JPH11510793A - 胃腸病に対する鼻腔内ワクチン接種 - Google Patents
胃腸病に対する鼻腔内ワクチン接種Info
- Publication number
- JPH11510793A JPH11510793A JP9505849A JP50584997A JPH11510793A JP H11510793 A JPH11510793 A JP H11510793A JP 9505849 A JP9505849 A JP 9505849A JP 50584997 A JP50584997 A JP 50584997A JP H11510793 A JPH11510793 A JP H11510793A
- Authority
- JP
- Japan
- Prior art keywords
- toxin
- composition
- difficile
- antigen
- immune response
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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- 239000011574 phosphorus Substances 0.000 description 1
- 238000005222 photoaffinity labeling Methods 0.000 description 1
- 229920002401 polyacrylamide Polymers 0.000 description 1
- 229920000136 polysorbate Polymers 0.000 description 1
- 230000002516 postimmunization Effects 0.000 description 1
- 230000002062 proliferating effect Effects 0.000 description 1
- 229960000856 protein c Drugs 0.000 description 1
- 238000011002 quantification Methods 0.000 description 1
- 238000010188 recombinant method Methods 0.000 description 1
- 230000003362 replicative effect Effects 0.000 description 1
- 210000002345 respiratory system Anatomy 0.000 description 1
- 230000032537 response to toxin Effects 0.000 description 1
- 238000005096 rolling process Methods 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 239000006152 selective media Substances 0.000 description 1
- 230000008313 sensitization Effects 0.000 description 1
- 235000020183 skimmed milk Nutrition 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 239000007790 solid phase Substances 0.000 description 1
- 230000028070 sporulation Effects 0.000 description 1
- 239000013589 supplement Substances 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 208000006379 syphilis Diseases 0.000 description 1
- 231100000563 toxic property Toxicity 0.000 description 1
- 238000003151 transfection method Methods 0.000 description 1
- 238000011426 transformation method Methods 0.000 description 1
- 238000013519 translation Methods 0.000 description 1
- OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 description 1
- 231100000397 ulcer Toxicity 0.000 description 1
- 238000000108 ultra-filtration Methods 0.000 description 1
- 210000002700 urine Anatomy 0.000 description 1
- 229940125575 vaccine candidate Drugs 0.000 description 1
- 230000002477 vacuolizing effect Effects 0.000 description 1
- 229940118696 vibrio cholerae Drugs 0.000 description 1
- 239000013603 viral vector Substances 0.000 description 1
- 210000005253 yeast cell Anatomy 0.000 description 1
- 239000012138 yeast extract Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/08—Clostridium, e.g. Clostridium tetani
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/12—Antidiarrhoeals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
- A61K2039/541—Mucosal route
- A61K2039/543—Mucosal route intranasal
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55544—Bacterial toxins
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Urology & Nephrology (AREA)
- Reproductive Health (AREA)
- Immunology (AREA)
- Microbiology (AREA)
- Endocrinology (AREA)
- Mycology (AREA)
- Epidemiology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US49922995A | 1995-07-07 | 1995-07-07 | |
| US08/499,229 | 1995-07-07 | ||
| PCT/US1996/010987 WO1997002835A1 (en) | 1995-07-07 | 1996-06-26 | Intranasal vaccination against gastrointestinal disease |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JPH11510793A true JPH11510793A (ja) | 1999-09-21 |
Family
ID=23984386
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP9505849A Pending JPH11510793A (ja) | 1995-07-07 | 1996-06-26 | 胃腸病に対する鼻腔内ワクチン接種 |
Country Status (8)
| Country | Link |
|---|---|
| EP (1) | EP0877623A1 (enrdf_load_stackoverflow) |
| JP (1) | JPH11510793A (enrdf_load_stackoverflow) |
| CN (1) | CN1195993A (enrdf_load_stackoverflow) |
| AU (1) | AU722653B2 (enrdf_load_stackoverflow) |
| CA (1) | CA2226392A1 (enrdf_load_stackoverflow) |
| NZ (1) | NZ312876A (enrdf_load_stackoverflow) |
| WO (1) | WO1997002835A1 (enrdf_load_stackoverflow) |
| ZA (1) | ZA965737B (enrdf_load_stackoverflow) |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2003513106A (ja) * | 1999-11-01 | 2003-04-08 | ムコバックス・ビー・ブイ | 家畜における乳腺分泌抗体の生産 |
| WO2008146830A1 (ja) * | 2007-05-28 | 2008-12-04 | The Kitasato Institute | パラ百日咳菌全菌体ワクチン組成物 |
| JP2010539172A (ja) * | 2007-09-14 | 2010-12-16 | サノフィ パスツール バイオロジクス カンパニー | クロストリジウム・ディフィシレトキソイドａおよびｂを含有する薬学的組成物 |
| JP2012510497A (ja) * | 2008-12-03 | 2012-05-10 | ベーリンガー インゲルハイム フェトメディカ ゲゼルシャフト ミット ベシュレンクテル ハフツング | ワクチンの生産方法 |
| JP2013512916A (ja) * | 2009-12-02 | 2013-04-18 | タフツ ユニバーシティー | 免疫原としてのＣｌｏｓｔｒｉｄｉｕｍｄｉｆｆｉｃｉｌｅの無毒の組換えホロトキシン |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6153201A (en) * | 1993-03-09 | 2000-11-28 | University Of Rochester | Oral immunization with papillomavirus virus-like particles |
| US6969520B2 (en) | 1997-10-20 | 2005-11-29 | Acambis Inc. | Active immunization against clostridium difficile disease |
| US6585975B1 (en) * | 1998-04-30 | 2003-07-01 | Acambis, Inc. | Use of Salmonella vectors for vaccination against helicobacter infection |
| US7074454B1 (en) | 1999-11-01 | 2006-07-11 | Mucovax Holding B.V. | Production of mammary secretion antibodies in farm animals |
| US6974573B2 (en) | 1999-11-01 | 2005-12-13 | Mucovax Holdings, B.V. | Antibody production in farm animals |
| GB0029919D0 (en) * | 2000-12-07 | 2001-01-24 | Chiron Spa | Helicobacter pylori prime & boost vaccination |
| EP4365196A3 (en) | 2011-04-22 | 2024-08-07 | Wyeth LLC | Compositions relating to a mutant clostridium difficile toxin and methods thereof |
| WO2013071409A1 (en) | 2011-11-18 | 2013-05-23 | National Research Council Of Canada (Nrc) | Clostridium difficile lipoteichoic acid and uses thereof |
| BR122016023101B1 (pt) | 2012-10-21 | 2022-03-22 | Pfizer Inc | Polipeptídeo, composição imunogênica que o compreende, bem como célula recombinante derivada de clostridium difficile |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4141970A (en) * | 1975-05-07 | 1979-02-27 | Internationale Octrooimaatschappij "Octropa" B.V. | Method for enhancing the resistance of new born mammalian young to gastro-intestinal infections |
| US4713240A (en) * | 1985-04-04 | 1987-12-15 | Research Corporation | Vaccines based on insoluble supports |
| US4944942A (en) * | 1987-08-27 | 1990-07-31 | Mobay Corporation | Intranasal vaccination of horses with inactivated microorganisms or antigenic material |
| JP2849632B2 (ja) * | 1988-04-08 | 1999-01-20 | 社団法人北里研究所 | ワクチン製剤 |
| US5601823A (en) * | 1989-10-31 | 1997-02-11 | Ophidian Pharmaceuticals, Inc. | Avian antitoxins to clostridium difficle toxin A |
| GB9209118D0 (en) * | 1992-04-28 | 1992-06-10 | Sb 120 Amsterdam Bv | Vaccine compositions |
| AU4773293A (en) * | 1992-07-16 | 1994-02-14 | Oxford University | Multiple particulate antigen delivery system |
-
1996
- 1996-06-26 WO PCT/US1996/010987 patent/WO1997002835A1/en not_active Application Discontinuation
- 1996-06-26 JP JP9505849A patent/JPH11510793A/ja active Pending
- 1996-06-26 AU AU64799/96A patent/AU722653B2/en not_active Ceased
- 1996-06-26 CA CA002226392A patent/CA2226392A1/en not_active Abandoned
- 1996-06-26 CN CN96196763A patent/CN1195993A/zh active Pending
- 1996-06-26 EP EP96924312A patent/EP0877623A1/en not_active Withdrawn
- 1996-06-26 NZ NZ312876A patent/NZ312876A/en unknown
- 1996-07-05 ZA ZA965737A patent/ZA965737B/xx unknown
Cited By (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2003513106A (ja) * | 1999-11-01 | 2003-04-08 | ムコバックス・ビー・ブイ | 家畜における乳腺分泌抗体の生産 |
| WO2008146830A1 (ja) * | 2007-05-28 | 2008-12-04 | The Kitasato Institute | パラ百日咳菌全菌体ワクチン組成物 |
| US8465754B2 (en) | 2007-05-28 | 2013-06-18 | Kitasato Daiichi Sankyo Vaccine Co., Ltd. | Bordetella parapertussis whole-cell vaccine composition |
| JP5398527B2 (ja) * | 2007-05-28 | 2014-01-29 | 北里第一三共ワクチン株式会社 | パラ百日咳菌全菌体ワクチン組成物 |
| JP2010539172A (ja) * | 2007-09-14 | 2010-12-16 | サノフィ パスツール バイオロジクス カンパニー | クロストリジウム・ディフィシレトキソイドａおよびｂを含有する薬学的組成物 |
| JP2014055174A (ja) * | 2007-09-14 | 2014-03-27 | Sanofi Pasteur Biologics Co | クロストリジウム・ディフィシレトキソイドａおよびｂを含有する薬学的組成物 |
| JP2017052773A (ja) * | 2007-09-14 | 2017-03-16 | サノフィ パスツール バイオロジクス リミテッド ライアビリティ カンパニー | クロストリジウム・ディフィシレトキソイドａおよびｂを含有する薬学的組成物 |
| US9687541B2 (en) | 2007-09-14 | 2017-06-27 | Sanofi Pastuer Biologies, LLC | Pharmaceutical compositions containing Clostridium difficile toxoids A and B |
| US10639362B2 (en) | 2007-09-14 | 2020-05-05 | Sanofi Pasteur Biologics, Llc | Pharmaceutical compositions containing Clostridium difficile toxoids A and B |
| JP2012510497A (ja) * | 2008-12-03 | 2012-05-10 | ベーリンガー インゲルハイム フェトメディカ ゲゼルシャフト ミット ベシュレンクテル ハフツング | ワクチンの生産方法 |
| JP2013512916A (ja) * | 2009-12-02 | 2013-04-18 | タフツ ユニバーシティー | 免疫原としてのＣｌｏｓｔｒｉｄｉｕｍｄｉｆｆｉｃｉｌｅの無毒の組換えホロトキシン |
Also Published As
| Publication number | Publication date |
|---|---|
| ZA965737B (en) | 1997-05-13 |
| EP0877623A4 (enrdf_load_stackoverflow) | 1998-11-18 |
| AU722653B2 (en) | 2000-08-10 |
| CA2226392A1 (en) | 1997-01-30 |
| AU6479996A (en) | 1997-02-10 |
| WO1997002835A1 (en) | 1997-01-30 |
| EP0877623A1 (en) | 1998-11-18 |
| NZ312876A (en) | 2000-06-23 |
| CN1195993A (zh) | 1998-10-14 |
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