JPH11513979A - カルバペネム中間体を合成するための改良されたプロセス - Google Patents

カルバペネム中間体を合成するための改良されたプロセス

Info

Publication number
JPH11513979A
JPH11513979A JP9504502A JP50450297A JPH11513979A JP H11513979 A JPH11513979 A JP H11513979A JP 9504502 A JP9504502 A JP 9504502A JP 50450297 A JP50450297 A JP 50450297A JP H11513979 A JPH11513979 A JP H11513979A
Authority
JP
Japan
Prior art keywords
compound
formula
substantially non
base
reactive solvent
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP9504502A
Other languages
English (en)
Japanese (ja)
Inventor
ヤン，チユンヒユア
修祥 安田
Original Assignee
メルク エンド カンパニー インコーポレーテッド
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9602921.0A external-priority patent/GB9602921D0/en
Application filed by メルク エンド カンパニー インコーポレーテッド filed Critical メルク エンド カンパニー インコーポレーテッド
Publication of JPH11513979A publication Critical patent/JPH11513979A/ja
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
    • C07D477/02—Preparation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages
    • C07F7/1872—Preparation; Treatments not provided for in C07F7/20
    • C07F7/188—Preparation; Treatments not provided for in C07F7/20 by reactions involving the formation of Si-O linkages

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
JP9504502A 1995-06-28 1996-06-24 カルバペネム中間体を合成するための改良されたプロセス Pending JPH11513979A (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US58595P 1995-06-28 1995-06-28
GB60/000,585 1996-02-13
GB9602921.0 1996-02-13
GBGB9602921.0A GB9602921D0 (en) 1996-02-13 1996-02-13 Improved process for synthesizing carbapenem intermediates
PCT/US1996/010783 WO1997001564A1 (en) 1995-06-28 1996-06-24 Improved process for synthesizing carbapenem intermediates

Publications (1)

Publication Number Publication Date
JPH11513979A true JPH11513979A (ja) 1999-11-30

Family

ID=26308678

Family Applications (1)

Application Number Title Priority Date Filing Date
JP9504502A Pending JPH11513979A (ja) 1995-06-28 1996-06-24 カルバペネム中間体を合成するための改良されたプロセス

Country Status (13)

Country Link
EP (1) EP0836607A1 (cs)
JP (1) JPH11513979A (cs)
KR (1) KR19990028406A (cs)
CN (1) CN1193322A (cs)
AR (1) AR002507A1 (cs)
AU (1) AU696543B2 (cs)
BR (1) BR9609338A (cs)
CA (1) CA2224439A1 (cs)
CZ (1) CZ419097A3 (cs)
EA (1) EA199800096A1 (cs)
HU (1) HUP9903016A3 (cs)
SK (1) SK176597A3 (cs)
WO (1) WO1997001564A1 (cs)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2732619A1 (en) 2008-07-30 2010-02-04 Ranbaxy Laboratories Limited Process for the preparation of carbapenem compounds
WO2011048583A1 (en) 2009-10-23 2011-04-28 Ranbaxy Laboratories Limited Process for the preparation of carbapenem compounds

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4683301A (en) * 1982-04-08 1987-07-28 Bristol-Myers Company Carbapenem antibiotics
JP2675625B2 (ja) * 1989-01-12 1997-11-12 鐘淵化学工業株式会社 エノールシリルエーテル化合物の製造方法
NZ234411A (en) * 1989-07-18 1991-05-28 Merck & Co Inc Preparation of 2-diazo-3-silyloxy-3-butenoate esters
DE3934100A1 (de) * 1989-10-12 1991-04-18 Bayer Ag Verfahren zur herstellung von 0-silylierten hydroxylverbindungen und ihre verwendung zur herstellung von estergruppen aufweisenden isocyanaten

Also Published As

Publication number Publication date
AU6392196A (en) 1997-01-30
BR9609338A (pt) 1999-05-11
KR19990028406A (ko) 1999-04-15
HUP9903016A3 (en) 2000-04-28
EP0836607A1 (en) 1998-04-22
AR002507A1 (es) 1998-03-25
EA199800096A1 (ru) 1998-08-27
CN1193322A (zh) 1998-09-16
WO1997001564A1 (en) 1997-01-16
SK176597A3 (en) 1998-07-08
MX9800041A (es) 1998-08-30
CA2224439A1 (en) 1997-01-16
CZ419097A3 (cs) 1998-07-15
AU696543B2 (en) 1998-09-10
HUP9903016A2 (hu) 2000-03-28

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