JPH0584458B2 - - Google Patents
Info
- Publication number
- JPH0584458B2 JPH0584458B2 JP61078983A JP7898386A JPH0584458B2 JP H0584458 B2 JPH0584458 B2 JP H0584458B2 JP 61078983 A JP61078983 A JP 61078983A JP 7898386 A JP7898386 A JP 7898386A JP H0584458 B2 JPH0584458 B2 JP H0584458B2
- Authority
- JP
- Japan
- Prior art keywords
- electrode
- enzyme
- enzyme sensor
- sensor according
- immobilized
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 108090000790 Enzymes Proteins 0.000 claims description 29
- 102000004190 Enzymes Human genes 0.000 claims description 29
- 239000002131 composite material Substances 0.000 claims description 9
- 239000000758 substrate Substances 0.000 claims description 9
- MHAJPDPJQMAIIY-UHFFFAOYSA-N Hydrogen peroxide Chemical compound OO MHAJPDPJQMAIIY-UHFFFAOYSA-N 0.000 claims description 6
- 229910052751 metal Inorganic materials 0.000 claims description 3
- 239000002184 metal Substances 0.000 claims description 3
- 239000010409 thin film Substances 0.000 claims description 3
- 229920000642 polymer Polymers 0.000 claims 1
- 229940088598 enzyme Drugs 0.000 description 20
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 description 4
- 238000004519 manufacturing process Methods 0.000 description 3
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 2
- 235000012000 cholesterol Nutrition 0.000 description 2
- 239000008103 glucose Substances 0.000 description 2
- 235000019420 glucose oxidase Nutrition 0.000 description 2
- 150000002500 ions Chemical class 0.000 description 2
- 239000012528 membrane Substances 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 230000009467 reduction Effects 0.000 description 2
- 239000004065 semiconductor Substances 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- YVXDRFYHWWPSOA-BQYQJAHWSA-N 1-methyl-4-[(e)-2-phenylethenyl]pyridin-1-ium Chemical group C1=C[N+](C)=CC=C1\C=C\C1=CC=CC=C1 YVXDRFYHWWPSOA-BQYQJAHWSA-N 0.000 description 1
- 108010089254 Cholesterol oxidase Proteins 0.000 description 1
- PHOQVHQSTUBQQK-SQOUGZDYSA-N D-glucono-1,5-lactone Chemical compound OC[C@H]1OC(=O)[C@H](O)[C@@H](O)[C@@H]1O PHOQVHQSTUBQQK-SQOUGZDYSA-N 0.000 description 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 1
- 239000004372 Polyvinyl alcohol Substances 0.000 description 1
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 1
- 238000007605 air drying Methods 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 1
- 239000003054 catalyst Substances 0.000 description 1
- 230000003197 catalytic effect Effects 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- GGCLNOIGPMGLDB-GYKMGIIDSA-N cholest-5-en-3-one Chemical compound C1C=C2CC(=O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 GGCLNOIGPMGLDB-GYKMGIIDSA-N 0.000 description 1
- NYOXRYYXRWJDKP-UHFFFAOYSA-N cholestenone Natural products C1CC2=CC(=O)CCC2(C)C2C1C1CCC(C(C)CCCC(C)C)C1(C)CC2 NYOXRYYXRWJDKP-UHFFFAOYSA-N 0.000 description 1
- 239000011248 coating agent Substances 0.000 description 1
- 238000000576 coating method Methods 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 239000012153 distilled water Substances 0.000 description 1
- 230000005669 field effect Effects 0.000 description 1
- 239000010408 film Substances 0.000 description 1
- 230000002070 germicidal effect Effects 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- 235000012209 glucono delta-lactone Nutrition 0.000 description 1
- 229960003681 gluconolactone Drugs 0.000 description 1
- 229910052739 hydrogen Inorganic materials 0.000 description 1
- 239000001257 hydrogen Substances 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- QSHDDOUJBYECFT-UHFFFAOYSA-N mercury Chemical compound [Hg] QSHDDOUJBYECFT-UHFFFAOYSA-N 0.000 description 1
- 229910052753 mercury Inorganic materials 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 238000005502 peroxidation Methods 0.000 description 1
- 238000006116 polymerization reaction Methods 0.000 description 1
- 229920002451 polyvinyl alcohol Polymers 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 238000007127 saponification reaction Methods 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
Landscapes
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP61078983A JPS62235556A (ja) | 1986-04-04 | 1986-04-04 | 複合化酵素センサ− |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP61078983A JPS62235556A (ja) | 1986-04-04 | 1986-04-04 | 複合化酵素センサ− |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS62235556A JPS62235556A (ja) | 1987-10-15 |
| JPH0584458B2 true JPH0584458B2 (enrdf_load_stackoverflow) | 1993-12-02 |
Family
ID=13677123
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP61078983A Granted JPS62235556A (ja) | 1986-04-04 | 1986-04-04 | 複合化酵素センサ− |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS62235556A (enrdf_load_stackoverflow) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2536780B2 (ja) * | 1988-11-10 | 1996-09-18 | 株式会社エー・アンド・デイ | 使い拾て型酵素電極 |
| US6306594B1 (en) | 1988-11-14 | 2001-10-23 | I-Stat Corporation | Methods for microdispensing patterened layers |
| US5212050A (en) * | 1988-11-14 | 1993-05-18 | Mier Randall M | Method of forming a permselective layer |
| US5063081A (en) * | 1988-11-14 | 1991-11-05 | I-Stat Corporation | Method of manufacturing a plurality of uniform microfabricated sensing devices having an immobilized ligand receptor |
| US5200051A (en) * | 1988-11-14 | 1993-04-06 | I-Stat Corporation | Wholly microfabricated biosensors and process for the manufacture and use thereof |
| JP4050974B2 (ja) * | 2002-10-17 | 2008-02-20 | 株式会社エスアールエル | 無線型センサ |
-
1986
- 1986-04-04 JP JP61078983A patent/JPS62235556A/ja active Granted
Also Published As
| Publication number | Publication date |
|---|---|
| JPS62235556A (ja) | 1987-10-15 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US5445920A (en) | Fabrication process of biosensor | |
| US4894339A (en) | Immobilized enzyme membrane for a semiconductor sensor | |
| Nakamoto et al. | A lift-off method for patterning enzyme-immobilized membranes in multi-biosensors | |
| JP3105919B2 (ja) | 完全マイクロ加工バイオセンサー、その製造方法およびその使用 | |
| Suzuki et al. | Fabrication of an oxygen electrode using semiconductor technology | |
| Hanazato et al. | Integrated multi-biosensors based on an ion-sensitive field-effect transistor using photolithographic techniques | |
| JPH0584458B2 (enrdf_load_stackoverflow) | ||
| Nakako et al. | Neutral lipid enzyme electrode based on ion-sensitive field effect transistors | |
| JPH0548418B2 (enrdf_load_stackoverflow) | ||
| US20150369770A1 (en) | Biosensor and method for manufacturing same | |
| JPS61218932A (ja) | イオン高感度電界効果トランジスタ及びその製造方法 | |
| JPH0623719B2 (ja) | 酵素センサ−の製造方法 | |
| JP2617745B2 (ja) | 細微狭小領域への生体触媒の固定化方法 | |
| JPH0365866B2 (enrdf_load_stackoverflow) | ||
| JPS6366454A (ja) | 酵素センサ−およびその製造方法 | |
| JPS6232351A (ja) | 酵素センサ− | |
| JP2530341B2 (ja) | グルコ―ス感応性ｆｅｔセンサおよびその製造方法 | |
| JPS6275346A (ja) | 酵素センサ− | |
| JP2567387B2 (ja) | グルコース感応ｆｅｔセンサ | |
| JPH0349388B2 (enrdf_load_stackoverflow) | ||
| JPS63186139A (ja) | 酵素固定化膜の選択的失活方法 | |
| JPS61262652A (ja) | グルコースセンサー | |
| JPS63241346A (ja) | プレ−ナ型バイオセンサの製造方法 | |
| JPH09159645A (ja) | 尿糖バイオセンサ | |
| JPH0515984B2 (enrdf_load_stackoverflow) |