JPH0671480B2 - Solid agent dissolution type dialysate supply device and method - Google Patents

Description

TECHNICAL FIELD The present invention relates generally to medical care, and more particularly to a dialysis solution supply device and a dialysis solution supply method used in the field of medical care, particularly in hemodialysis.

(Prior Art) Conventionally, a dialysate used for hemodialysis has been prepared by diluting an undiluted acetic acid dialysate such as acetate with water at the time of use. Since it is physiological, it has been widely used.

However, bicarbonate ions as sodium bicarbonate-based dialysis solution bicarbonate ^{_{(NaHCO 3) (HCO 3 -}} ) calcium ions is another component of the dialysate (Ca ⁺⁺⁾ and magnesium ions (Mg ⁺⁺⁾ and mixed When applied, they form their carbonates and become precipitates. Therefore, the dialyzing stock solution is divided into two types, a dialysate stock solution (solution A) and a concentrated sodium bicarbonate stock solution (solution B), and both solutions are diluted with water just before use.

Furthermore, since bacteria grow in the concentrated sodium bicarbonate solution, the bicarbonate dialysate has a problem of bacterial contamination of the dialysate.

(Problems to be solved by the invention) When a concentrated solution of sodium bicarbonate (NaHCO ₃ ) is released to the atmosphere
Due to the reaction of NaHCO ₃ → Na 2 CO ₃ + CO ₂ + H ₂ O, carbon dioxide (CO ₂ ) is released to the atmosphere, the bicarbonate concentration decreases with time, and the pH rises. As a result, calcium and magnesium in the dialysate precipitate as carbonates, causing changes in the components of the dialysate. Therefore, it becomes difficult for the dialysate prepared by diluting the stock solution to maintain the electrolyte concentration and pH stable. Since the correction of the electrolyte substance of the patient and the correction of the acid-base equilibrium are important items of dialysis, the change with time of the components of the bicarbonate dialysate was a serious problem.

Further, since the carbonate that has become a precipitate adheres to the inside of the dialysis machine and causes deterioration of the accuracy of the machine and a failure, maintenance problems are large. On the other hand, in the conventional system in which the dialysate stock solution is used to automatically dilute and prepare it, solution A and solution B are used.
Since the stock solution of the liquid is stored in a large container and usually has to be exposed to the atmosphere for one day or at least a half day, there is a drawback that the pH of the liquid in the tank B of the liquid concentrate is increased and bacterial growth occurs.

As a basic solution to the above problems, Japanese Patent Publication No. 1-55893
Japanese Patent Laid-Open No. 63-65874 and the like are proposed. In each of the proposals, a sodium bicarbonate solid agent was used by continuously and automatically dissolving it according to the required amount when preparing a dialysate, and solved the above-mentioned problems caused by the change over time of the sodium bicarbonate solution. It is a thing.

However, the above proposals are all related to the automatic dissolution of sodium bicarbonate solid solution, and the dialysate stock solution A is a method of using a liquid, such as transportation, storage, handling, and disposal of empty containers related to solution A. The economic problems of him remained.

(Means for Solving Problems) Therefore, the solid-solution-dissolving type dialysate supply device and method according to the present invention have been earnestly studied to further solve the above problems,
In the solid agent dissolving type dialysate supply device of the present invention, all of the dialysate stock solutions that were conventionally one stock solution (A solution) and one solid solution (sodium bicarbonate) were used as solid solutions, and were A solid solution and B solid solution. It is possible to perform dissolution dilution preparation.

Hereinafter, a specific configuration of the solid-solution-dissolving dialysate supply device and method according to the present invention will be described.

First, the configuration of the solid-solution-dissolving dialysate supply device of the first invention will be described. The invention first has an automatic dilution tank. Then, there is a dilution water supply means. The dilution water supply means supplies the dilution water to the automatic dilution tank. Further, there is an A solid agent automatic supply means. This A solid agent automatic supply means automatically supplies the A solid agent for dialysate to the above-mentioned automatic dilution tank. Then, there is B solid agent automatic supply means. The B solid agent automatic supply means automatically supplies the B solid agent for dialysate to the automatic dilution tank.
In addition, there is a first densitometer. The first densitometer controls the dissolution process of each solid agent in the automatic dilution tank.

And there is a second densitometer. This second densitometer monitors the dissolved concentration of each solid agent in the automatic dilution tank. In addition, there is a storage tank. And there is a liquid delivery pump. The liquid sending pump sends the dialysate in the automatic dilution tank to the storage tank. And there is a third densitometer. The third densitometer finally confirms the concentration of the dialysate in the storage tank. Further, there is a second liquid feed pump. The second liquid feed pump feeds a dialysate having an appropriate concentration whose concentration has been reconfirmed by the third concentration meter to the dialysis chamber.

Finally, there is an automatic repeater. This automatic repeating means automatically enters the next dissolving and diluting step when the transfer of the dialysate adjusted in the above-mentioned dilution tank to the storage tank is completed and the dialysate is prepared, and the remaining amount of the dialysate in the storage tank is set to a predetermined value. When the level drops to the level, the entire amount of dialysate in the dilution tank is transferred to the storage tank, and the above cycle is automatically repeated thereafter.

Next, the constitution of the solid agent-dissolving type dialysate continuous preparation supply method of the second invention will be described. First, water is supplied to the dilution tank by the automatic water supply means with a control valve. Next, water and each solid agent are sequentially supplied to the dilution tank by using the A solid agent supplying means and the B solid agent supplying means which are automatically controlled. At this time, the process is automatically advanced while the concentration measuring means automatically controls the concentration for each dissolving process of each solid agent. Then, if it is confirmed that the concentration of the dialysate has become appropriate, the dialysate is transferred to the next storage tank. Then, the concentration measuring means of the storage tank confirms the concentration of the dialysate again, and if the concentration is proper, the dialysate is supplied to the bedside hemodialyzer.

In the dilution tank, when the adjusted dialysate is completely transferred to the storage tank, it automatically enters the next dissolving and diluting step to prepare the dialysate, and dilutes when the remaining amount of dialysate in the storage tank falls to a predetermined level. Transfer all the dialysate in the tank to the storage tank.

After that, the above cycle is automatically repeated.

(Operation) First, the operation of the solid-solution-dissolving type dialysate continuous preparation feeder of the first invention will be described. First, the dilution water supply means supplies the dilution water to the automatic dilution tank. Next, the A solid agent automatic supply means automatically supplies the A solid agent for dialysate to the above automatic dilution tank. And, the B solid agent automatic supply means is
The B solid agent for dialysate is automatically supplied to the above automatic dilution tank. Further, the first densitometer controls the dissolution process of each solid agent in the above automatic dilution tank.

Then, the second densitometer monitors the dissolved concentration of each solid agent in the automatic dilution tank. Further, a liquid sending pump sends the dialysate in the automatic dilution tank to the storage tank. Then, the third densitometer finally confirms the concentration of the dialysate in the storage tank. Further, the second liquid sending pump sends to the dialysis chamber a dialysate having an appropriate concentration, the concentration of which has been reconfirmed by the third densitometer.

Finally, when the automatic repeating means completes the transfer of the dialysate adjusted in the above dilution tank to the storage tank, it automatically enters the next dissolving and diluting step to prepare the dialysate, and the remaining amount of dialysate in the storage tank remains. When the amount of the dialysate in the dilution tank is lowered to a predetermined level, the entire amount of dialysate is transferred to the storage tank and the above cycle is automatically repeated thereafter.

Next, the operation of the solid agent-dissolving type dialysate continuous preparation supply method of the second invention will be described. First, the dilution water is supplied to the dilution tank by the automatic water supply means with a control valve. Next,
Water and each solid agent are sequentially supplied to the dilution tank by using the A solid agent supplying means and the B solid agent supplying means which are automatically controlled.
At this time, the process can be automatically advanced while the concentration measuring means automatically controls the concentration for each dissolving process of each solid agent. Then, when it is confirmed that the concentration of the dialysate has become appropriate, the dialysate is transferred to the next storage tank. Then, the concentration measuring means of the storage tank confirms the concentration of the dialysate again, and if the concentration is proper, the dialysate is supplied to the bedside hemodialyzer.

In the dilution tank, when the adjusted dialysate is completely transferred to the storage tank, it automatically enters the next dissolving and diluting step to prepare the dialysate, and dilutes when the remaining amount of dialysate in the storage tank falls to a predetermined level. The entire amount of dialysate in the tank is transferred to the storage tank.

After that, the above cycle is automatically repeated.

(Example) Hereinafter, the solid-solution-dissolving type dialysate supply device and method according to the present invention will be described in detail with reference to the preferred embodiments shown in the accompanying drawings.

The drawings show a block diagram of an embodiment of the solid-solution-dissolving type dialysate supply device according to the present invention.

First, there is the automatic dilution tank 1. Next, there is the automatic water supply means 2. This automatic water supply means 2 is the dilution tank 1 described above.
Water is automatically supplied to. Then, there is the A solid medicine automatic supply means 3. The A solid agent automatic supply means 3 automatically supplies the A solid agent for dialysate to the automatic dilution tank 1. Further, there is B solid agent automatic supply means 4. The B solid agent automatic supply means 4 automatically supplies the B solid agent for dialysate to the automatic dilution tank 1.
Then, there is the first densitometer 6. This first densitometer 6
Controls the dissolution process of each solid agent in the automatic dilution tank 1.

In addition, there is a second densitometer. This second densitometer monitors the dissolved concentration of the solid agent in the dilution tank 1 described above. Finally, on the output side of the above automatic dilution tank 1,
There is a storage tank 5 that automatically receives the dialysate via the pump P2 for liquid delivery.

A pump for sending liquid is provided on the output side of the storage tank 5 described above.
P2 is provided.

The operation will be described above. First, a predetermined amount of water is automatically supplied from the automatic water supply means 2 to the automatic dilution tank 1. Next, the A-solidifying agent automatic supply means 3 automatically supplies the A-solidifying agent thereto to dissolve and dilute it and automatically dilute it to a preset concentration while automatically controlling the process by the first densitometer 6. .

Next, the B-solidifying agent is automatically supplied to the B-solidifying agent by the automatic B-solidifying agent supplying means 4, and is automatically diluted to a predetermined concentration while the process is automatically controlled by the first densitometer 6. . The concentration is monitored by the second densitometer 7 and the prepared dialysate is automatically transferred to the storage tank 5 by the transfer pump P1.
When the third densitometer 8 automatically confirms that the dialysate has an appropriate concentration, it is automatically supplied to the bedside hemodialyzer by the supply pump P2.

Finally, there is an automatic repeater not shown. This automatic repeating means automatically enters the next dissolving and diluting step when the dialysate adjusted in the above dilution tank 1 is completely transferred to the storage tank 5, prepares the dialysate, and leaves the dialysate in the storage tank 5. When the amount falls to a predetermined level, the entire amount of dialysate in the dilution tank 1 is transferred to the storage tank 5, and the above cycle is automatically repeated thereafter.

In addition, the dialyzer heating and deaeration functions were equipped with the same equipment as the conventional equipment.

(Effects of the Invention) The solid-solution-dissolving dialysate supply device and method according to the present invention enable stable operation of the device due to reduced precipitation of carbonate, and stabilize a highly safe dialysate at an accurate concentration. It has become possible to supply it as a product, which has brought great clinical advantages.

On the other hand, the use of the dialysis stock solution as a solid agent has an economical effect on transportation and handling. In addition, since the whole dialysate solution is made into a solid agent, the time until the solid agent is dissolved in water to become a dialysate and used is at least 1/30 to 1/60 of that of the conventional method, and the change of ingredients over time It ’s harder to get up,
It became possible to supply a stable dialysate solution. further,
The chance of bacterial contamination of the dialysate was also greatly improved and the safety of the dialysate was improved.

In addition, there is less maintenance of the carbonate on the equipment, creating a maintenance advantage. On the other hand, the storage container for dialysis stock solution, which was conventionally required for two, is no longer required, and the space around the dialysis solution supply device is saved.
The problem of disposing the stock solution container (usually a plastic tank containing 11 liters) has also been reduced.

Furthermore, each step including the confirmation of the concentration is automatically performed by the sequence control means. The main manual work is to first load each solidifying agent into the hopper for each solidifying agent.

If the pharmaceutical technology advances in the future and the A solid medicine and the B solid medicine are integrated, the solid medicine supplying means can be only one means.

[Brief description of drawings]

The drawings show a block diagram of an embodiment of the solid-solution-dissolving type dialysate supply device according to the present invention. DESCRIPTION OF SYMBOLS 1 ... Automatic dilution tank, 2 ... Automatic water supply means 3 ... A solid agent automatic supply means 4 ... B solid agent automatic supply means, 5 ... Storage tank 6 ... 1st concentration meter, 7 ... 2nd concentration meter 8 ... 2nd 3 densitometer

Claims (2)

[Claims] 1. An automatic dilution tank, dilution water supply means for supplying dilution water to the automatic dilution tank, A solid agent automatic supply means for automatically supplying A solid agent for dialysate to the automatic dilution tank, and the above automatic B for dialysate automatically supplied to the dilution tank B
Solid agent automatic supply means, a first densitometer for controlling the dissolution process of each solid agent in the automatic dilution tank, a second densitometer for monitoring the dissolved concentration of each solid agent in the automatic dilution tank, Storage tank, pump for sending dialysate in the automatic dilution tank to the storage tank, third concentration meter for finally confirming concentration of dialysate in the storage tank, third concentration meter The concentration of the dialysate is reconfirmed by the second pump for sending the dialysate to the dialysis chamber, and the dialysate adjusted by the dilution tank is transferred to the storage tank. It consists of an automatic repeater that prepares a dialysate solution containing the dialysate, and when the remaining amount of dialysate in the storage tank falls to a predetermined level, the entire amount of dialysate in the dilution tank is transferred to the storage tank and the above cycle is repeated automatically. Continuous solid-solution-dissolved dialysate characterized by Agent supply device. 2. A dilution tank is supplied with water by means of a control valve-equipped automatic water supply means, and water and each solid medicine are sequentially supplied to the dilution tank by means of an automatically controlled A solid agent supplying means and B solid agent supplying means. At this time, the process is automatically advanced while the concentration measuring means automatically controls the concentration for each dissolving process of each solid agent. Then, when it is confirmed that the concentration of the dialysate has become appropriate, the dialysate is transferred to the next storage tank, and the concentration measuring means of the storage tank again confirms the concentration of the dialysate, If the concentration is proper, this dialysate is supplied to the bedside hemodialyzer. In the dilution tank, when the adjusted dialysate is completely transferred to the storage tank, it automatically enters the next dissolving and diluting step to prepare the dialysate, and dilutes when the remaining amount of dialysate in the storage tank falls to a predetermined level. Transfer all the dialysate in the tank to the storage tank. Thereafter, the solid agent-dissolving type dialysate continuous supply method is characterized in that the above-mentioned cycle is automatically repeated.