JPH0820520A - Skin external preparation with high humectancy - Google Patents
Skin external preparation with high humectancyInfo
- Publication number
- JPH0820520A JPH0820520A JP15438094A JP15438094A JPH0820520A JP H0820520 A JPH0820520 A JP H0820520A JP 15438094 A JP15438094 A JP 15438094A JP 15438094 A JP15438094 A JP 15438094A JP H0820520 A JPH0820520 A JP H0820520A
- Authority
- JP
- Japan
- Prior art keywords
- external preparation
- polyol
- skin external
- skin
- trimethylglycine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Abstract
Description
【０００１】[0001]
【産業上の利用分野】本発明は、トリメチルグリシン
（別名：ベタイン、グリシンベタイン、アルキルジメチ
ルベタイン）とポリオールを併用して成る保湿力の高い
皮膚外用剤に関する。なお、本発明にかかる皮膚外用剤
とは、身体を清潔にし、あるいは皮膚を健全に保つため
に使用するものであり、例えば、化粧水、乳液、クリー
ム、ジェルで代表される。BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a skin external preparation having a high moisturizing effect, which comprises a combination of trimethylglycine (also known as betaine, glycine betaine, alkyldimethyl betaine) and a polyol. The external preparation for skin according to the present invention is used for cleansing the body or keeping the skin healthy, and is represented by, for example, lotion, emulsion, cream and gel.
【０００２】[0002]
【従来の技術】従来、皮膚外用剤に用いられる保湿剤と
しては、尿素、グリセロール、プロピレングリコール、
ソルビット、ポリエチレングリコール、ジプロピレング
リコール、１，３−ブチレングリコール、ジグリセロー
ル、マンニトール、ＰＯＥメチルグリコシド、その他生
体高分子等が用いられてきた。BACKGROUND OF THE INVENTION Conventional moisturizers used for external preparations for skin include urea, glycerol, propylene glycol,
Sorbite, polyethylene glycol, dipropylene glycol, 1,3-butylene glycol, diglycerol, mannitol, POE methyl glycoside, and other biopolymers have been used.
【０００３】[0003]
【発明が解決しようとする課題】しかし、これらの保湿
剤に於いては使用直後の保湿力は充分であるものの、効
果が長く続かないという欠点があり、使用者の満足を得
る物ではなかった。However, although these moisturizers have sufficient moisturizing power immediately after use, they have the drawback that the effect does not last long and are not satisfactory for users. .
【０００４】[0004]
【課題を解決するための手段】前記課題を解決するため
に鋭意検討を行った結果、保湿剤として使用される
（１）式で表されるトリメチルグリシンにポリオールを
併用したものに著しい改善効果がある事を見いだし、こ
の知見に基づいて本発明をなすにいたった。すなわち、
本発明は、式（１）で表されるトリメチルグリシンと、
ポリオールを併用する事を特徴とする保湿力の高い皮膚
外用剤である。[Means for Solving the Problems] As a result of intensive studies to solve the above problems, a remarkable improvement effect is obtained in the case where trimethylglycine represented by the formula (1) used as a moisturizer is combined with a polyol. They found out a certain thing and made the present invention based on this finding. That is,
The present invention comprises trimethylglycine represented by the formula (1),
A skin external preparation with high moisturizing power, characterized by using a polyol together.
【０００５】本発明で言うポリオールとは、グリセロー
ル、ジグリセロール、プロピレングリコール、１，３−
ブチレングリコール、ポリエチレングリコール、ソルビ
トール、マンニトール、ジプロピレングリコール、ジグ
リセロール等を単独叉は混合物の形で用いる事が可能で
あり、望ましくは、グリセロール、ジグリセロール、プ
ロピレングリコール、１，３−ブチレングリコール、ポ
リエチレングリコールを用いる。The polyols referred to in the present invention are glycerol, diglycerol, propylene glycol, 1,3-
Butylene glycol, polyethylene glycol, sorbitol, mannitol, dipropylene glycol, diglycerol and the like can be used alone or in the form of a mixture, preferably glycerol, diglycerol, propylene glycol, 1,3-butylene glycol, Polyethylene glycol is used.
【０００６】なお、本発明の皮膚外用剤は通常用いられ
る方法に従って、製造、充填、流通する事ができる。The external preparation for skin of the present invention can be manufactured, filled and distributed according to a method usually used.
【０００７】[0007]
【実施例】以下、実施例を挙げて本発明を具体的に説明
するが、本発明はこれに依って限定を受けるものではな
い。EXAMPLES The present invention will be specifically described below with reference to examples, but the present invention is not limited thereto.
【０００８】[0008]
【実施例１】トリメチルグリシン１重量部に対し、市販
の親水性軟膏５９重量部とグリセロール４０重量部を加
え、６０℃にて均一になるまで混和し、撹拌しながら固
化せさせて皮膚外用剤１を得た。[Example 1] To 1 part by weight of trimethylglycine, 59 parts by weight of a commercially available hydrophilic ointment and 40 parts by weight of glycerol were added, mixed at 60 ° C until uniform, and solidified with stirring to give a skin external preparation. Got 1.
【０００９】[0009]
【比較例１】水１０重量部に対し、市販の親水性軟膏９
０重量部を加え、６０℃にて均一になるまで混和し、撹
拌しながら固化させて皮膚外用剤２を得た。[Comparative Example 1] Commercially available hydrophilic ointment 9 against 10 parts by weight of water
0 parts by weight was added, and the mixture was mixed at 60 ° C. until uniform and solidified with stirring to obtain a skin external preparation 2.
【００１０】[0010]
【試験例１】実施例１、比較例１に示した皮膚外用剤
１、２および尿素を１０％含有する市販保湿剤製剤を健
康成人ボランティア１５名（平均年齢３２才）の、前腕
屈側（４ｃｍ×４ｃｍ）に外用剤を均一（１平方センチ
メートルあたり１．２５マイクロリットル）に塗布し
た。Test Example 1 A commercially available moisturizing agent formulation containing the external preparations 1 and 2 for skin and 10% urea shown in Example 1 and Comparative Example 1 was applied to the forearm flexion side of 15 healthy adult volunteers (average age 32 years). The external preparation was uniformly applied (1.25 microliters per square centimeter) to 4 cm × 4 cm.
【００１１】塗布前と塗布直後、塗布後２時間の電導度
を測定した。なお、電導度の測定には、ＩＢＳ社製３．
５ＭＨｚ高周波電導度測定装置（電極外径外周４ミリメ
ートル、直径２ミリメートルの中心電極を有する測定用
電極を装着）を用いた。この結果表１に示す様な効果を
得た。The electrical conductivity was measured before coating, immediately after coating, and 2 hours after coating. In addition, for the measurement of the electric conductivity, 3.
A 5 MHz high frequency conductivity measuring device (equipped with a measuring electrode having a center electrode with an outer diameter of the outer circumference of 4 mm and a diameter of 2 mm) was used. As a result, the effects shown in Table 1 were obtained.
【００１２】[0012]
【表１】 [Table 1]
【００１３】何れの皮膚外用剤に於いても塗布直後には
その部位の水分保持性能が良くなり、その結果として角
層水分含有量が上昇する。特に、市販保湿剤製剤は、皮
膚外用剤１および２の３倍近い値を示し、一見最も優れ
た保湿力を有するように思われた。しかし、時間が経過
すると角層水分含有量は低下し、皮膚外用剤２と市販保
湿剤製剤は塗布前と統計的有意性が無くなった。しか
し、皮膚外用剤１は２時間経過後も塗布前と比較して有
意に角層水分量が高かった。更に、２時間経過後の角層
水分含有量を皮膚外用剤１と市販保湿製剤について比較
したところ、皮膚外用剤１の方が有意に高く、皮膚外用
剤１は市販保湿製剤より水分保持能力が優れている事を
見いだした。Immediately after the application of any external preparation for skin, the water-retaining property of the site is improved, and as a result, the water content of the stratum corneum is increased. In particular, the commercially available moisturizer formulation showed a value almost three times that of the skin external preparations 1 and 2, and seemed to have the apparently best moisturizing power. However, over time, the water content of the stratum corneum decreased, and the skin external preparation 2 and the commercial moisturizer formulation lost statistical significance as compared with before application. However, the external preparation for skin 1 had a significantly higher water content in the stratum corneum even after 2 hours compared to before application. Furthermore, when the moisture content of the stratum corneum after 2 hours was compared between the skin external preparation 1 and the commercial moisturizing preparation, the skin external preparation 1 was significantly higher, and the skin external preparation 1 had a higher water retention capacity than the commercial moisturizing preparation. I found it to be excellent.
【００１４】[0014]
【発明の効果】本発明の組成物はグリシンベタインとポ
リオールを併用する事に依って保湿性を長時間にわたっ
て維持する。The composition of the present invention maintains the moisturizing property for a long time by using glycine betaine and a polyol together.
Claims (3)
ンとポリオールを併用する事を特徴とする保湿力の高い
皮膚外用剤。 【化１】 1. A skin external preparation having high moisturizing power, which is characterized by using trimethylglycine represented by the following formula (1) and a polyol together. Embedded image
ル、プロピレングリコール、１，３−ブチレングリコー
ル、ポリエチレングリコールである事を特徴とする請求
項１の保湿力の高い皮膚外用剤。2. The external moisturizing skin preparation according to claim 1, wherein the polyol is glycerol, diglycerol, propylene glycol, 1,3-butylene glycol, or polyethylene glycol.
１０重量部、望ましくは０．１〜３重量部であり、ポリ
オールの含有量が０．０１〜６０重量部、望ましくは５
〜４０重量部である事を特徴とする請求項１の保湿力の
高い皮膚外用剤。3. The content of trimethylglycine is 0.01-.
10 parts by weight, preferably 0.1 to 3 parts by weight, and the content of polyol is 0.01 to 60 parts by weight, preferably 5
The external preparation for skin having high moisturizing power according to claim 1, wherein the external preparation is about 40 parts by weight.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP15438094A JPH0820520A (en) | 1994-07-06 | 1994-07-06 | Skin external preparation with high humectancy |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP15438094A JPH0820520A (en) | 1994-07-06 | 1994-07-06 | Skin external preparation with high humectancy |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JPH0820520A true JPH0820520A (en) | 1996-01-23 |
Family
ID=15582886
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP15438094A Pending JPH0820520A (en) | 1994-07-06 | 1994-07-06 | Skin external preparation with high humectancy |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPH0820520A (en) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6156293A (en) * | 1997-01-03 | 2000-12-05 | Finnfedds Finland Ltd. | Moistening preparation |
| US6436385B2 (en) | 1996-09-26 | 2002-08-20 | Cultor Corporation | Preparation protecting skin from mechanical irritation |
| JP2006143636A (en) * | 2004-11-18 | 2006-06-08 | Asahi Kasei Chemicals Corp | Makeup foundation |
| JP2011093835A (en) * | 2009-10-29 | 2011-05-12 | Noevir Co Ltd | Skin care preparation |
-
1994
- 1994-07-06 JP JP15438094A patent/JPH0820520A/en active Pending
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6436385B2 (en) | 1996-09-26 | 2002-08-20 | Cultor Corporation | Preparation protecting skin from mechanical irritation |
| US6156293A (en) * | 1997-01-03 | 2000-12-05 | Finnfedds Finland Ltd. | Moistening preparation |
| JP2006143636A (en) * | 2004-11-18 | 2006-06-08 | Asahi Kasei Chemicals Corp | Makeup foundation |
| JP2011093835A (en) * | 2009-10-29 | 2011-05-12 | Noevir Co Ltd | Skin care preparation |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| A02 | Decision of refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A02 Effective date: 20001003 |