JPH09507028A - イエルシニア ペスチス (Yersinia pestis)感染から防御するための生細菌ベクターを含むワクチン組成物 - Google Patents
イエルシニア ペスチス (Yersinia pestis)感染から防御するための生細菌ベクターを含むワクチン組成物Info
- Publication number
- JPH09507028A JPH09507028A JP7517658A JP51765895A JPH09507028A JP H09507028 A JPH09507028 A JP H09507028A JP 7517658 A JP7517658 A JP 7517658A JP 51765895 A JP51765895 A JP 51765895A JP H09507028 A JPH09507028 A JP H09507028A
- Authority
- JP
- Japan
- Prior art keywords
- microorganism
- plasmid
- recombinant dna
- dna
- seq
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
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- 239000013598 vector Substances 0.000 title claims description 13
- 239000000203 mixture Substances 0.000 title abstract description 6
- 206010035148 Plague Diseases 0.000 title description 12
- 230000001580 bacterial effect Effects 0.000 title description 2
- 244000005700 microbiome Species 0.000 claims abstract description 54
- 239000013612 plasmid Substances 0.000 claims abstract description 32
- 108090000623 proteins and genes Proteins 0.000 claims abstract description 30
- 241001465754 Metazoa Species 0.000 claims abstract description 29
- 102000004169 proteins and genes Human genes 0.000 claims abstract description 25
- 210000000936 intestine Anatomy 0.000 claims abstract description 13
- 230000028993 immune response Effects 0.000 claims abstract description 12
- 239000000427 antigen Substances 0.000 claims abstract description 9
- 108091007433 antigens Proteins 0.000 claims abstract description 9
- 102000036639 antigens Human genes 0.000 claims abstract description 9
- 241000293869 Salmonella enterica subsp. enterica serovar Typhimurium Species 0.000 claims abstract description 8
- 230000001131 transforming effect Effects 0.000 claims abstract description 5
- 241001467018 Typhis Species 0.000 claims abstract 2
- 108020004511 Recombinant DNA Proteins 0.000 claims description 30
- 241000607479 Yersinia pestis Species 0.000 claims description 27
- 101150033549 caf1 gene Proteins 0.000 claims description 23
- 101100394265 Schizosaccharomyces pombe (strain 972 / ATCC 24843) hba1 gene Proteins 0.000 claims description 17
- 101150052693 cnot7 gene Proteins 0.000 claims description 17
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- 244000309464 bull Species 0.000 description 2
- AIYUHDOJVYHVIT-UHFFFAOYSA-M caesium chloride Chemical compound [Cl-].[Cs+] AIYUHDOJVYHVIT-UHFFFAOYSA-M 0.000 description 2
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- LOKCTEFSRHRXRJ-UHFFFAOYSA-I dipotassium trisodium dihydrogen phosphate hydrogen phosphate dichloride Chemical compound P(=O)(O)(O)[O-].[K+].P(=O)(O)([O-])[O-].[Na+].[Na+].[Cl-].[K+].[Cl-].[Na+] LOKCTEFSRHRXRJ-UHFFFAOYSA-I 0.000 description 2
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- NHBKXEKEPDILRR-UHFFFAOYSA-N 2,3-bis(butanoylsulfanyl)propyl butanoate Chemical compound CCCC(=O)OCC(SC(=O)CCC)CSC(=O)CCC NHBKXEKEPDILRR-UHFFFAOYSA-N 0.000 description 1
- 108091026890 Coding region Proteins 0.000 description 1
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- 108010006519 Molecular Chaperones Proteins 0.000 description 1
- 241001494479 Pecora Species 0.000 description 1
- 102100037204 Sal-like protein 1 Human genes 0.000 description 1
- 241000607734 Yersinia <bacteria> Species 0.000 description 1
- 208000026935 allergic disease Diseases 0.000 description 1
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- 230000000890 antigenic effect Effects 0.000 description 1
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- RWYFURDDADFSHT-RBBHPAOJSA-N diane Chemical compound OC1=CC=C2[C@H]3CC[C@](C)([C@](CC4)(O)C#C)[C@@H]4[C@@H]3CCC2=C1.C1=C(Cl)C2=CC(=O)[C@@H]3CC3[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@@](C(C)=O)(OC(=O)C)[C@@]1(C)CC2 RWYFURDDADFSHT-RBBHPAOJSA-N 0.000 description 1
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/24—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Enterobacteriaceae (F), e.g. Citrobacter, Serratia, Proteus, Providencia, Morganella, Yersinia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/74—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Biochemistry (AREA)
- Medicinal Chemistry (AREA)
- Zoology (AREA)
- Molecular Biology (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Biophysics (AREA)
- Biomedical Technology (AREA)
- Microbiology (AREA)
- Plant Pathology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Veterinary Medicine (AREA)
- Oncology (AREA)
- General Chemical & Material Sciences (AREA)
- Physics & Mathematics (AREA)
- Communicable Diseases (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB9326425.7 | 1993-12-24 | ||
GB939326425A GB9326425D0 (en) | 1993-12-24 | 1993-12-24 | Vaccine compositions |
PCT/GB1994/002818 WO1995018231A1 (en) | 1993-12-24 | 1994-12-23 | Vaccine compositions comprising live bacterial vectors for protection against yersinia pestis injection |
Publications (1)
Publication Number | Publication Date |
---|---|
JPH09507028A true JPH09507028A (ja) | 1997-07-15 |
Family
ID=10747201
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP7517658A Pending JPH09507028A (ja) | 1993-12-24 | 1994-12-23 | イエルシニア ペスチス (Yersinia pestis)感染から防御するための生細菌ベクターを含むワクチン組成物 |
Country Status (6)
Country | Link |
---|---|
EP (1) | EP0741786A1 (de) |
JP (1) | JPH09507028A (de) |
AU (1) | AU1322295A (de) |
CA (1) | CA2179639A1 (de) |
GB (1) | GB9326425D0 (de) |
WO (1) | WO1995018231A1 (de) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20070043215A1 (en) * | 1996-08-27 | 2007-02-22 | Heath David G | Recombinant f1-v plague vaccine |
WO1998024912A2 (en) * | 1996-12-04 | 1998-06-11 | Heska Corporation | Recombinant plague vaccine |
EP1176966B1 (de) * | 1999-04-12 | 2013-04-03 | THE GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES | Oligodeoxynukleotide und deren verwendung zur induktion einer immunreaktion |
GB9921275D0 (en) * | 1999-09-10 | 1999-11-10 | Secr Defence | Recombinant microorganisms |
ATE378348T1 (de) | 2000-01-14 | 2007-11-15 | Us Health | Oligodeoxynukleotide und ihre verwendung zur induktion einer immunreaktion |
GB0220257D0 (en) | 2002-08-31 | 2002-10-09 | Secr Defence | Vaccine |
US7344718B2 (en) | 2003-01-31 | 2008-03-18 | University Of North Dakota | Yersinia species compositions |
WO2012178078A2 (en) | 2011-06-22 | 2012-12-27 | University Of North Dakota | Use of yscf, truncated yscf and yscf homologs as adjuvants |
EP2852405B1 (de) | 2012-05-23 | 2019-03-13 | The United States of America, as represented by The Secretary, Department of Health and Human Services | Salmonella typhi ty21a zur expression eines yersinia pestis f1-v-fusionsproteins und verwendungen davon |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0474891A1 (de) * | 1990-09-08 | 1992-03-18 | BEHRINGWERKE Aktiengesellschaft | Vektoren für die Expression malarialer Antigene an der Oberfläche von Salmonella Vakzinstämmen |
DK0556333T3 (da) * | 1990-11-09 | 2003-07-14 | Univ Washington | Avirulente Salmonella mikrober, der omfatter en mutation i cdt genet, og anvendelser deraf |
-
1993
- 1993-12-24 GB GB939326425A patent/GB9326425D0/en active Pending
-
1994
- 1994-12-23 CA CA002179639A patent/CA2179639A1/en not_active Abandoned
- 1994-12-23 EP EP95904620A patent/EP0741786A1/de not_active Withdrawn
- 1994-12-23 WO PCT/GB1994/002818 patent/WO1995018231A1/en not_active Application Discontinuation
- 1994-12-23 AU AU13222/95A patent/AU1322295A/en not_active Abandoned
- 1994-12-23 JP JP7517658A patent/JPH09507028A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
AU1322295A (en) | 1995-07-17 |
WO1995018231A1 (en) | 1995-07-06 |
CA2179639A1 (en) | 1995-07-06 |
GB9326425D0 (en) | 1994-02-23 |
EP0741786A1 (de) | 1996-11-13 |
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