JPH06505974A - 抗癌化合物 - Google Patents

抗癌化合物

Info

Publication number
JPH06505974A
JPH06505974A JP4506050A JP50605092A JPH06505974A JP H06505974 A JPH06505974 A JP H06505974A JP 4506050 A JP4506050 A JP 4506050A JP 50605092 A JP50605092 A JP 50605092A JP H06505974 A JPH06505974 A JP H06505974A
Authority
JP
Japan
Prior art keywords
amino
dihydro
ylmethyl
methyl
glutamic acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP4506050A
Other languages
English (en)
Japanese (ja)
Inventor
ビセット，グラハム・マイケル・フレイザー
ジャックマン，アン・レズリー
ジョドレル，ダンカン・イアン
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Imperial Chemical Industries Ltd
Original Assignee
Imperial Chemical Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Imperial Chemical Industries Ltd filed Critical Imperial Chemical Industries Ltd
Publication of JPH06505974A publication Critical patent/JPH06505974A/ja
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/95—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in positions 2 and 4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
    • C07D239/88—Oxygen atoms
    • C07D239/90—Oxygen atoms with acyclic radicals attached in position 2 or 3

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP4506050A 1991-03-19 1992-03-18 抗癌化合物 Pending JPH06505974A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB9105771.1 1991-03-19
GB919105771A GB9105771D0 (en) 1991-03-19 1991-03-19 Anti-cancer compounds
PCT/GB1992/000476 WO1992016512A1 (en) 1991-03-19 1992-03-18 Anti-cancer compounds

Publications (1)

Publication Number Publication Date
JPH06505974A true JPH06505974A (ja) 1994-07-07

Family

ID=10691801

Family Applications (1)

Application Number Title Priority Date Filing Date
JP4506050A Pending JPH06505974A (ja) 1991-03-19 1992-03-18 抗癌化合物

Country Status (18)

Country Link
US (1) US5444061A (https=)
EP (1) EP0509643A1 (https=)
JP (1) JPH06505974A (https=)
AU (1) AU655970B2 (https=)
CA (1) CA2106583A1 (https=)
CZ (1) CZ195393A3 (https=)
FI (1) FI934106A7 (https=)
GB (2) GB9105771D0 (https=)
HU (1) HUT67177A (https=)
IE (1) IE920853A1 (https=)
IL (1) IL101281A0 (https=)
MX (1) MX9201183A (https=)
NO (1) NO933341L (https=)
NZ (1) NZ242023A (https=)
SK (1) SK100993A3 (https=)
TW (1) TW203608B (https=)
WO (1) WO1992016512A1 (https=)
ZA (1) ZA921985B (https=)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9205907D0 (en) * 1992-03-18 1992-04-29 Cancer Res Inst Royal Anti-cancer compounds
GB9223352D0 (en) * 1992-11-06 1992-12-23 Ici Plc Tricyclic compounds
GB9408936D0 (en) * 1994-05-05 1994-06-22 Cancer Res Inst Anti-cancer compounds
BR9610422A (pt) * 1995-08-30 1999-07-13 Searle & Co Derivados de meta-guanidina uréia tiouréia ou ácido aminobenzóico azacíclico como antagonistas de integrina
GB9904275D0 (en) 1999-02-24 1999-04-21 Cancer Res Campaign Tech Anti-cancer compounds
US6545004B1 (en) * 1999-10-27 2003-04-08 Cytokinetics, Inc. Methods and compositions utilizing quinazolinones
US7671200B2 (en) * 1999-10-27 2010-03-02 Cytokinetics, Inc. Quinazolinone KSP inhibitors
US7230000B1 (en) 1999-10-27 2007-06-12 Cytokinetics, Incorporated Methods and compositions utilizing quinazolinones
WO2003070701A2 (en) * 2002-02-15 2003-08-28 Cytokinetics, Inc. Syntheses of quinazolinones
US7214800B2 (en) * 2002-05-09 2007-05-08 Cytokinetics, Inc. Compounds, compositions, and methods
CA2485148A1 (en) * 2002-05-09 2003-11-20 Cytokinetics, Inc. Pyrimidinone compounds, compositions and methods
EP1513820A4 (en) * 2002-05-23 2006-09-13 Cytokinetics Inc COMPOUNDS, COMPOSITIONS AND METHODS
WO2003106426A1 (en) * 2002-06-14 2003-12-24 Cytokinetics, Inc. Compounds, compositions, and methods
US20030236430A1 (en) * 2002-06-21 2003-12-25 Allen David Robert Preparation of protected amino acids
AU2003256805A1 (en) * 2002-07-23 2004-02-09 Cytokinetics, Inc. Compounds compositions and methods
US20040048853A1 (en) * 2002-08-21 2004-03-11 Gustave Bergnes Compounds, compositions, and methods
WO2004034972A2 (en) 2002-09-30 2004-04-29 Cytokinetics, Inc. Compounds, compositions, and methods
JP2007510652A (ja) * 2003-11-03 2007-04-26 サイトキネティクス・インコーポレーテッド ピリミジン−４−オン化合物、組成物、および方法
EP1680420A4 (en) * 2003-11-07 2008-09-24 Cytokinetics Inc COMPOUNDS, COMPOSITIONS AND METHODS
EP1692112A4 (en) * 2003-12-08 2008-09-24 Cytokinetics Inc COMPOUNDS, COMPOSITIONS, AND METHODS
DK2150514T3 (en) 2007-04-11 2019-02-18 Merck & Cie 18F-LABELED FOLATES
KR102431436B1 (ko) 2014-08-29 2022-08-10 테스 파마 에스.알.엘. α-아미노-β-카복시뮤콘산 세미알데히드 데카복실라제의 억제제
US12030875B2 (en) 2018-09-07 2024-07-09 PIC Therapeutics, Inc. EIF4E inhibitors and uses thereof
AU2021230289A1 (en) 2020-03-03 2022-09-29 PIC Therapeutics, Inc. eIF4E inhibitors and uses thereof
JP2024534127A (ja) 2021-08-25 2024-09-18 ピク セラピューティクス， インコーポレイテッド ｅＩＦ４Ｅ阻害剤及びその使用
US12157732B2 (en) 2021-08-25 2024-12-03 PIC Therapeutics, Inc. eIF4E inhibitors and uses thereof

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3069468D1 (en) * 1979-12-19 1984-11-22 Nat Res Dev Quinazoline derivatives, processes for their preparation, compositions containing them and their use as anti-cancer agents
GB8513754D0 (en) * 1985-05-31 1985-07-03 Jones T R Anti-cancer quinazoline derivatives
US4746659A (en) * 1985-12-30 1988-05-24 Sri International Diastereomers of 10-alkyl-10-deazaminopterins and process for preparing the same
GB8607683D0 (en) * 1986-03-27 1986-04-30 Ici Plc Anti-tumor agents
US5187167A (en) * 1986-03-27 1993-02-16 Imperial Chemical Industries Plc Pharmaceutical compositions comprising quinazolin-4-one derivatives
GB8625019D0 (en) * 1986-10-18 1986-11-19 Wellcome Found Compounds
GB8707053D0 (en) * 1987-03-25 1987-04-29 Ici Plc Anti-tumour agents
US4767761A (en) * 1987-11-04 1988-08-30 Dana-Farber Cancer Institute, Inc. Ornithine derivatives and their use as methotrexate-resistant cell inhibitors
GB8727737D0 (en) * 1987-11-26 1987-12-31 Ici Plc Antitumour agents
GB8809978D0 (en) * 1988-04-27 1988-06-02 Ici Plc Anti-tumour agents
US5252573A (en) * 1988-12-15 1993-10-12 Imperial Chemical Industries Plc Anti-tumor agents
GB8829296D0 (en) * 1988-12-15 1989-01-25 Ici Plc Anti-tumour compounds
US4996207A (en) * 1990-01-18 1991-02-26 Nair Madhavan G Three new non-polyglutamatable deazaaminopterins
DE69111891T2 (de) * 1990-05-17 1996-04-04 Smith & Nephew United Inc Elektrisch leitender und adstringierender Film sowie filmbildende Zusammensetzung zur Verwendung auf der Haut.
IL98167A0 (en) * 1990-05-30 1992-06-21 Ici Plc Anti-tumour quinazoline derivatives,processes for their preparation and pharmaceutical compositions comprising them

Also Published As

Publication number Publication date
NZ242023A (en) 1993-12-23
TW203608B (https=) 1993-04-11
HUT67177A (en) 1995-02-28
HU9302636D0 (en) 1993-12-28
NO933341D0 (no) 1993-09-20
CA2106583A1 (en) 1992-09-20
FI934106A7 (fi) 1993-11-18
GB2253849B (en) 1995-01-18
GB9205906D0 (en) 1992-04-29
NO933341L (no) 1993-11-18
GB9105771D0 (en) 1991-05-01
US5444061A (en) 1995-08-22
AU655970B2 (en) 1995-01-19
FI934106A0 (fi) 1993-09-20
MX9201183A (es) 1994-06-30
ZA921985B (en) 1993-09-20
SK100993A3 (en) 1994-08-10
WO1992016512A1 (en) 1992-10-01
CZ195393A3 (en) 1994-07-13
IL101281A0 (en) 1992-11-15
IE920853A1 (en) 1992-09-23
EP0509643A1 (en) 1992-10-21
AU1371692A (en) 1992-10-21
GB2253849A (en) 1992-09-23

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