JPH11206871A - 生体内分解吸収性の骨固定材およびその製造方法 - Google Patents
生体内分解吸収性の骨固定材およびその製造方法Info
- Publication number
- JPH11206871A JPH11206871A JP10052638A JP5263898A JPH11206871A JP H11206871 A JPH11206871 A JP H11206871A JP 10052638 A JP10052638 A JP 10052638A JP 5263898 A JP5263898 A JP 5263898A JP H11206871 A JPH11206871 A JP H11206871A
- Authority
- JP
- Japan
- Prior art keywords
- biodegradable
- absorbable
- polymer
- hydroxyapatite
- material according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 210000000988 bone and bone Anatomy 0.000 title claims abstract description 40
- 239000000463 material Substances 0.000 title claims abstract description 37
- 238000001727 in vivo Methods 0.000 title claims abstract 6
- 238000004519 manufacturing process Methods 0.000 title claims description 4
- 229920000642 polymer Polymers 0.000 claims abstract description 28
- 229910052588 hydroxylapatite Inorganic materials 0.000 claims abstract description 23
- XYJRXVWERLGGKC-UHFFFAOYSA-D pentacalcium;hydroxide;triphosphate Chemical compound [OH-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O XYJRXVWERLGGKC-UHFFFAOYSA-D 0.000 claims abstract description 23
- 229920000747 poly(lactic acid) Polymers 0.000 claims abstract description 17
- 239000004626 polylactic acid Substances 0.000 claims abstract description 17
- 239000000203 mixture Substances 0.000 claims abstract description 12
- 150000002484 inorganic compounds Chemical class 0.000 claims abstract description 10
- 229910010272 inorganic material Inorganic materials 0.000 claims abstract description 10
- 229920001577 copolymer Polymers 0.000 claims abstract description 9
- 238000012999 compression bending Methods 0.000 claims abstract description 8
- 230000003287 optical effect Effects 0.000 claims abstract description 4
- JJTUDXZGHPGLLC-UHFFFAOYSA-N lactide Chemical compound CC1OC(=O)C(C)OC1=O JJTUDXZGHPGLLC-UHFFFAOYSA-N 0.000 claims abstract 2
- UQDJGEHQDNVPGU-UHFFFAOYSA-N serine phosphoethanolamine Chemical group [NH3+]CCOP([O-])(=O)OCC([NH3+])C([O-])=O UQDJGEHQDNVPGU-UHFFFAOYSA-N 0.000 claims 1
- 230000015556 catabolic process Effects 0.000 abstract description 6
- 238000006731 degradation reaction Methods 0.000 abstract description 6
- 238000010521 absorption reaction Methods 0.000 abstract description 5
- 238000005452 bending Methods 0.000 abstract description 4
- 230000003292 diminished effect Effects 0.000 abstract 2
- 229930182470 glycoside Natural products 0.000 abstract 1
- 230000007062 hydrolysis Effects 0.000 description 11
- 238000006460 hydrolysis reaction Methods 0.000 description 11
- 239000003513 alkali Substances 0.000 description 9
- JVTAAEKCZFNVCJ-REOHCLBHSA-N L-lactic acid Chemical compound C[C@H](O)C(O)=O JVTAAEKCZFNVCJ-REOHCLBHSA-N 0.000 description 8
- 238000000034 method Methods 0.000 description 8
- 238000000465 moulding Methods 0.000 description 7
- 238000000354 decomposition reaction Methods 0.000 description 6
- 238000001356 surgical procedure Methods 0.000 description 6
- 238000001125 extrusion Methods 0.000 description 5
- JJTUDXZGHPGLLC-IMJSIDKUSA-N 4511-42-6 Chemical compound C[C@@H]1OC(=O)[C@H](C)OC1=O JJTUDXZGHPGLLC-IMJSIDKUSA-N 0.000 description 4
- 206010017076 Fracture Diseases 0.000 description 4
- 230000000052 comparative effect Effects 0.000 description 4
- 238000002156 mixing Methods 0.000 description 4
- 208000010392 Bone Fractures Diseases 0.000 description 3
- AEMRFAOFKBGASW-UHFFFAOYSA-N Glycolic acid Natural products OCC(O)=O AEMRFAOFKBGASW-UHFFFAOYSA-N 0.000 description 3
- KWYUFKZDYYNOTN-UHFFFAOYSA-M Potassium hydroxide Chemical compound [OH-].[K+] KWYUFKZDYYNOTN-UHFFFAOYSA-M 0.000 description 3
- AXCZMVOFGPJBDE-UHFFFAOYSA-L calcium dihydroxide Chemical compound [OH-].[OH-].[Ca+2] AXCZMVOFGPJBDE-UHFFFAOYSA-L 0.000 description 3
- 239000013078 crystal Substances 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 description 3
- 230000014759 maintenance of location Effects 0.000 description 3
- 241000283690 Bos taurus Species 0.000 description 2
- UXVMQQNJUSDDNG-UHFFFAOYSA-L Calcium chloride Chemical compound [Cl-].[Cl-].[Ca+2] UXVMQQNJUSDDNG-UHFFFAOYSA-L 0.000 description 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 description 2
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 2
- TWRXJAOTZQYOKJ-UHFFFAOYSA-L Magnesium chloride Chemical compound [Mg+2].[Cl-].[Cl-] TWRXJAOTZQYOKJ-UHFFFAOYSA-L 0.000 description 2
- WCUXLLCKKVVCTQ-UHFFFAOYSA-M Potassium chloride Chemical compound [Cl-].[K+] WCUXLLCKKVVCTQ-UHFFFAOYSA-M 0.000 description 2
- 238000004873 anchoring Methods 0.000 description 2
- 239000012620 biological material Substances 0.000 description 2
- 229940036811 bone meal Drugs 0.000 description 2
- 239000002374 bone meal Substances 0.000 description 2
- 239000001110 calcium chloride Substances 0.000 description 2
- 229910001628 calcium chloride Inorganic materials 0.000 description 2
- 239000000920 calcium hydroxide Substances 0.000 description 2
- 229910001861 calcium hydroxide Inorganic materials 0.000 description 2
- 239000000919 ceramic Substances 0.000 description 2
- 230000008859 change Effects 0.000 description 2
- 230000008034 disappearance Effects 0.000 description 2
- -1 for example Chemical compound 0.000 description 2
- 230000002706 hydrostatic effect Effects 0.000 description 2
- 238000002513 implantation Methods 0.000 description 2
- 229960000448 lactic acid Drugs 0.000 description 2
- 230000000399 orthopedic effect Effects 0.000 description 2
- 239000002504 physiological saline solution Substances 0.000 description 2
- 229920001432 poly(L-lactide) Polymers 0.000 description 2
- 239000000843 powder Substances 0.000 description 2
- 230000001737 promoting effect Effects 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 230000002194 synthesizing effect Effects 0.000 description 2
- 210000000115 thoracic cavity Anatomy 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- JIAARYAFYJHUJI-UHFFFAOYSA-L zinc dichloride Chemical compound [Cl-].[Cl-].[Zn+2] JIAARYAFYJHUJI-UHFFFAOYSA-L 0.000 description 2
- 206010020843 Hyperthermia Diseases 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- ATJFFYVFTNAWJD-UHFFFAOYSA-N Tin Chemical compound [Sn] ATJFFYVFTNAWJD-UHFFFAOYSA-N 0.000 description 1
- 230000002378 acidificating effect Effects 0.000 description 1
- 230000002411 adverse Effects 0.000 description 1
- 229920003232 aliphatic polyester Polymers 0.000 description 1
- 229910052783 alkali metal Inorganic materials 0.000 description 1
- 150000001412 amines Chemical class 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 239000012237 artificial material Substances 0.000 description 1
- 235000011148 calcium chloride Nutrition 0.000 description 1
- 206010061592 cardiac fibrillation Diseases 0.000 description 1
- 210000000038 chest Anatomy 0.000 description 1
- 150000001805 chlorine compounds Chemical class 0.000 description 1
- 239000002131 composite material Substances 0.000 description 1
- 230000006835 compression Effects 0.000 description 1
- 238000007906 compression Methods 0.000 description 1
- 230000001054 cortical effect Effects 0.000 description 1
- 230000006866 deterioration Effects 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 238000010828 elution Methods 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 230000002600 fibrillogenic effect Effects 0.000 description 1
- 239000000834 fixative Substances 0.000 description 1
- 230000009477 glass transition Effects 0.000 description 1
- 235000011187 glycerol Nutrition 0.000 description 1
- 230000035876 healing Effects 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 229920001519 homopolymer Polymers 0.000 description 1
- 238000000886 hydrostatic extrusion Methods 0.000 description 1
- 150000004679 hydroxides Chemical class 0.000 description 1
- 230000036031 hyperthermia Effects 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 238000001746 injection moulding Methods 0.000 description 1
- 239000004310 lactic acid Substances 0.000 description 1
- 235000014655 lactic acid Nutrition 0.000 description 1
- 229940057995 liquid paraffin Drugs 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 229910001629 magnesium chloride Inorganic materials 0.000 description 1
- 235000011147 magnesium chloride Nutrition 0.000 description 1
- VTHJTEIRLNZDEV-UHFFFAOYSA-L magnesium dihydroxide Chemical compound [OH-].[OH-].[Mg+2] VTHJTEIRLNZDEV-UHFFFAOYSA-L 0.000 description 1
- 239000000347 magnesium hydroxide Substances 0.000 description 1
- 229910001862 magnesium hydroxide Inorganic materials 0.000 description 1
- 238000002844 melting Methods 0.000 description 1
- 230000008018 melting Effects 0.000 description 1
- 229910052751 metal Inorganic materials 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 229910021645 metal ion Inorganic materials 0.000 description 1
- 150000002739 metals Chemical class 0.000 description 1
- 230000007935 neutral effect Effects 0.000 description 1
- WWZKQHOCKIZLMA-UHFFFAOYSA-N octanoic acid Chemical compound CCCCCCCC(O)=O WWZKQHOCKIZLMA-UHFFFAOYSA-N 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 238000013001 point bending Methods 0.000 description 1
- 239000002861 polymer material Substances 0.000 description 1
- 239000002685 polymerization catalyst Substances 0.000 description 1
- 238000006116 polymerization reaction Methods 0.000 description 1
- 239000001103 potassium chloride Substances 0.000 description 1
- 235000011164 potassium chloride Nutrition 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 230000008439 repair process Effects 0.000 description 1
- 238000007151 ring opening polymerisation reaction Methods 0.000 description 1
- 238000005096 rolling process Methods 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 239000007858 starting material Substances 0.000 description 1
- 238000010998 test method Methods 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- 230000001960 triggered effect Effects 0.000 description 1
- 230000003313 weakening effect Effects 0.000 description 1
- 239000011592 zinc chloride Substances 0.000 description 1
- 235000005074 zinc chloride Nutrition 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/12—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
- A61L31/125—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix
- A61L31/127—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix containing fillers of phosphorus-containing inorganic materials
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Vascular Medicine (AREA)
- Epidemiology (AREA)
- Materials Engineering (AREA)
- Engineering & Computer Science (AREA)
- Heart & Thoracic Surgery (AREA)
- Surgery (AREA)
- Inorganic Chemistry (AREA)
- Composite Materials (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Materials For Medical Uses (AREA)
Priority Applications (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP10052638A JPH11206871A (ja) | 1998-01-27 | 1998-01-27 | 生体内分解吸収性の骨固定材およびその製造方法 |
| US09/154,101 US6232384B1 (en) | 1998-01-27 | 1998-09-16 | Bone fixation materials and methods for their preparation |
| EP98117643A EP0933089B1 (en) | 1998-01-27 | 1998-09-17 | Bone fixation materials and methods for preparation |
| DE69810747T DE69810747T2 (de) | 1998-01-27 | 1998-09-17 | Knochenbefestigungsmaterial und Verfahren zur Herstellung desselben |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP10052638A JPH11206871A (ja) | 1998-01-27 | 1998-01-27 | 生体内分解吸収性の骨固定材およびその製造方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPH11206871A true JPH11206871A (ja) | 1999-08-03 |
| JPH11206871A5 JPH11206871A5 (enrdf_load_stackoverflow) | 2005-08-11 |
Family
ID=12920384
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP10052638A Pending JPH11206871A (ja) | 1998-01-27 | 1998-01-27 | 生体内分解吸収性の骨固定材およびその製造方法 |
Country Status (4)
| Country | Link |
|---|---|
| US (1) | US6232384B1 (enrdf_load_stackoverflow) |
| EP (1) | EP0933089B1 (enrdf_load_stackoverflow) |
| JP (1) | JPH11206871A (enrdf_load_stackoverflow) |
| DE (1) | DE69810747T2 (enrdf_load_stackoverflow) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2007313009A (ja) * | 2006-05-25 | 2007-12-06 | Terumo Corp | ステント |
| JP2009240413A (ja) * | 2008-03-28 | 2009-10-22 | Gunze Ltd | 骨接合材料 |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH11206871A (ja) * | 1998-01-27 | 1999-08-03 | Bmg:Kk | 生体内分解吸収性の骨固定材およびその製造方法 |
| US6406498B1 (en) * | 1998-09-04 | 2002-06-18 | Bionx Implants Oy | Bioactive, bioabsorbable surgical composite material |
| US7699879B2 (en) * | 2003-10-21 | 2010-04-20 | Warsaw Orthopedic, Inc. | Apparatus and method for providing dynamizable translations to orthopedic implants |
| US20050085814A1 (en) * | 2003-10-21 | 2005-04-21 | Sherman Michael C. | Dynamizable orthopedic implants and their use in treating bone defects |
| US20050136764A1 (en) * | 2003-12-18 | 2005-06-23 | Sherman Michael C. | Designed composite degradation for spinal implants |
| US7378144B2 (en) * | 2004-02-17 | 2008-05-27 | Kensey Nash Corporation | Oriented polymer implantable device and process for making same |
| US20100191292A1 (en) * | 2004-02-17 | 2010-07-29 | Demeo Joseph | Oriented polymer implantable device and process for making same |
| EP1931401A2 (en) | 2005-09-09 | 2008-06-18 | University of Arkansas at Little Rock | System and method for tissue generation and bone regeneration |
| US8936805B2 (en) | 2005-09-09 | 2015-01-20 | Board Of Trustees Of The University Of Arkansas | Bone regeneration using biodegradable polymeric nanocomposite materials and applications of the same |
| US9763788B2 (en) | 2005-09-09 | 2017-09-19 | Board Of Trustees Of The University Of Arkansas | Bone regeneration using biodegradable polymeric nanocomposite materials and applications of the same |
| CA2650542C (en) | 2006-04-25 | 2016-09-13 | Teleflex Medical Incorporated | Calcium phosphate polymer composite and method |
| CN106730043B (zh) * | 2016-12-19 | 2022-09-20 | 苏州西脉新诚生物科技有限公司 | 一种高强度可吸收骨折内固定骨螺钉 |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4539981A (en) * | 1982-11-08 | 1985-09-10 | Johnson & Johnson Products, Inc. | Absorbable bone fixation device |
| US4550449A (en) * | 1982-11-08 | 1985-11-05 | Johnson & Johnson Products Inc. | Absorbable bone fixation device |
| US4655777A (en) * | 1983-12-19 | 1987-04-07 | Southern Research Institute | Method of producing biodegradable prosthesis and products therefrom |
| US4781183A (en) * | 1986-08-27 | 1988-11-01 | American Cyanamid Company | Surgical prosthesis |
| JPS6368155A (ja) * | 1986-09-11 | 1988-03-28 | グンゼ株式会社 | 骨接合ピン |
| FI82805C (fi) * | 1988-12-23 | 1991-04-25 | Biocon Oy | En polymer fixeringskivkonstruktion foer kirurgiskt bruk. |
| US5108755A (en) * | 1989-04-27 | 1992-04-28 | Sri International | Biodegradable composites for internal medical use |
| EP0453624B1 (en) * | 1990-04-25 | 1999-01-13 | Descente Ltd. | Highly moisture-absorptive fiber |
| US5080665A (en) * | 1990-07-06 | 1992-01-14 | American Cyanamid Company | Deformable, absorbable surgical device |
| EP0523926A3 (en) * | 1991-07-15 | 1993-12-01 | Smith & Nephew Richards Inc | Prosthetic implants with bioabsorbable coating |
| JP2825703B2 (ja) * | 1992-06-18 | 1998-11-18 | シャープ株式会社 | 画像形成装置 |
| CA2205231C (en) * | 1995-09-14 | 2008-03-18 | Takiron Co., Ltd. | Material for osteosynthesis and composite implant material, and production processes thereof |
| US5686540A (en) * | 1995-09-29 | 1997-11-11 | Dainippon Ink And Chemicals, Inc. | Process for the preparation of lactic acid-based polyester |
| JPH11206871A (ja) * | 1998-01-27 | 1999-08-03 | Bmg:Kk | 生体内分解吸収性の骨固定材およびその製造方法 |
-
1998
- 1998-01-27 JP JP10052638A patent/JPH11206871A/ja active Pending
- 1998-09-16 US US09/154,101 patent/US6232384B1/en not_active Expired - Fee Related
- 1998-09-17 DE DE69810747T patent/DE69810747T2/de not_active Expired - Lifetime
- 1998-09-17 EP EP98117643A patent/EP0933089B1/en not_active Expired - Lifetime
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2007313009A (ja) * | 2006-05-25 | 2007-12-06 | Terumo Corp | ステント |
| JP2009240413A (ja) * | 2008-03-28 | 2009-10-22 | Gunze Ltd | 骨接合材料 |
Also Published As
| Publication number | Publication date |
|---|---|
| EP0933089B1 (en) | 2003-01-15 |
| EP0933089A2 (en) | 1999-08-04 |
| DE69810747T2 (de) | 2003-07-10 |
| EP0933089A3 (en) | 2000-11-02 |
| US6232384B1 (en) | 2001-05-15 |
| DE69810747D1 (de) | 2003-02-20 |
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Legal Events
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| A621 | Written request for application examination |
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Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20081014 |
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