JPH0690992A - Method for displaying 'radiation exposed' of blood preserving bag for transfusion and blood preserving bag for transfusion with 'radiaiton exposed' display - Google Patents

Abstract

PURPOSE:To prevent the wrong use of an unexposed or overexposed blood preserving bag for transfusion as the bag exposed to a correct dose by making it possible to visually and easily discriminate whether or not the blood preserv ing bag for transfusion (blood for transfusion) is radiation exposed or unexposed or if the exposure is within a prescribed adequate range. CONSTITUTION:The blood preserving bag for transfusion is constituted by integrally mounting a radiation exposure display body 13 having a radiation sensitive material (radiation photosensitive material) 14 which generates a color change by radiation exposure and color samples 16a, 16b corresponding to the max. value and min. value of exposure doses to a bag body 11. The 'radiation exposed' display and a check as to whether the exposure dose is within the prescribed adequate range are executed by comparing the color change of the radiation sensitive material 14 with the color samples.

Description

Detailed Description of the Invention

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a method for indicating the irradiation of a blood storage bag for blood transfusion that has been irradiated and the blood storage bag for blood transfusion that has not been irradiated, and a method for indicating irradiation. The present invention relates to a blood storage bag for blood transfusion with a display.

[0002]

2. Description of the Related Art In recent years, GVHD (Graft Versu
s Host Disease: Graft-versus-host disease) is a problem. For this prevention, an appropriate dose of X-rays should be applied to the blood before transfusion.
It is said that it is effective to irradiate radiations such as γ-rays and electron beams, for example, X-rays of 15 to 50 gray (1,500 to 5,000 rad), and it is becoming popular now. By the way, such irradiation of blood is usually performed in a state where the blood is put in a storage bag (blood storage bag for blood transfusion), but a blood storage bag for blood transfusion before irradiation and a blood transfusion after irradiation are used. There is no change in appearance with the blood storage bag for blood transfusion, and there is a risk that the blood storage bag for transfusion before irradiation may be mistakenly used as the blood storage bag for blood transfusion after irradiation.

[0003]

As described above, in the conventional blood transfusion bag for blood transfusion, no apparent change is observed between before and after irradiation of the blood. There is a possibility that it may be used as a blood storage bag for transfusion after irradiation, and there is a problem that the safety against GVHD is low.

On the other hand, the applicant can easily distinguish between the blood storage bag for blood transfusion that has been irradiated and the blood storage bag for blood transfusion that has not been irradiated, and after accidentally irradiating the blood storage bag for blood transfusion before irradiation. Patent application for an invention relating to a method for indicating the irradiation completion of a blood transfusion bag for transfusion and a blood storage bag for transfusion with radiation irradiation, which can prevent the blood storage bag from being used as a blood transfusion bag for blood transfusion and enhance the safety against GVHD Flat 4
Filed under −121754. In this patent application, by irradiating radiation to a blood storage bag body for blood transfusion, which is integrally attached with a radiation irradiation indicator provided with a radiation-sensitive substance (radiosensitive substance) that changes color upon irradiation, A technique has been disclosed in which a radiation-sensitive substance is caused to undergo a color change to perform a radiation-irradiated display.

However, with this technique described above, it is confirmed that the radiation dose applied to the blood transfusion bag for transfusion is the lower limit value of the required irradiation dose, for example, 15 gray or more, but the upper limit value of the required irradiation dose, For example, it cannot be confirmed that it is less than 50 gray. It is also important to confirm that the upper limit of the required irradiation dose is not exceeded, because blood is likely to be damaged by radiation when the irradiation dose to blood is too high. The present invention provides means for confirming and displaying that the radiation dose applied to the blood transfusion bag for transfusion is between the upper limit value and the lower limit value of the required irradiation dose.

[0006]

In order to achieve the above-mentioned object, the present invention provides a blood transfusion in which a radiation irradiation indicator comprising at least a radiation sensitive substance which changes color upon irradiation with radiation is integrally attached. In the method for indicating the irradiation completion of a blood storage bag for blood transfusion for causing the radiation-sensitive substance to change color by irradiating the main body of a blood-containing bag with radiation, the blood transfusion for the radiation irradiation display body is performed. It is provided with means for identifying that the irradiation dose to the bag body containing the blood for use is between a predetermined maximum value and a minimum value (Claim 1).

Further, in the blood storage bag for blood transfusion with a radiation irradiation completed display, which is integrally attached to the bag body, a radiation irradiation display body comprising at least a radiation sensitive substance which changes color upon irradiation with radiation. The irradiation indicator is provided with means for identifying that the irradiation dose to the bag body containing the blood for transfusion is between a predetermined maximum value and a predetermined minimum value (claim 2).

[0008]

[Function] When the bag body containing blood for transfusion is irradiated with radiation,
Radiation is inevitably applied to the radiation irradiation indicator integrally attached to the body of the blood transfusion bag. For this reason, radiation is inevitably applied to the radiation-sensitive display body provided in the radiation irradiation display body. Therefore, a color change occurs in the radiation-sensitive substance provided on the radiation irradiation display, and it is displayed that the blood transfusion bag for blood transfusion (blood for transfusion) has been irradiated.

Here, in the case of the present invention, the irradiation dose to the main body of the blood transfusion bag on the radiation irradiation indicator is between a predetermined maximum value (for example, 50 Gy) and a minimum value (for example, 15 Gy). Since the means for identifying is provided, it is possible to visually check whether the blood transfusion bag for blood transfusion has been irradiated or not, and at the same time, it is possible to easily determine whether or not the irradiation dose is within an appropriate range.

As a result, it is possible to prevent the blood storage bag for blood transfusion before irradiation from being mistakenly used as the blood storage bag for blood transfusion after irradiation, and to use the blood storage bag for blood transfusion that has been overly irradiated. GVHD because it will not be done
The safety against

[0011]

DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS A first embodiment of the present invention will be described below with reference to FIGS. FIG. 1 is a sectional view showing a first embodiment of a blood storage bag for blood transfusion with a radiation irradiation display according to the present invention, and FIG. 2 is a plan view of the same. In both of these figures, 11 is a bag body in which blood for transfusion is put. Here, blood products include blood products (red blood cells, platelets, plasma, etc.) in addition to normal blood. The bag body 11 itself has the same material and shape as those conventionally known, and is provided with a blood inlet / outlet opening 12a and a blood inlet / outlet spare 12b. Reference numeral 13 denotes a radiation irradiation display body including at least a radiation-sensitive substance (radiosensitive substance) 14 that changes color by radiation irradiation. As shown in FIG. 3, the radiation irradiating display 13 has a disk-shaped radiation-sensitive substance 14 and color samples 16a and 16b after radiation of the radiation-sensitive substance 14 on a mount 17. Be prepared for. The color sample 16a corresponds to the color change of the radiation-sensitive substance 14 when the radiation irradiation corresponding to the lower limit value of the required radiation irradiation dose is applied (hereinafter, referred to as a lower limit color sample). The color sample 16b corresponds to the color change of the radiation-sensitive substance 14 when the radiation irradiation corresponding to the required upper limit value of the radiation irradiation dose is given (hereinafter, referred to as the upper limit color sample).

The radiation irradiation display 13 is directly attached to the surface of the bag body 11, or a pocket 18 made of a transparent, non-moisture impermeable substance is formed in the bag body 11 and inserted into the pocket 18. It is integrally attached to the bag body 11 by sealing the insertion port. When the radiation irradiation display 13 is directly attached to the surface of the bag body 11, the radiation-sensitive substance 14 is covered and protected by a transparent non-moisture permeable substance (not shown). The radiation-sensitive substance 14 of the radiation irradiation indicator 13 to be inserted into the pocket 18 may also be protected by being covered with a transparent and non-moisture permeable substance (not shown) as described above. 1
The material forming 8 need not be impermeable to moisture. Further, the radiation irradiation display body 13 is attached to both the front side and the back side (the upper surface side and the lower surface side in FIG. 1) of the bag body 11 here. Examples of the radiation-sensitive substance (radiation-sensitive substance) 14 include Japanese Patent Application No. 1-66285 (Japanese Patent Application Laid-Open No. 2-245688) and Japanese Patent Application No. 1-95798.
3-35493).

In the first embodiment, the radiation irradiation display 13
As shown in FIG. 3, the radiation-sensitive substance 14 and the color samples 16a, 1
Although 6b is provided on the same mount, both need not necessarily be provided on the same mount and may be provided on different mounts. That is, if both are integrally attached to the blood-storing bag main body 11 for transfusion and provided so as to be observed in comparison, the purpose is achieved, and therefore the range in which the purpose is achieved It may be separately attached inside. In this case, the radiation-sensitive substance 14 needs to be attached with a non-moisture permeable treatment, but the color samples 16a and 16b can be attached without such a treatment.

When irradiating blood for blood transfusion for the prevention of the onset of GVHD, radiation is performed with blood for blood transfusion (not shown) in the bag body 11 of the blood preservation bag for blood transfusion of the present invention. Then, X-rays are emitted from above (or below) in FIG. When the bag main body 11 containing blood for transfusion is irradiated with a required irradiation dose of radiation, the radiation irradiation display 13 integrally attached to the bag main body 11 is also inevitably irradiated with radiation. Therefore, the radiation irradiation display 13
A color change occurs in the radiation-sensitive substance 14, and it is displayed that the blood transfusion bag for blood transfusion (blood for transfusion) has been irradiated.

At this time, since the radiation-sensitive substance 14 causes a color change corresponding to the irradiation dose, this color change is compared with the lower limit color sample 16a and the upper limit color sample 16b, and the color change between the two color samples is compared. If it is a color, the radiation dose to the blood-storing bag body 11 for transfusion is normal, and if it is the color outside both color samples, it is determined that there is an excess or deficiency in the radiation dose, and the amount is insufficient. Re-irradiation of radiation will be performed on the above items, and disposal of the excess will be performed.

As in the present invention, since the radiation irradiation indicator 13 is integrally attached to the bag body 11 and is irradiated with radiation, the blood storage bag for transfusion before irradiation is erroneously transfused after irradiation. It can be reliably prevented from being used as a blood storage bag for use, and it is possible to identify when there is an excess or deficiency of the irradiation dose, and to take a dire measure against them.

In the above embodiment, the radiation irradiation display 1 is used.
3 are attached to both the upper surface side and the lower surface side of the bag body 11 in FIG. 1, but only one of them may be attached.
It may be embedded in the peripheral portion of. When attached to both the upper surface side and the lower surface side of the bag body 11, the upper surface side senses the radiation irradiation dose, and the lower surface side senses the radiation transmission dose. Since the radiation is attenuated by the permeation of the bag body 11 containing blood for transfusion, it is necessary to attach the radiation irradiation indicator 13 to both the upper surface side and the lower surface side of the bag body 11 as in the above-mentioned embodiment. This is useful for judging whether the blood has been effectively applied to the whole blood in the main body 11. Further, when the radiation irradiation indicator 13 is embedded in the peripheral portion of the bag body 11 as described above, when the blood storage bags for blood transfusion are stacked in several stages and the radiation is similarly applied, the radiation irradiation is performed as in the above-described embodiment. The irradiation indicator 13 may be attached to the upper and lower surfaces of the bag body 11 as an alternative.

Next, a second embodiment of the present invention will be described with reference to FIG.
And FIG. 5 will be described. FIG. 4 is a plan view showing a second embodiment of the blood storage bag for blood transfusion of the present invention. FIG. 5 is a perspective view showing an example of the radiation irradiation display body in FIG. In FIG. 4, the bag body 11 in which blood for transfusion is put is shown in FIG.
However, the mounting positions of the radiation irradiation display 13a and the pocket 18 are different.

In the second embodiment, the radiation irradiation display 13a
Is constructed as shown in FIG. A radiation-sensitive substance 14 and a radiation-sensitive substance 19 with a filter, which are formed in a disk shape, and color samples 15 and 16 of the radiation-sensitive substance before and after irradiation with radiation are arranged on a mount 17. The lower limit color sample 16a is used as the color sample after irradiation with radiation. The radiation-sensitive substance with filter 19 has transparent and radiation-absorbing filters 20 attached in front of and behind the radiation-sensitive substance 14. Lead glass or the like may be used as the filter 20. The purpose of using this filter 20 is to appropriately reduce the radiation dose received by the radiation-sensitive substance 14. In this case, when the radiation irradiation of 50 Gy is performed, it is necessary to reduce this to 15 Gy (to a dose of 30%). . When selecting a filter, the material (composition) and thickness of the filter must be determined in consideration of the radiation quality.

The mounting position of the pocket 18 is the bag body 11
It is necessary to dispose the radiation-sensitive substance with filter 19 at a position where it does not overlap with blood. This is because the radiation-sensitive substance with filter 19 absorbs radiation, and the radiation dose received by the blood on the back side thereof is reduced, which is to prevent it. In the case of this embodiment, since only one radiation irradiation indicator is required, the pocket 18
Only one needs to be attached.

Also in the case of this embodiment, as in the case of the first embodiment of the present invention, it may be embedded in the peripheral portion of the bag body 11, and further the radiation-sensitive substance 14 and the radiation-sensitive substance with filter 19 may be used. The color samples 15 and 16 may be provided on separate mounts and attached to the blood bag body 11 for blood transfusion. When the main body 11 of the blood transfusion bag of the present embodiment is irradiated with radiation at a necessary irradiation dose, the radiation-sensitive substance 14 and the radiation-sensitive substance with filter 19 of the radiation irradiation display 13a change color. The color change at this time is the lower limit color sample 16a in the radiation sensitive substance 14.
Radiation-sensitive substance with filter 1
In No. 9, the color change occurs between the unirradiated color sample 15 and the lower limit color sample 16a. Discoloration of the radiation-sensitive substance 14 is an unirradiated color sample 1
5 and the lower limit color sample 16a, the radiation irradiation is insufficient, and the radiation-sensitive substance with filter 19
If the discoloration is stronger than the lower limit color swatch 16a, it means that the radiation irradiation is excessive, so that it is necessary to appropriately treat each case as described in the first embodiment of the present invention.

[0022]

As described above, according to the present invention, a blood storage bag for blood transfusion can be obtained by integrally attaching a radiation irradiation indicator equipped with a radiation-sensitive substance that changes color upon irradiation with radiation to the bag body. Comparing the color change of the radiation-sensitive substance and the color sample, since it is configured to determine whether the radiation-exposed indication and the radiation irradiation amount are within the required limit by the color change of the radiation-sensitive substance. Thus, it is possible to easily discriminate between the blood storage bag for transfusion that has been irradiated and the blood storage bag that has not been irradiated, and to confirm that the radiation dose is within a predetermined appropriate range. As a result, the blood storage bag for transfusion before irradiation is prevented from being mistakenly used as a blood storage bag for transfusion after irradiation, and waste blood is transfused by using the blood for transfusion that is overly irradiated. Since it does not occur, the safety against GVHD can be improved.

[Brief description of drawings]

FIG. 1 is a sectional view showing an embodiment of a blood storage bag for blood transfusion of the present invention.

FIG. 2 is a plan view of the same.

FIG. 3 is a perspective view showing an example of a radiation irradiation display body in FIGS. 1 and 2.

FIG. 4 is a plan view showing a second embodiment of the blood storage bag for transfusion of the present invention.

FIG. 5 is a perspective view showing an example of a radiation irradiation display body in FIG.

[Explanation of symbols]

 11 Bag body 12a Blood inlet / outlet port 12b Blood outlet / inlet spare 13 Radiation irradiation indicator 13a Radiation irradiation indicator 14 Radiation sensitive substance (Radiosensitive substance) 15 Color sample of radiation sensitive substance before irradiation 16 Radiation sensitive substance after irradiation Color sample 16a Color sample after irradiation of lower radiation dose 16b Color sample after irradiation of upper radiation dose 17 Mount 18 Pocket 19 Radiation-sensitive substance with filter 20 Filter

Claims (2)

[Claims] 1. A radiation-sensitive substance by irradiating radiation to a bag body containing blood for transfusion, to which a radiation-irradiated display body, which is at least provided with a radiation-sensitive substance that changes color upon irradiation with radiation, is integrally attached. In the method of indicating the irradiation completion of the blood transfusion bag for blood transfusion that causes a color change to be displayed on the irradiation body, the irradiation dose to the bag body containing the blood for transfusion in the irradiation display body is a predetermined maximum value. A method for indicating that a blood storage bag for transfusion has been irradiated, comprising means for identifying that the blood storage bag is within a minimum value. 2. A blood storage bag for blood transfusion with a pre-irradiated display, wherein a radiation irradiation indicator comprising at least a radiation-sensitive substance that changes color upon irradiation with radiation is integrally attached to the bag body. Irradiation display main body provided with means for identifying that the irradiation dose to the main body containing the blood for transfusion is between a predetermined maximum value and minimum value. Blood storage bag.