JPH0633104B2 - Sealed container - Google Patents

Description

TECHNICAL FIELD The present invention relates to a hermetically sealed container for injection cartridges, ampoules and the like and a method for hermetically sealing them, and is particularly used in the field of pharmaceutical production and the like.

2. Description of the Related Art As shown in FIG. 3, a cartridge which is filled with an injection solution has its mouth closed tightly with a rubber stopper (11) having a top plate, and then an aluminum plate (12) for a flange of the cartridge (2). The part (2a) and the top plate part (11a) of the rubber stopper were wrapped and wrapped to be sealed.

Further, the ampoule filled with the injection solution was sealed by heating and sealing the tip of its mouth.

Problems to be Solved by the Invention: In the conventional method for sealing injection cartridges and vials,
Two steps, a sealing step with a rubber stopper and an aluminum winding step, are required, and a mechanical device therefor is required.

In addition, although the ampoule for injection can be sealed only by heating and sealing the tip of its mouth, it is not only complicated because it requires a cut on the neck of the ampoule when used, but also a fine glass piece generated by the ampoule cut is in the injection solution. There was a problem that it might get mixed in.

Means for Solving the Problems: The inventors of the present invention have earnestly studied to develop a container which is sealed in a convenient state for use, and a method of simply sealing, and as a result, a certain viscous resin has been found to be present. The present invention has been completed by finding that if the mouth of a container is sealed by utilizing the property of being solidified in a normal atmosphere, it can be used as easily as a stopper in a conventional injection cartridge or the like.

The sealed container of the present invention is obtained by injecting a viscous resin having a glass adhesive property and having a property of solidifying in a normal atmosphere so as to come into contact with the inner wall of the mouth of the container and solidifying in the mouth. To be

The resin used to form the plug according to the present invention has adhesiveness to glass, has a property of solidifying by reaction with moisture in a normal atmosphere, and is sealed before use. Any material can be used as long as it maintains viscosity in the container. The resin having these properties may be a so-called one-liquid type that solidifies in a normal atmosphere by itself, or a so-called two-liquid type that solidifies in a normal atmosphere by the addition of a catalyst or the like. May be. Specifically, as one-pack type, one-pack type RTV rubber KE 347, KE 3
The 475 (all trade names, manufactured by Shin-Etsu Chemical Co., Ltd.) silicone rubber is also a two-component RTV, a two-component RTV.
Examples of preferable resins include silicone rubbers of rubbers KE 103, KE16, KE1091, and KE1092 (all trade names, manufactured by Shin-Etsu Chemical Co., Ltd.).

The container of the present invention is preferably a container that does not open when the contents in the container are used and the contents are discharged and used through an injection needle or the like inserted in the stopper. Typical examples of such a container include a cartridge, an ampoule, a vial filled with an injectable drug, and other containers having an inner diameter of about 7 mm or less can be sealed by the method of the present invention.

When the resin is a one-pack type, the viscous resin contained in the closed container is injected and solidified so as to come into contact with the inner wall of the mouth of the container to be sealed. At that time, hot air or hot and humid air may be applied to the vicinity of the mouth of the container to promote solidification. In addition, the thickness of the plug formed of the solidified resin can be appropriately adjusted by adjusting the resin injection speed or selecting the type of resin.

If the resin is a two-part type, mix the two parts immediately before use,
Thereafter, a plug is formed in the same manner as in the case of the one-pack type.

Examples: Hereinafter, the method of the present invention will be specifically described with reference to Examples.

Example 1 A one-pack type silicone rubber KE 347 T (trade name, manufactured by Shin-Etsu Chemical Co., Ltd.) was injected so as to come into contact with the inner wall of the mouth (inner diameter 3.2 mm) of a cartridge filled with an injection solution, and allowed to stand. Allow the resin to solidify. A longitudinal section of the cartridge thus sealed is shown in FIG.

Example 2 Two-component silicone rubber KE 1091 (trade name, so as to come into contact with the mouth of an ampoule filled with an injection solution (inner diameter 5.5 mm)
(Shin-Etsu Chemical Co., Ltd.) is mixed well and injected, and allowed to stand to solidify the resin. A longitudinal section of the ampoule thus sealed is shown in FIG.

EFFECT OF THE INVENTION According to the method of the present invention, the container can be sealed by a simple operation of injecting the resin so as to contact the inner wall of the mouth of the container to be sealed and solidifying the resin. The stopper formed of the solidified resin is elastic and can be used by inserting an injection needle like a conventional injection cartridge or vial. Further, when the method of the present invention is applied to an ampoule for injection, the cutting at the neck of the ampoule, which has been performed when the conventional ampoule for injection is used, becomes unnecessary, and accordingly, the fine glass piece generated accompanying the ampoule cut is eliminated. It is also possible to solve the problem that the liquid may be mixed in the injection solution.

[Brief description of drawings]

1 is a vertical sectional view of an injection cartridge sealed according to a first embodiment of the method of the present invention, and FIG. 2 is a vertical sectional view of an injection ampoule sealed according to a second embodiment of the method of the present invention. FIG. 3 is a vertical cross-sectional view of an injection cartridge sealed by a conventional method. (1) …… A plug made of solidified resin, (2) ……
Cartridge main body, (3) …… Ampule main body.

Claims (2)

[Claims] 1. A viscous resin having a glass adhesive property and having a property of solidifying in a normal atmosphere is injected so as to come into contact with the inner wall of the mouth of a container, and solidified and sealed in the mouth. Characteristic sealed container. 2. A viscous resin having a glass adhesive property and a property of being solidified in a normal atmosphere is injected so as to come into contact with the inner wall of the mouth of the container, and is solidified in the mouth. How to seal the container.