JPH06321743A - Oral cavity cleaning agent - Google Patents

Abstract

PURPOSE:To obtain an oral cavity cleaning agent such as toothpaste, liquid dentifrice, mouth washing solution, etc., showing excellent removing effect on bacterial plaque. CONSTITUTION:This oral cavity cleaning agent contains 0.1-2% dimethyl sulfoxides as concentration in application to oral cavity. By using the cleaning agent, bacterial plaque which has been able to be removed only by physical means can be simply eliminated by a means such as gargling. Since dimethyl sulfoxide has strong permeating and diffusing action, the influence of chemical solution is wider and deeper than conventional mouth washing solutions and dimethyl silfoxide spreads to the whole parts of teeth and simultaneously exhibits dissolving action on bacterial plaque, tighetening effect on swelling of the gum, antiflammatory action, antimicrobial action, analgesic action, etc. Dimethyl sulfoxide has low toxicity and is safe even in drinking mistakenly by any chance.

Description

Detailed Description of the Invention

[0001]

[Industrial application] The present invention relates to a mouthwash such as toothpaste, liquid toothpaste, mouthwash for the purpose of removing plaque.

[0002]

2. Description of the Related Art It is said that 80% of Japanese people over 35 years old have some kind of gingival disease, and 80% of Japanese people over 40 years old lose their teeth due to periodontal disease. The cause of these is plaque. Dental plaque is a white to yellowish white organic deposit attached to the surface of teeth, which is composed of food residues, saliva components, etc., bacteria and bacterial metabolites, and cannot be easily removed only by rinsing. Therefore, bacterial metabolites stimulate the gingiva and cause gingivitis. When gingivitis occurs, food residues tend to accumulate, which further promotes inflammation. Further, when the gingival tissue is destroyed and the bone supporting the teeth is inflamed, periodontal disease occurs.

In the oral cavity, such an extremely troublesome vicious cycle is repeated. Since plaque cannot be completely removed by a normal brushing operation, the present situation is that periodontal disease is present at a high rate even though there are no people who brush their teeth. Further, the oral cavity is apt to be injured by press-fitting a piece of food and the like, which is also a factor for exacerbating periodontal disease and stomatitis. Also,
Tobacco tar on the teeth is difficult to remove with normal dentifrice, and it has been necessary to increase the amount of abrasive, but it is also a cause of abrasion of enamel and damage of gums. The present invention has been made as a means for improving such a situation.

[0004]

In recent years, a lot of dental plaque removal products have been developed and put into practical use due to the increased awareness of oral care. Among them, mouthwash has rapidly spread because of its plaque control effect and ease of use. The mouthwash is made up of a combination of a plaque solubilizing agent, a bactericidal agent, and an additive (fragrance, flavoring agent, pH adjusting agent, coloring agent, solvent, etc.). Conventional mouthwashes containing only a plaque solubilizer had a problem of insufficient plaque removal effect. Therefore, with respect to dental plaque that cannot be completely removed, many products use a bactericidal agent together to suppress the growth thereof. However, in this case, new problems such as irritation of the oral mucosa and damage to the mucous membrane by the bactericide, coloring of the tongue and teeth, and changes in the bacterial flora occur. In addition, in order to mask the unpleasant taste of the liquid medicine and impart a refreshing sensation, it is common to add a corrigent or a cooling agent. Are often used.

In order to eliminate the vicious cycle of plaque and gingivitis, gingivitis and periodontal disease as described above, it is important to remove the plaque that causes the vicious cycle and suppress unnecessary inflammatory reactions in the oral cavity. It becomes an issue.

[0006] In many cases, a bactericide is mixed in conventional products, but a drug having a bactericidal effect has an action of preventing an inflammatory reaction by sterilizing in the oral cavity and suppressing plaque growth. On the other hand, new problems such as mucosal injury and irritation, coloring of tongue and teeth, and changes in bacterial flora occur.

Most of mouthwashes contain ethanol for the purpose of dissolving flavoring agents, cooling agents and the like and for desensitizing taste. However, recently, there is a concern that ethanol in mouthwash has a high risk of cancer, and reduction of ethanol is also an issue.

[0008] In the oral cavity, small scratches are constantly generated due to press-fitting of food pieces, improper use of toothpicks, toothbrushes, etc. This is an aggravating factor for periodontal disease and stomatitis. It suppresses inflammatory reaction and reduces tissue damage. That is also an important issue.

[0009] Tobacco tars adhering to the teeth were difficult to remove and required an increased amount of abrasive dentifrice. Not only this problem, but in general, toothpaste containing abrasives and improper toothbrush operation damage the gums over the years, and tooth abrasion grooves occur at the boundary between the teeth and the gums. Things will come to seep.

[0010]

The present invention relates to a mouthwash containing dimethyl sulfoxide (DMSO: C ₂ H ₆ OS). The present invention is the first time that a mouthwash containing dimethyl sulfoxide has been found to be able to easily remove dental plaque, which was conventionally removable only by physical means, by means such as gargle. Examples of mouthwashes include water toothpaste, mouthwash, mouthwash, and the like. The concentration of dimethyl sulfoxide at the time of oral application is 0.
1-2% is suitable.

To the mouthwash, a proper amount of a cooling agent, an aromatic agent, and a flavoring agent, which are generally known for the purpose of flavoring, are added. Also,
An appropriate amount of a generally known bactericide is added in order to have a sufficient plaque formation suppressing effect.

The concentration of dimethyl sulfoxide is 0.
A plaque-dissolving action appears from 1%, but a thicker one is more effective. However, if it is too thick, it will be difficult to deal with flavoring agents and flavoring agents, so the upper limit of the concentration when applied in the oral cavity is 2
% Is appropriate.

Dimethyl sulfoxide has an excellent effect as a mouthwash in various respects in addition to the effect of removing plaque. That is, dimethyl sulfoxide has strong penetration
Since it has a diffusing effect, the effect of the chemical solution is broader and deeper than that of the conventional mouthwash and the like, and has an effect of spreading to every corner of the tooth. Dimethyl sulfoxide simultaneously has a plaque-dissolving action, a swelling action on gums, an anti-inflammatory action, a bacteriostatic action, and an analgesic action, so that it is not always necessary to mix these components.

When a germicide is added to dimethyl sulfoxide, the mouthwash becomes more meaningful. That is,
In addition to the plaque growth inhibitory effect of the bactericide, the negative effect of mucosal injury (the effect of bactericide to reduce tissue damage) works. Since dimethyl sulfoxide has a strong penetrating action, the retention time of the drug solution in the oral cavity is prolonged, and the drug effect is prolonged. As a result, for example,
It is also possible to reduce the effective concentration of the bactericide. Dimethyl sulfoxide has the action of dissolving tobacco tar on the teeth, and when used in combination with a toothbrush, brings about a remarkable effect of removing tar. Dimethyl sulfoxide has low toxicity and is safe even if accidentally swallowed.

Since dimethylsulfoxide has a high solubility in water or an organic solvent, it can be sufficiently dissolved even when it is a poorly soluble substance when a bactericidal agent, a cooling agent, an aromatic agent, and a flavoring agent are added. Therefore, there is an effect that it is possible to reduce the amount of ethanol, which has a risk of cancer.

As described above, the mouthwash containing dimethyl sulfoxide can simplify and reduce other components, so that it has a large economical effect and is hard to freeze.

The present invention will be described in more detail below with reference to examples and test examples.

[0018]

【Example】

[Example 1-3] Dimethyl sulfoxide 100% stock solution 1
Dilute ml to 50 ml water. As needed, bactericide (chlorhexidine gluconate), solubilizer (polyoxyethylene hydrogenated castor oil, cooling agent (l-menthol), fragrance (mint flavor), flavoring agent (sodium saccharinate) are added in appropriate amounts. A mouthwash was prepared by appropriately diluting the mouthwash with water and used for the test.

Example 1 Dimethyl sulfoxide 2.0% 1-Menthol 0.4% Mint flavor 0.04% Sodium saccharinate 0.2% Purified water balance 100% in total.

Example 2 Dimethyl sulfoxide 0.1% Chlorhexidyl gluconate 0.1% l-Menthol 0.1% Mint flavor 0.01% Sodium saccharinate 0.05% Purified water balance 100% in total.

Example 3 Dimethyl sulfoxide 0.1% Polyoxyethylene hydrogenated castor oil 0.1% l-menthol 0.1% Mint flavor 0.01% Sodium saccharinate 0.05% Purified water balance 100% [ Test Example] Test Method The test was repeated once a day for each subject with the plaque accumulation period as one day. First, plaque is dyed before washing the mouth. Regarding the plaque index PI of the pre-cleansing tooth surface, the staining status of the upper and lower anterior teeth was determined by visual observation, and the interdental PI before cleansing was determined.
Was determined by the degree of dyeing on the interdental brush when the interdental brush was scraped off. After washing the mouth,
Similarly, the post-washing tooth surface PI was visually observed, and the post-washing interdental portion PI was determined by examining another interdental portion with an interdental brush.

Judgment Method The plaque index PI (plaque index) was determined by the degree of staining with a commercially available plaque stain (Red No. 104).

PI = 3: a large amount of dental plaque, PI = 2: medium dental plaque, PI = 1: thin-film dental plaque PI = 0: no dental plaque [Test Example 1] Combination test with oral cavity cleaner, oral cavity cleaning Container (Portadent N- made by Ricoh Elemex
The PI values of the interdental part before and after cleaning were compared using the mouthwash of Example 1-3 and the commercially available cleaning solution in 1).

The results are shown in Table 1.

[0025]

[Table 1]

Bactericide: Chlorhexidine gluconate Solubilizer: Polyoxyethylene hydrogenated castor oil Commercial product 1: Chlorhexidine gluconate Commercial product 2: Polyoxyethylene hydrogenated castor oil Commercial product 3: Chlorhexidine gluconate + polyoxyethylene hydrogenated castor oil [Test Example 2] In a test by mouth rinsing (the liquid was bite so as to pass between the teeth and rinsed strongly for about 20 seconds), a dimethylsulfoxide-containing mouthwash and a commercial product were compared. Table 2 shows the change in PI value between the teeth. Table 3 shows changes in PI value on the tooth surface.

[0027]

[Table 2]

Commercial product 4: Mainly solubilizing agent propylene glycol + ethanol Commercial product 5: Solubilizing agent + germicide Polyoxyethylene hydrogenated castor oil + cetylpyridinium chloride + ethanol Commercial product 6: Solubilizer + germicide polyoxy Ethylene hydrogenated castor oil + chlorhexidine gluconate + ethanol

[0029]

[Table 3]

Table 4 shows the effect of each concentration of dimethyl sulfoxide.

[0031]

[Table 4]

[0032]

EFFECTS OF THE INVENTION The mouthwash containing dimethyl sulfoxide according to the present invention has an excellent effect in removing plaque.

Claims (1)

[Claims] 1. When dimethyl sulfoxide is applied to the oral cavity, 0.1
A mouthwash containing ~ 2%.