Chimica Spa | Derivati n_cicloalchilaminoetilbenzamidici, loro preparazione e composizioni farmaceutiche che li contengono. |
| GB8823040D0 (en) * | 1988-09-30 | 1988-11-09 | Lilly Sa | Organic compounds & their use as pharmaceuticals |
| GB8823042D0 (en) * | 1988-09-30 | 1988-11-09 | Lilly Sa | Organic compounds & their use as pharmaceuticals |
| GB8823041D0 (en) * | 1988-09-30 | 1988-11-09 | Lilly Sa | Organic compounds & their use as pharmaceuticals |
| FR2640139A1 (fr) * | 1988-12-14 | 1990-06-15 | Delagrange Laboratoires | Application de benzamides substitues comme gastromoteurs |
| IT1266992B1 (it) * | 1993-04-16 | 1997-01-24 | Alfa Wassermann Spa | Composti eterociclici, a struttura correlabile alle banzammidi, attivi nelle patologie gastro-intestinali, ad attivita' procinetica ed |
| US20040192781A1 (en) * | 2003-03-31 | 2004-09-30 | Haley Eugene T. | Method of administration for metoclopramide and pharmaceutical formulation therefor |
| US20050137265A1 (en) * | 2003-03-31 | 2005-06-23 | Haley Eugene T. | Rapidly dissolving metoclopramide solid oral dosage and method thereof |
| AU2005263577C1 (en) | 2004-07-16 | 2010-08-26 | Proteosys Ag | Muscarinic antagonists with PARP and SiR modulating activity as cytoprotective agents |
| US20100099772A1 (en) | 2006-11-20 | 2010-04-22 | Bean Bruce P | Methods, compositions, and kits for treating pain and pruritis |
| US20110294791A1 (en) | 2009-01-13 | 2011-12-01 | Proteosys Ag | Pirenzepine as an agent in cancer treatment |
| WO2011006073A1 (en) | 2009-07-10 | 2011-01-13 | President And Fellows Of Harvard College | Permanently charged sodium and calcium channel blockers as anti-inflammatory agents |
| TR201811221T4 (tr) | 2011-08-25 | 2018-08-27 | Evoke Pharma Inc | Dişi gastroparezi ile ilişkili semptomların tedavisi. |
| EP2895457B1 (en) | 2012-09-17 | 2020-05-20 | Nektar Therapeutics | Oligomer-containing benzamide-based compounds |
| CA2994545A1 (en) | 2015-08-03 | 2017-02-09 | President And Fellows Of Harvard College | Charged ion channel blockers and methods for use |
| BR112021001966A2 (pt) | 2018-08-15 | 2021-04-27 | Pharmacyl Ab | composto, composição farmacêutica, uso de um composto, e, método para o tratamento de uma doença resultante de inflamação patológica |
| KR20210045414A (ko) | 2018-08-15 | 2021-04-26 | 파마실 아베 | 병리학적 염증에 대한 새로운 의학적 치료 |
| SG11202109713PA (en) | 2019-03-11 | 2021-10-28 | Nocion Therapeutics Inc | Ester substituted ion channel blockers and methods for use |
| KR20210145166A (ko) | 2019-03-11 | 2021-12-01 | 녹시온 테라퓨틱스 인코포레이티드 | 하전된 이온 채널 차단제 및 사용 방법 |
| US10828287B2 (en) | 2019-03-11 | 2020-11-10 | Nocion Therapeutics, Inc. | Charged ion channel blockers and methods for use |
| US10780083B1 (en) | 2019-03-11 | 2020-09-22 | Nocion Therapeutics, Inc. | Charged ion channel blockers and methods for use |
| KR20210143791A (ko) | 2019-03-11 | 2021-11-29 | 녹시온 테라퓨틱스 인코포레이티드 | 하전된 이온 채널 차단제 및 사용 방법 |
| MX2022005335A (es) | 2019-11-06 | 2022-08-17 | Nocion Therapeutics Inc | Bloqueadores de canales ionicos cargados y metodos de uso. |
| US10933055B1 (en) | 2019-11-06 | 2021-03-02 | Nocion Therapeutics, Inc. | Charged ion channel blockers and methods for use |
| US11717500B2 (en) | 2020-02-03 | 2023-08-08 | Pharmacyl Ab | Treatment of spondyloarthritis |
| IL295950A (en) | 2020-03-11 | 2022-10-01 | Nocion Therapeutics Inc | Charged ion channel blockers and methods of use |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BE620543A (US20030204162A1-20031030-M00001.png) * | ||||
| US2460139A (en) * | 1945-07-21 | 1949-01-25 | Wallace & Tiernan Inc | Alkamine esters of 2-chloro-4-amino benzoic acid |
| US2691025A (en) * | 1951-03-30 | 1954-10-05 | Sterling Drug Inc | N-(tertiary-aminoalkyl)-2, 4-disubstituted-benzamides and their preparation |
| US2810718A (en) * | 1953-07-02 | 1957-10-22 | Abbott Lab | Basic salicylamides |
| GB797476A (en) * | 1955-09-09 | 1958-07-02 | Bristol Lab Inc | Amides of trialkoxybenzoic acids |
| US2910488A (en) * | 1958-01-22 | 1959-10-27 | Merck & Co Inc | Aniline derivatives |
| NL281394A (US20030204162A1-20031030-M00001.png) * | 1961-07-25 |
-
0
- NL NL281394D patent/NL281394A/xx unknown
-
1961
- 1961-07-25 FR FR869010A patent/FR1313758A/fr not_active Expired
-
1962
- 1962-06-19 ES ES278660A patent/ES278660A1/es not_active Expired
- 1962-07-09 CH CH820062A patent/CH425763A/fr unknown
- 1962-07-17 US US210554A patent/US3177252A/en not_active Expired - Lifetime
- 1962-07-20 FI FI1373/62A patent/FI42075B/fi active
- 1962-07-24 SE SE6911318*3A patent/SE372009B/xx unknown
- 1962-07-24 DK DK329262AA patent/DK106557C/da active
- 1962-07-24 SE SE8200/62A patent/SE313555B/xx unknown
- 1962-08-10 BR BR140890/62A patent/BR6240890D0/pt unknown
-
1964
- 1964-12-31 OA OA51312A patent/OA01153A/xx unknown
-
1965
- 1965-09-14 US US487327A patent/US3312739A/en not_active Expired - Lifetime
-
1966
- 1966-06-01 JP JP41035355A patent/JPS5145651B1/ja active Pending
-
1970
- 1970-11-11 JP JP45099379A patent/JPS5216104B1/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| CH425763A (fr) | 1966-12-15 |
| SE313555B (US20030204162A1-20031030-M00001.png) | 1969-08-18 |
| DK106557C (da) | 1967-02-20 |
| BR6240890D0 (pt) | 1973-06-14 |
| NL281394A (US20030204162A1-20031030-M00001.png) | |
| ES278660A1 (es) | 1962-10-16 |
| US3312739A (en) | 1967-04-04 |
| OA01153A (fr) | 1968-08-07 |
| FR1313758A (fr) | 1963-01-04 |
| US3177252A (en) | 1965-04-06 |
| FI42075B (US20030204162A1-20031030-M00001.png) | 1970-02-02 |
| JPS5216104B1 (US20030204162A1-20031030-M00001.png) | 1977-05-06 |
| SE372009B (US20030204162A1-20031030-M00001.png) | 1974-12-09 |
