JPH0772430A - Contact lens - Google Patents

Abstract

PURPOSE:To obtain a contact lens having excellent anti-contamination property against protein or the like, good wettability and excellent fitting property for eyes by performing graft polymn. of a monomer component containing vinyl monomers having a specified phosphatide-like structure to the surface of the base material of the contact lens. CONSTITUTION:The vinyl momomer having a specified phosphatide-like structure is a vinyl monomer A expressed by formula. When carbon numbers of R1, R2, R3 in the formula are >=9, production of the lens is difficult. The vinyl monomer A is, for example, 2-(methacryloyloxy)ethyl-2'-(trimethylammonio) ethylphosphate or 2-(acryloyoxy)ethyl-2'-(trimethylammonio)ethylphosphate. The vinyl monomer A can be synthesized. This contact lens is obtd. by graft polymn. of the monomer component containing the vinyl momomer A to the surface of the contact lens base material.

Description

Detailed Description of the Invention

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a contact lens, and more particularly to a contact lens surface-modified by graft-polymerizing a vinyl monomer having a specific phospholipid-like structure.

[0002]

2. Description of the Related Art Conventionally used contact lenses include a hard contact lens made of a polymer having methyl methacrylate as a main component and a soft contact lens having a hydrophilic monomer having a 2-hydroxyethyl methacrylate monomer as a main component. There are contact lenses etc.

Since the hard contact lens is non-hydrated, it has an advantage in contact lens hygiene, but it is necessary for good eye metabolism and continuous wear. The oxygen permeability is insufficient.

In order to solve these problems, Japanese Patent Publication No. 58-4327 and Japanese Patent Publication No. 60-25766 disclose a material which is relatively safe to the living body and has high oxygen permeability. It has been proposed to use silicone-based polymers such as polysiloxanes and silicon-containing methacrylate polymers. However, since the silicone-based polymer is highly hydrophobic, it has a drawback that it feels like a foreign substance when worn on the eyes, and that proteins and lipids in the tear fluid adhere to the silicone polymer and are easily soiled. Such adhered matter may cause the lens to cloud and cause poor vision, or the adhered matter may act as a protrusion on the surface to cause damage due to friction with eye tissues such as cornea and conjunctiva,
It causes a decrease in oxygen permeability. To remove such deposits, for example, a surfactant such as a cleaning liquid may be added to
A common method is to drop 3 drops and scrub with a finger. However, it is difficult to completely remove the deposits by rubbing with a hand, and there is a risk that the hard contact lens may be damaged by the force of the finger.

In order to solve these problems, JP-A-5-19213 proposes a method of hydrophilizing the contact lens surface by plasma treatment or the like, and a method of grafting a hydrophilic monomer. Not enough performance has been obtained yet. Further, Japanese Patent Publication No. 3-14838 proposes a contact lens having a phospholipid-like structure on the lens surface, but the compound having the phospholipid-like structure has problems that it is difficult to produce and poor in stability. is there.

On the other hand, in the case of soft contact lenses,
Since it has water content, it is excellent in wearability, but it has a problem in hygiene, so it is necessary to care for the lens by boiling disinfection, hydrogen peroxide disinfection, etc.

[0007]

SUMMARY OF THE INVENTION An object of the present invention is to provide a contact lens which has an excellent anti-staining property against proteins and the like and which can be removed by washing with light water even if protein stains are attached. To provide.

Another object of the present invention is to provide a contact lens which has good wettability and is excellent in wearing feeling.

[0009]

According to the present invention, a monomer component containing a vinyl monomer having a phospholipid-like structure represented by the following general formula 2 (hereinafter referred to as vinyl monomer A) is added to the surface of a contact lens substrate. Provided is a contact lens characterized by being graft-polymerized with.

[0010]

[Chemical 2]

The present invention will be described in more detail below.

The vinyl monomer having a specific phospholipid-like structure used in the present invention is the vinyl monomer A represented by the general formula 2. In the formula, when R ₁ , R ₂ , and R ₃ have 9 or more carbon atoms, the production is difficult.

As the vinyl monomer A, for example, 2
-(Methacryloyloxy) ethyl-2 '-(trimethylammonio) ethyl phosphate, 2- (acryloyloxy) ethyl-2'-(trimethylammonio) ethyl phosphate, 2- (methacryloyloxy) ethyl-2 '-(triethyl Ammonio) ethyl phosphate, 2- (acryloyloxy) ethyl-2 '-(triethylammonio) ethyl phosphate, 2- (methacryloyloxy) ethyl-2'-(triethanolammonio) ethyl phosphate, 2- (acryloyloxy) ) Ethyl-2 '-(triethanolammonio) ethyl phosphate, 2- (methacryloyloxy) isopropyl-2'-(trimethylammonio) ethyl phosphate, 2- (acryloyloxy) isopropyl-
2 '-(trimethylammonio) ethyl phosphate,
4- (methacryloyloxy) butyl-2 '-(trimethylammonio) ethyl phosphate, 4- (acryloyloxy) butyl-2'-(trimethylammonio)
Ethyl phosphate, 6- (methacryloyloxy) hexyl-2 '-(trimethylammonio) ethyl phosphate, 6- (acryloyloxy) hexyl-2'-
(Trimethylammonio) ethyl phosphate, 9-
(Methacryloyloxy) nonyl-2 '-(trimethylammonio) ethyl phosphate, 9- (acryloyloxy) nonyl-2'-(trimethylammonio) ethyl phosphate, 2- (vinyloxy) ethyl-2'-
(Trimethylammonio) ethyl phosphate, 2-
(Allyloxy) ethyl-2 '-(trimethylammonio) ethyl phosphate, 2- (p-vinylbenzyloxy) ethyl-2'-(trimethylammonio) ethyl phosphate, 2- (p-vinylbenzoyloxy) ethyl-2 '-(Trimethylammonio) ethyl phosphate, 2- (styryloxy) ethyl-2'-(trimethylammonio) ethyl phosphate, 2- (acryloylamino) ethyl-2 '-(trimethylammonio)
Ethyl phosphate, 2- (ethoxyfumaroyloxy) ethyl-2 '-(trimethylammonio) ethyl phosphate, 2- (isopropoxyfumaroyloxy)
Ethyl-2 '-(trimethylammonio) ethyl phosphate, 2- (t-butoxyfumaroyloxy) ethyl-2'-(trimethylammonio) ethyl phosphate, 2- (cyclohexyloxyfumaroyloxy) ethyl-2'- (Trimethylammonio) ethyl phosphate, 2- (ethoxyfumaroyloxy) ethyl-2 '
-(Triethanolammonio) ethyl phosphate,
2- (Ethoxymaleoyloxy) ethyl-2 '-(trimethylammonio) ethyl phosphate, 2- (isopropoxymaleoyloxy) ethyl-2'-(trimethylammonio) ethyl phosphate, 2- (t-butoxymale) Oiloxy) ethyl-2 '-(trimethylammonio) ethyl phosphate, 2- (cyclohexyloxymaleoyloxy) ethyl-2'-(trimethylammonio) ethyl phosphate, 2- (ethoxymaleoyloxy) ethyl-2 ' -(Triethanolammonio) ethyl phosphate, 2-α-methoxyitaconoyloxy) ethyl-2 '-(trimethylammonio)
Ethyl phosphate, 2- (β-methoxyitaconoyloxy) ethyl-2 ′-(trimethylammonyl) ethyl phosphate, 2- (α-ethoxyitaconoyloxy) ethyl-2 ′-(trimethylammonio) ethyl phosphate, 2 -(Β-Ethoxyitaconoyloxy)
Ethyl-2 ′-(trimethylammonio) ethyl phosphate, 2- (α-propoxyitaconoyloxy) ethyl-2 ′-(trimethylammonio) ethyl phosphate, 2- (β-propoxyitaconoyloxy) ethyl-2 ′ -(Trimethylammonio) ethyl phosphate, 2- (α- (2-hydroxyethyloxy) itaconoyloxy) ethyl-2 '-(trimethylammonio) ethyl phosphate, 2- (β- (2-hydroxyethyloxy)) Itaconoyloxy) ethyl-2'-
(Trimethylammonio) ethyl phosphate, 3-
(Α-Methoxyitaconoyloxy) propyl-2′-
(Trimethylammonio) ethyl phosphate, 3-
(Β-Methoxyitaconoyloxy) propyl-2′-
(Trimethylammonio) ethyl phosphate, 4-
(Α-Methoxyitaconoyloxy) butyl-2′-
(Trimethylammonio) ethyl phosphate, 4-
(Β-Methoxyitaconoyloxy) butyl-2′-
(Trimethylammonio) ethyl phosphate, 5-
(Α-Methoxyitaconoyloxy) -3-oxapentyl-2 ′-(trimethylammonio) ethyl phosphate, 5- (β-methoxyitaconoyloxy) -3-
Oxapentyl-2 ′-(trimethylammonio) ethyl phosphate, 5- (α-methoxyitaconoyloxy) -3-oxa-2,5-dimethylpentyl-2′-
(Trimethylammonio) ethyl phosphate, 5-
(Β-Methoxyitaconoyloxy) -3-oxa-
2,5-Dimethylpentyl-2 '-(trimethylammonio) ethyl phosphate, 8- (α-methoxyitaconoyloxy) -3,6-dioxaoctyl-2'-
(Trimethylammonio) ethyl phosphate, 8-
(Β-methoxyitaconoyloxy) -3,6-dioxaoctyl-2 ′-(trimethylammonio) ethyl phosphate and the like can be mentioned.

The vinyl monomer A can be synthesized by a known method or the like. For example, in the case of synthesizing 2- (methacryloyloxy) ethyl-2 ′-(trimethylammonio) ethyl phosphate, hydroxyethyl methacrylate and 2-chloro-2-oxo-1,3,2-dioxaphosphorane are used. Is reacted in the presence of an amine to give (2-oxo-1,3,2
-Dioxaphosphoryloxy) ethylmethacrylate, then a method of reacting trimethylamine, or by reacting hydroxyethylmethacrylate and 2-bromoethylphosphoryldichloride to obtain (meth) acryloyloxyethyl-2-bromoethylphosphate, Then, it can be synthesized by a method of reacting trimethylamine or the like. Further, 2- (ethoxyfumaroyloxy) ethyl-2 '-(trimethylammonio) ethyl phosphate can be synthesized by, for example, ethyl-hydroxyethyl fumarate and 2-chloro-2-oxo-
1,3,2-dioxaphosphorane is reacted in the presence of amine to give ethyl-2 '-(2-oxo-1,3,2-dioxaphosphoroyloxy) ethyl fumarate, then trimethylamine It can be synthesized by a reaction method or the like. Each synthesized compound is preferably purified by a known method such as recrystallization before being subjected to the graft polymerization described later.

The vinyl monomer A used in the present invention is
In addition to the contact lens substrate, for example, polyethylene film, polypropylene, polyvinyl chloride, polyvinylidene chloride, polyvinylidene fluoride acetate, polyester, polyvinyl alcohol, polystyrene, even if the same graft polymerization is performed on the polycarbonate, the same surface modification The effect can be obtained, and it can be applied to medical products such as various packaging materials, agricultural water retention materials, blood circuits, intraocular lenses, and artificial organs.

The contact lens of the present invention can be obtained by graft-polymerizing the monomer component containing the vinyl monomer A on the surface of the contact lens substrate.

As the monomer component other than the vinyl monomer A, a monofunctional vinyl monomer copolymerizable with the vinyl monomer A, a crosslinkable polyfunctional monomer or the like can be used.

Examples of the monofunctional vinyl monomer include styrene, methylstyrene, methyl nucleus-substituted styrene, chloro nucleus-substituted styrene, methyl (meth) acrylate, ethyl (meth) acrylate, n-butyl (meth).
Acrylate, (meth) acrylic acid, (meth) acrylamide, N, N-dimethyl (meth) acrylamide, 2
-Hydroxyethyl (meth) acrylate, N-vinylpyrrolidone, vinylpyridine, vinyl acetate, vinyl propionate, vinyl pivalate, methyl vinyl ether,
Examples thereof include ethyl vinyl ether, n-butyl vinyl ether, diethyl itaconate and di-n-butyl itaconate.

Examples of the crosslinkable polyfunctional monomer include allyl (meth) acrylate, ethylene glycol di (meth) acrylate, diethylene glycol di (meth) acrylate, triethylene glycol (meth) acrylate, tetraethylene glycol di (meth). ) Acrylate, neopentyl glycol di (meth)
Acrylate, 1,4-butanediol di (meth) acrylate, divinylbenzene, diallyl phthalate, diethylene glycol bisallyl carbonate, N, N '
-Methylenebisacrylamide, triallyl trimellitate, triallyl cyanurate, divinyl adipate and the like can be mentioned.

When such other copolymerizable monomer component is used, as the polymerization initiator, for example, 2,
2'-azobis (2,4-isobutyronitrile), azobiscyclohexanecarbonitrile, benzoyl peroxide, methyl ethyl ketone peroxide, t-butyl hydroperoxide, t-butyl peroxide, t
-Butyl peroxypivalate, dicumyl peroxide, diisopropyl peroxy dicarbonate and the like can also be used.

When the other copolymerizable monomer component is used, the charging ratio of the vinyl mono-A and the other monomer component is 1000 parts by weight or less of the other monomer component with respect to 100 parts by weight of the vinyl monomer A. , Especially 500
˜0 parts by weight is preferred.

In the contact lens of the present invention, the monomer component containing the vinyl monomer A is graft-polymerized on the surface of the contact lens substrate, for example, a method of polymerizing using active radiation such as ultraviolet rays, plasma or γ rays; A method of introducing a peroxide bond into a contact lens substrate to polymerize it by ozone treatment; a peracid bond,
A method of blending a monomer having an azo bond, a mercapto group and the like into a contact lens substrate and polymerizing it; a method of polymerizing using a cerium salt; a method of polymerizing using a persulfate salt and a lithium halide system; an alkylboron system The method of polymerizing using, etc. can be preferably mentioned,
Specifically, (1) under an argon stream of 0.1 to 0.01 Torr, after subjecting the contact lens substrate to glow discharge treatment, air is introduced and deaerated, and then in a constant temperature bath at 50 to 100 ° C. Monomer solution containing vinyl monomer A and 0.5-2
(2) As in the case of the glow discharge treatment, the contact lens substrate is irradiated with ultraviolet rays using a high-pressure mercury lamp in the air, and then degassed for 5 hours.
A method of graft polymerization by a method of reacting with a monomer solution containing vinyl monomer A for 0.5 to 20 hours in a constant temperature bath of 0 to 100 ° C., (3) a sensitizer such as benzophenone, anthraquinone and benzoyl peroxide A method of graft-polymerizing a contact lens base material in a monomer solution containing vinyl monomer A blended with, and irradiating with a high-pressure mercury lamp under degassing. (4) On the other hand, a contact lens group containing a hydroxyl group In the case of materials, a method of graft polymerization using a cerium salt, specifically, a monomer solution (pH of cerium (IV) ammonium nitrate)
(1 or less), and a method of graft polymerization under degassing or argon atmosphere (in this case,
The cerium ion in the monomer solution attacks the carbon atom bonded to the hydroxyl group in the contact lens substrate, so that a radical is generated on the carbon atom or oxygen atom to initiate graft polymerization).

In the present invention, the graft ratio of the monomer component containing the vinyl monomer A onto the surface of the contact lens substrate cannot be determined because the amount of the component graft-polymerized is very small, but the contact angle with water is lowered. It can be seen that the surface was grafted. In addition, it can be confirmed by a photoelectron spectrometer (XPS) that phosphorus atoms and nitrogen atoms are present on the surface.

In the present invention, the contact lens base material is not particularly limited to hard contact lenses, semi-hard contact lenses, soft contact lenses, silicone rubber lenses and the like. A contact lens obtained by a known method or the like can be used as it is as the contact lens substrate of the present invention. Preferably, for example, as the component constituting the hard contact lens substrate, an alkyl ester such as methyl methacrylate, ethyl methacrylate, t-butyl methacrylate, dimethyl itaconate, di-t-butyl fumarate; γ-methacryloyloxypropyl- Silicone-containing methacrylic acid esters such as tris (trimethylsiloxy) silane; pentamethyl-3,3-bis (trimethylsiloxy) trisiloxanylstyrene, hexamethyl-
Silicone-containing styrene derivatives such as 3,3-bis (trimethylsiloxy) trisiloxanyl styrene; t-butoxycarbonyl fumaroyloxypropyl-tris (trimethylsiloxy) silane, isopropoxycarbonyl fumaroyloxypropyl-tris (trimethylsiloxy) Silicone-containing fumaric acid ester such as silane, isoamyloxycarbonyl fumaroyloxypropyl-tris (trimethylsiloxy) silane; trifluoroethyl methacrylate, hexafluoroisopropyl methacrylate, α-isopropyl-β-hexafluoroisopropyl itaconate, isopropyl hexafluoroisopropyl Fluoroalkyl ester such as fumarate;
Preferred examples include cross-linking agents such as ethylene glycol dimethacrylate and triethyl glycol dimethacrylate; and polymers obtained by polymerizing hydrophilicity-imparting monomers such as 2-hydroxyethyl methacrylate, N-vinylpyrrolidone and methacrylic acid. Further, as a component constituting the soft contact lens base material, hydrophilicity such as 2-hydroxyethylmethacrylate, N-vinylpyrrolidone, methacrylic acid, acrylamide, 2- (methacryloyloxy) ethyl-2 '-(trimethylammonio) ethylphosphoric acid, etc. Monomers; ethylene glycol dimethacrylate, triethylene glycol dimethacrylate,
Preferable examples include cross-linking agents such as methylenebisacrylamide; polymers obtained by polymerizing methacrylic acid alkyl esters such as methyl methacrylate, ethyl methacrylate and n-butyl methacrylate.

[0025]

EFFECTS OF THE INVENTION The contact lens of the present invention is graft-polymerized with a vinyl monomer having a specific phospholipid-like structure on the surface, so that the lens surface becomes hydrophilic,
It has good wettability, is excellent in wearing feeling, is excellent in anti-staining property against proteins and the like, and even if proteins are attached, it can be removed by lightly washing with water.

[0026]

EXAMPLES The present invention will be described in more detail with reference to Examples and Comparative Examples, but the present invention is not limited thereto.

[0027]

Examples 1 to 3 γ-methacryloyloxypropyl-
50 g of tris (trimethylsiloxy) silane, 2,
20 g of 2,2-trifluoroethyl methacrylate,
25 g of methyl methacrylate and 4.75 g of ethylene glycol dimethacrylate were added with 2, 2 as a polymerization initiator.
2'-azobis (2,4-isobutyronitrile) 0.2
5 g was added and copolymerized under conditions of 70 ° C. for 10 hours to obtain a hard contact lens substrate I.

2- (methacryloyloxy) ethyl-
2 '-(Trimethylammonio) ethyl phosphate 1
0 g and 2.5 g of triethylene glycol dimethacrylate as a cross-linking agent were dissolved in water to 100 ml to prepare a graft monomer aqueous solution, and the resulting hard contact lens substrate I was subjected to the following grafting methods A to C. Graft polymerization treatment was carried out to obtain a contact lens.

Grafting method A: The lens substrate was placed in a discharge device (6 cm between electrodes, voltage between electrodes 270 V, frequency 60 Hz), and glow discharge treatment was performed for 5 seconds in an argon atmosphere of 0.04 torr. did. After exposing the lens base material subjected to the discharge treatment to the air, the lens base material was put into a test tube, an aqueous graft monomer solution was added thereto, and the atmosphere was replaced with argon gas, and then the tube was vacuum-sealed. Place the test tube in an 80 ° C constant temperature bath.
It was placed for 0 minutes, and the graft monomer was graft-polymerized on the surface of the lens substrate.

Grafting method B: A lens substrate was placed 5 cm below a light source of a 500 W mercury lamp, and ultraviolet rays were irradiated in the air. The lens substrate irradiated with ultraviolet rays was placed in a test tube, an aqueous graft monomer solution was added, and the atmosphere was replaced with argon gas, and then the tube was vacuum-sealed. The test tube was placed in a thermostat at 80 ° C. for 60 minutes to graft polymerize the graft monomer on the surface of the lens substrate.

Grafting method C: The lens substrate was treated in the ozone stream obtained by the ozone generator. After the ozone adsorbed on the lens substrate was removed under reduced pressure, the lens substrate was placed in a test tube, an aqueous graft monomer solution was added, and the atmosphere was replaced with argon gas, and then the tube was sealed under reduced pressure. Test tube at 60 ℃
The sample was placed in the constant temperature bath for 60 minutes, and the graft monomer was graft-polymerized on the surface of the lens substrate.

Next, the contact angle of the obtained contact lens and the amount of adsorbed protein were measured. The contact angle is measured by a contact angle measuring device using a droplet method (Kyowa Interface Science Co., Ltd., trade name “CA-
A ”), and the protein adsorption amount was measured using a contact lens after polymerization treatment with 6 mg of bovine serum albumin.
/ Ml phosphate buffer salt solution (hereinafter referred to as PBS) at 37 ° C for 3 hours to adsorb proteins and
After lightly rinsing in the tube, put the lens in a test tube and wash with 0.5% sodium dodecylbenzenesulfonate aqueous solution to peel off the albumin adsorbed on the surface of the base material, and then remove the albumin in the test tube solution. Product name "Micro BC
A kit ”(manufactured by PIRCE). The measurement results are shown in Table 1.

[0033]

Comparative Example 1 The contact angle and protein adsorption amount of the untreated contact lens substrate I were measured in the same manner as in Example 1. The measurement results are shown in Table 1.

[0034]

Examples 4 to 9 and Comparative Examples 2 and 3 A contact lens was prepared in the same manner as in Example 1 except that the grafting monomer and the grafting method shown in Table 1 were used, and the contact angle and the protein adsorption amount were measured. The measurement results are shown in Table 1.

[0035]

[Table 1]

[0036]

Example 10 20 g of 2,2,2-trifluoromethyl methacrylate and 0.5 g of t-butylperoxyethyl methacrylate were further added to the components used in the hard contact lens substrate I, and the mixture was polymerized at 60 ° C. for 20 hours. Other than the above, copolymerization was performed in the same manner as the hard contact lens substrate I to obtain a hard contact lens substrate II.

Obtained Hard Contact Lens Substrate II
A contact lens was prepared in the same manner as in Example 1 except that the above was subjected to a graft polymerization treatment by the following grafting method D, and the contact angle and the protein adsorption amount were measured. The measurement results are shown in Table 2.

Grafting method D: Substrate II was added to the grafting monomer aqueous solution contained in a test tube and replaced with argon gas, and then the tube was vacuum sealed. The test tube was placed in a thermostat at 80 ° C. for 2 hours to graft-polymerize the graft monomer on the surface of the lens substrate.

[0039]

Comparative Example 4 The contact angle and the protein adsorption amount of the untreated hard contact lens substrate II were measured in the same manner as in Example 10. The measurement results are shown in Table 2.

[0040]

Examples 11 to 13 and Comparative Example 5 The contact angle and the protein adsorption amount were measured in the same manner as in Example 10 except that the grafting monomer shown in Table 2 was used as the grafting monomer. The measurement results are shown in Table 2.

[0041]

[Table 2]

[0042]

Example 14 2-Hydroxyethyl methacrylate 9
5 g and diethylene glycol dimethacrylate 4.7
5 g, 2,2'-azobis (2,2 'as a polymerization initiator
4-isobutyronitrile) and 0.25 g are added, and 70
Water-containing soft contact lens substrate III was obtained by copolymerization at 10 ° C. for 10 hours.

A contact lens was prepared in the same manner as in Example 1 except that the obtained hydrous soft contact lens substrate III was subjected to a graft polymerization treatment by the following grafting method E, and the amount of adsorbed protein was measured. Table 3 shows the measurement results
Shown in.

Grafting method E: The lens substrate III was added to a test tube containing a graft monomer aqueous solution containing selenium ammonium nitrate, the atmosphere was replaced with argon gas, and the tube was vacuum-sealed. The test tube was placed in a constant temperature bath at 40 ° C. for 1 hour to graft-polymerize the graft monomer on the surface of the lens substrate.

[0045]

Comparative Example 6 The protein adsorption amount of the untreated substrate III was measured in the same manner as in Example 14. The measurement results are shown in Table 3.

[0046]

Examples 15 to 17 and Comparative Example 7 A contact lens was prepared in the same manner as in Example 14 except that the graft monomer shown in Table 3 was used as the graft monomer, and the protein adsorption amount was measured. The measurement results are shown in Table 3.

[0047]

[Table 3]

 ─────────────────────────────────────────────────── ─── Continuation of front page (72) Nobuo Nakabayashi 5-6-20 Koganehara, Matsudo-shi, Chiba Prefecture (72) Kazuhiko Ishihara 6-5-9-201 Kamimizumoto-cho, Kodaira-shi, Tokyo

Claims (1)

[Claims] 1. A monomer component containing a vinyl monomer having a phospholipid-like structure represented by the following general formula 1,
A contact lens characterized by being graft-polymerized on the surface of a contact lens substrate. [Chemical 1]