JPH10506265A - 免疫調節オリゴヌクレオチド - Google Patents
免疫調節オリゴヌクレオチドInfo
- Publication number
- JPH10506265A JPH10506265A JP8504991A JP50499196A JPH10506265A JP H10506265 A JPH10506265 A JP H10506265A JP 8504991 A JP8504991 A JP 8504991A JP 50499196 A JP50499196 A JP 50499196A JP H10506265 A JPH10506265 A JP H10506265A
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- oligonucleotide
- cells
- odn
- cpg
- cell
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
- A61K31/7125—Nucleic acids or oligonucleotides having modified internucleoside linkage, i.e. other than 3'-5' phosphodiesters
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
- A61P31/22—Antivirals for DNA viruses for herpes viruses
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/117—Nucleic acids having immunomodulatory properties, e.g. containing CpG-motifs
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55561—CpG containing adjuvants; Oligonucleotide containing adjuvants
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/17—Immunomodulatory nucleic acids
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/31—Chemical structure of the backbone
- C12N2310/315—Phosphorothioates
Abstract
Description
Claims (1)
- 【特許請求の範囲】 1.式I:5’X1X2CGX3X43'に従う少なくとも1つの核酸配列を含む、免疫刺 激オリゴヌクレオチド: ここで、CGは、該オリゴヌクレオチドに免疫刺激能力を付与する非メチル化Cp Gジヌクレオチドであり;X1およびX2の少なくとも1つはプリンであり;そして 、X3およびX4の少なくとも1つはピリミジンである。 2.前記式Iがパリンドロームではない、請求項1に記載の免疫刺激オリゴヌ クレオチド。 3.X1がプリンヌクレオチドである、請求項2に記載のオリゴヌクレオチド。 4.X4がピリミジンヌクレオチドである、請求項2に記載のオリゴヌクレオチ ド。 5.X1の5'側にさらにチミジンヌクレオチドを含む、請求項2に記載のオリゴ ヌクレオチド。 6.前記式Iのヌクレオチド配列が、5’GACGTT 3'、5’AGCGTT 3'、5’AACGC T 3'、5’CTCGAC 3'、5’GTCGGT 3'、5’GACGTT 3'、5’TTCGAT 3'、5’AACGAT 3'および5’ATCGAC 3'からなる群から選択される、請求項2に記載のオリゴヌク レオチド。 7.前記式Iの配列を含む前記オリゴヌクレオチドの5'末端および3'末端のヌ クレオチド配列がポリGヌクレオチドである、請求項1〜6のいずれかに記載の オリゴヌクレオチド。 8.1つ以上のホスフェート骨格修飾を有する、請求項1〜7のいずれかに記 載のオリゴヌクレオチド。 9.前記1つ以上のホスフェート骨格修飾が、ホスホロチオエート修飾である 、請求項8に記載のオリゴヌクレオチド。 10.約6〜約100のヌクレオチドを含む、請求項1〜9のいずれかに記載のオ リゴヌクレオチド。 11.約6〜約40のヌクレオチドを含む、請求項1〜9のいずれかに記載のオリ ゴヌクレオチド。 12.請求項1に記載のオリゴヌクレオチドと標的化手段とを有する、オリゴヌ クレオチド送達複合体。 13.前記標的化手段が、コレステロール、ビロソーム、リポソーム、脂質およ び標的細胞特異的結合因子からなる群から選択される、請求項12に記載のオリゴ ヌクレオチド送達複合体。 14.免疫系不全にかかっているかまたはかかりやすいヒトを含む動物の予防ま たは処置のための薬品を製造するための、請求項1〜11のいずれかに記載のオリ ゴヌクレオチドあるいは請求項12または13に記載のオリゴヌクレオチド送達複合 体の使用。 15.前記免疫系不全が、ウィルス、細菌、真菌または寄生体の感染によって引 き起こされる、請求項14に記載の使用。 16.ガンにかかっているヒトを含む動物の処置のための薬品を製造するための 、請求項1〜11のいずれかに記載のオリゴヌクレオチドあるいは請求項12または 13に記載のオリゴヌクレオチド送達複合体の使用。 17.ワクチンに対する動物の免疫応答を増大させるためにワクチン投与前また はワクチン投与と同時にヒトを含む動物に投与するためのアジュバントを調製す るための、請求項1〜11のいずれかに記載のオリゴヌクレオチドあるいは請求項 12または13に記載のオリゴヌクレオチド送達複合体の使用。 18.免疫系の活性化に関連する疾病にかかりやすいヒトを含む動物の予防のた めの薬品を製造するための、請求項1〜11のいずれかに記載のオリゴヌクレオチ ドあるいは請求項12または13に記載のオリゴヌクレオチド送達複合体の使用。 19.前記免疫系の活性化に関連する疾病が、自己免疫疾患である、請求項18に 記載の使用。 20.前記免疫系の活性化が、細菌、真菌または寄生体の感染によって引き起こ される、請求項19に記載の使用。 21.請求項1〜11のいずれかに記載のオリゴヌクレオチドあるいは請求項12ま たは13に記載のオリゴヌクレオチド送達複合体と、薬学的に受容可能なキャリア とを含む、薬学的処方物。 22.別の治療剤をさらに含む、請求項21に記載の薬学的処方物。 23.少なくとも1つのメチル化CGジヌクレオチドを含む免疫中性オリゴヌクレ オチドと、薬学的に受容可能なキャリアとを含む、薬学的処方物。 24.ヒトを含む動物の免疫系の活性化に関連する疾病の予防または処置のため の薬品を調製するための、請求項23に記載の免疫中性オリゴヌクレオチドの使用 。 25.前記疾病が全身性紅斑性狼瘡である、請求項24に記載の使用。 26.前記疾病が敗血症である、請求項24に記載の使用。 27.前記メチル化CGジヌクレオチドが、5-メチルシトシンである、請求項24に 記載の使用。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US27635894A | 1994-07-15 | 1994-07-15 | |
US08/276,358 | 1994-07-15 | ||
PCT/US1995/001570 WO1996002555A1 (en) | 1994-07-15 | 1995-02-07 | Immunomodulatory oligonucleotides |
Related Child Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2002302338A Division JP2003144184A (ja) | 1994-07-15 | 2002-10-16 | 免疫調節オリゴヌクレオチド |
JP2003178741A Division JP4126252B2 (ja) | 1994-07-15 | 2003-06-23 | 免疫調節オリゴヌクレオチド |
JP2003178740A Division JP2004024261A (ja) | 1994-07-15 | 2003-06-23 | 免疫調節オリゴヌクレオチド |
Publications (2)
Publication Number | Publication Date |
---|---|
JPH10506265A true JPH10506265A (ja) | 1998-06-23 |
JP3468773B2 JP3468773B2 (ja) | 2003-11-17 |
Family
ID=23056334
Family Applications (7)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP50499196A Expired - Lifetime JP3468773B2 (ja) | 1994-07-15 | 1995-02-07 | 免疫調節オリゴヌクレオチド |
JP2002302338A Withdrawn JP2003144184A (ja) | 1994-07-15 | 2002-10-16 | 免疫調節オリゴヌクレオチド |
JP2003178740A Withdrawn JP2004024261A (ja) | 1994-07-15 | 2003-06-23 | 免疫調節オリゴヌクレオチド |
JP2003178741A Expired - Lifetime JP4126252B2 (ja) | 1994-07-15 | 2003-06-23 | 免疫調節オリゴヌクレオチド |
JP2004069838A Withdrawn JP2004215670A (ja) | 1994-07-15 | 2004-03-11 | 免疫調節オリゴヌクレオチド |
JP2008015654A Withdrawn JP2008169216A (ja) | 1994-07-15 | 2008-01-25 | 免疫調節オリゴヌクレオチド |
JP2009057160A Withdrawn JP2009148296A (ja) | 1994-07-15 | 2009-03-10 | 免疫調節オリゴヌクレオチド |
Family Applications After (6)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2002302338A Withdrawn JP2003144184A (ja) | 1994-07-15 | 2002-10-16 | 免疫調節オリゴヌクレオチド |
JP2003178740A Withdrawn JP2004024261A (ja) | 1994-07-15 | 2003-06-23 | 免疫調節オリゴヌクレオチド |
JP2003178741A Expired - Lifetime JP4126252B2 (ja) | 1994-07-15 | 2003-06-23 | 免疫調節オリゴヌクレオチド |
JP2004069838A Withdrawn JP2004215670A (ja) | 1994-07-15 | 2004-03-11 | 免疫調節オリゴヌクレオチド |
JP2008015654A Withdrawn JP2008169216A (ja) | 1994-07-15 | 2008-01-25 | 免疫調節オリゴヌクレオチド |
JP2009057160A Withdrawn JP2009148296A (ja) | 1994-07-15 | 2009-03-10 | 免疫調節オリゴヌクレオチド |
Country Status (12)
Country | Link |
---|---|
US (1) | US6194388B1 (ja) |
EP (4) | EP1167378B1 (ja) |
JP (7) | JP3468773B2 (ja) |
AT (3) | ATE509102T1 (ja) |
AU (1) | AU713040B2 (ja) |
CA (2) | CA2194761C (ja) |
DE (2) | DE69535036T3 (ja) |
DK (1) | DK0772619T4 (ja) |
ES (3) | ES2320315T5 (ja) |
HK (3) | HK1043598A1 (ja) |
PT (1) | PT772619E (ja) |
WO (1) | WO1996002555A1 (ja) |
Cited By (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2002522510A (ja) * | 1998-08-10 | 2002-07-23 | アクウィラ・バイオファーマシューティカルズ・インコーポレイテッド | Cpgおよびサポニンアジュバントの組成物並びにその方法 |
JP2002539265A (ja) * | 1999-03-19 | 2002-11-19 | アシスタンス ピュブリック−オピト ド パリ | 抗腫瘍活性を有する薬剤を製造するための安定化オリゴヌクレオチドの使用 |
JP2003505431A (ja) * | 1999-07-21 | 2003-02-12 | レキシジェン ファーマシューティカルズ コーポレイション | タンパク質抗原およびペプチド抗原の免疫原性を増強するためのfc融合タンパク質 |
JP2003507341A (ja) * | 1999-08-19 | 2003-02-25 | ダイナバックス テクノロジーズ コーポレイション | 免疫刺激配列およびそれを使用するための組成物を用いて免疫応答を調節するための方法およびそれを使用するための組成物 |
JP2003509341A (ja) * | 1999-08-27 | 2003-03-11 | イネックス ファーマスーティカルズ コーポレイション | サイトカインの分泌刺激および免疫応答の誘導組成物 |
JP2005502611A (ja) * | 2001-06-29 | 2005-01-27 | カイロン コーポレイション | Hcve1e2ワクチン組成物 |
WO2005063264A1 (ja) * | 2003-12-25 | 2005-07-14 | Japan Science And Technology Agency | 免疫活性増強剤とこれを用いた免疫活性の増強方法 |
WO2006035939A1 (ja) * | 2004-09-30 | 2006-04-06 | Osaka University | 免疫刺激オリゴヌクレオチドおよびその医薬用途 |
JP2006514933A (ja) * | 2002-11-21 | 2006-05-18 | ベイヒル セラピューティクス インコーポレーティッド | 疾患を予防および治療するための方法および免疫調節核酸組成物 |
JPWO2004100965A1 (ja) * | 2003-05-15 | 2006-07-13 | 独立行政法人科学技術振興機構 | 免疫刺激剤 |
WO2007139190A1 (ja) | 2006-05-31 | 2007-12-06 | Toray Industries, Inc. | 免疫刺激オリゴヌクレオチド及びその医薬用途 |
JP2008063342A (ja) * | 1999-04-19 | 2008-03-21 | Glaxosmithkline Biologicals Sa | ワクチン |
US8080554B2 (en) | 2001-12-12 | 2011-12-20 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Methods for using extracellular adenosine inhibitors and adenosine receptor inhibitors to enhance immune response and inflammation |
WO2015108047A1 (ja) * | 2014-01-15 | 2015-07-23 | 株式会社新日本科学 | 免疫誘導活性を有するキラル核酸アジュバンド及び免疫誘導活性剤 |
WO2015108046A1 (ja) * | 2014-01-15 | 2015-07-23 | 株式会社新日本科学 | 抗アレルギー作用を有するキラル核酸アジュバンド及び抗アレルギー剤 |
WO2015108048A1 (ja) * | 2014-01-15 | 2015-07-23 | 株式会社新日本科学 | 抗腫瘍作用を有するキラル核酸アジュバンド及び抗腫瘍剤 |
Families Citing this family (808)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5849719A (en) | 1993-08-26 | 1998-12-15 | The Regents Of The University Of California | Method for treating allergic lung disease |
US6727230B1 (en) * | 1994-03-25 | 2004-04-27 | Coley Pharmaceutical Group, Inc. | Immune stimulation by phosphorothioate oligonucleotide analogs |
EP1167378B1 (en) * | 1994-07-15 | 2011-05-11 | University of Iowa Research Foundation | Immunomodulatory oligonucleotides |
US20030026782A1 (en) * | 1995-02-07 | 2003-02-06 | Arthur M. Krieg | Immunomodulatory oligonucleotides |
US6207646B1 (en) * | 1994-07-15 | 2001-03-27 | University Of Iowa Research Foundation | Immunostimulatory nucleic acid molecules |
US7935675B1 (en) * | 1994-07-15 | 2011-05-03 | University Of Iowa Research Foundation | Immunostimulatory nucleic acid molecules |
US6429199B1 (en) | 1994-07-15 | 2002-08-06 | University Of Iowa Research Foundation | Immunostimulatory nucleic acid molecules for activating dendritic cells |
US6239116B1 (en) | 1994-07-15 | 2001-05-29 | University Of Iowa Research Foundation | Immunostimulatory nucleic acid molecules |
US7422902B1 (en) * | 1995-06-07 | 2008-09-09 | The University Of British Columbia | Lipid-nucleic acid particles prepared via a hydrophobic lipid-nucleic acid complex intermediate and use for gene transfer |
US5981501A (en) * | 1995-06-07 | 1999-11-09 | Inex Pharmaceuticals Corp. | Methods for encapsulating plasmids in lipid bilayers |
AU1463097A (en) | 1996-01-04 | 1997-08-01 | Rican Limited | Helicobacter pylori bacterioferritin |
WO1997028259A1 (en) * | 1996-01-30 | 1997-08-07 | The Regents Of The University Of California | Gene expression vectors which generate an antigen specific immune response and methods of using the same |
FR2750704B1 (fr) | 1996-07-04 | 1998-09-25 | Rhone Poulenc Rorer Sa | Procede de production d'adn therapeutique |
US5856462A (en) * | 1996-09-10 | 1999-01-05 | Hybridon Incorporated | Oligonucleotides having modified CpG dinucleosides |
ES2241042T3 (es) | 1996-10-11 | 2005-10-16 | The Regents Of The University Of California | Conjugados de polinucleotido inmunoestimulador/ molecula inmunomoduladora. |
AU768178B2 (en) * | 1996-10-11 | 2003-12-04 | Regents Of The University Of California, The | Immunostimulatory polynucleotide/immunomodulatory molecule conjugates |
EP0855184A1 (en) * | 1997-01-23 | 1998-07-29 | Grayson B. Dr. Lipford | Pharmaceutical composition comprising a polynucleotide and an antigen especially for vaccination |
US6214806B1 (en) | 1997-02-28 | 2001-04-10 | University Of Iowa Research Foundation | Use of nucleic acids containing unmethylated CPC dinucleotide in the treatment of LPS-associated disorders |
CA2283557A1 (en) * | 1997-03-10 | 1998-09-17 | Heather L. Davis | Use of nucleic acids containing unmethylated cpg dinucleotide as an adjuvant |
US6406705B1 (en) * | 1997-03-10 | 2002-06-18 | University Of Iowa Research Foundation | Use of nucleic acids containing unmethylated CpG dinucleotide as an adjuvant |
US6426334B1 (en) | 1997-04-30 | 2002-07-30 | Hybridon, Inc. | Oligonucleotide mediated specific cytokine induction and reduction of tumor growth in a mammal |
DE69841002D1 (de) | 1997-05-14 | 2009-09-03 | Univ British Columbia | Hochwirksame verkapselung von nukleinsäuren in lipidvesikeln |
US20030104044A1 (en) * | 1997-05-14 | 2003-06-05 | Semple Sean C. | Compositions for stimulating cytokine secretion and inducing an immune response |
JP2001526688A (ja) * | 1997-05-19 | 2001-12-18 | メルク エンド カンパニー インコーポレーテッド | オリゴヌクレオチドアジュバント |
WO1998052581A1 (en) * | 1997-05-20 | 1998-11-26 | Ottawa Civic Hospital Loeb Research Institute | Vectors and methods for immunization or therapeutic protocols |
US6589940B1 (en) | 1997-06-06 | 2003-07-08 | Dynavax Technologies Corporation | Immunostimulatory oligonucleotides, compositions thereof and methods of use thereof |
EP1374894A3 (en) * | 1997-06-06 | 2004-09-22 | Dynavax Technologies Corporation | Immunostimulatory oligonucleotides, compositions thereof and methods of use thereof |
US20040006034A1 (en) * | 1998-06-05 | 2004-01-08 | Eyal Raz | Immunostimulatory oligonucleotides, compositions thereof and methods of use thereof |
DE69840850D1 (de) * | 1997-06-06 | 2009-07-09 | Dynavax Tech Corp | Inhibitoren von immunstimulatorischen dna sequenz aktivität |
AU757175B2 (en) | 1997-09-05 | 2003-02-06 | Regents Of The University Of California, The | Use of immunostimulatory oligonucleotides for preventing or reducing antigen-stimulated, granulocyte-mediated inflammation |
GB9724531D0 (en) | 1997-11-19 | 1998-01-21 | Smithkline Biolog | Novel compounds |
SI1659178T1 (sl) | 1998-02-05 | 2010-07-30 | Glaxosmithkline Biolog Sa | Postopek za čiščenje ali proizvodnjo MAGE proteina |
US20020147143A1 (en) | 1998-03-18 | 2002-10-10 | Corixa Corporation | Compositions and methods for the therapy and diagnosis of lung cancer |
AU760549B2 (en) * | 1998-04-03 | 2003-05-15 | University Of Iowa Research Foundation, The | Methods and products for stimulating the immune system using immunotherapeutic oligonucleotides and cytokines |
NZ506603A (en) * | 1998-04-09 | 2002-10-25 | Smithkline Beecham Biolog S | Adjuvant compositions comprising polyoxyethylene ether or polyoxyethylene ester |
GB9808866D0 (en) | 1998-04-24 | 1998-06-24 | Smithkline Beecham Biolog | Novel compounds |
JP2002513763A (ja) * | 1998-05-06 | 2002-05-14 | ユニバーシティ オブ アイオワ リサーチ ファウンデーション | Cpgオリゴヌクレオチドを使用して寄生生物感染および関連する疾患を予防および処置するための方法 |
CA2328406A1 (en) * | 1998-05-14 | 1999-11-18 | Hermann Wagner | Methods for regulating hematopoiesis using cpg-oligonucleotides |
CN102274272A (zh) | 1998-05-19 | 2011-12-14 | 研究发展基金会 | 三萜组合物和它们的使用方法 |
DK1077722T3 (da) * | 1998-05-22 | 2006-11-27 | Ottawa Health Research Inst | Fremgangsmåder og produkter til induktion af mukosaimmunitet |
KR19990086271A (ko) * | 1998-05-27 | 1999-12-15 | 손경식 | 면역세포의 신규한 엔도뉴클레아제 및 이를 사용한 면역보조제 |
US6881561B1 (en) | 1998-05-27 | 2005-04-19 | Cheil Jedang Corporation | Endonuclease of immune cell, process for producing the same and immune adjuvant using the same |
US6562798B1 (en) * | 1998-06-05 | 2003-05-13 | Dynavax Technologies Corp. | Immunostimulatory oligonucleotides with modified bases and methods of use thereof |
US20030022854A1 (en) * | 1998-06-25 | 2003-01-30 | Dow Steven W. | Vaccines using nucleic acid-lipid complexes |
US20040247662A1 (en) * | 1998-06-25 | 2004-12-09 | Dow Steven W. | Systemic immune activation method using nucleic acid-lipid complexes |
US6693086B1 (en) * | 1998-06-25 | 2004-02-17 | National Jewish Medical And Research Center | Systemic immune activation method using nucleic acid-lipid complexes |
EP1100807A1 (en) * | 1998-07-27 | 2001-05-23 | University Of Iowa Research Foundation | STEREOISOMERS OF CpG OLIGONUCLEOTIDES AND RELATED METHODS |
EP2280031B1 (en) | 1998-07-31 | 2015-04-15 | International Institute of Cancer Immunology, Inc. | Cancer antigens based on products of the tumor suppressor gene WT1 |
CN1348463A (zh) | 1998-08-07 | 2002-05-08 | 华盛顿大学 | 免疫学单纯疱疹病毒抗原及其使用方法 |
WO2000014262A2 (en) * | 1998-09-09 | 2000-03-16 | Genzyme Corporation | Methylation of plasmid vectors |
FR2783170B1 (fr) * | 1998-09-11 | 2004-07-16 | Pasteur Merieux Serums Vacc | Emulsion immunostimulante |
US6692752B1 (en) | 1999-09-08 | 2004-02-17 | Smithkline Beecham Biologicals S.A. | Methods of treating human females susceptible to HSV infection |
ATE326239T1 (de) * | 1998-09-18 | 2006-06-15 | Dynavax Tech Corp | Verfahren zur behandlung von ig-e assozierten krankheiten und zusammensetzungen zur verwendung in diesen verfahren |
US20030235557A1 (en) | 1998-09-30 | 2003-12-25 | Corixa Corporation | Compositions and methods for WT1 specific immunotherapy |
WO2000020039A1 (en) * | 1998-10-05 | 2000-04-13 | The Regents Of The University Of California | Methods and adjuvants for stimulating mucosal immunity |
DE69935606T9 (de) | 1998-10-16 | 2021-03-11 | Glaxosmithkline Biologicals S.A. | Adjuvanzsysteme und impfstoffe |
KR20100132086A (ko) | 1998-12-08 | 2010-12-16 | 코릭사 코포레이션 | 클라미디아 감염을 치료 및 진단하기 위한 조성물 및 이를 포함하는 약제학적 조성물 및 진단 키트 |
CA2354028A1 (en) | 1998-12-08 | 2000-06-15 | Smithkline Beecham Biologicals S.A. | Neisseria meningitidis basb041 polypeptides and encoding polynucleotides and uses thereof |
US20020119158A1 (en) | 1998-12-17 | 2002-08-29 | Corixa Corporation | Compositions and methods for the therapy and diagnosis of ovarian cancer |
US6579973B1 (en) | 1998-12-28 | 2003-06-17 | Corixa Corporation | Compositions for the treatment and diagnosis of breast cancer and methods for their use |
US7198920B1 (en) * | 1999-01-29 | 2007-04-03 | Corika Corporation | HER-2/neu fusion proteins |
WO2000045849A2 (en) * | 1999-02-05 | 2000-08-10 | Genzyme Corporation | Use of cationic lipids to generate anti-tumor immunity |
US7776343B1 (en) | 1999-02-17 | 2010-08-17 | Csl Limited | Immunogenic complexes and methods relating thereto |
ES2242604T3 (es) | 1999-02-26 | 2005-11-16 | Chiron Corporation | Microemulsiones con macroparticulas y microparticulas adsorbidas. |
EP1154790B1 (en) | 1999-02-26 | 2004-10-20 | Chiron S.r.l. | Enhancement of bactericidal activity of neisseria antigens with oligonucleotides containing cg motifs |
EP2270169A3 (en) | 1999-03-12 | 2011-06-15 | GlaxoSmithKline Biologicals SA | Neisseria meningitidis antigenic polypeptides, corresponding polynucleotides and protective antibodies |
GB9909077D0 (en) | 1999-04-20 | 1999-06-16 | Smithkline Beecham Biolog | Novel compositions |
NZ513841A (en) | 1999-03-19 | 2001-09-28 | Smithkline Beecham Biolog S | Vaccine against Streptococcus pneumoniae |
JP2000262247A (ja) * | 1999-03-19 | 2000-09-26 | Asama Kasei Kk | 免疫調節剤、免疫調節食品および免疫調節飼料 |
CN1370182A (zh) | 1999-04-02 | 2002-09-18 | 科里克萨有限公司 | 用于治疗和诊断肺癌的化合物和方法 |
US6977245B2 (en) | 1999-04-12 | 2005-12-20 | The United States Of America As Represented By The Department Of Health And Human Services | Oligodeoxynucleotide and its use to induce an immune response |
WO2000061151A2 (en) | 1999-04-12 | 2000-10-19 | The Government Of The United States Of America, Represented By The Secretary, Department Of Health And Human Services | Oligodeoxynucleotide and its use to induce an immune response |
US6558670B1 (en) | 1999-04-19 | 2003-05-06 | Smithkline Beechman Biologicals S.A. | Vaccine adjuvants |
WO2000067023A1 (en) * | 1999-04-29 | 2000-11-09 | Coley Pharmaceutical Gmbh | Screening for immunostimulatory dna functional modifyers |
GB9915204D0 (en) * | 1999-06-29 | 1999-09-01 | Smithkline Beecham Biolog | Vaccine |
WO2001000232A2 (en) * | 1999-06-29 | 2001-01-04 | Smithkline Beecham Biologicals S.A. | Use of cpg as an adjuvant for hiv vaccine |
US6514948B1 (en) | 1999-07-02 | 2003-02-04 | The Regents Of The University Of California | Method for enhancing an immune response |
FR2795963A1 (fr) * | 1999-07-08 | 2001-01-12 | Pasteur Merieux Serums Vacc | Polynucleotide immunostimulant |
GB9918319D0 (en) | 1999-08-03 | 1999-10-06 | Smithkline Beecham Biolog | Vaccine composition |
US20050226890A1 (en) * | 1999-08-12 | 2005-10-13 | Cohen David I | Tat-based vaccine compositions and methods of making and using same |
DK1221955T3 (da) * | 1999-09-25 | 2006-01-30 | Univ Iowa Res Found | Immunstimulerende nukleinsyre |
US6949520B1 (en) | 1999-09-27 | 2005-09-27 | Coley Pharmaceutical Group, Inc. | Methods related to immunostimulatory nucleic acid-induced interferon |
DE60038971D1 (de) | 1999-10-22 | 2008-07-03 | Aventis Pasteur | Verfahren zur erregung und/oder verstärkung der immunantwort gegen tumorantigene |
US7223398B1 (en) | 1999-11-15 | 2007-05-29 | Dynavax Technologies Corporation | Immunomodulatory compositions containing an immunostimulatory sequence linked to antigen and methods of use thereof |
AU2593701A (en) * | 1999-12-21 | 2001-07-03 | Regents Of The University Of California, The | Method for preventing an anaphylactic reaction |
ATE378348T1 (de) | 2000-01-14 | 2007-11-15 | Us Health | Oligodeoxynukleotide und ihre verwendung zur induktion einer immunreaktion |
AT409085B (de) * | 2000-01-28 | 2002-05-27 | Cistem Biotechnologies Gmbh | Pharmazeutische zusammensetzung zur immunmodulation und herstellung von vakzinen |
WO2001055341A2 (en) * | 2000-01-31 | 2001-08-02 | The Regents Of The University Of California | Immunomodulatory polynucleotides in treatment of an infection by an intracellular pathogen |
US7585847B2 (en) * | 2000-02-03 | 2009-09-08 | Coley Pharmaceutical Group, Inc. | Immunostimulatory nucleic acids for the treatment of asthma and allergy |
FR2805265B1 (fr) * | 2000-02-18 | 2002-04-12 | Aventis Pasteur | Oligonucleotides immunostimulants |
FR2805264B1 (fr) * | 2000-02-18 | 2002-04-12 | Aventis Pasteur | Oligonucleotides immunostimulants |
AU2001256156B2 (en) * | 2000-02-23 | 2006-01-05 | Smithkline Beecham Biologicals S.A. | Novel compounds |
US20030130217A1 (en) * | 2000-02-23 | 2003-07-10 | Eyal Raz | Method for treating inflammatory bowel disease and other forms of gastrointestinal inflammation |
CA2399550A1 (en) * | 2000-02-23 | 2001-08-30 | The Regents Of The University Of California | Method for treating inflammatory bowel disease and other forms of gastrointestinal inflammation |
US20040002068A1 (en) | 2000-03-01 | 2004-01-01 | Corixa Corporation | Compositions and methods for the detection, diagnosis and therapy of hematological malignancies |
US20040131628A1 (en) * | 2000-03-08 | 2004-07-08 | Bratzler Robert L. | Nucleic acids for the treatment of disorders associated with microorganisms |
US7157437B2 (en) | 2000-03-10 | 2007-01-02 | Dynavax Technologies Corporation | Methods of ameliorating symptoms of herpes infection using immunomodulatory polynucleotide sequences |
US7129222B2 (en) * | 2000-03-10 | 2006-10-31 | Dynavax Technologies Corporation | Immunomodulatory formulations and methods for use thereof |
US20010046967A1 (en) | 2000-03-10 | 2001-11-29 | Gary Van Nest | Methods of preventing and treating respiratory viral infection using immunomodulatory polynucleotide |
US20030129251A1 (en) | 2000-03-10 | 2003-07-10 | Gary Van Nest | Biodegradable immunomodulatory formulations and methods for use thereof |
US20020098199A1 (en) | 2000-03-10 | 2002-07-25 | Gary Van Nest | Methods of suppressing hepatitis virus infection using immunomodulatory polynucleotide sequences |
US20020142978A1 (en) * | 2000-04-07 | 2002-10-03 | Eyal Raz | Synergistic improvements to polynucleotide vaccines |
CA2407114A1 (en) | 2000-04-21 | 2001-11-01 | Corixa Corporation | Compounds and methods for treatment and diagnosis of chlamydial infection |
ATE513913T1 (de) | 2000-05-10 | 2011-07-15 | Sanofi Pasteur Ltd | Durch mage minigene kodierte immunogene polypeptide und ihre verwendungen |
CA2409221C (en) | 2000-05-19 | 2010-10-26 | Corixa Corporation | Prophylactic and therapeutic treatment of infectious and other diseases with mono- and disaccharide-based compounds |
ATE526994T1 (de) | 2000-06-20 | 2011-10-15 | Corixa Corp | Mtb32a antigen aus mycobakterium tuberculosis mit inaktivierter protease aktivität und fusionsproteine die das antigen enthalten |
AU7013401A (en) | 2000-06-22 | 2002-01-02 | Univ Iowa Res Found | Methods for enhancing antibody-induced cell lysis and treating cancer |
AR029540A1 (es) | 2000-06-28 | 2003-07-02 | Corixa Corp | COMPOSICIONES Y METODOS PARA EL DIAGNoSTICO Y LA TERAPIA DE CA NCER DE PULMoN |
GB0108364D0 (en) | 2001-04-03 | 2001-05-23 | Glaxosmithkline Biolog Sa | Vaccine composition |
AP1695A (en) | 2000-06-29 | 2006-12-17 | Glaxosmithkline Biologicals Sa | Multivalent vaccine composition. |
US7229623B1 (en) | 2000-08-03 | 2007-06-12 | Corixa Corporation | Her-2/neu fusion proteins |
KR100917101B1 (ko) * | 2000-08-04 | 2009-09-15 | 도요 보세키 가부시키가이샤 | 플렉시블 금속적층체 및 그 제조방법 |
UA79735C2 (uk) | 2000-08-10 | 2007-07-25 | Глаксосмітклайн Байолоджікалз С.А. | Очищення антигенів вірусу гепатиту b (hbv) для використання у вакцинах |
US20080044435A1 (en) * | 2004-03-16 | 2008-02-21 | Cohen David I | Tat-Based Tolerogen Compositions and Methods of Making and Using Same |
AU2001285421A1 (en) * | 2000-08-10 | 2002-02-18 | Henry M. Jackson Foundation For The Advancement Of Military Medicine | Vaccine against rsv |
JP2005503320A (ja) * | 2000-08-25 | 2005-02-03 | イエダ・リサーチ・アンド・デベロツプメント・カンパニー・リミテツド | CpG−含有ポリヌクレオチドで自己免疫疾患を処置または防止する方法 |
EP1366077B1 (en) * | 2000-09-15 | 2011-05-25 | Coley Pharmaceutical GmbH | PROCESS FOR HIGH THROUGHPUT SCREENING OF CpG-BASED IMMUNO-AGONIST/ANTAGONIST |
GB0022742D0 (en) | 2000-09-15 | 2000-11-01 | Smithkline Beecham Biolog | Vaccine |
ES2377077T3 (es) | 2000-10-18 | 2012-03-22 | Glaxosmithkline Biologicals S.A. | Vacunas que comprenden al antígeno MAGE unido a un fragmento de proteína D |
CA2881568C (en) | 2000-10-27 | 2019-09-24 | Novartis Vaccines And Diagnostics, Inc. | Nucleic acids and proteins from streptococcus groups a & b |
WO2006091720A2 (en) * | 2000-12-08 | 2006-08-31 | 3M Innovative Properties Company | Compositions and methods for targeted delivery of immune response modifiers |
US6677347B2 (en) * | 2000-12-08 | 2004-01-13 | 3M Innovative Properties Company | Sulfonamido ether substituted imidazoquinolines |
ES2307568T3 (es) | 2000-12-08 | 2008-12-01 | Coley Pharmaceutical Gmbh | Acidos nucleicos de tipo cpg y metodos de uso de los mismos. |
WO2002052002A2 (en) * | 2000-12-27 | 2002-07-04 | Dynavax Technologies Corporation | Immunomodulatory polynucleotides and methods of using the same |
KR20030070102A (ko) * | 2001-01-12 | 2003-08-27 | 아마토 세이야쿠 가부시키가이샤 | 항알레르기제 |
CA2434573A1 (en) * | 2001-01-12 | 2002-07-18 | Amato Pharmaceutical Products, Ltd. | Agent for protection against microorganism infection |
US7128911B2 (en) | 2001-01-19 | 2006-10-31 | Cytos Biotechnology Ag | Antigen arrays for treatment of bone disease |
WO2002060457A1 (fr) * | 2001-01-24 | 2002-08-08 | Amato Pharmaceutical Products,Ltd. | Agents anti-stress |
DE10105234A1 (de) | 2001-02-02 | 2002-08-29 | Schoeller Textil Ag Sevelen | Textile Fläche |
GB0103171D0 (en) | 2001-02-08 | 2001-03-28 | Smithkline Beecham Biolog | Vaccine composition |
GB0105360D0 (en) * | 2001-03-03 | 2001-04-18 | Glaxo Group Ltd | Chimaeric immunogens |
DE60224508T2 (de) | 2001-03-22 | 2008-12-24 | International Institute of Cancer Immunology, Inc., Suita-shi | Wti-modifiziertes peptid |
US20030050268A1 (en) * | 2001-03-29 | 2003-03-13 | Krieg Arthur M. | Immunostimulatory nucleic acid for treatment of non-allergic inflammatory diseases |
JP2005504513A (ja) | 2001-05-09 | 2005-02-17 | コリクサ コーポレイション | 前立腺癌の治療及び診断のための組成物及び方法 |
WO2002094845A2 (en) | 2001-05-21 | 2002-11-28 | Intercell Ag | Method for stabilising of nucleic acids |
US6818787B2 (en) * | 2001-06-11 | 2004-11-16 | Xenoport, Inc. | Prodrugs of GABA analogs, compositions and uses thereof |
GB0115176D0 (en) | 2001-06-20 | 2001-08-15 | Chiron Spa | Capular polysaccharide solubilisation and combination vaccines |
ES2487645T3 (es) * | 2001-06-21 | 2014-08-22 | Dynavax Technologies Corporation | Compuestos inmunomoduladores quiméricos y métodos de uso de los mismos |
US7785610B2 (en) * | 2001-06-21 | 2010-08-31 | Dynavax Technologies Corporation | Chimeric immunomodulatory compounds and methods of using the same—III |
CA2452382A1 (en) | 2001-07-10 | 2003-01-23 | Corixa Corporation | Compositions and methods for delivery of proteins and adjuvants encapsulated in microspheres |
GB0118249D0 (en) | 2001-07-26 | 2001-09-19 | Chiron Spa | Histidine vaccines |
US7666674B2 (en) | 2001-07-27 | 2010-02-23 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Use of sterically stabilized cationic liposomes to efficiently deliver CPG oligonucleotides in vivo |
GB0121591D0 (en) | 2001-09-06 | 2001-10-24 | Chiron Spa | Hybrid and tandem expression of neisserial proteins |
US20030148316A1 (en) * | 2001-08-01 | 2003-08-07 | Lipford Grayson B. | Methods and compositions relating to plasmacytoid dendritic cells |
WO2003025119A2 (en) * | 2001-08-03 | 2003-03-27 | Medarex, Inc. | Compositions comprising immunostimulatory oligonucleotides and uses thereof to enhance fc receptor-mediated immunotherapies |
EP1420829A4 (en) | 2001-08-07 | 2006-05-17 | Dynavax Tech Corp | IMMUNOMODULATING COMPOSITIONS, FORMULATIONS AND METHOD FOR THEIR USE |
WO2003020884A2 (en) * | 2001-08-14 | 2003-03-13 | The Government Of The United States Of America As Represented By The Secretary Of Health And Human Services | Method for rapid generation of mature dendritic cells |
US7361352B2 (en) | 2001-08-15 | 2008-04-22 | Acambis, Inc. | Influenza immunogen and vaccine |
DE60229422D1 (de) | 2001-08-17 | 2008-11-27 | Coley Pharm Gmbh | Kombinations-motif-immunstimulierende oligonukleotide mit verbesserter wirkung |
JP4319908B2 (ja) | 2001-08-24 | 2009-08-26 | ユニバーシティ オブ ビクトリア イノベーション アンド ディベロップメント コーポレーション | プロテアーゼ活性化配列を含むプロアエロリシンおよび前立腺癌の治療のための使用方法 |
WO2003020889A2 (en) * | 2001-08-30 | 2003-03-13 | 3M Innovative Properties Company | Methods of maturing plasmacytoid dendritic cells using immune response modifier molecules |
JP2005501917A (ja) * | 2001-09-07 | 2005-01-20 | ザ トラスティーズ オブ ボストン ユニバーシティ | 免疫複合体関連疾患を処置するための方法および組成物 |
EP1425040A2 (en) * | 2001-09-14 | 2004-06-09 | Cytos Biotechnology AG | In vivo activation of antigen presenting cells for enhancement of immune responses induced by virus like particles |
AU2002339224B2 (en) * | 2001-09-14 | 2008-10-09 | Kuros Us Llc | Packaging of immunostimulatory substances into virus-like particles: method of preparation and use |
NZ531814A (en) | 2001-09-20 | 2005-10-28 | Glaxo Group Ltd | Vaccines |
WO2003027313A2 (en) | 2001-09-24 | 2003-04-03 | The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | SUPPRESSORS OF CpG OLIGONUCLEOTIDES AND METHODS OF USE |
US20030119774A1 (en) * | 2001-09-25 | 2003-06-26 | Marianna Foldvari | Compositions and methods for stimulating an immune response |
EP1447092A4 (en) * | 2001-09-28 | 2007-07-11 | Haruo Sugiyama | METHODS OF INDUCING ANTIGEN-SPECIFIC T CELLS |
JP5230891B2 (ja) | 2001-09-28 | 2013-07-10 | 株式会社癌免疫研究所 | 抗原特異的t細胞の新規な誘導方法 |
AR045702A1 (es) | 2001-10-03 | 2005-11-09 | Chiron Corp | Composiciones de adyuvantes. |
EP1451581A4 (en) * | 2001-10-05 | 2006-01-11 | Coley Pharm Gmbh | AGONISTS AND ANTAGONISTS OF THE SIGNALING OF THE GREAT-SIMILAR RECEPTOR 3 |
WO2003094836A2 (en) * | 2001-10-12 | 2003-11-20 | University Of Iowa Research Foundation | Methods and products for enhancing immune responses using imidazoquinoline compounds |
TW200303759A (en) * | 2001-11-27 | 2003-09-16 | Schering Corp | Methods for treating cancer |
US20050250716A1 (en) * | 2001-12-07 | 2005-11-10 | Intercell Ag | Immunostimulatory oligodeoxynucleotides |
ES2405405T3 (es) | 2001-12-17 | 2013-05-31 | Corixa Corporation | Composiciones y procedimientos para la terapia y el diagnóstico de enfermedad inflamatoria del intestino |
US8466116B2 (en) | 2001-12-20 | 2013-06-18 | The Unites States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Use of CpG oligodeoxynucleotides to induce epithelial cell growth |
US7615227B2 (en) * | 2001-12-20 | 2009-11-10 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Use of CpG oligodeoxynucleotides to induce angiogenesis |
CA2471092A1 (en) * | 2001-12-21 | 2003-07-10 | Antigenics Inc. | Compositions comprising immunoreactive reagents and saponins, and methods of use thereof |
CN1646501A (zh) * | 2002-02-07 | 2005-07-27 | 科瓦伦特合伙责任有限公司 | 纳米膜和薄膜组合物 |
US20040034223A1 (en) * | 2002-02-07 | 2004-02-19 | Covalent Partners, Llc. | Amphiphilic molecular modules and constructs based thereon |
US8088388B2 (en) * | 2002-02-14 | 2012-01-03 | United Biomedical, Inc. | Stabilized synthetic immunogen delivery system |
JP4646516B2 (ja) | 2002-02-20 | 2011-03-09 | ノバルティス バクシンズ アンド ダイアグノスティックス,インコーポレーテッド | 吸着したポリペプチド含有分子を有する微粒子 |
US7351413B2 (en) * | 2002-02-21 | 2008-04-01 | Lorantis, Limited | Stabilized HBc chimer particles as immunogens for chronic hepatitis |
EP2258712A3 (en) | 2002-03-15 | 2011-05-04 | Multicell Immunotherapeutics, Inc. | Compositions and Methods to Initiate or Enhance Antibody and Major-histocompatibility Class I or Class II-restricted T Cell Responses by Using Immunomodulatory, Non-coding RNA Motifs |
US20070037769A1 (en) * | 2003-03-14 | 2007-02-15 | Multicell Immunotherapeutics, Inc. | Compositions and methods to treat and control tumors by loading antigen presenting cells |
CA2479187A1 (en) * | 2002-03-15 | 2003-09-25 | Astral, Inc. | Immunostimulatory double stranded rna and methods of inducing, enhancing or modulating the immune response |
WO2003086280A2 (en) * | 2002-04-04 | 2003-10-23 | Coley Pharmaceutical Gmbh | Immunostimulatory g,u-containing oligoribonucleotides |
US20030224013A1 (en) * | 2002-04-19 | 2003-12-04 | Cole Garry T. | Methods for protection against Coccidioides spp. infection using Coccidioides spp. urea amidohydrolase (Ure) protein |
WO2003094963A2 (en) * | 2002-05-10 | 2003-11-20 | Inex Pharmaceuticals Corporation | Methylated immunostimulatory oligonucleotides and methods of using the same |
US20040009943A1 (en) * | 2002-05-10 | 2004-01-15 | Inex Pharmaceuticals Corporation | Pathogen vaccines and methods for using the same |
US20040009944A1 (en) * | 2002-05-10 | 2004-01-15 | Inex Pharmaceuticals Corporation | Methylated immunostimulatory oligonucleotides and methods of using the same |
US20040013649A1 (en) * | 2002-05-10 | 2004-01-22 | Inex Pharmaceuticals Corporation | Cancer vaccines and methods of using the same |
KR100456681B1 (ko) * | 2002-05-22 | 2004-11-10 | 주식회사 대웅 | 박테리아의 염색체 dna 파쇄물과 비독성리포폴리사카라이드를 포함하는 면역강화 및 조절 조성물 |
CA2388049A1 (en) | 2002-05-30 | 2003-11-30 | Immunotech S.A. | Immunostimulatory oligonucleotides and uses thereof |
SE0201701D0 (sv) * | 2002-06-05 | 2002-06-05 | Gotovax Ab | Treatment of epithelial tumors and infections |
US20040009949A1 (en) * | 2002-06-05 | 2004-01-15 | Coley Pharmaceutical Group, Inc. | Method for treating autoimmune or inflammatory diseases with combinations of inhibitory oligonucleotides and small molecule antagonists of immunostimulatory CpG nucleic acids |
BR0311995A (pt) * | 2002-06-20 | 2005-04-05 | Cytos Biotechnology Ag | Partìculas semelhantes a vìrus empacotadas para o uso como adjuvantes: método de preparação e uso |
US7575742B2 (en) | 2002-06-28 | 2009-08-18 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Method of treating autoimmune diseases with interferon-beta and IL-2R antagonist |
US7569553B2 (en) * | 2002-07-03 | 2009-08-04 | Coley Pharmaceutical Group, Inc. | Nucleic acid compositions for stimulating immune responses |
US7576066B2 (en) * | 2002-07-03 | 2009-08-18 | Coley Pharmaceutical Group, Inc. | Nucleic acid compositions for stimulating immune responses |
US7807803B2 (en) * | 2002-07-03 | 2010-10-05 | Coley Pharmaceutical Group, Inc. | Nucleic acid compositions for stimulating immune responses |
US7605138B2 (en) * | 2002-07-03 | 2009-10-20 | Coley Pharmaceutical Group, Inc. | Nucleic acid compositions for stimulating immune responses |
DE10229872A1 (de) | 2002-07-03 | 2004-01-29 | Curevac Gmbh | Immunstimulation durch chemisch modifizierte RNA |
US20040053880A1 (en) * | 2002-07-03 | 2004-03-18 | Coley Pharmaceutical Group, Inc. | Nucleic acid compositions for stimulating immune responses |
AU2003255969A1 (en) * | 2002-07-17 | 2004-02-02 | Coley Pharmaceutical Gmbh | Use of cpg nucleic acids in prion-disease |
DE60335755D1 (de) | 2002-07-18 | 2011-02-24 | Univ Washington | Pharmazeutische Zusammensetzungen, die immunologisch aktive Herpes simplex Virus Proteinfragmente enthalten |
EP1523557A2 (en) | 2002-07-24 | 2005-04-20 | Intercell AG | Antigens encoded by alternative reading frame from pathogenic viruses |
EP1575504A4 (en) | 2002-08-01 | 2009-11-04 | Us Gov Health & Human Serv | METHOD FOR THE TREATMENT OF INFLAMMATORY ARTHROPATHIES WITH SUPPRESSORS OF THE CPG OLIGONUCLEOTIDES |
DK2255826T3 (en) | 2002-08-02 | 2016-06-20 | Glaxosmithkline Biologicals Sa | Neisserial vaccine compositions comprising a combination of antigens. |
DK1545597T3 (da) | 2002-08-15 | 2011-01-31 | 3M Innovative Properties Co | Immunstimulerende sammensætninger og fremgangsmåde til stimulering af en immunrespons |
AR040996A1 (es) * | 2002-08-19 | 2005-04-27 | Coley Pharm Group Inc | Acidos nucleicos inmunoestimuladores |
GB0220194D0 (en) | 2002-08-30 | 2002-10-09 | Chiron Spa | Improved vesicles |
EP1537418A2 (en) | 2002-09-13 | 2005-06-08 | Intercell AG | Method for isolating hepatitis c virus peptides |
US20040106741A1 (en) * | 2002-09-17 | 2004-06-03 | Kriesel Joshua W. | Nanofilm compositions with polymeric components |
US8263091B2 (en) * | 2002-09-18 | 2012-09-11 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Method of treating and preventing infections in immunocompromised subjects with immunostimulatory CpG oligonucleotides |
AU2003268737A1 (en) * | 2002-10-02 | 2004-04-23 | Mochida Pharmaceutical Co., Ltd. | Novel method of constructing monoclonal antibody |
US8043622B2 (en) | 2002-10-08 | 2011-10-25 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Method of treating inflammatory lung disease with suppressors of CpG oligonucleotides |
CN102174533A (zh) | 2002-10-15 | 2011-09-07 | 英特塞尔股份公司 | 编码b族链球菌粘着因子的核酸、b族链球菌的粘着因子和它们的用途 |
ES2594758T3 (es) | 2002-10-23 | 2016-12-22 | Glaxosmithkline Biologicals S.A. | Procedimientos de vacunación contra la malaria |
CA2503457A1 (en) * | 2002-10-25 | 2004-05-06 | University Of Connecticut Health Center | Apparatus and method for immunotherapy of a cancer through controlled cell lysis |
CN1753687A (zh) | 2002-10-29 | 2006-03-29 | 科勒制药集团股份有限公司 | Cpg寡核苷酸在治疗丙型肝炎病毒感染中的应用 |
AU2003304107B2 (en) * | 2002-11-01 | 2008-05-15 | The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Method of preventing infections from bioterrorism agents with immunostimulatory CpG oligonucleotides |
US7491509B2 (en) | 2003-02-03 | 2009-02-17 | Fraunhofer Usa, Inc. | System for expression of genes in plants |
WO2004046177A2 (en) | 2002-11-15 | 2004-06-03 | Chiron Srl | Unexpected surface proteins in neisseria meningitidis |
GB0227346D0 (en) | 2002-11-22 | 2002-12-31 | Chiron Spa | 741 |
JP2006512927A (ja) | 2002-12-11 | 2006-04-20 | コーリー ファーマシューティカル グループ,インコーポレイテッド | 5’cpg核酸およびその使用方法 |
WO2004052293A2 (en) * | 2002-12-11 | 2004-06-24 | Hawaii Biotech, Inc. | Recombinant vaccine against flavivirus infection |
US20050287170A1 (en) * | 2002-12-11 | 2005-12-29 | Hawaii Biotech, Inc. | Subunit vaccine against West Nile viral infection |
KR100525321B1 (ko) * | 2002-12-13 | 2005-11-02 | 안웅식 | 파필로마바이러스 항원 단백질 및CpG-올리고데옥시뉴클레오타이드를 포함하는파필로마바이러스 유발 질환의 예방 또는 치료용 약제학적조성물 |
AU2003302743B2 (en) * | 2002-12-23 | 2008-09-04 | Dynavax Technologies Corporation | Branched immunomodulatory compounds and methods of using the same |
ATE544772T1 (de) | 2002-12-23 | 2012-02-15 | Dynavax Tech Corp | Immunstimulierende sequenz-oligonukleotide und verwendungsverfahren dafür |
US8158768B2 (en) | 2002-12-23 | 2012-04-17 | Dynavax Technologies Corporation | Immunostimulatory sequence oligonucleotides and methods of using the same |
CA2511512C (en) | 2002-12-27 | 2013-10-29 | Chiron Corporation | Immunogenic compositions containing phospholipid |
EP2572714A1 (en) | 2002-12-30 | 2013-03-27 | 3M Innovative Properties Company | Immunostimulatory Combinations |
JP4838706B2 (ja) | 2003-01-06 | 2011-12-14 | コリクサ コーポレイション | 所定のアミノアルキルグルコサミニドフォスフェート化合物及びそれらの使用 |
US7960522B2 (en) | 2003-01-06 | 2011-06-14 | Corixa Corporation | Certain aminoalkyl glucosaminide phosphate compounds and their use |
EP1592302A4 (en) * | 2003-02-13 | 2007-04-25 | 3M Innovative Properties Co | METHODS AND COMPOSITIONS ASSOCIATED WITH IMMUNE RESPONSE MODIFIER COMPOUNDS AND TOLL-LIKE RECEPTOR 8 |
ATE491463T1 (de) | 2003-02-20 | 2011-01-15 | Univ Connecticut Health Ct | Verfahren zur herstellung von alpha (2) makroglobulin-antigen-molekül-komplexen |
GB2398783A (en) | 2003-02-26 | 2004-09-01 | Antonio Lanzavecchia | A method for producing immortalised human B memory lymphocytes |
WO2004075865A2 (en) * | 2003-02-27 | 2004-09-10 | 3M Innovative Properties Company | Selective modulation of tlr-mediated biological activity |
EP1601365A4 (en) | 2003-03-04 | 2009-11-11 | 3M Innovative Properties Co | PROPHYLACTIC TREATMENT OF UV-INDUCED EPIDERMAL NEOPLASIA |
ES2330334T3 (es) | 2003-03-04 | 2009-12-09 | Intercell Ag | Antigenos de streptococcus pyogenes. |
WO2004080292A2 (en) | 2003-03-13 | 2004-09-23 | 3M Innovative Properties Company | Method of tattoo removal |
ATE556711T1 (de) * | 2003-03-13 | 2012-05-15 | 3M Innovative Properties Co | Verfahren zur verbesserung der hautqualität |
ES2562456T3 (es) | 2003-03-24 | 2016-03-04 | Valneva Austria Gmbh | Uso de un adyuvante que induce una respuesta inmune Th1 para mejorar las respuestas inmunes |
US20040192585A1 (en) | 2003-03-25 | 2004-09-30 | 3M Innovative Properties Company | Treatment for basal cell carcinoma |
AU2004224761A1 (en) | 2003-03-26 | 2004-10-07 | Cytos Biotechnology Ag | HIV-peptide-carrier-conjugates |
CA2520181A1 (en) * | 2003-03-26 | 2004-10-14 | Astral Inc. | Selected rna motifs to include cell death and/or apoptosis |
US7537767B2 (en) | 2003-03-26 | 2009-05-26 | Cytis Biotechnology Ag | Melan-A- carrier conjugates |
EP2182065A3 (en) | 2003-03-31 | 2010-09-15 | Intercell AG | Staphylococcus epidermidis antigens |
AU2004226605A1 (en) * | 2003-04-02 | 2004-10-14 | Coley Pharmaceutical Group, Ltd. | Immunostimulatory nucleic acid oil-in-water formulations for topical application |
EP1617871A4 (en) * | 2003-04-10 | 2010-10-06 | 3M Innovative Properties Co | DISTRIBUTION OF IMMUNE-RESPONSE-MODIFYING COMPOUNDS USING PARTICULATE CARRIER MATERIALS CONTAINING METAL |
US20040265351A1 (en) * | 2003-04-10 | 2004-12-30 | Miller Richard L. | Methods and compositions for enhancing immune response |
SE0301109D0 (sv) * | 2003-04-14 | 2003-04-14 | Mallen Huang | Nucleotide vaccine composition |
EP2314719A1 (en) | 2003-04-15 | 2011-04-27 | Intercell AG | S. pneumoniae antigens |
EP1617845A4 (en) * | 2003-04-28 | 2006-09-20 | 3M Innovative Properties Co | COMPOSITIONS AND METHODS FOR INDUCING OPOID RECEPTORS |
WO2004099242A2 (en) | 2003-05-07 | 2004-11-18 | Intercell Ag | Streptococcus agalactiae antigens i + ii |
ES2427641T3 (es) | 2003-05-22 | 2013-10-31 | Ibio, Inc. | Molécula vehículo recombinante para la expresión, el suministro y la purificación de polipéptidos diana |
CN102304527A (zh) | 2003-05-30 | 2012-01-04 | 英特塞尔股份公司 | 肠球菌抗原 |
ES2328697T5 (es) | 2003-06-02 | 2017-07-25 | Novartis Vaccines And Diagnostics, Inc. | Composiciones inmunogénicas basadas en micropartículas que comprenden toxoide adsorbido y un antígeno que contiene un polisacárido |
US7803386B2 (en) | 2003-06-05 | 2010-09-28 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Poly-gamma-glutamic conjugates for eliciting immune responses directed against bacilli |
US7410975B2 (en) * | 2003-06-20 | 2008-08-12 | Coley Pharmaceutical Group, Inc. | Small molecule toll-like receptor (TLR) antagonists |
KR20060031607A (ko) * | 2003-07-10 | 2006-04-12 | 사이토스 바이오테크놀로지 아게 | 패킹된 바이러스-양 입자 |
US20050013812A1 (en) * | 2003-07-14 | 2005-01-20 | Dow Steven W. | Vaccines using pattern recognition receptor-ligand:lipid complexes |
CA2534313C (en) * | 2003-08-05 | 2013-03-19 | 3M Innovative Properties Company | Formulations containing an immune response modifier |
JP2007502288A (ja) * | 2003-08-12 | 2007-02-08 | スリーエム イノベイティブ プロパティズ カンパニー | オキシム置換イミダゾ含有化合物 |
US20060035242A1 (en) | 2004-08-13 | 2006-02-16 | Michelitsch Melissa D | Prion-specific peptide reagents |
WO2005018574A2 (en) * | 2003-08-25 | 2005-03-03 | 3M Innovative Properties Company | Immunostimulatory combinations and treatments |
AU2004268625B2 (en) * | 2003-08-27 | 2011-03-31 | 3M Innovative Properties Company | Aryloxy and arylalkyleneoxy substituted imidazoquinolines |
EP1663222A4 (en) * | 2003-09-02 | 2008-05-21 | 3M Innovative Properties Co | METHODS RELATING TO THE TREATMENT OF GIANCES |
JP2007504269A (ja) * | 2003-09-05 | 2007-03-01 | スリーエム イノベイティブ プロパティズ カンパニー | Cd5+b細胞リンパ腫の治療方法 |
US8541002B2 (en) | 2003-09-12 | 2013-09-24 | Agenus Inc. | Vaccine for treatment and prevention of herpes simplex virus infection |
CA2536139A1 (en) * | 2003-09-25 | 2005-04-07 | Coley Pharmaceutical Group, Inc. | Nucleic acid-lipophilic conjugates |
US8574596B2 (en) | 2003-10-02 | 2013-11-05 | Glaxosmithkline Biologicals, S.A. | Pertussis antigens and use thereof in vaccination |
ES2544477T3 (es) * | 2003-10-03 | 2015-08-31 | 3M Innovative Properties Company | Imidazoquinolinas sustituidas con alcoxi |
US7544697B2 (en) * | 2003-10-03 | 2009-06-09 | Coley Pharmaceutical Group, Inc. | Pyrazolopyridines and analogs thereof |
US20090075980A1 (en) * | 2003-10-03 | 2009-03-19 | Coley Pharmaceutical Group, Inc. | Pyrazolopyridines and Analogs Thereof |
WO2005034979A2 (en) * | 2003-10-11 | 2005-04-21 | Inex Pharmaceuticals Corporation | Methods and compositions for enhancing innate immunity and antibody dependent cellular cytotoxicity |
UA88457C2 (ru) * | 2003-10-30 | 2009-10-26 | Коли Фармасьютикал Гмбх | Иммуностимулирующая нуклеиновая кислота с улучшенной иммуностимулирующей эффективностью |
US20050239733A1 (en) * | 2003-10-31 | 2005-10-27 | Coley Pharmaceutical Gmbh | Sequence requirements for inhibitory oligonucleotides |
WO2005041891A2 (en) * | 2003-10-31 | 2005-05-12 | 3M Innovative Properties Company | Neutrophil activation by immune response modifier compounds |
US20050100983A1 (en) * | 2003-11-06 | 2005-05-12 | Coley Pharmaceutical Gmbh | Cell-free methods for identifying compounds that affect toll-like receptor 9 (TLR9) signaling |
CA2545774A1 (en) | 2003-11-14 | 2005-06-02 | 3M Innovative Properties Company | Oxime substituted imidazo ring compounds |
EP1682544A4 (en) * | 2003-11-14 | 2009-05-06 | 3M Innovative Properties Co | HYDROXYLAMINE SUBSTITUTED IMIDAZO RING COMPOUNDS |
NZ547467A (en) * | 2003-11-25 | 2010-06-25 | 3M Innovative Properties Co | Substituted imidazo ring system and methods |
US20050277127A1 (en) * | 2003-11-26 | 2005-12-15 | Epitomics, Inc. | High-throughput method of DNA immunogen preparation and immunization |
US20050287118A1 (en) * | 2003-11-26 | 2005-12-29 | Epitomics, Inc. | Bacterial plasmid with immunological adjuvant function and uses thereof |
US20050226878A1 (en) * | 2003-12-02 | 2005-10-13 | 3M Innovative Properties Company | Therapeutic combinations and methods including IRM compounds |
WO2005055932A2 (en) * | 2003-12-02 | 2005-06-23 | 3M Innovative Properties Company | Therapeutic combinations and methods including irm compounds |
ATE554106T1 (de) | 2003-12-23 | 2012-05-15 | Arbor Vita Corp | Antikörper für onkogene stämme von hpv und verfahren zu deren verwendung |
JP2007517035A (ja) * | 2003-12-29 | 2007-06-28 | スリーエム イノベイティブ プロパティズ カンパニー | アリールアルケニルおよびアリールアルキニル置換されたイミダゾキノリン |
EP1699788A2 (en) * | 2003-12-30 | 2006-09-13 | 3M Innovative Properties Company | Imidazoquinolinyl, imidazopyridinyl and imidazonaphthyridinyl sulfonamides |
EP1699398A4 (en) * | 2003-12-30 | 2007-10-17 | 3M Innovative Properties Co | IMPROVING THE IMMUNE RESPONSE |
US7973016B2 (en) * | 2004-01-23 | 2011-07-05 | Joslin Diebetes Center | Methods of treating, reducing, or preventing autoimmune conditions |
WO2005076972A2 (en) | 2004-02-05 | 2005-08-25 | The Ohio State University Research Foundation | Chimeric vegf peptides |
US20050181035A1 (en) * | 2004-02-17 | 2005-08-18 | Dow Steven W. | Systemic immune activation method using non CpG nucleic acids |
TW200533750A (en) * | 2004-02-19 | 2005-10-16 | Coley Pharm Group Inc | Immunostimulatory viral RNA oligonucleotides |
WO2005090968A1 (en) * | 2004-03-16 | 2005-09-29 | Inist Inc. | Tat-based immunomodulatory compositions and methods of their discovery and use |
US7820175B2 (en) | 2004-03-19 | 2010-10-26 | Herbal Spring, Llc | Herbal therapy for the treatment of food allergy |
US8697873B2 (en) * | 2004-03-24 | 2014-04-15 | 3M Innovative Properties Company | Amide substituted imidazopyridines, imidazoquinolines, and imidazonaphthyridines |
TWI235440B (en) * | 2004-03-31 | 2005-07-01 | Advanced Semiconductor Eng | Method for making leadless semiconductor package |
US20070166384A1 (en) * | 2004-04-09 | 2007-07-19 | Zarraga Isidro Angelo E | Methods , composition and preparations for delivery of immune response modifiers |
CN101426524A (zh) * | 2004-04-28 | 2009-05-06 | 3M创新有限公司 | 用于粘膜接种疫苗的组合物和方法 |
EP1751612B1 (en) | 2004-05-06 | 2009-02-25 | The Government of the United States of America, as represented by the Secretary of the Department of Health and Human Services | Methods and compositions for the treatment of uveitis |
WO2006031264A2 (en) | 2004-05-25 | 2006-03-23 | Oregon Health And Science University | Siv and hiv vaccination using rhcmv- and hcmv-based vaccine vectors |
DK1765310T3 (en) | 2004-05-28 | 2016-01-11 | Oryxe | MIXING for transdermal delivery of LAV AND HØJMOLEKYLVÆGTFORBINDELSER |
US20050267145A1 (en) * | 2004-05-28 | 2005-12-01 | Merrill Bryon A | Treatment for lung cancer |
WO2005123080A2 (en) * | 2004-06-15 | 2005-12-29 | 3M Innovative Properties Company | Nitrogen-containing heterocyclyl substituted imidazoquinolines and imidazonaphthyridines |
WO2006009832A1 (en) * | 2004-06-18 | 2006-01-26 | 3M Innovative Properties Company | Substituted imidazo ring systems and methods |
US8026366B2 (en) * | 2004-06-18 | 2011-09-27 | 3M Innovative Properties Company | Aryloxy and arylalkyleneoxy substituted thiazoloquinolines and thiazolonaphthyridines |
WO2006065280A2 (en) * | 2004-06-18 | 2006-06-22 | 3M Innovative Properties Company | Isoxazole, dihydroisoxazole, and oxadiazole substituted imidazo ring compounds and methods |
WO2006038923A2 (en) * | 2004-06-18 | 2006-04-13 | 3M Innovative Properties Company | Aryl substituted imidazonaphthyridines |
JP2008506789A (ja) * | 2004-07-18 | 2008-03-06 | シーエスエル、リミテッド | インターフェロン−ガンマ応答強化を誘発するための免疫刺激複合体及びオリゴヌクレオチド処方物 |
ES2534288T3 (es) | 2004-08-03 | 2015-04-21 | Innate Pharma | Composiciones terapéuticas contra el cáncer que seleccionan como objetivo 4Ig-B7-H3 |
GB0417494D0 (en) | 2004-08-05 | 2004-09-08 | Glaxosmithkline Biolog Sa | Vaccine |
US20060045886A1 (en) * | 2004-08-27 | 2006-03-02 | Kedl Ross M | HIV immunostimulatory compositions |
WO2006026760A2 (en) * | 2004-09-02 | 2006-03-09 | 3M Innovative Properties Company | 1-amino imidazo-containing compounds and methods |
EP2305295B1 (en) | 2004-09-22 | 2015-04-01 | GlaxoSmithKline Biologicals SA | Antibody composition for use in vaccination against staphylococcei |
PT1791858E (pt) | 2004-09-24 | 2010-07-26 | Intercell Ag | PROTENA DE CáPSIDE VP1 MODIFICADA DO PARVOVRUS B19 |
AU2005294129B2 (en) | 2004-10-08 | 2010-12-23 | The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services, Centers For Disease Control And Prevention | Modulation of replicative fitness by using less frequently used synonymous codons |
US20070243215A1 (en) * | 2004-10-08 | 2007-10-18 | Miller Richard L | Adjuvant for Dna Vaccines |
MY159370A (en) * | 2004-10-20 | 2016-12-30 | Coley Pharm Group Inc | Semi-soft-class immunostimulatory oligonucleotides |
US7332324B2 (en) | 2004-12-03 | 2008-02-19 | University Of Toledo | Attenuated vaccine useful for immunizations against Coccidioides spp. infections |
WO2006063072A2 (en) * | 2004-12-08 | 2006-06-15 | 3M Innovative Properties Company | Immunomodulatory compositions, combinations and methods |
WO2006065751A2 (en) | 2004-12-13 | 2006-06-22 | Government Of The United States Of America, Represented By The Secretary, Department Of Health And Human Services | Cpg oligonucleotide prodrugs, compositions thereof and associated therapeutic methods |
US8034938B2 (en) | 2004-12-30 | 2011-10-11 | 3M Innovative Properties Company | Substituted chiral fused [1,2]imidazo[4,5-c] ring compounds |
ES2392647T3 (es) | 2004-12-30 | 2012-12-12 | 3M Innovative Properties Company | Compuestos tetracíclicos quirales que inducen la biosíntesis de interferón |
WO2006071997A2 (en) | 2004-12-30 | 2006-07-06 | 3M Innovative Properties Company | Treatment for cutaneous metastases |
LT2682126T (lt) | 2005-01-27 | 2017-02-27 | Children`s Hospital & Research Center at Oakland | Gna1870 pagrindu gaminamos pūslelių pavidalo vakcinos, skirtos plataus spektro apsaugai nuo neisseria meningitidis sukeltų ligų |
WO2006084251A2 (en) | 2005-02-04 | 2006-08-10 | Coley Pharmaceutical Group, Inc. | Aqueous gel formulations containing immune reponse modifiers |
US7968563B2 (en) | 2005-02-11 | 2011-06-28 | 3M Innovative Properties Company | Oxime and hydroxylamine substituted imidazo[4,5-c] ring compounds and methods |
JP2008531018A (ja) * | 2005-02-24 | 2008-08-14 | コーリー ファーマシューティカル グループ,インコーポレイテッド | 免疫刺激性オリゴヌクレオチド |
GB0504436D0 (en) | 2005-03-03 | 2005-04-06 | Glaxosmithkline Biolog Sa | Vaccine |
US8101345B1 (en) | 2005-03-25 | 2012-01-24 | Isis Pharmaceuticals, Inc. | Proinflammatory nucleic acids |
AU2006229968A1 (en) | 2005-03-31 | 2006-10-05 | Corixa Corporation | Vaccines against Chlamydial infection |
EP1869043A2 (en) | 2005-04-01 | 2007-12-26 | Coley Pharmaceutical Group, Inc. | Pyrazolopyridine-1,4-diamines and analogs thereof |
AU2006232375A1 (en) | 2005-04-01 | 2006-10-12 | Coley Pharmaceutical Group, Inc. | 1-substituted pyrazolo (3,4-c) ring compounds as modulators of cytokine biosynthesis for the treatment of viral infections and neoplastic diseases |
WO2006110656A2 (en) * | 2005-04-08 | 2006-10-19 | Chimerix, Inc. | Compounds, compositions and methods for the treatment of viral infections and other medical disorders |
SG161260A1 (en) * | 2005-04-08 | 2010-05-27 | Coley Pharm Group Inc | Methods for treating infectious disease exacerbated asthma |
JP2008535862A (ja) | 2005-04-08 | 2008-09-04 | キメリクス,インコーポレイテッド | ポックスウイルス感染の治療のための化合物、組成物および方法 |
US20080193474A1 (en) * | 2005-04-25 | 2008-08-14 | Griesgraber George W | Immunostimulatory Compositions |
US20060241076A1 (en) * | 2005-04-26 | 2006-10-26 | Coley Pharmaceutical Gmbh | Modified oligoribonucleotide analogs with enhanced immunostimulatory activity |
KR20150036658A (ko) | 2005-04-29 | 2015-04-07 | 글락소스미스클라인 바이오로지칼즈 에스.에이. | 결핵균 감염을 예방 또는 치료하기 위한 신규한 방법 |
CN101238145B (zh) | 2005-06-14 | 2013-04-24 | 普罗陶克斯有限公司 | 修饰的成孔蛋白在制备治疗或预防良性前列腺增生的药物中的应用 |
AU2006261342B2 (en) | 2005-06-15 | 2012-02-02 | The Ohio State University Research Foundation | Her-2 peptides |
GB0513421D0 (en) | 2005-06-30 | 2005-08-03 | Glaxosmithkline Biolog Sa | Vaccines |
ES2450593T3 (es) | 2005-07-01 | 2014-03-25 | Index Pharmaceuticals Ab | Método inmunoestimulante |
PL2179737T3 (pl) | 2005-07-01 | 2014-01-31 | Index Pharmaceuticals Ab | Sposób do modulowania wrażliwości na steroidy |
US20090117132A1 (en) * | 2005-07-07 | 2009-05-07 | Pfizer, Inc. | Anti-Ctla-4 Antibody and Cpg-Motif-Containing Synthetic Oligodeoxynucleotide Combination Therapy for Cancer Treatment |
WO2007008904A2 (en) * | 2005-07-08 | 2007-01-18 | The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Targeting poly-gamma-glutamic acid to treat staphylococcus epidermidis and related infections |
KR20080043775A (ko) | 2005-07-11 | 2008-05-19 | 글로브이뮨 | 표적 치료용 회피 돌연변이체에 대한 면역 반응의 유발방법 및 조성물 |
WO2007117264A2 (en) | 2005-08-03 | 2007-10-18 | Fraunhofer Usa, Inc. | Compositions and methods for production of immunoglobulins |
US20100130425A1 (en) | 2005-09-09 | 2010-05-27 | Oregon Health & Science University | Use of toll-like receptor ligands in treating excitotoxic injury, ischemia and/or hypoxia |
BRPI0616235A2 (pt) * | 2005-09-16 | 2011-06-14 | Coley Pharm Gmbh | acido ribonuclÉico monofilamentado imunoestimulante com cadeia principal de fosfodiÉster |
KR20080047463A (ko) * | 2005-09-16 | 2008-05-28 | 콜리 파마슈티칼 게엠베하 | 뉴클레오티드 변형에 의한 짧은 간섭 리보핵산(sirna)의 면역자극 특성의 조절 |
WO2007041190A2 (en) * | 2005-09-30 | 2007-04-12 | The University Of Iowa Research Foundation | Polymer-based delivery system for immunotherapy of cancer |
CA2625969A1 (en) | 2005-10-28 | 2007-05-03 | Index Pharmaceuticals Ab | Composition and method for the prevention, treatment and/or alleviation of an inflammatory disease |
AU2006318464B2 (en) | 2005-11-25 | 2011-02-17 | Zoetis Belgium Sa | Immunostimulatory oligoribonucleotides |
PL2347775T3 (pl) | 2005-12-13 | 2020-11-16 | President And Fellows Of Harvard College | Rusztowania do przeszczepiania komórek |
US20070184068A1 (en) | 2005-12-14 | 2007-08-09 | Cytos Biotechnology Ag | Immunostimulatory nucleic acid packaged particles for the treatment of hypersensitivity |
NZ569168A (en) | 2005-12-22 | 2012-02-24 | Glaxosmithkline Biolog Sa | Streptococcus pneumoniae polysaccharide conjugate vaccine comprising 19F-DT conjugate |
GB0607088D0 (en) | 2006-04-07 | 2006-05-17 | Glaxosmithkline Biolog Sa | Vaccine |
WO2007082105A2 (en) | 2006-01-16 | 2007-07-19 | Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Chlamydia vaccine |
CN101374859B (zh) | 2006-01-17 | 2014-11-26 | 阿恩·福斯格伦 | 新的表面外露流感嗜血菌蛋白质(蛋白质E;pE) |
EP1984405A4 (en) | 2006-02-13 | 2010-06-30 | Fraunhofer Usa Inc | INFLUENZA ANTIGENS, VACCINE COMPOSITIONS AND ASSOCIATED METHODS |
EP2405002B1 (en) | 2006-02-15 | 2014-09-24 | AdiuTide Pharmaceuticals GmbH | Compositions and methods for oligonucleotide formulations |
EP1988896A4 (en) * | 2006-02-22 | 2011-07-27 | 3M Innovative Properties Co | CONJUGATES TO MODIFY IMMUNE REACTIONS |
BRPI0708912B8 (pt) | 2006-03-14 | 2021-07-27 | Univ Oregon Health & Science | métodos in vitro para detecção de mycobacterium tuberculosis e de células t expressando cd8 que especificamente reconhecem seq id no: 11 em um indivíduo |
EA020459B1 (ru) | 2006-03-30 | 2014-11-28 | Глаксосмитклайн Байолоджикалс С.А. | Иммуногенная композиция |
WO2007119815A1 (ja) | 2006-04-14 | 2007-10-25 | Kyowa Hakko Kirin Co., Ltd. | Toll様受容体9作動薬 |
EP2390361A1 (en) | 2006-06-02 | 2011-11-30 | GlaxoSmithKline Biologicals SA | Method for identifying whether a patient will be responder or not to immunotherapy based on the differential expression of the IL7R gene |
KR100906970B1 (ko) | 2006-06-03 | 2009-07-10 | 주식회사 바이오씨에스 | 피부 면역질환에 대한 CpG 올리고데옥시뉴클레오티드의치료학적 용도 |
WO2007143582A2 (en) * | 2006-06-05 | 2007-12-13 | Baylor College Of Medicine | Reversal of the suppressive function of specific t cells via toll-like receptor 8 signaling |
JP5275982B2 (ja) | 2006-06-12 | 2013-08-28 | グラクソスミスクライン バイオロジカルズ ソシエテ アノニム | ワクチン |
SG172696A1 (en) | 2006-06-12 | 2011-07-28 | Cytos Biotechnology Ag | Processes for packaging oligonucleotides into virus-like particles of rna bacteriophages |
EP2059531A1 (en) | 2006-07-07 | 2009-05-20 | Intercell AG | Small streptococcus pyogenes antigens and their use |
US8153116B2 (en) | 2006-07-11 | 2012-04-10 | University Of Connecticut | Use of conditional plasmodium strains lacking an essential gene in malaria vaccination |
WO2008094183A2 (en) * | 2006-07-11 | 2008-08-07 | University Of Connecticut | Use of conditional plasmodium strains lacking nutrient transporters in malaria vaccination |
WO2008008432A2 (en) * | 2006-07-12 | 2008-01-17 | Coley Pharmaceutical Group, Inc. | Substituted chiral fused( 1,2) imidazo (4,5-c) ring compounds and methods |
DE102006035618A1 (de) * | 2006-07-31 | 2008-02-07 | Curevac Gmbh | Nukleinsäure der Formel (I): GlXmGn, insbesondere als immunstimulierendes Adjuvanz |
AU2007280690C1 (en) | 2006-07-31 | 2012-08-23 | Curevac Gmbh | Nucleic acid of formula (I): GIXmGn, or (II): CIXmCn, in particular as an immune-stimulating agent/adjuvant |
EA016417B1 (ru) | 2006-09-07 | 2012-04-30 | Глаксосмитклайн Байолоджикалс С.А. | Способ получения вакцины |
AU2007295927A1 (en) | 2006-09-15 | 2008-03-20 | Intercell Ag | Borrelia antigens |
US20090181078A1 (en) | 2006-09-26 | 2009-07-16 | Infectious Disease Research Institute | Vaccine composition containing synthetic adjuvant |
CN101516396B (zh) | 2006-09-26 | 2013-10-09 | 传染性疾病研究院 | 包含合成佐剂的疫苗组合物 |
PT2078080E (pt) * | 2006-09-27 | 2015-09-18 | Coley Pharm Gmbh | Análogos dos oligonucleotídeos cpg que contêm análogos t hidrofóbicos com atividade imunoestimulante potenciada |
US20100144846A1 (en) * | 2006-10-26 | 2010-06-10 | Coley Pharmaceutical Gmbh | Oligoribonucleotides and uses thereof |
EP3564674B1 (en) | 2006-11-01 | 2021-08-25 | Ventana Medical Systems, Inc. | Haptens, hapten conjugates, compositions thereof and method for their preparation and use |
WO2008057529A2 (en) * | 2006-11-06 | 2008-05-15 | Coley Pharmaceutical Group, Inc. | Peptide-based vaccine compositions to endogenous cholesteryl ester transfer protein (cetp) |
US8252757B2 (en) * | 2006-11-09 | 2012-08-28 | Dynavax Technologies Corporation | Long term disease modification using immunostimulatory oligonucleotides |
EP1923069A1 (en) | 2006-11-20 | 2008-05-21 | Intercell AG | Peptides protective against S. pneumoniae and compositions, methods and uses relating thereto |
US20080149123A1 (en) | 2006-12-22 | 2008-06-26 | Mckay William D | Particulate material dispensing hairbrush with combination bristles |
EP2266592A3 (en) | 2007-01-12 | 2012-08-08 | Intercell AG | Protective proteins of S. agalactiae, combinations thereof and methods of using the same |
JP5596980B2 (ja) | 2007-02-28 | 2014-10-01 | アメリカ合衆国 | ブラキュリポリペプチドおよび使用方法 |
ES2609418T3 (es) | 2007-03-02 | 2017-04-20 | Glaxosmithkline Biologicals Sa | Procedimiento novedoso y composiciones |
MX2009009530A (es) * | 2007-03-07 | 2010-05-19 | Nventa Biopharmaceuticals Corp | Composiciones de acidos nucleicos cerrados bicatenarios. |
AU2008229295B2 (en) | 2007-03-19 | 2014-05-22 | Globelmmune, Inc. | Compositions and methods for targeted ablation of mutational escape of targeted therapies for cancer |
DK2136836T3 (en) | 2007-04-04 | 2017-04-10 | Infectious Disease Res Inst | Immunogenic compositions with mycobacterium tuberculosis polypeptides and fusions thereof |
AR066405A1 (es) | 2007-04-20 | 2009-08-19 | Glaxosmithkline Biolog Sa | Vacuna |
US8778348B2 (en) | 2007-04-28 | 2014-07-15 | Ibio Inc. | Trypanosoma antigens, vaccine compositions, and related methods |
UY31064A1 (es) | 2007-05-02 | 2009-01-05 | Glaxosmithkline Biolog Sa | Vacuna |
JP2010532657A (ja) | 2007-05-02 | 2010-10-14 | インターセル アーゲー | クレブシエラ属の抗原 |
EP2160465B1 (en) * | 2007-05-04 | 2013-01-02 | Index Pharmaceuticals AB | Tumour growth inhibitory compounds and methods of their use |
MX2009012482A (es) * | 2007-05-17 | 2009-12-02 | Coley Pharm Group Inc | Oligonucleotidos de clase a con potencia inmunoestimuladora. |
DK2170353T3 (en) * | 2007-05-18 | 2015-07-27 | Adiutide Pharmaceuticals Gmbh | The phosphate-modified oligonucleotide analogs with immunostimulatory activity |
CA2687178C (en) * | 2007-05-23 | 2014-02-04 | Ventana Medical Systems, Inc. | Polymeric carriers for immunohistochemistry and in situ hybridization |
TW200911304A (en) | 2007-05-24 | 2009-03-16 | Glaxosmithkline Biolog Sa | Lyophillised antigen composition |
EP2012122A1 (en) | 2007-07-06 | 2009-01-07 | Medigene AG | Mutated parvovirus structural proteins as vaccines |
ES2602610T3 (es) | 2007-05-31 | 2017-02-21 | Medigene Ag | Proteína estructural mutada de un parvovirus |
CA2690271A1 (en) | 2007-06-18 | 2008-12-24 | Intercell Ag | Chlamydia antigens |
BRPI0813307C1 (pt) | 2007-06-26 | 2021-05-25 | Glaxosmithkline Biologicals Sa | composição imunogênica, vacina, e, processo para fabricar a vacina |
WO2009006479A2 (en) | 2007-07-02 | 2009-01-08 | Etubics Corporation | Methods and compositions for producing an adenovirus vector for use with multiple vaccinations |
US8404252B2 (en) | 2007-07-11 | 2013-03-26 | Fraunhofer Usa, Inc. | Yersinia pestis antigens, vaccine compositions, and related methods |
ES2539818T3 (es) | 2007-08-02 | 2015-07-06 | Biondvax Pharmaceuticals Ltd. | Vacunas contra la gripe multiepitópicas multiméricas |
WO2009020553A2 (en) | 2007-08-03 | 2009-02-12 | President And Fellows Of Harvard College | Chlamydia antigens |
US7879812B2 (en) | 2007-08-06 | 2011-02-01 | University Of Iowa Research Foundation | Immunomodulatory oligonucleotides and methods of use therefor |
AP2010005166A0 (en) | 2007-08-13 | 2010-02-28 | Glaxosmithkline Biolog Sa | Vaccines |
CN101835487A (zh) * | 2007-08-21 | 2010-09-15 | 戴纳瓦克斯技术公司 | 制备和使用流感蛋白质的组合物和方法 |
EP2185160B1 (en) | 2007-08-31 | 2019-02-13 | Neurimmune Holding AG | Method of providing patient specific immune response in amyloidoses and protein aggregation disorders |
WO2009030254A1 (en) | 2007-09-04 | 2009-03-12 | Curevac Gmbh | Complexes of rna and cationic peptides for transfection and for immunostimulation |
NZ583796A (en) | 2007-09-17 | 2011-12-22 | Oncomethylome Sciences Sa | Improved detection of mage-a expression |
CN101820908A (zh) * | 2007-10-09 | 2010-09-01 | 科利制药公司 | 包含改性糖部分的免疫刺激寡核苷酸类似物 |
EA201692127A1 (ru) | 2007-11-07 | 2017-08-31 | Селлдекс Терапьютикс Инк. | Антитела, связывающиеся с человеческим dec-205 |
WO2010008411A1 (en) | 2007-11-09 | 2010-01-21 | The Salk Institute For Biological Studies | Use of tam receptor inhibitors as immunoenhancers and tam activators as immunosuppressors |
US8637053B2 (en) | 2007-12-03 | 2014-01-28 | President And Fellows Of Harvard College | Chlamydia antigens |
WO2009076158A1 (en) | 2007-12-07 | 2009-06-18 | Novartis Ag | Compositions for inducing immune responses |
DK2222710T3 (en) | 2007-12-24 | 2016-10-03 | Id Biomedical Corp Quebec | Recombinant RSV antigens. |
CN102670628B (zh) * | 2008-01-25 | 2015-11-25 | 奇默里克斯公司 | 治疗病毒感染的方法 |
DK2176408T5 (en) | 2008-01-31 | 2015-12-14 | Curevac Gmbh | Nucleic acids comprising FORMULA (NuGiXmGnNv) a AND DERIVATIVES AS IMMUNE STIMULATING AGENTS / ADJUVANTS. |
CA2715460C (en) | 2008-02-13 | 2020-02-18 | President And Fellows Of Harvard College | Continuous cell programming devices |
US10383887B2 (en) * | 2008-02-20 | 2019-08-20 | New York University | Preventing and treating amyloid-beta deposition by stimulation of innate immunity |
US9511131B2 (en) | 2008-03-10 | 2016-12-06 | Children's Hospital & Research Center Oakland | Chimeric factor H binding proteins (fHBP) containing a heterologous B domain and methods of use |
CA2718473A1 (en) | 2008-03-17 | 2009-09-24 | Intercell Ag | Peptides protective against s. pneumoniae and compositions, methods and uses relating thereto |
ES2922534T3 (es) | 2008-04-18 | 2022-09-16 | Massachusetts Gen Hospital | Inmunoterapias que emplean vacunas autoensamblantes |
US8815817B2 (en) * | 2008-05-15 | 2014-08-26 | Dynavax Technologies Corporation | Long term disease modification using immunostimulatory oligonucleotides |
US8222225B2 (en) | 2008-05-21 | 2012-07-17 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Method of treating pneumoconiosis with oligodeoxynucleotides |
US9415006B2 (en) | 2008-05-23 | 2016-08-16 | The Regents Of The University Of Michigan | Immunogenic compositions comprising nanoemulsion and hepatitis B virus immunogen and methods of using the same |
US8703490B2 (en) | 2008-06-05 | 2014-04-22 | Ventana Medical Systems, Inc. | Compositions comprising nanomaterials and method for using such compositions for histochemical processes |
TWI351288B (en) * | 2008-07-04 | 2011-11-01 | Univ Nat Pingtung Sci & Tech | Cpg dna adjuvant in avian vaccines |
MY172788A (en) | 2008-08-01 | 2019-12-12 | Gamma Vaccines Pty Ltd | Influenza vaccines |
EP2385371B1 (en) | 2008-09-22 | 2014-10-22 | Oregon Health and Science University | Methods for detecting a mycobacterium tuberculosis infection |
US20100092526A1 (en) | 2008-09-26 | 2010-04-15 | Nanobio Corporation | Nanoemulsion therapeutic compositions and methods of using the same |
US8734803B2 (en) | 2008-09-28 | 2014-05-27 | Ibio Inc. | Humanized neuraminidase antibody and methods of use thereof |
WO2010037408A1 (en) | 2008-09-30 | 2010-04-08 | Curevac Gmbh | Composition comprising a complexed (m)rna and a naked mrna for providing or enhancing an immunostimulatory response in a mammal and uses thereof |
HUE028497T2 (en) * | 2008-10-16 | 2016-12-28 | The Univ Of Saskatchewan | Combination adjuvant composition |
US9732324B2 (en) | 2008-10-23 | 2017-08-15 | Cornell University | Anti-viral method |
WO2010048731A1 (en) * | 2008-10-31 | 2010-05-06 | Christopher John Ong | Aminoacyl trna-synthetase inhibitors as broad-spectrum immunosuppressive agents |
WO2010057197A1 (en) | 2008-11-17 | 2010-05-20 | The Regents Of The University Of Michigan | Cancer vaccine compositions and methods of using the same |
ES2866623T3 (es) | 2008-11-24 | 2021-10-19 | Massachusetts Inst Technology | Métodos y composiciones para el suministro localizado de nanopartículas a un tumor |
RU2015151857A (ru) | 2008-12-02 | 2019-01-15 | Уэйв Лайф Сайенсес Джапан, Инк. | Способ синтеза модифицированных по атому фосфора нуклеиновых кислот |
JP2012510284A (ja) | 2008-12-03 | 2012-05-10 | プロイェクト、デ、ビオメディシナ、シーマ、ソシエダッド、リミターダ | ワクチンの開発のためのフェノール可溶性モジュリンの使用 |
BRPI0922132A2 (pt) | 2008-12-03 | 2018-10-23 | Protea Vaccine Tech Ltd | fragmentos glutamil trna sintetase (gts). |
US8552165B2 (en) | 2008-12-09 | 2013-10-08 | Heather Davis | Immunostimulatory oligonucleotides |
PE20142330A1 (es) | 2008-12-09 | 2015-01-14 | Pfizer Vaccines Llc | Vacuna de peptido ch3 de ige |
CN102333538B (zh) | 2008-12-09 | 2014-01-15 | 科勒制药集团有限公司 | 免疫刺激性寡核苷酸 |
BRPI1005670A8 (pt) | 2009-01-05 | 2017-12-26 | Epitogenesis Inc | composições adjuvantes e processos de uso. |
US20110312525A1 (en) | 2009-01-20 | 2011-12-22 | Bruce Acres | Soluble icam-1 as biomarker for prediction of therapeutic response |
US20100234283A1 (en) | 2009-02-04 | 2010-09-16 | The Ohio State University Research Foundation | Immunogenic epitopes, peptidomimetics, and anti-peptide antibodies, and methods of their use |
EP2424882A2 (en) | 2009-02-05 | 2012-03-07 | Intercell AG | Peptides protective against e. faecalis, methods and uses relating thereto |
WO2010092176A2 (en) | 2009-02-13 | 2010-08-19 | Intercell Ag | Nontypable haemophilus influenzae antigens |
WO2010099472A2 (en) | 2009-02-27 | 2010-09-02 | The U.S.A. Of America, As Represented By The Secretary, Department Of Health And Human Services | Spanx-b polypeptides and their use |
WO2010105815A2 (en) | 2009-03-17 | 2010-09-23 | Oncomethylome Sciences S.A. | Improved detection of gene expression |
WO2010111292A1 (en) | 2009-03-23 | 2010-09-30 | Nanirx, Inc. | Treatment of cancer with immunostimulatory hiv tat derivative polypeptides |
MX2011010061A (es) | 2009-03-24 | 2011-11-18 | Transgene Sa | Biomarcador para monitorear pacientes. |
WO2010115118A2 (en) | 2009-04-03 | 2010-10-07 | Antigenics, Inc. | Methods for preparing and using multichaperone-antigen complexes |
US20120058493A1 (en) | 2009-04-17 | 2012-03-08 | Bruce Acres | Biomarker for monitoring patients |
KR20120022984A (ko) * | 2009-04-21 | 2012-03-12 | 셀렉타 바이오사이언시즈, 인크. | Th1 편향 반응을 제공하는 면역나노치료법 |
CA2757620C (en) | 2009-04-30 | 2016-04-26 | Coley Pharmaceutical Group, Inc. | Pneumococcal vaccine and uses thereof |
BRPI1012078A2 (pt) | 2009-05-27 | 2019-09-24 | Glaxosmithkline Biologicals Sa | construto de proteína, composição imunogênica, molécula de ácido nucleico , métodos de induzir uma resposta imune a casb7439 e de tratar um animal humano ou não-humano, e, uso de uma composição imunogênica |
EA201791383A1 (ru) | 2009-05-27 | 2018-06-29 | Селекта Байосайенсиз, Инк. | Наноносители, имеющие компоненты с различными скоростями высвобождения |
RU2560182C2 (ru) | 2009-06-05 | 2015-08-20 | Инфекшес Дизиз Рисерч Инститьют | Синтетические глюкопиранозиллипидные адъюванты |
CA2765511C (en) | 2009-06-16 | 2015-05-12 | The Regents Of The University Of Michigan | Nanoemulsion vaccines |
MA33449B1 (fr) | 2009-06-24 | 2012-07-03 | Glaxosmithkline Biolog Sa | Antigènes recombinants du vrs |
MX2012000036A (es) | 2009-06-24 | 2012-02-28 | Glaxosmithkline Biolog Sa | Vacuna. |
RU2612521C2 (ru) | 2009-07-06 | 2017-03-09 | Онтории, Инк. | Новые пролекарства нуклеиновых кислот и способы их применения |
CN102483405B (zh) | 2009-07-10 | 2015-12-02 | 特朗斯吉有限公司 | 用于选择患者的生物标志物及相关方法 |
TW201116294A (en) | 2009-07-15 | 2011-05-16 | Novartis Ag | RSV F protein compositions and methods for making same |
US8614200B2 (en) | 2009-07-21 | 2013-12-24 | Chimerix, Inc. | Compounds, compositions and methods for treating ocular conditions |
MX2012001194A (es) * | 2009-07-30 | 2012-03-07 | Pfizer Vaccines Llc | Peptidos tau antigenicos y usos de los mismos. |
US20110033515A1 (en) * | 2009-08-04 | 2011-02-10 | Rst Implanted Cell Technology | Tissue contacting material |
GB0913680D0 (en) | 2009-08-05 | 2009-09-16 | Glaxosmithkline Biolog Sa | Immunogenic composition |
GB0913681D0 (en) | 2009-08-05 | 2009-09-16 | Glaxosmithkline Biolog Sa | Immunogenic composition |
CN102596980A (zh) | 2009-08-26 | 2012-07-18 | Rna公司 | 源自脂磷壁酸的糖脂及含有该糖脂的组合物 |
WO2011026111A1 (en) | 2009-08-31 | 2011-03-03 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Oral delivery of a vaccine to the large intestine to induce mucosal immunity |
US20110053829A1 (en) | 2009-09-03 | 2011-03-03 | Curevac Gmbh | Disulfide-linked polyethyleneglycol/peptide conjugates for the transfection of nucleic acids |
NO2473605T3 (ja) | 2009-09-03 | 2018-09-08 | ||
CN102573886A (zh) * | 2009-09-17 | 2012-07-11 | 相互制药公司 | 用抗病毒剂治疗哮喘的方法 |
GB0917457D0 (en) | 2009-10-06 | 2009-11-18 | Glaxosmithkline Biolog Sa | Method |
WO2011041391A1 (en) | 2009-09-29 | 2011-04-07 | Fraunhofer Usa, Inc. | Influenza hemagglutinin antibodies, compositions, and related methods |
CN102782138A (zh) | 2009-10-07 | 2012-11-14 | Uvic工业合伙公司 | 包含热敏性转基因的疫苗 |
WO2011042548A1 (en) | 2009-10-09 | 2011-04-14 | Sanofi-Aventis | Polypeptides for binding to the "receptor for advanced glycation endproducts" as well as compositions and methods involving the same |
EP2308896A1 (en) | 2009-10-09 | 2011-04-13 | Sanofi-aventis | Polypeptides for binding to the "receptor for advanced glycation endproducts" as well as compositions and methods involving the same |
EP2319871A1 (en) | 2009-11-05 | 2011-05-11 | Sanofi-aventis | Polypeptides for binding to the "receptor for advanced glycation endproducts" as well as compositions and methods involving the same |
WO2011047340A1 (en) | 2009-10-16 | 2011-04-21 | The United States Of America, As Represented By The Secretary, Department Of Health & Human Services | Insertion of foreign genes in rubella virus and their stable expression in a live, attenuated viral vaccine |
GB0919117D0 (en) | 2009-10-30 | 2009-12-16 | Glaxosmithkline Biolog Sa | Process |
EP3360566B1 (en) | 2009-11-20 | 2019-12-25 | Oregon Health&Science University | Methods for detecting a mycobacterium tuberculosis infection |
WO2011067758A2 (en) | 2009-12-02 | 2011-06-09 | Protea Vaccine Technologies Ltd. | Immunogenic fragments and multimers from streptococcus pneumoniae proteins |
SG10201408505SA (en) | 2009-12-22 | 2015-02-27 | Celldex Therapeutics Inc | Vaccine compositions |
FR2954703B1 (fr) | 2009-12-28 | 2013-12-13 | Chu Nantes | Agonistes des recepteurs tlr 4 et 9 pour prevenir les complications septiques de l'immunodepression post-traumatique chez les patients hospitalises pour traumatismes severes |
AU2011216243B2 (en) | 2010-02-12 | 2015-07-09 | Chimerix, Inc. | Nucleoside phosphonate salts |
WO2011101332A1 (en) | 2010-02-16 | 2011-08-25 | Proyecto De Biomedicina Cima, S.L. | Compositions based on the fibronectin extracellular domain a for the treatment of melanoma |
US8685416B2 (en) | 2010-03-02 | 2014-04-01 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Compositions and methods for the treatment of cancer |
EP2542670A2 (en) | 2010-03-05 | 2013-01-09 | President and Fellows of Harvard College | Induced dendritic cell compositions and uses thereof |
GB201003920D0 (en) | 2010-03-09 | 2010-04-21 | Glaxosmithkline Biolog Sa | Method of treatment |
GB201003924D0 (en) | 2010-03-09 | 2010-04-21 | Glaxosmithkline Biolog Sa | Immunogenic composition |
BR112012022688A2 (pt) | 2010-03-10 | 2018-05-22 | Glaxosmithkline Biologicals Sa | proteína de fusão, vesícula da membrana externa isolada, polinucleotídeo, composição farmacêutica, vacina, método para tratamento ou prevenção de infecção ou doença por neisseria, uso e método para fabricar uma proteína de fusão |
WO2011112599A2 (en) | 2010-03-12 | 2011-09-15 | The United States Of America, As Represented By The Secretary. Department Of Health & Human Services | Immunogenic pote peptides and methods of use |
BR112012023501A2 (pt) | 2010-03-19 | 2016-05-31 | Massachusetts Inst Technology | vesículas lipídicas multilamelares, composição farmacêutica e método |
US20110229556A1 (en) * | 2010-03-19 | 2011-09-22 | Massachusetts Institute Of Technology | Lipid-coated polymer particles for immune stimulation |
US9149432B2 (en) | 2010-03-19 | 2015-10-06 | Massachusetts Institute Of Technology | Lipid vesicle compositions and methods of use |
GB201005005D0 (en) * | 2010-03-25 | 2010-05-12 | Angeletti P Ist Richerche Bio | New vaccine |
AU2011238670B2 (en) | 2010-03-30 | 2015-04-23 | Children's Hospital & Research Center Oakland | Factor H binding proteins (FHBP) with altered properties and methods of use thereof |
NZ602892A (en) | 2010-04-13 | 2014-08-29 | Celldex Therapeutics Inc | Antibodies that bind human cd27 and uses thereof |
AU2011248620B2 (en) | 2010-04-26 | 2015-11-26 | Chimerix, Inc. | Methods of treating retroviral infections and related dosage regimes |
PT2772265T (pt) | 2010-05-14 | 2018-04-20 | Univ Oregon Health & Science | Vectores de hcmv e rhcmv recombinantes e seus usos |
NO2575876T3 (ja) | 2010-05-26 | 2018-05-05 | ||
DK2575878T3 (en) * | 2010-05-28 | 2018-08-13 | Zoetis Belgium S A | VACCINES INCLUDING CHOLESTEROL AND CPG AS THE ONLY ADJUVENT CARRIER MOLECULES |
WO2011154878A1 (en) | 2010-06-07 | 2011-12-15 | Pfizer Vaccines Llc | Ige ch3 peptide vaccine |
US8658603B2 (en) | 2010-06-16 | 2014-02-25 | The Regents Of The University Of Michigan | Compositions and methods for inducing an immune response |
CN103025876A (zh) | 2010-07-30 | 2013-04-03 | 库瑞瓦格有限责任公司 | 用于转染和免疫刺激的核酸与二硫化物交联的阳离子成分的复合体 |
DK2753352T4 (da) | 2010-09-03 | 2022-09-12 | Valneva Austria Gmbh | Isoleret polypeptid af toxin a og toxin b proteinerne fra c. difficile og anvendelser deraf |
AR082925A1 (es) | 2010-09-08 | 2013-01-16 | Medigene Ag | Proteinas estructurales mutadas por parvovirus con epitopo de celulas b de proteccion cruzada, producto y metodos relacionados |
GB201015132D0 (en) | 2010-09-10 | 2010-10-27 | Univ Bristol | Vaccine composition |
EP3431100B1 (en) | 2010-09-14 | 2021-09-08 | University of Pittsburgh- Of the Commonwealth System of Higher Education | Computationally optimized broadly reactive antigens for influenza |
US10428019B2 (en) | 2010-09-24 | 2019-10-01 | Wave Life Sciences Ltd. | Chiral auxiliaries |
US9168292B2 (en) | 2010-09-27 | 2015-10-27 | Crucell Holland B.V. | Heterologous prime boost vaccination regimen against malaria |
CN103237565B (zh) | 2010-10-06 | 2017-10-31 | 哈佛学院董事会 | 用于基于材料的细胞疗法的可注射的成孔水凝胶 |
WO2012057904A1 (en) | 2010-10-27 | 2012-05-03 | Infectious Disease Research Institute | Mycobacterium tuberculosis antigens and combinations thereof having high seroreactivity |
EP2640190A4 (en) | 2010-11-05 | 2016-05-11 | Selecta Biosciences Inc | MODIFIED NICOTINIC COMPOUNDS AND ASSOCIATED METHODS |
ES2859673T3 (es) | 2010-11-08 | 2021-10-04 | Infectious Disease Res Inst | Vacunas que comprenden polipéptidos de nucleósido hidrolasa no específica y esterol 24-c-metiltransferasa (SMT) para el tratamiento y el diagnóstico de la leishmaniasis |
BR112013014599A2 (pt) | 2010-12-14 | 2016-09-27 | Glaxosmithkline Biolog Sa | composição imunogênica, uso de uma composição imunogênica, processo para preparar uma composição imunogênica, método para a fabricação de uma composição imunogênca estável, e, kit |
CA2825403C (en) | 2011-01-27 | 2023-02-21 | Gamma Vaccines Pty Limited | Vaccines comprising a combination of gamma irradiated influenza virus and a further immunogen |
WO2012114323A1 (en) | 2011-02-22 | 2012-08-30 | Biondvax Pharmaceuticals Ltd. | Multimeric multiepitope polypeptides in improved seasonal and pandemic influenza vaccines |
US20140004142A1 (en) | 2011-03-02 | 2014-01-02 | Pfizer Inc. | Pcsk9 vaccine |
EP2505640A1 (en) | 2011-03-29 | 2012-10-03 | Neo Virnatech, S.L. | Vaccine compositions for birnavirus-borne diseases |
GB201106357D0 (en) | 2011-04-14 | 2011-06-01 | Pessi Antonello | Composition and uses thereof |
EA027236B1 (ru) | 2011-04-08 | 2017-07-31 | Иммьюн Дизайн Корп. | Иммуногенные композиции и способы применения таких композиций для индукции гуморального и клеточного иммунного ответа |
TW201302779A (zh) | 2011-04-13 | 2013-01-16 | Glaxosmithkline Biolog Sa | 融合蛋白質及組合疫苗 |
WO2012149307A2 (en) | 2011-04-27 | 2012-11-01 | Immune Design Corp. | Synthetic long peptide (slp)-based vaccines |
FR2975600B1 (fr) | 2011-05-24 | 2013-07-05 | Assist Publ Hopitaux De Paris | Agents pour le traitement de tumeurs |
EP2713737B1 (en) | 2011-06-01 | 2016-04-20 | Janus Biotherapeutics, Inc. | Novel immune system modulators |
KR102052215B1 (ko) | 2011-06-01 | 2019-12-04 | 야누스 바이오테라퓨틱스, 인크. | 신규한 면역 시스템 조절제 |
US9475804B2 (en) | 2011-06-03 | 2016-10-25 | 3M Innovative Properties Company | Heterobifunctional linkers with polyethylene glycol segments and immune response modifier conjugates made therefrom |
MX355623B (es) | 2011-06-03 | 2018-04-25 | 3M Innovative Properties Co | Hidrazino-1h-imidazoquinolin-4-aminas y conjugados elaborados a partir de las mismas. |
CA2838188C (en) | 2011-06-04 | 2017-04-18 | Rochester General Hospital Research Institute | Compositions and methods related to p6 of haemophilus influenzae |
WO2012170678A1 (en) | 2011-06-07 | 2012-12-13 | Fraunhofer Usa, Inc. | In vivo de-glycosylation of recombinant proteins by co-expression with pngase f |
KR102033185B1 (ko) | 2011-06-17 | 2019-10-16 | 유니버시티 오브 테네시 리서치 파운데이션 | 그룹 a 스트렙토콕쿠스 다가 백신 |
US9580475B2 (en) | 2011-06-20 | 2017-02-28 | University of Pittsburgh—of the Commonwealth System of Higher Education | Computationally optimized broadly reactive antigens for H1N1 influenza |
US20150030586A1 (en) | 2011-06-21 | 2015-01-29 | Sarah Ellen Warren | Compositions and methods for the therapy and diagnosis of cancer |
WO2013007703A1 (en) * | 2011-07-08 | 2013-01-17 | Universität Zürich | CLASS A CpG OLIGONUCLEOTIDES FOR PREVENTION OF VIRAL INFECTION IN CATS |
MX347361B (es) | 2011-07-19 | 2017-04-12 | Wave Life Sciences Ltd | Metodos para la sintesis de acidos nucleicos funcionalizados. |
US20130023736A1 (en) | 2011-07-21 | 2013-01-24 | Stanley Dale Harpstead | Systems for drug delivery and monitoring |
EP2736537A4 (en) | 2011-07-29 | 2015-04-15 | Selecta Biosciences Inc | SYNTHETIC NANOTRANSPORTERS FOR THE PRODUCTION OF HUMOROUS AND CYTOTOXIC T-LYMPHOCY (CTL) IMMUNE REACTIONS |
GB201114919D0 (en) | 2011-08-30 | 2011-10-12 | Glaxosmithkline Biolog Sa | Method |
US20140348865A1 (en) | 2011-09-12 | 2014-11-27 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Ser. | Immunogens based on an hiv-1 v1v2 site-of-vulnerability |
DK2758432T3 (da) | 2011-09-16 | 2019-06-03 | Ucb Biopharma Sprl | Neutraliserende antistoffer mod hovedtoksinerne TcdA og TcdB fra Clostridium difficile |
EP2572725B1 (en) | 2011-09-21 | 2015-07-08 | Ruprecht-Karls-Universität Heidelberg | MSI-specific frameshift peptides (FSP) for prevention and treatment of cancer |
WO2013049535A2 (en) | 2011-09-30 | 2013-04-04 | The United States Of America, As Represented By The Secretary, Department Of Health & Human Services | Influenza vaccine |
US9873694B2 (en) | 2011-10-04 | 2018-01-23 | Janus Biotherapeutics, Inc. | Imidazole quinoline-based immune system modulators |
US20140286983A1 (en) | 2011-10-20 | 2014-09-25 | The Government of the USA as represented by the Secretaryof the Dept. of Health and Human Services | Dengue virus e-glycoprotein polypeptides containing mutations that eliminate immunodominant cross-reactive epitopes |
EP2780034A1 (en) | 2011-11-14 | 2014-09-24 | Crucell Holland B.V. | Heterologous prime-boost immunization using measles virus-based vaccines |
EP2596806A1 (en) | 2011-11-25 | 2013-05-29 | Index Pharmaceuticals AB | Method for prevention of colectomy |
EA201491081A1 (ru) | 2012-01-16 | 2016-11-30 | Элизабет Маккенна | Композиции и способы для лечения заболеваний и расстройств печени |
US20140086849A1 (en) | 2012-09-21 | 2014-03-27 | Elizabeth McKenna | Naturally-Occurring CpG Oligonucleotide Compositions and Therapeutic Applications Thereof |
WO2013113326A1 (en) | 2012-01-31 | 2013-08-08 | Curevac Gmbh | Pharmaceutical composition comprising a polymeric carrier cargo complex and at least one protein or peptide antigen |
CN104136456A (zh) | 2012-02-07 | 2014-11-05 | 高等教育联邦系统-匹兹堡大学 | 以计算方式优化的h3n2、h2n2和b型流感病毒的广泛反应性抗原 |
SI2811981T1 (sl) | 2012-02-07 | 2019-08-30 | Infectious Disease Research Institute | Izboljšanje adjuvantne formulacije, ki obsegajo TLR4 agoniste in postopki za uporabo le-teh |
IN2014DN05695A (ja) | 2012-02-13 | 2015-05-15 | Univ Pittsburgh | |
WO2013142808A1 (en) | 2012-03-23 | 2013-09-26 | The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Pathogenic phlebovirus isolates and compositions and methods of use |
WO2013150518A1 (en) | 2012-04-01 | 2013-10-10 | Rappaport Family Institute For Research In The Medical Sciences | Extracellular matrix metalloproteinase inducer (emmprin) peptides and binding antibodies |
HUE047973T2 (hu) | 2012-04-16 | 2020-05-28 | Harvard College | Mezoporózus szilíciumdioxid készítmények immunválaszok modulálására |
EP2841098A4 (en) | 2012-04-23 | 2016-03-02 | Allertein Therapeutics Llc | NANOPARTICLES FOR THE TREATMENT OF ALLERGIES |
NZ701324A (en) | 2012-05-04 | 2016-09-30 | Pfizer | Prostate-associated antigens and vaccine-based immunotherapy regimens |
ES2673556T3 (es) | 2012-05-16 | 2018-06-22 | Immune Design Corp. | Vacunas para el VHS-2 |
EP2666785A1 (en) | 2012-05-23 | 2013-11-27 | Affiris AG | Complement component C5a-based vaccine |
US9409956B2 (en) | 2012-05-23 | 2016-08-09 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Salmonella typhi Ty21a expressing Yersinia pestis F1-V fusion protein and uses thereof |
CN104428008B (zh) | 2012-05-24 | 2020-10-09 | 美国政府(由卫生和人类服务部的部长所代表) | 多价脑膜炎球菌缀合物及制备缀合物的方法 |
US9687542B2 (en) | 2012-06-19 | 2017-06-27 | The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Rift valley fever virus replicon particles and use thereof |
JP6246121B2 (ja) | 2012-07-13 | 2017-12-13 | 株式会社新日本科学 | キラル核酸アジュバント |
US9982257B2 (en) | 2012-07-13 | 2018-05-29 | Wave Life Sciences Ltd. | Chiral control |
US9598458B2 (en) | 2012-07-13 | 2017-03-21 | Wave Life Sciences Japan, Inc. | Asymmetric auxiliary group |
RU2659149C2 (ru) | 2012-08-03 | 2018-06-28 | Инфекшес Дизиз Рисерч Инститьют | Композиции и способы для лечения активной инфекции mycobacterium tuberculosis |
US20140037680A1 (en) | 2012-08-06 | 2014-02-06 | Glaxosmithkline Biologicals, S.A. | Novel method |
JP2015525794A (ja) | 2012-08-06 | 2015-09-07 | グラクソスミスクライン バイオロジカルズ ソシエテ アノニム | 乳児においてrsv及び百日咳菌に対する免疫応答を惹起するための方法 |
WO2014031178A1 (en) | 2012-08-24 | 2014-02-27 | Etubics Corporation | Replication defective adenovirus vector in vaccination |
EP2703483A1 (en) | 2012-08-29 | 2014-03-05 | Affiris AG | PCSK9 peptide vaccine |
US10973892B2 (en) | 2012-09-04 | 2021-04-13 | Bavarian Nordic A/S | Methods and compositions for enhancing vaccine immune responses |
WO2014043535A1 (en) | 2012-09-14 | 2014-03-20 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Compositions for the treatment of cancer |
WO2014043518A1 (en) | 2012-09-14 | 2014-03-20 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Brachyury protein, non-poxvirus non-yeast vectors encoding brachyury protein, and their use |
US10232035B2 (en) | 2012-09-14 | 2019-03-19 | The Regents Of The University Of Colorado, A Body Corporate | Conditionally replication deficient herpes virus and use thereof in vaccines |
PL2912186T3 (pl) | 2012-10-24 | 2021-06-14 | Platelet Targeted Therapeutics Llc | Leczenie ukierunkowane na płytki krwi |
RU2644677C2 (ru) | 2012-12-13 | 2018-02-13 | Рупрехт-Карлс-Университэт Гейдельберг | Мсн-специфичные пептиды со смещенной рамкой считывания (псрс) для предотвращения и лечения рака |
AU2014203896B2 (en) | 2013-01-07 | 2018-05-31 | The Trustees Of The University Of Pennsylvania | Compositions and methods for treating cutaneous T cell lymphoma |
EP2948469A4 (en) | 2013-01-23 | 2016-11-02 | Univ Leland Stanford Junior | STABILIZED HEPATITIS B CORE POLYPEPTIDE |
EP2968521A2 (en) | 2013-03-15 | 2016-01-20 | GlaxoSmithKline Biologicals S.A. | Vaccine |
EP2978447B1 (en) | 2013-03-28 | 2019-05-08 | Infectious Disease Research Institute | Vaccines comprising leishmania polypeptides for the treatment and diagnosis of leishmaniasis |
WO2014165679A1 (en) | 2013-04-03 | 2014-10-09 | Allertein Therapeutics, Llc | Novel nanoparticle compositions |
AU2014253791B2 (en) | 2013-04-18 | 2019-05-02 | Immune Design Corp. | GLA monotherapy for use in cancer treatment |
EP2986717A1 (en) | 2013-04-19 | 2016-02-24 | The Regents of The University of California | Lone star virus |
WO2015132619A1 (en) | 2013-05-15 | 2015-09-11 | The Governors Of The University Of Alberta | E1e2 hcv vaccines and methods of use |
US9463198B2 (en) | 2013-06-04 | 2016-10-11 | Infectious Disease Research Institute | Compositions and methods for reducing or preventing metastasis |
GB201310008D0 (en) | 2013-06-05 | 2013-07-17 | Glaxosmithkline Biolog Sa | Immunogenic composition for use in therapy |
WO2014201245A1 (en) | 2013-06-12 | 2014-12-18 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Tlr-9 agonist with tlr-7 and/or tlr-8 agonist for treating tumors |
CA2919268C (en) | 2013-07-25 | 2023-09-05 | Exicure, Inc. | Spherical nucleic acid-based constructs as immunostimulatory agents for prophylactic and therapeutic use |
EP3632458A1 (en) | 2013-07-26 | 2020-04-08 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods and pharmaceutical compositions for the treatment of bacterial infections |
SG11201600709TA (en) | 2013-08-05 | 2016-02-26 | Glaxosmithkline Biolog Sa | Combination immunogenic compositions |
SG11201510746WA (en) | 2013-08-21 | 2016-03-30 | Curevac Ag | Respiratory syncytial virus (rsv) vaccine |
CA2925304C (en) | 2013-09-27 | 2023-04-18 | Massachusetts Institute Of Technology | Carrier-free biologically-active protein nanostructures |
US10010606B2 (en) | 2013-09-30 | 2018-07-03 | Los Alamos National Security, Llc | Mosaic conserved region HIV immunogenic polypeptides |
EP3052127A1 (en) | 2013-10-04 | 2016-08-10 | PIN Pharma, Inc. | Immunostimulatory hiv tat derivative polypeptides for use in cancer treatment |
JP2016535989A (ja) | 2013-11-01 | 2016-11-24 | ファイザー・インク | 前立腺関連抗原を発現させるためのベクター |
US10208102B2 (en) | 2013-11-01 | 2019-02-19 | University Of Oslo | Albumin variants and uses thereof |
US10357554B2 (en) | 2013-11-11 | 2019-07-23 | The United States Of America, As Represented By The Secretary Of The Army | AMA-1 epitopes, antibodies, compositions, and methods of making and using the same |
CA2929126C (en) | 2013-11-13 | 2020-01-07 | University Of Oslo | Outer membrane vesicles and uses thereof |
EP3069138B1 (en) | 2013-11-15 | 2019-01-09 | Oslo Universitetssykehus HF | Ctl peptide epitopes and antigen-specific t cells, methods for their discovery, and uses thereof |
WO2015077442A2 (en) | 2013-11-20 | 2015-05-28 | La Jolla Institute For Allergy And Immunology | Grass pollen immunogens and methods and uses for immune response modulation |
EP3071228A2 (en) | 2013-11-20 | 2016-09-28 | La Jolla Institute for Allergy and Immunology | Pan pollen immunogens and methods and uses thereof for immune response modulation |
HUE056105T2 (hu) | 2013-11-28 | 2022-01-28 | Bavarian Nordic As | Készítmények és eljárások fokozott immunválasz indukálására poxvírusvektorok alkalmazásával |
JP6758185B2 (ja) | 2013-12-13 | 2020-09-23 | ザ ユナイテッド ステイツ オブ アメリカ, アズ リプレゼンテッド バイ ザ セクレタリー, デパートメント オブ ヘルス アンド ヒューマン サービシーズ | マルチエピトープtarpペプチドワクチンおよびその使用 |
WO2015092710A1 (en) | 2013-12-19 | 2015-06-25 | Glaxosmithkline Biologicals, S.A. | Contralateral co-administration of vaccines |
WO2015103167A2 (en) | 2013-12-31 | 2015-07-09 | Infectious Disease Research Institute | Single vial vaccine formulations |
CA2936712A1 (en) | 2014-01-16 | 2015-07-23 | Meena | Chiral design |
SG11201605883UA (en) | 2014-01-21 | 2016-08-30 | Immune Design Corp | Compositions for use in the treatment of allergic conditions |
IL296681A (en) | 2014-01-21 | 2022-11-01 | Pfizer | Immunogenic preparations that include conjugated capsular saccharide antigens and their uses |
DK3096783T3 (da) | 2014-01-21 | 2021-08-02 | Pfizer | Streptococcus pneumoniae-kapselpolysaccharider og konjugater deraf |
DK3583947T3 (da) | 2014-01-21 | 2023-11-06 | Pfizer | Streptococcus pneumoniae-kapselpolysaccharider og konjugater deraf |
US11160855B2 (en) | 2014-01-21 | 2021-11-02 | Pfizer Inc. | Immunogenic compositions comprising conjugated capsular saccharide antigens and uses thereof |
WO2015123291A1 (en) | 2014-02-11 | 2015-08-20 | The Usa, As Represented By The Secretary, Dept. Of Health And Human Services | Pcsk9 vaccine and methods of using the same |
TW201620927A (zh) | 2014-02-24 | 2016-06-16 | 葛蘭素史密斯克藍生物品公司 | Uspa2蛋白質構築體及其用途 |
WO2015131053A1 (en) | 2014-02-28 | 2015-09-03 | Alk-Abelló A/S | Polypeptides derived from phl p and methods and uses thereof for immune response modulation |
CA2936286A1 (en) | 2014-04-01 | 2015-10-08 | Curevac Ag | Polymeric carrier cargo complex for use as an immunostimulating agent or as an adjuvant |
EP3134104B1 (en) | 2014-04-25 | 2018-12-26 | Tria Bioscience Corp. | Synthetic hapten carrier compositions and methods |
WO2015168379A2 (en) | 2014-04-30 | 2015-11-05 | President And Fellows Of Harvard College | Combination vaccine devices and methods of killing cancer cells |
CA2986096A1 (en) | 2014-05-30 | 2015-12-03 | Sanofi Pasteur Inc. | Expression and conformational analysis of engineered influenza hemagglutinin |
EP2952893A1 (en) | 2014-06-04 | 2015-12-09 | Institut d'Investigació Biomèdica de Bellvitge (IDIBELL) | Method for detecting antibody-secreting B cells specific for HLA |
PL3164113T3 (pl) | 2014-06-04 | 2019-09-30 | Exicure, Inc. | Wielowartościowe dostarczanie modulatorów immunologicznych w liposomowych kolistych kwasach nukleinowych do zastosowań profilaktycznych lub terapeutycznych |
BR112016028816A8 (pt) | 2014-06-13 | 2021-07-20 | Glaxosmithkline Biologicals Sa | combinação imunogênica, método para obter uma resposta imunológica específica, uso de uma combinação imunogênica, e, regime de vacinação para prevenção, redução ou tratamento de infecção por vírus sincicial respiratório |
EP3169352A1 (en) | 2014-07-15 | 2017-05-24 | Immune Design Corp. | Prime-boost regimens with a tlr4 agonist adjuvant and a lentiviral vector |
EP3169699A4 (en) | 2014-07-18 | 2018-06-20 | The University of Washington | Cancer vaccine compositions and methods of use thereof |
WO2016012385A1 (en) | 2014-07-21 | 2016-01-28 | Sanofi Pasteur | Vaccine composition comprising ipv and cyclodextrins |
EP3398948A3 (en) | 2014-08-22 | 2018-12-05 | Janus Biotherapeutics, Inc. | 2,4,6,7-tetrasubstituted pteridine compounds and methods of synthesis and use thereof |
MX2017004448A (es) | 2014-10-06 | 2017-10-23 | Exicure Inc | Compuestos anti-factor de necrosis tumoral (tnf). |
EP4112076A1 (en) | 2014-10-10 | 2023-01-04 | The Regents of The University of Michigan | Nanoemulsion compositions for preventing, suppressing or eliminating allergic and inflammatory disease |
MA40920A (fr) | 2014-11-07 | 2017-09-12 | Takeda Vaccines Inc | Vaccins de la main, du pied et de la bouche, et procédés de fabrication et d'utilisation de ceux-ci |
AU2015252119A1 (en) | 2014-11-07 | 2016-05-26 | Takeda Vaccines, Inc. | Hand, foot, and mouth vaccines and methods of manufacture and use thereof |
CA2968531A1 (en) | 2014-11-21 | 2016-05-26 | Northwestern University | The sequence-specific cellular uptake of spherical nucleic acid nanoparticle conjugates |
AU2015359503B2 (en) | 2014-12-10 | 2019-05-09 | Glaxosmithkline Biologicals Sa | Method of treatment |
AU2015365583B2 (en) | 2014-12-19 | 2021-10-28 | Regenesance B.V. | Antibodies that bind human C6 and uses thereof |
WO2016109310A1 (en) | 2014-12-31 | 2016-07-07 | Checkmate Pharmaceuticals, Llc | Combination tumor immunotherapy |
CA2974237C (en) | 2015-01-09 | 2021-07-20 | Etubics Corporation | Methods and compositions for combination immunotherapy |
SI3244917T1 (sl) | 2015-01-15 | 2023-07-31 | Pfizer Inc. | Imunogenske kompozicije za uporabo v pnevmokoknih cepivih |
EP3250250A4 (en) | 2015-01-30 | 2019-05-22 | President and Fellows of Harvard College | PERITUMORAL AND INTRATUMORAL MATERIALS FOR CANCER THERAPY |
CA3014427A1 (en) | 2015-02-13 | 2016-08-18 | Icahn School Of Medicine At Mount Sinai | Rna containing compositions and methods of their use |
WO2016140702A1 (en) | 2015-03-03 | 2016-09-09 | The United States Of America, As Represented By The Secretary, Department Of Health & Human Serivces | Display platform from bacterial spore coat proteins |
EP3268034A4 (en) | 2015-03-05 | 2018-11-14 | Northwestern University | Non-neuroinvasive viruses and uses thereof |
EP3268037B1 (en) | 2015-03-09 | 2022-08-31 | Celldex Therapeutics, Inc. | Cd27 agonists |
WO2016154010A1 (en) | 2015-03-20 | 2016-09-29 | Makidon Paul | Immunogenic compositions for use in vaccination against bordetella |
JP6903046B2 (ja) | 2015-03-26 | 2021-07-14 | ジーピーエヌ ワクチン プロプライアタリー リミティド | 連鎖球菌ワクチン |
EP3280464A4 (en) | 2015-04-10 | 2018-09-26 | President and Fellows of Harvard College | Immune cell trapping devices and methods for making and using the same |
US11149087B2 (en) | 2015-04-20 | 2021-10-19 | Etubics Corporation | Methods and compositions for combination immunotherapy |
WO2016180852A1 (en) | 2015-05-12 | 2016-11-17 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods for preparing antigen-specific t cells from an umbilical cord blood sample |
EP3294324A1 (en) | 2015-05-13 | 2018-03-21 | Agenus Inc. | Vaccines for treatment and prevention of cancer |
RU2017140856A (ru) | 2015-05-26 | 2019-06-26 | Огайо Стейт Инновейшн Фаундейшн | Стратегия вакцинации против вируса свиного гриппа вакциной на основе наночастиц |
AU2016270979B2 (en) | 2015-06-02 | 2020-11-12 | Sanofi Pasteur Inc. | Engineered influenza antigenic polypeptides and immunogenic compositions thereof |
JP6886410B2 (ja) | 2015-06-10 | 2021-06-16 | ザ ユナイテッド ステイツ オブ アメリカ, アズ リプレゼンテッド バイ ザ セクレタリー, デパートメント オブ ヘルス アンド ヒューマン サービシーズ | 核酸含有組成物の作製および精製のためのプロセス |
JP2018518511A (ja) * | 2015-06-26 | 2018-07-12 | バイエル・アニマル・ヘルス・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツングBayer Animal Health Gmbh | 細胞質dna監視分子の調節方法 |
RU2721128C2 (ru) | 2015-07-21 | 2020-05-18 | Пфайзер Инк. | Иммуногенные композиции, содержащие конъюгированные антигены капсульного сахарида, наборы, содержащие эти композиции, и их применения |
WO2017027843A1 (en) | 2015-08-12 | 2017-02-16 | Massachusetts Institute Of Technology | Cell surface coupling of nanoparticles |
CN108024914A (zh) | 2015-09-17 | 2018-05-11 | Jrx生物技术有限公司 | 改善皮肤的水合作用或润湿作用的方法 |
WO2017059280A1 (en) | 2015-10-02 | 2017-04-06 | The University Of North Carolina At Chapel Hill | Novel pan-tam inhibitors and mer/axl dual inhibitors |
US10548970B2 (en) | 2015-10-05 | 2020-02-04 | The United States Of America, As Represented By The Secretary, Department Of Health & Human Services | Human rotavirus G9P[6] strain and use as a vaccine |
GB201518668D0 (en) | 2015-10-21 | 2015-12-02 | Glaxosmithkline Biolog Sa | Immunogenic Comosition |
WO2017075570A1 (en) | 2015-10-30 | 2017-05-04 | The United States Of America, As Represented By Secretary, Department Of Health And Human Sevices | Compositions and methods for the treatment of her2-expressing solid tumors |
WO2017085586A1 (en) | 2015-11-20 | 2017-05-26 | Pfizer Inc. | Immunogenic compositions for use in pneumococcal vaccines |
US11672866B2 (en) | 2016-01-08 | 2023-06-13 | Paul N. DURFEE | Osteotropic nanoparticles for prevention or treatment of bone metastases |
PL3407910T3 (pl) | 2016-01-29 | 2022-08-16 | Bavarian Nordic A/S | Rekombinowana zmodyfikowana szczepionka przeciwko wirusowi krowianki ankara (mva) przeciwko wirusowi zapalenia mózgu koni |
WO2017136837A1 (en) | 2016-02-06 | 2017-08-10 | President And Fellows Of Harvard College | Recapitulating the hematopoietic niche to reconstitute immunity |
CA3017356A1 (en) | 2016-03-10 | 2017-09-14 | Aperisys, Inc. | Antigen-binding fusion proteins with modified hsp70 domains |
KR20180127320A (ko) | 2016-03-14 | 2018-11-28 | 유니버시티에트 이 오슬로 | 변경된 FcRn 결합을 갖는 조작된 면역글로불린 |
WO2017158421A1 (en) | 2016-03-14 | 2017-09-21 | University Of Oslo | Anti-viral engineered immunoglobulins |
EP3436066A1 (en) | 2016-04-01 | 2019-02-06 | Checkmate Pharmaceuticals, Inc. | Fc receptor-mediated drug delivery |
EA201892362A1 (ru) | 2016-04-18 | 2019-04-30 | Селлдекс Терапьютикс, Инк. | Агонистические антитела, которые связываются с cd40 человека, и варианты их применения |
WO2017189448A1 (en) | 2016-04-25 | 2017-11-02 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Bivalent immunogenic conjugate for malaria and typhoid |
DK3458475T3 (da) | 2016-05-16 | 2022-09-12 | Access To Advanced Health Inst | Formulering, der indeholder tlr-agonist, og anvendelsesfremgangsmåder |
WO2017201390A1 (en) | 2016-05-19 | 2017-11-23 | The Regents Of The University Of Michigan | Novel adjuvant compositions |
KR20190009308A (ko) | 2016-05-21 | 2019-01-28 | 인펙셔스 디지즈 리서치 인스티튜트 (아이디알아이) | 2차 결핵 및 비결핵성 마이코박테리아 감염을 치료하기 위한 조성물 및 방법 |
SG11201810332TA (en) | 2016-05-27 | 2018-12-28 | Etubics Corp | Neoepitope vaccine compositions and methods of use thereof |
MX2021010105A (es) | 2016-06-01 | 2022-06-16 | Infectious Disease Res Inst | Particulas de nanoalumbre que contienen un agente de dimensionamiento. |
CA3026096A1 (en) | 2016-06-02 | 2017-12-07 | Sanofi Pasteur Inc. | Engineered influenza antigenic polypeptides and immunogenic compositions thereof |
MA45159A (fr) | 2016-06-03 | 2019-04-10 | Sanofi Pasteur Inc | Polypeptides d'hémagglutinine d'influenza modifiés |
WO2017218533A1 (en) | 2016-06-13 | 2017-12-21 | Torque Therapeutics, Inc. | Methods and compositions for promoting immune cell function |
US10947277B2 (en) | 2016-06-13 | 2021-03-16 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Nucleic acids encoding zika virus-like particles and their use in zika virus vaccines and diagnostic assays |
GB201610599D0 (en) | 2016-06-17 | 2016-08-03 | Glaxosmithkline Biologicals Sa | Immunogenic Composition |
US11780924B2 (en) | 2016-06-21 | 2023-10-10 | University Of Oslo | HLA binding vaccine moieties and uses thereof |
WO2018009603A1 (en) | 2016-07-08 | 2018-01-11 | The United State of America, as represented by the Secretary, Department of Health and Human Service | Chimeric west nile/zika viruses and methods of use |
WO2018009604A1 (en) | 2016-07-08 | 2018-01-11 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Chimeric dengue/zika viruses live-attenuated zika virus vaccines |
CA3030427A1 (en) | 2016-07-13 | 2018-01-18 | President And Fellows Of Harvard College | Antigen-presenting cell-mimetic scaffolds and methods for making and using the same |
US11241489B2 (en) | 2016-08-05 | 2022-02-08 | Sanofi Pasteur Inc. | Multivalent pneumococcal polysaccharide-protein conjugate composition |
WO2018027123A1 (en) | 2016-08-05 | 2018-02-08 | Sanofi Pasteur, Inc. | Multivalent pneumococcal polysaccharide-protein conjugate composition |
MX2019002178A (es) | 2016-08-23 | 2019-09-18 | Glaxosmithkline Biologicals Sa | Peptidos de fusion con antigenos enlazados a fragmentos cortos de cadena invariante (cd74). |
US11364304B2 (en) | 2016-08-25 | 2022-06-21 | Northwestern University | Crosslinked micellar spherical nucleic acids |
CA3036218A1 (en) | 2016-09-16 | 2018-03-22 | Infectious Disease Research Institute | Vaccines comprising mycobacterium leprae polypeptides for the prevention, treatment, and diagnosis of leprosy |
EP3518966A1 (en) | 2016-09-29 | 2019-08-07 | GlaxoSmithKline Biologicals S.A. | Compositions and methods of treatment of persistent hpv infection |
WO2018065622A1 (en) * | 2016-10-07 | 2018-04-12 | Secarna Pharmaceuticals Gmbh & Co Kg | Immunosuppression-reverting oligonucleotides inhibiting the expression of cd39 |
US10172933B2 (en) | 2016-10-31 | 2019-01-08 | The United States Of America, As Represented By The Secretary Of Agriculture | Mosaic vaccines for serotype a foot-and-mouth disease virus |
WO2018096396A1 (en) | 2016-11-22 | 2018-05-31 | University Of Oslo | Albumin variants and uses thereof |
GB201620968D0 (en) | 2016-12-09 | 2017-01-25 | Glaxosmithkline Biologicals Sa | Adenovirus polynucleotides and polypeptides |
US11084850B2 (en) | 2016-12-16 | 2021-08-10 | The Pirbright Institute | Recombinant prefusion RSV F proteins and uses thereof |
HRP20220573T1 (hr) | 2017-01-20 | 2022-06-10 | Pfizer Inc. | Imunogeni pripravci, namijenjeni upotrebi u pneumokoknim cjepivima |
US11344629B2 (en) | 2017-03-01 | 2022-05-31 | Charles Jeffrey Brinker | Active targeting of cells by monosized protocells |
WO2018162450A1 (en) | 2017-03-06 | 2018-09-13 | Fundación Para La Investigación Médica Aplicada | New inmunostimulatory compositions comprising an entity of cold inducible rna-binding protein with an antigen for the activation of dendritic cells |
WO2018178265A1 (en) | 2017-03-31 | 2018-10-04 | Glaxosmithkline Intellectual Property Development Limited | Immunogenic composition, use and method of treatment |
JP2020515587A (ja) | 2017-03-31 | 2020-05-28 | グラクソスミスクライン、インテレクチュアル、プロパティー、ディベロップメント、リミテッドGlaxosmithkline Intellectual Property Development Limited | 免疫原性組成物、使用及び処置方法 |
AU2018253918A1 (en) | 2017-04-19 | 2019-10-31 | Institute For Research In Biomedicine | Plasmodium sporozoite npdp peptides as vaccine and target novel malaria vaccines and antibodies binding to |
WO2018201090A1 (en) | 2017-04-28 | 2018-11-01 | Exicure, Inc. | Synthesis of spherical nucleic acids using lipophilic moieties |
CA3066915A1 (en) | 2017-06-11 | 2018-12-20 | Molecular Express, Inc. | Methods and compositions for substance use disorder vaccine formulations and uses thereof |
AU2018285694A1 (en) | 2017-06-15 | 2020-01-16 | Access To Advanced Health Institute | Nanostructured lipid carriers and stable emulsions and uses thereof |
BR112020001255A2 (pt) | 2017-07-21 | 2020-07-28 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | composições imunogênicas de neisseria meningitidis |
JP2020530478A (ja) | 2017-08-14 | 2020-10-22 | グラクソスミスクライン バイオロジカルズ ソシエテ アノニム | 免疫応答を強化する方法 |
US11123415B2 (en) | 2017-08-16 | 2021-09-21 | Ohio State Innovation Foundation | Nanoparticle compositions for Salmonella vaccines |
JP7285828B2 (ja) | 2017-09-05 | 2023-06-02 | トルク セラピューティクス, インコーポレイテッド | 治療用タンパク質組成物ならびにその作製および使用方法 |
US20210069319A1 (en) | 2017-09-07 | 2021-03-11 | University Of Oslo | Vaccine molecules |
US20220118076A1 (en) | 2017-09-07 | 2022-04-21 | University Of Oslo | Vaccine molecules |
AU2018330494A1 (en) | 2017-09-08 | 2020-03-26 | Mina Therapeutics Limited | HNF4a saRNA compositions and methods of use |
CN111315406A (zh) | 2017-09-08 | 2020-06-19 | 传染病研究所 | 包括皂苷的脂质体调配物及其使用方法 |
KR20200117981A (ko) | 2017-11-03 | 2020-10-14 | 다케다 백신즈 인코포레이티드 | 지카 백신 및 면역원성 조성물, 그리고 이를 이용하는 방법들 |
US11235046B2 (en) | 2017-11-04 | 2022-02-01 | Nevada Research & Innovation Corporation | Immunogenic conjugates and methods of use thereof |
BR112020011845A2 (pt) * | 2017-12-15 | 2020-11-24 | Bayer Animal Health Gmbh | composições imunoestimulatórias |
WO2019126197A1 (en) | 2017-12-18 | 2019-06-27 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Bacterial polysaccharide-conjugated carrier proteins and use thereof |
CN111741767A (zh) | 2017-12-19 | 2020-10-02 | 麻省理工学院 | 抗原-佐剂偶联剂和使用方法 |
GB201721576D0 (en) | 2017-12-21 | 2018-02-07 | Glaxosmithkline Biologicals Sa | Hla antigens and glycoconjugates thereof |
GB201721582D0 (en) | 2017-12-21 | 2018-02-07 | Glaxosmithkline Biologicals Sa | S aureus antigens and immunogenic compositions |
CN111629751A (zh) | 2018-01-22 | 2020-09-04 | 美国政府(由卫生和人类服务部的部长所代表) | 广泛保护性灭活流感病毒疫苗 |
CN111836639A (zh) | 2018-01-26 | 2020-10-27 | 河谷细胞有限公司 | 用于联合癌症疫苗和免疫辅助疗法的组合物和方法 |
JP2021513840A (ja) | 2018-02-16 | 2021-06-03 | 2エー ファーマ アーベー | 自己免疫疾患の処置のためのパルボウイルス構造タンパク質 |
EP3527223A1 (en) | 2018-02-16 | 2019-08-21 | 2A Pharma AB | Mutated parvovirus structural protein |
CA3034912A1 (en) | 2018-02-28 | 2019-08-28 | Pfizer Inc. | Il-15 variants and uses thereof |
US11633471B2 (en) | 2018-03-06 | 2023-04-25 | Unm Rainforest Innovations | Compositions and methods for reducing serum triglycerides |
JP7329529B2 (ja) | 2018-03-28 | 2023-08-18 | サノフィ パスツール インコーポレイテッド | ヘマグルチニンを含む広範に防御的なワクチン組成物を生成する方法 |
CN112512565A (zh) | 2018-04-03 | 2021-03-16 | 赛诺菲 | 抗原性流感-铁蛋白多肽 |
EP3773698A1 (en) | 2018-04-03 | 2021-02-17 | Sanofi | Ferritin proteins |
MX2020010199A (es) | 2018-04-03 | 2021-01-08 | Sanofi Sa | Polipeptidos antigenicos del virus sincitial respiratorio. |
CN112584858A (zh) | 2018-04-03 | 2021-03-30 | 赛诺菲 | 抗原性ospa多肽 |
CN112512566A (zh) | 2018-04-03 | 2021-03-16 | 赛诺菲 | 抗原性爱泼斯坦-巴尔病毒多肽 |
SG11202010011RA (en) | 2018-04-17 | 2020-11-27 | Celldex Therapeutics Inc | Anti-cd27 and anti-pd-l1 antibodies and bispecific constructs |
US11434292B2 (en) | 2018-05-23 | 2022-09-06 | Pfizer Inc. | Antibodies specific for CD3 and uses thereof |
MX2020012607A (es) | 2018-05-23 | 2021-01-29 | Pfizer | Anticuerpos especificos para gucy2c y sus usos. |
JP2021526831A (ja) | 2018-06-12 | 2021-10-11 | グラクソスミスクライン バイオロジカルズ ソシエテ アノニム | アデノウイルスポリヌクレオチド及びポリペプチド |
MX2021000548A (es) | 2018-07-19 | 2021-07-02 | Glaxosmithkline Biologicals Sa | Procesos para preparar polisacáridos en seco. |
WO2020030572A1 (en) | 2018-08-07 | 2020-02-13 | Glaxosmithkline Biologicals Sa | Processes and vaccines |
US11260119B2 (en) | 2018-08-24 | 2022-03-01 | Pfizer Inc. | Escherichia coli compositions and methods thereof |
JP7320601B2 (ja) | 2018-09-11 | 2023-08-03 | 上▲海▼市公共▲衛▼生▲臨▼床中心 | 広域スペクトルな抗インフルエンザワクチン免疫原及びその使用 |
KR20210124205A (ko) | 2018-12-04 | 2021-10-14 | 더 락커펠러 유니버시티 | Hiv 백신 면역원 |
WO2020115171A1 (en) | 2018-12-06 | 2020-06-11 | Glaxosmithkline Biologicals Sa | Immunogenic compositions |
US20220054632A1 (en) | 2018-12-12 | 2022-02-24 | Glaxosmithkline Biologicals Sa | Modified carrier proteins for o-linked glycosylation |
EP3894547A1 (en) | 2018-12-12 | 2021-10-20 | The United States of America, as represented by The Secretary, Department of Health and Human Services | Recombinant mumps virus vaccine expressing genotype g fusion and hemagglutinin-neuraminidase proteins |
WO2020121159A1 (en) | 2018-12-12 | 2020-06-18 | Pfizer Inc. | Immunogenic multiple hetero-antigen polysaccharide-protein conjugates and uses thereof |
US20220023410A1 (en) | 2018-12-14 | 2022-01-27 | University Of Georgia Research Foundation, Inc. | Crimean-congo hemorrhagic fever virus replicon particles and use thereof |
US20220184158A1 (en) | 2018-12-21 | 2022-06-16 | Glaxosmithkline Biologicals Sa | Methods of inducing an immune response |
US20220370606A1 (en) | 2018-12-21 | 2022-11-24 | Pfizer Inc. | Combination Treatments Of Cancer Comprising A TLR Agonist |
GB201901608D0 (en) | 2019-02-06 | 2019-03-27 | Vib Vzw | Vaccine adjuvant conjugates |
EP3946446A1 (en) | 2019-04-02 | 2022-02-09 | Sanofi | Antigenic multimeric respiratory syncytial virus polypeptides |
WO2020208502A1 (en) | 2019-04-10 | 2020-10-15 | Pfizer Inc. | Immunogenic compositions comprising conjugated capsular saccharide antigens, kits comprising the same and uses thereof |
WO2020212461A1 (en) | 2019-04-18 | 2020-10-22 | Glaxosmithkline Biologicals Sa | Antigen binding proteins and assays |
KR20220010478A (ko) | 2019-05-20 | 2022-01-25 | 발네바 에스이 | 기도 감염의 치료 또는 예방용 서브유닛 백신 |
US20220249646A1 (en) | 2019-05-25 | 2022-08-11 | Infectious Disease Research Institute | Composition and method for spray drying an adjuvant vaccine emulsion |
US20220233672A1 (en) | 2019-05-31 | 2022-07-28 | Universidad De Chile | An immunogenic formulation that induces protection against shiga toxin-producing escherichia coli (stec) |
EP3770269A1 (en) | 2019-07-23 | 2021-01-27 | GlaxoSmithKline Biologicals S.A. | Quantification of bioconjugate glycosylation |
JP2022543281A (ja) | 2019-08-05 | 2022-10-11 | グラクソスミスクライン バイオロジカルズ ソシエテ アノニム | 免疫原性組成物 |
JP2022545181A (ja) | 2019-08-30 | 2022-10-26 | ユニバーシティ オブ ロチェスター | がん治療のためのセプチン阻害剤 |
EP3799884A1 (en) | 2019-10-01 | 2021-04-07 | GlaxoSmithKline Biologicals S.A. | Immunogenic compositions |
JP2021087420A (ja) | 2019-11-01 | 2021-06-10 | ファイザー・インク | Escherichia coli組成物およびその方法 |
US20220396797A1 (en) | 2019-11-15 | 2022-12-15 | Infectious Disease Research Institute | Rig-i agonist and adjuvant formulation for tumor treatment |
CN114728051A (zh) | 2019-11-22 | 2022-07-08 | 葛兰素史克生物有限公司 | 细菌糖糖缀合物疫苗的剂量和施用 |
BR112022009723A2 (pt) | 2019-12-17 | 2022-08-09 | Pfizer | Anticorpos específicos para cd47, pd-l1, e usos dos mesmos |
BR112022010228A2 (pt) | 2019-12-17 | 2022-09-06 | Us Health | Vacinas de parasita de leishmania viva atenuada com características de segurança aumentadas |
IL295632A (en) | 2020-02-23 | 2022-10-01 | Pfizer | Escherichia coli preparations and their methods |
JP2023515829A (ja) | 2020-02-28 | 2023-04-14 | サノフィ パスツール インコーポレイテッド | 小児対象のための高用量インフルエンザワクチン |
US11213482B1 (en) | 2020-03-05 | 2022-01-04 | University of Pittsburgh—Of the Commonwealth System of Higher Educat | SARS-CoV-2 subunit vaccine and microneedle array delivery system |
CN116323668A (zh) | 2020-07-17 | 2023-06-23 | 辉瑞公司 | 治疗性抗体及其用途 |
JP7407081B2 (ja) | 2020-07-20 | 2023-12-28 | 三菱重工機械システム株式会社 | 印刷機および印刷機の後片付け方法 |
WO2022051022A1 (en) | 2020-09-04 | 2022-03-10 | Infectious Disease Research Institute | Co-lyophilized rna and nanostructured lipid carrier |
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EP4319804A2 (en) | 2021-04-09 | 2024-02-14 | Valneva SE | Human metapneumo virus vaccine |
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WO2023288263A1 (en) | 2021-07-16 | 2023-01-19 | The Board Of Trustees Of The University Of Illinois | Universal vaccine for influenza virus based on tetrameric m2 protein incorporated into nanodiscs |
WO2023018817A1 (en) | 2021-08-11 | 2023-02-16 | Sanofi Pasteur Inc. | Truncated influenza neuraminidase and methods of using the same |
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WO2023081798A1 (en) | 2021-11-05 | 2023-05-11 | Sanofi Pasteur Inc. | Multivalent influenza vaccines comprising recombinant hemagglutinin and neuraminidase and methods of using the same |
WO2023077521A1 (en) | 2021-11-08 | 2023-05-11 | Celldex Therapeutics, Inc | Anti-ilt4 and anti-pd-1 bispecific constructs |
WO2023083964A1 (en) | 2021-11-11 | 2023-05-19 | 2A Pharma Ab | Parvovirus structural protein against beta- and gamma-hpv |
US20230310571A1 (en) | 2021-11-30 | 2023-10-05 | Sanofi Pasteur Inc. | Human metapneumovirus vaccines |
WO2023102388A1 (en) | 2021-11-30 | 2023-06-08 | Sanofi Pasteur Inc. | Human metapneumovirus viral vector-based vaccines |
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WO2023161817A1 (en) | 2022-02-25 | 2023-08-31 | Pfizer Inc. | Methods for incorporating azido groups in bacterial capsular polysaccharides |
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WO2023218322A1 (en) | 2022-05-11 | 2023-11-16 | Pfizer Inc. | Process for producing of vaccine formulations with preservatives |
WO2023232901A1 (en) | 2022-06-01 | 2023-12-07 | Valneva Austria Gmbh | Clostridium difficile vaccine |
WO2024003239A1 (en) | 2022-06-29 | 2024-01-04 | Bavarian Nordic A/S | RECOMBINANT MODIFIED saRNA (VRP) AND VACCINIA VIRUS ANKARA (MVA) PRIME-BOOST REGIMEN |
Family Cites Families (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE2034118A1 (en) † | 1970-07-09 | 1972-01-13 | Seinfeld, Hugo, Brendel, Walter, Prof Dr . 8000 München | Xenogenic nucleic acids for enhancing antigenicity - of peptides and proteins |
US4956296A (en) * | 1987-06-19 | 1990-09-11 | Genex Corporation | Cloned streptococcal genes encoding protein G and their use to construct recombinant microorganisms to produce protein G |
US5059519A (en) | 1986-07-01 | 1991-10-22 | University Of Massachusetts Medical School | Oligonucleotide probes for the determination of the proclivity for development of autoimmune diseases |
CA1339596C (en) | 1987-08-07 | 1997-12-23 | New England Medical Center Hospitals, Inc. | Viral expression inhibitors |
US5786189A (en) * | 1989-11-29 | 1998-07-28 | Smithkline Beecham Biologicals (S.A.) | Vaccine |
US5248670A (en) | 1990-02-26 | 1993-09-28 | Isis Pharmaceuticals, Inc. | Antisense oligonucleotides for inhibiting herpesviruses |
JPH04352724A (ja) * | 1990-07-27 | 1992-12-07 | Mitsui Toatsu Chem Inc | 免疫調節型治療剤 |
EP0468520A3 (en) * | 1990-07-27 | 1992-07-01 | Mitsui Toatsu Chemicals, Inc. | Immunostimulatory remedies containing palindromic dna sequences |
ATE154947T1 (de) | 1990-08-16 | 1997-07-15 | Isis Pharmaceuticals Inc | Oligonukleotide zur modulation der effekte von cytomegalovirusinfektionen |
US5234811A (en) * | 1991-09-27 | 1993-08-10 | The Scripps Research Institute | Assay for a new gaucher disease mutation |
WO1993010138A1 (en) | 1991-11-18 | 1993-05-27 | Tanox Biosystems, Inc. | Anti-sense oligonucleotides for isotype-specific suppression of immunoglobulin production |
ES2095657T3 (es) | 1992-07-24 | 1997-02-16 | Kumiai Chemical Industry Co | Derivado de triazol, procedimiento de obtencion del mismo, un agente de control de plagas y metodo de control de plagas. |
US5585479A (en) * | 1992-07-24 | 1996-12-17 | The United States Of America As Represented By The Secretary Of The Navy | Antisense oligonucleotides directed against human ELAM-I RNA |
DE69316369D1 (en) † | 1992-07-27 | 1998-02-19 | Hybridon Inc | Oligonukleotid alkylphosphonothiate |
WO1994029461A1 (en) | 1993-06-11 | 1994-12-22 | Commonwealth Scientific And Industrial Research Organisation | Method for specific silencing of genes by dna methylation |
WO1995026204A1 (en) | 1994-03-25 | 1995-10-05 | Isis Pharmaceuticals, Inc. | Immune stimulation by phosphorothioate oligonucleotide analogs |
EP1167378B1 (en) * | 1994-07-15 | 2011-05-11 | University of Iowa Research Foundation | Immunomodulatory oligonucleotides |
US5629052A (en) | 1995-02-15 | 1997-05-13 | The Procter & Gamble Company | Method of applying a curable resin to a substrate for use in papermaking |
-
1995
- 1995-02-07 EP EP01202813A patent/EP1167378B1/en not_active Expired - Lifetime
- 1995-02-07 DE DE69535036T patent/DE69535036T3/de not_active Expired - Lifetime
- 1995-02-07 ES ES01202811T patent/ES2320315T5/es not_active Expired - Lifetime
- 1995-02-07 US US08/386,063 patent/US6194388B1/en not_active Expired - Lifetime
- 1995-02-07 EP EP01202811A patent/EP1167377B2/en not_active Expired - Lifetime
- 1995-02-07 DK DK95911630.2T patent/DK0772619T4/da active
- 1995-02-07 AT AT01202813T patent/ATE509102T1/de not_active IP Right Cessation
- 1995-02-07 AT AT01202811T patent/ATE420171T1/de not_active IP Right Cessation
- 1995-02-07 EP EP95911630A patent/EP0772619B2/en not_active Expired - Lifetime
- 1995-02-07 WO PCT/US1995/001570 patent/WO1996002555A1/en active IP Right Grant
- 1995-02-07 CA CA002194761A patent/CA2194761C/en not_active Expired - Lifetime
- 1995-02-07 JP JP50499196A patent/JP3468773B2/ja not_active Expired - Lifetime
- 1995-02-07 EP EP01202814A patent/EP1167379A3/en not_active Ceased
- 1995-02-07 ES ES01202813T patent/ES2366201T3/es not_active Expired - Lifetime
- 1995-02-07 PT PT95911630T patent/PT772619E/pt unknown
- 1995-02-07 AU AU19127/95A patent/AU713040B2/en not_active Expired
- 1995-02-07 DE DE69535905T patent/DE69535905D1/de not_active Expired - Lifetime
- 1995-02-07 CA CA002560114A patent/CA2560114A1/en not_active Abandoned
- 1995-02-07 ES ES95911630T patent/ES2267100T5/es not_active Expired - Lifetime
- 1995-02-07 AT AT95911630T patent/ATE328890T1/de active
-
2002
- 2002-05-13 HK HK02103584.4A patent/HK1043598A1/zh unknown
- 2002-06-26 HK HK02104747.6A patent/HK1044950A1/zh not_active IP Right Cessation
- 2002-06-26 HK HK02104746.7A patent/HK1044949B/zh not_active IP Right Cessation
- 2002-10-16 JP JP2002302338A patent/JP2003144184A/ja not_active Withdrawn
-
2003
- 2003-06-23 JP JP2003178740A patent/JP2004024261A/ja not_active Withdrawn
- 2003-06-23 JP JP2003178741A patent/JP4126252B2/ja not_active Expired - Lifetime
-
2004
- 2004-03-11 JP JP2004069838A patent/JP2004215670A/ja not_active Withdrawn
-
2008
- 2008-01-25 JP JP2008015654A patent/JP2008169216A/ja not_active Withdrawn
-
2009
- 2009-03-10 JP JP2009057160A patent/JP2009148296A/ja not_active Withdrawn
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