JPH1071125A - Method for measuring artery/vein diameter ration of eyebottom - Google Patents

Method for measuring artery/vein diameter ration of eyebottom

Info

Publication number
JPH1071125A
JPH1071125A JP8228071A JP22807196A JPH1071125A JP H1071125 A JPH1071125 A JP H1071125A JP 8228071 A JP8228071 A JP 8228071A JP 22807196 A JP22807196 A JP 22807196A JP H1071125 A JPH1071125 A JP H1071125A
Authority
JP
Japan
Prior art keywords
arteriovenous
blood vessel
pair
blood vessels
center
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP8228071A
Other languages
Japanese (ja)
Inventor
Sakuichi Otsuka
Katsuyoshi Tanabe
Hidetoshi Yagi
秀俊 八木
作一 大塚
勝義 田邊
Original Assignee
Nippon Telegr & Teleph Corp <Ntt>
日本電信電話株式会社
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nippon Telegr & Teleph Corp <Ntt>, 日本電信電話株式会社 filed Critical Nippon Telegr & Teleph Corp <Ntt>
Priority to JP8228071A priority Critical patent/JPH1071125A/en
Publication of JPH1071125A publication Critical patent/JPH1071125A/en
Pending legal-status Critical Current

Links

Abstract

(57) [Summary] [PROBLEMS] To automatically measure an arteriovenous diameter ratio of a fundus image to save a doctor's diagnosis and to provide objective measurement data to effectively use the data. A fundus image is input (102), and an optic disc and its center C are obtained (103). Two concentric circles having different set radii are drawn with the center C as a center, and a region enclosed between them is selected (104). A blood vessel is extracted in this area (105), and the circumference of the concentric circle having the smaller radius is scanned to determine the distance between blood vessels on the circumference for a plurality of blood vessels (106). Two blood vessels are selected as blood vessel pair candidates (107). A candidate without crossover or branching in the above-mentioned region is selected from the candidate blood vessel pair (108), and the blood vessel diameter and luminance value are measured to determine an arteriovenous pair (109). The arteriovenous diameter ratio of the arteriovenous pair is measured and digitized (110), and the data is stored and stored together with the input image and patient information (111).

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a method for measuring a ratio of an arteriovenous diameter of a fundus necessary for writing a finding of a fundus image.

[0002]

2. Description of the Related Art Fundus examinations have become widespread as one item of examinations for adult diseases and the like in medical examinations and medical checkups. As one of the examination items, there is an item called arteriovenous diameter ratio, and it is necessary for a doctor to measure and record this value when entering a finding. In this measurement work, the physician decides on the fundus image a place suitable for measurement based on knowledge and experience, and at a glance the diameter of the artery / vein at that place, measures the value, for example, a numerical value of 2: 3 Enter the ratio of arteriovenous diameter in the chart. At this time, sometimes a caliper is used,
At present, data and measurement are not digitized.

[0003]

However, the technique of measuring the artery and vein of the fundus, which relies on the knowledge and experience of the doctor,
Ophthalmologists have to deal with a large amount of data, which is a burdensome operation using nerves.
Fundus examinations in health examinations and health checkups are becoming increasingly important in the future, and the number of examination populations may increase. This problem is expected to become more apparent. In addition, doctors qualitatively describe subjective diagnosis contents in medical records based on their knowledge and experience. For this reason, there is a problem that it is difficult to objectively use data due to a difference in criteria between doctors due to differences in doctors and a variation in criteria within an individual doctor due to differences in day and time. In addition, since the measurement data is not electronically stored in a database, there is a problem that past data is not effectively used.

SUMMARY OF THE INVENTION The present invention has been made to solve the above-mentioned conventional problems, and a measurable arteriovenous pair is selected, and an arteriovenous diameter ratio of a fundus image is automatically measured to save a doctor's diagnosis. It is an object of the present invention to provide a method of measuring the ratio of arteriovenous diameter of the fundus, which provides objective measurement data and makes effective use of the data.

[0005]

In order to achieve the above object, a method of measuring a ratio of arteriovenous diameter of a fundus according to the present invention comprises the steps of: inputting a fundus image; Obtaining a center of the optic papilla; selecting an area between two concentric circles or concentric arcs of different radii with the center of the obtained optic papilla as the center of the circle; Extracting blood vessels in the extracted region, scanning the circumference of the smaller concentric circle or concentric arc, and determining the inter-vascular distance on the circumference for the extracted plurality of blood vessels, A step of selecting two blood vessels in which the obtained distance between blood vessels is smaller than a predetermined value as a blood vessel pair, and a blood vessel pair that does not intersect or branch in the region. Selection process Measuring the blood vessel diameter and the brightness value of the selected blood vessel pair and determining an arteriovenous pair based on the blood vessel diameter and the brightness value, and measuring and quantifying the arteriovenous diameter ratio of the determined arteriovenous pair. And a step of performing.

In the above-described method for measuring the ratio of arteriovenous diameters of the fundus, in the process of measuring the blood vessel diameter and the brightness value of the selected blood vessel pair and determining the arteriovenous pair based on the blood vessel diameter and the brightness value, a plurality of motions are determined. In the process of determining a vein pair, measuring the arteriovenous diameter ratio of the determined arteriovenous pair, and numerically calculating the arteriovenous diameter ratio of the plurality of arteriovenous pairs, Measuring the average value of the arteriovenous diameter ratios or selecting one of the arteriovenous diameter ratios of the plurality of arteriovenous pairs based on the measurement value evaluation index to obtain a numerical value provides objective measurement data. Preferred above.

In addition, the above-described method for measuring the ratio of the arteriovenous diameter of the fundus to the eye has a new process of storing the digitized data together with the input image and patient information and storing the information, This is suitable for effective use of the diameter ratio measurement data.

In the present invention, the optic papilla and its center are detected from the input fundus image, and 2
The measurement area suitable for measurement is limited using concentric circles of two different radii, blood vessels in this area are extracted, and a blood vessel pair candidate is selected from the distance between the blood vessels. The arteriovenous pair is determined based on the blood vessel diameter and the brightness value, and the arteriovenous diameter ratio is calculated from the vessel diameter of the arteriovenous pair. And provide objective measurement data. Further, by accumulating the calculated measurement data together with the input fundus image and the patient information, the objective measurement data obtained above can be effectively used.

The optic disc and the center of the optic disc need not be exact, but are used as the centers when concentric circles are obtained. Concentric circles may be arcs. In this manner, a plurality of arteriovenous pair candidates on the fundus image are automatically selected, the blood vessel diameter is measured, and the arteriovenous diameter ratio is measured, and a plurality of numerical data of the arteriovenous diameter ratio is provided to a doctor or the like. I do. A doctor or the like selects an appropriate one from among a plurality of numerical data based on knowledge and experience, and the selected appropriate numerical data is used, for example, on a recording medium or the like to obtain a fundus image or , Patient name,
It is stored and stored together with the patient information such as the ID, the measurement position, and the remarks. At this time, the number of numerical data of the arteriovenous diameter ratio of the arteriovenous pair presented to the doctor or the like is limited to one rather than a plurality in order to further reduce the labor of the diagnosis of the doctor and obtain the objectivity of the measurement data. It is also possible to present an average value of the measured values in a plurality of pairs of arteries and veins.

[0010]

Embodiments of the present invention will be described below in detail with reference to the drawings.

FIG. 1 is a flowchart of an arteriovenous ratio measuring method according to the present invention. In the figure, 101 is a start, 102 is a process for inputting a fundus image, and 103 is a optic disc and a center C of the optic disc. Processing 104 is different in radius (r1, r2 (r1) about the center C of the optic disc.
1 <r2)) a process of selecting a region surrounded by two concentric circles (C1, C2); 105, a process of extracting blood vessels in the selected measurement region; and 106, a smaller concentric circle (radius). r1) a process of scanning the circumference to obtain the distance between blood vessels; 107, a process of selecting a pair of candidate blood vessels;
8 is a process of selecting only a blood vessel set consisting of blood vessels that do not intersect or branch in the selected area; 109 is a process of measuring the blood vessel diameter and the brightness value of the blood vessel set to determine an arteriovenous blood vessel pair;
110 is a process of measuring and digitizing a plurality of pairs of arteriovenous diameter ratios,
111 indicates a process of storing data, and 112 indicates an end.

FIG. 2 is a block diagram showing an example of a configuration for implementing the arteriovenous diameter ratio measuring method of the present invention. In FIG. 2, reference numeral 201 denotes an input image, 202 denotes an input unit, 203 denotes a display unit, 204 is an image storage unit, 205 is a data storage unit, 20
6 is a measurement unit, 207 is a blood vessel extraction unit, 208 is an area extraction unit, 209 is a control unit, 210 is character code data, 211
Indicates a search unit.

FIG. 3 is a schematic diagram of a fundus image showing an example of detecting the center of the optic papilla and an example of selecting a measurement area. In the figure, 301 is the optic papilla, 302 is the center C of the optic papilla, 303 , 304 are concentric circles (C1, C2) about the center C302 of the optic papilla, and 305, 306 are radii r1, r2 (r1 <r) of the concentric circles C1, C2, respectively.
2) and 307 are arteries, 308 is a vein, and 309 is a selected measurement area.

FIG. 4 is a schematic view of an example of an extracted image of a measurement area, in which 401 is an artery, 402 is a vein, 403, 4
04 is a concentric circle (C) centered on the center C of the optic disc.
1, C2).

FIG. 5 is a view showing an example of a blood vessel extracted image. In the figure, 501 is the center C of the optic disc, 502 and 503 are concentric circles (C1, C2) centered on the center 501 of the optic disc, respectively. 504 is a blood vessel pair candidate, 505 is an artery,
Reference numeral 506 denotes a vein, 507 denotes a midpoint V of the blood vessel width on the concentric circle C1, 508 denotes an intervascular angle θk, and 509 denotes an intervascular distance dk.

FIG. 6 is an enlarged view of the measuring place, in which FIG.
01 is an artery, 602 is a vein, 603 is a center line m in the blood vessel, 604 is a straight line n perpendicular to the center line m of the blood vessel, 605 is a point P on the center line m of the blood vessel, and 606 is the length L of the blood vessel. Is shown.

First, when a fundus image 201 to be processed is input through the input unit 202 (102), the control unit 2
From step 09, the area extracting unit 208 determines the optic papilla and the center C302 of the optic papilla (103), and has different radii about the center C; 302 of the optic papilla (r1; 305, r2; 306 (r1) <R2)) It is instructed to execute a series of processing (104) of selecting an area 309 between two concentric circles (C1; 303, C2; 304).

The process (103) for obtaining the optic disc and the center C; 302 of the optic disc is performed by utilizing the fact that the optic disc is generally bright on the fundus image, and
On an image having a resolution of × T, an image in which the optic papilla is shown near the center is performed as follows. First, the luminance value I of each pixel is set as i in the horizontal direction and j in the vertical direction.
(I, j) by projecting the sum M i, obtaining the N j.

M i = Σ j = 1 S I (i, j) N j = Σ i = 1 T I (i, j) Next, i , j taking maxM i and maxN j are represented by the optic disc center C As 302; Next, different radii about the center C; 302 of the optic disc (r1; 30)
5, r2; 306 (r1 <r2)) two concentric circles (C
1; 303, C2; 304) between the regions 309
In the process (104) of selecting, the radius r1; 305 and the radius r2; 306 are set such that an appropriate portion is selected in consideration of the size of the image, the resolution, the average size of the optic disc, and the like. Use a preset constant. FIG. 4 shows an example of an extracted image of a measurement area between two concentric circles. The term “appropriate portion” as used herein refers to an image in which blood vessels travel straight from the concentric circle C1 to the concentric circle C2 without branching or crossing.

Next, the control unit 209 controls the blood vessel extraction unit 207.
Then, an instruction to execute a process (105) of extracting blood vessels in the selected measurement area 309 is issued. Blood vessel extraction unit 2
At 07, a process for extracting blood vessels by performing image processing such as smoothing processing and binarization processing on the measurement area 309 is performed. At this time, small regions and blood vessels that do not pass from the concentric circle C1 to the concentric circle C2 are removed. Assuming that the number of blood vessels extracted here is K, after calculating the midpoint V501 of the blood vessel width on the circumference of the concentric circle C1, the distance dk (k = 1, 2,
.., K-1) 509 or the blood vessel angle θk 508 is obtained.

Next, the measuring section 206 scans the circumference of the smaller concentric circle (radius r1) to obtain the distance between blood vessels (106), and selects a pair of candidate blood vessels (10).
7), a process of selecting only a blood vessel group consisting of blood vessels that do not cross or branch in the selected region (108), a process of measuring a blood vessel diameter and a brightness value of the blood vessel group and determining an arteriovenous blood vessel pair ( 109), executing a process (110) of measuring and digitizing a plurality of pairs of arteriovenous diameter ratios,
The image is displayed on the display unit 203 through the control unit 209 together with the fundus image.

In the process for obtaining the distance between blood vessels, two blood vessels having a short distance between blood vessels dk509 or a small angle between blood vessels θk508 in adjacent blood vessels are selected as a pair of blood vessels. Next, only a pair of blood vessels not crossing or branching within the measurement area 309 is selected from the blood vessel set. Further, the average blood vessel diameter and the average luminance are measured for the blood vessels forming the blood vessel group that is the blood vessel pair candidate. The average blood vessel diameter is a straight line n60 perpendicular to a point P605 on the center line m603 of the blood vessel obtained by thinning the blood vessel.
4 is the length of the blood vessel at the point P605, and the average value of the thickness when the point P605 is moved on the straight line n at a constant length L606 is the average blood vessel diameter of the blood vessel. . As the average luminance, the average value of the luminance of the blood vessel at a certain length L606 is defined as the average luminance.

Next, a blood vessel set that does not contradict the finding that the artery is brighter and thinner than the vein is selected, and the bright and thin blood vessel in this blood vessel set is determined as an artery, and the other is determined as a vein, and the arteriovenous diameter ratio is calculated. At this time, a plurality of pairs of arteriovenous diameter ratios can be used as numerical data as they are, but in addition, the result of performing an arithmetic operation such as averaging on the plurality of pairs of arteriovenous diameter ratios is used as the arteriovenous Using the results of ranking multiple arteriovenous diameter ratios using the diameter ratio or the reliability of measurement (accuracy of image processing) as an index, and using only one arteriovenous ratio based on the ranking It can also be determined as a diameter ratio.

If the measurement cannot be performed because the optic disc is not shown on the fundus image or the blood vessel is missing due to a medical condition, a display indicating that measurement is not possible and data are presented to the doctor. And accumulate.

A determination as to whether or not to store a plurality of arteriovenous diameter ratio data presented on the display unit 203 is made to the control unit 209 via the input unit 202 by the character / symbol data 210 using a mouse or the like. . At this time, it is also possible to correct the arteriovenous diameter ratio data measured via the input unit 202 using the character / symbol data 210 from a keyboard or the like, and to pass it to the control unit 209.

Finally, the patient name, patient ID, remarks, etc. are input from the input unit 202 as character / symbol data 210 using a keyboard, a mouse, or the like, and are stored in the data storage unit 205 through the control unit 209 together with the arteriovenous diameter ratio data. You.

The fundus image is also given an index common to the data stored in the data storage unit 205 such as a patient ID, and stored in the image storage unit 204 via the control unit 209.

In order to search the stored data, the character / symbol data 210 is input to the input unit 20 using a keyboard or a mouse.
2 through the control unit 209 and the search unit 2
11, the data of the patient is displayed by the data storage unit 205, and the fundus image is displayed by the image storage unit 204 on the display unit 203 through the control unit 209.

[0029]

As described above, when the measuring method of the present invention is used, a blood vessel is extracted from a fundus image, an arteriovenous blood vessel pair is selected, and the arteriovenous diameter ratio is automatically measured by image processing. As a result, doctors can perform work that used to be performed using nerves in the past by using a machine, which saves labor and improves the efficiency of diagnosis for doctors and others, and has the effect of spreading medical examinations. is there.

Further, since the measurement data is provided by automatic processing using a computer or the like, the effect that objective data utilization can be achieved is obtained. In addition, when the measurement data is stored and stored electronically, The effect that data can be reused and used effectively can be obtained.

[Brief description of the drawings]

FIG. 1 is a flowchart showing an embodiment of an arteriovenous diameter ratio measuring method according to an embodiment of the present invention.

FIG. 2 is a block diagram showing an example of a configuration for executing an arteriovenous diameter ratio measuring method according to the embodiment;

FIG. 3 is a schematic diagram of a fundus image showing an example of detection of the center of the optic papilla and an example of selection of a measurement region displayed on a display in the embodiment.

FIG. 4 is a schematic diagram of an example of an extracted image of a measurement region displayed on a display in the embodiment.

FIG. 5 is a diagram showing an example of a blood vessel extraction image displayed on a display in the embodiment.

FIG. 6 is an enlarged view of a measurement location of an example of a blood vessel extraction image displayed on a display in the embodiment.

[Explanation of symbols]

101: Start 102: Processing for inputting a fundus image 103: Processing for finding the optic papilla and the center C of the optic papilla 104: Surrounded by two concentric circles C1, C2 having different radii about the center C of the optic papilla A process of selecting a region during the period 105... A process of extracting blood vessels in the selected region 106... A process of scanning the smaller concentric circle and obtaining a distance between blood vessels 107. Processing 108: Processing of selecting only a blood vessel group consisting of blood vessels that do not cross or branch in the selected area 109: Processing of measuring the blood vessel diameter and luminance value of the blood vessel group to determine an arteriovenous blood vessel pair 110 ... Processing for measuring and digitizing a plurality of pairs of arteriovenous diameter ratios 111 ... Data storage processing 112 ... End 201 ... Input image 202 ... Input unit 203 ... Display unit 204 ... Image storage 205 data storage unit 206 measurement unit 207 blood vessel extraction unit 208 region extraction unit 209 control unit 210 character code data 211 search unit 301 optic nerve head 302 optic nerve head center C 303 concentric circle C1 304 ... Concentric circle C2 305 ... Radius r1 306 ... Radius r2 307 ... Artery 308 ... Vein 309 ... Measurement area 401 ... Artery 402 ... Vein 403 ... Concentric circle C1 404 ... Concentric circle C2 501 ... Center of optic nerve head C 502 ... Concentric circle C1 503 ... Concentric circle C2 504: blood vessel pair candidate 505: artery 506: vein 507: midpoint of blood vessel width V 508: intervascular angle θk 509: intervascular distance dk 601: artery 602: vein 603: center line m of blood vessel 604: center of blood vessel A straight line n 605... P 606...

Claims (3)

    [Claims]
  1. A step of inputting a fundus image; a step of obtaining an optic disc and a center of the optic disc from the input fundus image; and a step of setting the center of the obtained optic disc to the center of a circle. Selecting a region between two concentric circles or concentric arcs of radius; extracting blood vessels within the selected region; scanning over the circumference of the smaller concentric circle or concentric arc. Determining a distance between blood vessels on the circumference for the plurality of extracted blood vessels; and determining two blood vessels whose calculated distance between blood vessels is smaller than a predetermined value as blood vessel pair candidates. Selecting a blood vessel pair candidate that does not cross or branch in the region as a blood vessel pair; measuring a blood vessel diameter and a luminance value of the selected blood vessel pair; Based on And determining a vein pairs, measurement method of the fundus arteriovenous diameter ratio and having a the steps of: digitizing the measured arteriovenous diameter ratio of arteriovenous pair said determined.
  2. 2. In the step of measuring the blood vessel diameter and the luminance value of the selected blood vessel pair and determining an arteriovenous pair based on the blood vessel diameter and the luminance value, a plurality of arteriovenous pairs are determined. In the step of measuring and digitizing the arteriovenous diameter ratio of the vein pair, the arteriovenous diameter ratio of the plurality of arteriovenous pairs is measured, and the average value of the arteriovenous diameter ratio of the plurality of arteriovenous pairs is calculated. The method according to claim 1, wherein one of the arteriovenous diameter ratios of the plurality of arteriovenous pairs is selected and digitized based on a measurement value evaluation index. .
  3. 3. An image in which the digitized data is input,
    The method according to claim 1 or 2, further comprising a step of storing and storing together with the patient information.
JP8228071A 1996-08-29 1996-08-29 Method for measuring artery/vein diameter ration of eyebottom Pending JPH1071125A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP8228071A JPH1071125A (en) 1996-08-29 1996-08-29 Method for measuring artery/vein diameter ration of eyebottom

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP8228071A JPH1071125A (en) 1996-08-29 1996-08-29 Method for measuring artery/vein diameter ration of eyebottom

Publications (1)

Publication Number Publication Date
JPH1071125A true JPH1071125A (en) 1998-03-17

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ID=16870746

Family Applications (1)

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Country Status (1)

Country Link
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Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2007319403A (en) * 2006-05-31 2007-12-13 Topcon Corp Medical support system, apparatus, and program
JP2008513067A (en) * 2004-09-21 2008-05-01 イメドース ゲーエムベーハー Method and apparatus for analyzing retinal blood vessels in digital images
JP2009189586A (en) * 2008-02-14 2009-08-27 Nec Corp Fundus image analysis method, its instrument and program
JP2014193225A (en) * 2013-03-29 2014-10-09 Nidek Co Ltd Fundus image processing device and fundus image processing program
US10376166B2 (en) 2015-01-19 2019-08-13 Statumanu Icp Aps Method and apparatus for non-invasive assessment of intracranial pressure

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2008513067A (en) * 2004-09-21 2008-05-01 イメドース ゲーエムベーハー Method and apparatus for analyzing retinal blood vessels in digital images
JP2007319403A (en) * 2006-05-31 2007-12-13 Topcon Corp Medical support system, apparatus, and program
JP2009189586A (en) * 2008-02-14 2009-08-27 Nec Corp Fundus image analysis method, its instrument and program
JP2014193225A (en) * 2013-03-29 2014-10-09 Nidek Co Ltd Fundus image processing device and fundus image processing program
US10376166B2 (en) 2015-01-19 2019-08-13 Statumanu Icp Aps Method and apparatus for non-invasive assessment of intracranial pressure

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