JPH0558867A - Dermal external preparation - Google Patents

Abstract

PURPOSE:To provide the subject preparation excellent in sweating-inhibitory activity, comprising aluminum hydroxychloride, a polyol, lower monohydric alcohol and water. CONSTITUTION:The objective external preparation comprises (A) 0.01-60wt.% of aluminum hydroxychloride, (B) 0.01-20wt.% of a polyol (e.g. 1,3-butanediol), (C) 3-60wt.% of a lower monohydric alcohol (e.g. ethanol), and (D) 1-96.98wt.% of water. The present preparation is used in the form of face lotion, lotion, body lotion, deodorant lotion, deodorant spray, hair tonic, or milky lotion, having excellent sweating-inhibitory effect by mere application on the skin, being useful as a sweating-inhibitory external preparation, esp. for open sites such as the body and face, and, when applied on the face, being excellent in the inhibitory effect on makeup spoilage due to sweating.

Description

Detailed Description of the Invention

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a skin external preparation having an excellent antiperspirant action.

[0002]

2. Description of the Related Art As adverse effects of excessive sweating, there are axillary odor, discoloration of makeup, stickiness of the body, and the like.
In order to prevent this, various antiperspirants have been conventionally used especially for underarm use. Aluminum hydroxychloride is widely known as a typical component of this antiperspirant. Aluminum hydroxychloride is not irritating to the skin and is mild, and thus has come to be widely used especially for axilla.

[0003]

However, the most widely used aluminum hydroxychloride does not exhibit a sufficient perspiration inhibiting effect unless it is kept in contact with the skin in an aqueous solution for a certain period of time. When the contained aqueous solution is applied to an open site such as a face instead of a closed site such as an axilla, the solution dries immediately, so that there is a problem that a perspiration suppressing effect is hardly observed. Therefore, an object of the present invention is to provide an external preparation for skin which contains aluminum hydroxychloride and has an excellent antiperspirant effect by simply applying it to the skin.

[0004]

Therefore, the present inventors have
As a result of repeated research to solve such problems, when aluminum hydroxide is used in combination with polyols, lower monohydric alcohol and water, it is excellent even when used on open areas such as the face only by applying it to the skin. The present invention has been completed based on the finding that an antiperspirant effect can be obtained.

That is, the present invention provides an external preparation for skin which is characterized by containing aluminum hydroxy chloride, polyols, a lower monohydric alcohol and water.

Aluminum hydroxychloride used in the external preparation for skin of the present invention is blended as a perspiration inhibiting agent, and is represented by the following formula (1). [Al ₂ (OH) ₅ ] Cl.2-3H ₂ O (1) As this aluminum hydroxychloride, for example, that sold by Hoechst AG under the trade name LOCRON can be used. The amount of the aluminum hydroxy chloride compounded is not particularly limited as long as it has an antiperspirant effect, but is 0.01 to 60% by weight (hereinafter simply referred to as%) in the external preparation of the present invention, particularly 0.1 to It is preferably 10%.

Examples of polyols include propylene glycol, isoprene glycol (manufactured by Kuraray Co., Ltd.),
1,3-butanediol, dipropylene glycol, glycerin, diglycerin, triglycerin, polyglycerin, trimethylolpropane, erythritol, pentaerythritol, sorbitan, sorbitol, glucose, maltitol, saccharose, trehalose, sugar or sugar derivative ethylene. Oxide or propylene oxide adduct, polyethylene glycol and the like,
Particularly preferred are ethylene oxide adducts of sugar derivatives such as glycerin, sorbitol, maltitol, and polyoxyethylene methyl glucoside. These alone or 2
Used in combination with more than one species. These polyols can be blended in the external preparation for skin of the present invention in an amount of 0.01 to 20%, preferably 0.1 to 10%.

Examples of the lower monohydric alcohol include ethanol and isopropanol, which may be used alone or in combination. These lower monohydric alcohols are contained in the skin external preparation of the present invention in an amount of 3 to 60%, particularly 1%.
It is preferable to add 0 to 20%.

In the external preparation for skin of the present invention, water is 1
˜96.98%, particularly preferably 5 to 85.5%.

The external preparation for skin of the present invention can be used as a lotion, lotion, body lotion, deodorant lotion, deodorant spray, hair tonic, emulsion, etc. The production method thereof is not particularly limited, and it can be prepared according to a conventional method. Be seen.

In addition to the above-mentioned essential components, the external preparation for skin of the present invention contains various additives such as moisturizers, touch improvers, pH adjusters, preservatives, as long as the effects of the present invention are not impaired.
Medicinal agents, solid fats, liquid oils, silicone oils, ultraviolet absorbers, chelating agents, surfactants, fragrances, powders and the like can be added. Here, examples of the moisturizer include amino acids, sodium pyrrolidonecarboxylate, polyoxypropylene fatty acid ester, and the like; examples of the texture-improving agent include polymers such as cationized cellulose, silicones such as polyether-modified silicone, and dimethylpolysiloxane. ,
Proteins such as atelocollagen K, fibroin, elastin and the like; pH adjusters such as lactic acid-sodium lactate and citric acid-sodium citrate buffers; preservatives such as urea, methyl paraben, ethyl paraben, Propyl paraben, butyl paraben, sodium benzoate and the like can be mentioned; as the medicinal agents, tocopherols, horse chestnut extract, β-glycyrrhetinic acid, various fungicides and the like can be mentioned. Examples of solid fats include polyunsaturated fatty acid derivatives (for example, those having two or more double bonds at C12-24), such as monounsaturated fatty acids, diglycerides, triglycerides, lower alcohol esters or amides of polyunsaturated fatty acids. Phospholipids,
Examples thereof include glycolipids and sphingolipids. Examples of other solid fats include cholesterol fatty acid esters and glyceryl ethers. As the surfactant, polyoxyethylene sorbitan monopalmitate,
Polyoxyethylene sorbitan monostearate, tetraoleic acid polyoxyethylene sorbit, glycerol monostearate, sorbitan monostearate,
Nonionic surfactants such as polyoxyethylene hydrogenated castor oil and sodium polyoxyethylene lauryl ether phosphate may be mentioned.

[0012]

The external preparation for skin of the present invention has an excellent antiperspirant effect only when applied to the skin, and therefore is particularly useful as an external preparation for the perspiration control of open areas such as the body and face, and further on the face. When used, it has an excellent effect of preventing makeup from being damaged by sweat.

[0013]

EXAMPLES The present invention will now be described in detail with reference to examples, but the scope of the present invention is not limited to these examples. In the following examples, the amount of sweating was measured as follows. The upper arm side of the subject's forearm is used vertically in two places, one is the sample application section and the other is the control section. Sample is 200μ in the area of 2cm × 4cm
Apply 1 and air dry. One hour after the application of the sample, a 2 cm × 4 cm dry filter paper is placed on the sample application part and the control part, and the sample is covered with 2.5 cm × 4.5 cm parafilm and then sealed with tape. The test subject is allowed to enter a room at 40 ° C. and a humidity of 60% for 10 minutes, forcibly sweats, and the sweat is collected on a filter paper. The water content of the collected sweat was measured by the Karl Fischer method and used as the sweat rate. The perspiration inhibition rate by applying the sample was calculated by the following formula.

[0014]

[Equation 1]

Example 1 (Composition) Aluminum hydroxychloride 0.5 1,3-butanediol 4.0 Ethanol 10.0 Water 85.5 100.0 (g) (Production method) Aluminum hydroxychloride and polyols ( 1,3-butyl glycerin) was dissolved, and this was mixed with a lower alcohol (ethanol) and dissolved to prepare the solution. (Evaluation) As a result of conducting the above clinical test on 10 male and 10 female test subjects, a sweat inhibition rate of 36% was shown.

Example 2 By the same production method as in Example 1, an external skin preparation having the following composition was obtained. (Composition) Aluminum hydroxychloride 5.0 Glycerin 5.0 Ethanol 15.0 Water 75.0 100.0 (g) When this external preparation for skin was clinically tested in the same manner as in Example 1, it was 31.5%. The rate of inhibition of sweating was shown.

Example 3 A skin external preparation having the following composition was obtained by the same production method as in Example 1. (Composition) Aluminum hydroxychloride 3.0 Propylene glycol 8.0 Ethanol 20.0 Water 69.0 100.0 (g) When this external preparation for skin was subjected to the same clinical test as in Example 1, 27.6% was obtained. The rate of inhibition of sweating was shown.

Example 4 (Lotion) (Composition) (1) Aluminum hydroxychloride 0.5 (2) Propylene glycol 4.0 (3) Dipropylene glycol 4.0 (4) Polyoxyethylene (EO = 20) Sorbitan monolaurate 1.5 (5) Polyoxyethylene (EO = 80) lauryl alcohol ether 0.5 (6) Glycerin 3.0 (7) Ethanol 10.0 (8) Water 76.5 100.0 (g ) (Production method) (6), (1), (2) and (3) in water (8)
Is dissolved at room temperature. On the other hand, (4) and (5) are dissolved in ethanol (7) at room temperature. Toner lotion was obtained by mixing these solutions at room temperature. (Evaluation) When the same clinical test as in Example 1 was carried out, this lotion showed a perspiration inhibition rate of 32.4%.

Example 5 (Deodorant spray for body) (Undiluted solution composition) (1) Aluminum hydroxychloride 6.0 (2) Isopropyl myristate ester 2.0 (3) Trioleyl phosphate ester 3.0 (4) Glycerin 5.0 (5) Water 5.0 (6) Ethanol 79.0 100.0 (g) (Production method) (2) to (4) are dissolved in ethanol (6) at room temperature. On the other hand, (1) is dissolved in water (5). These solutions were mixed at room temperature to obtain a stock solution. A pressure-resistant can was filled with the stock solution, and then a valve was attached and then LPG was filled to obtain a deodorant spray. (Evaluation) When the same clinical test as in Example 1 was carried out, this deodorant spray showed a 29.5% antiperspirant rate.

Example 6 (Deodorant lotion for body) (Composition) (1) Aluminum hydroxychloride 20.0 (2) Glycerin 1.0 (3) Propylene glycol 5.0 (4) Polyoxyethylene (EO = 20) Oleyl alcohol ether 0.5 (5) ethanol 25.0 (6) water 48.5 100.0 (g) (production method) (1) to (3) are dissolved in water (6) at room temperature.
On the other hand, (4) is dissolved in ethanol (5) at room temperature. These solutions were mixed to obtain a deodorant lotion. (Evaluation) When the same clinical test as in Example 1 was carried out, this deodorant lotion showed a perspiration inhibiting rate of 31.0%.

Claims (1)

[Claims] 1. A skin external preparation containing aluminum hydroxy chloride, polyols, a lower monohydric alcohol and water.