JPH04506810A - テクネチウム放射性薬剤の新しいコア - Google Patents
テクネチウム放射性薬剤の新しいコアInfo
- Publication number
- JPH04506810A JPH04506810A JP2513310A JP51331090A JPH04506810A JP H04506810 A JPH04506810 A JP H04506810A JP 2513310 A JP2513310 A JP 2513310A JP 51331090 A JP51331090 A JP 51331090A JP H04506810 A JPH04506810 A JP H04506810A
- Authority
- JP
- Japan
- Prior art keywords
- complex
- technetium
- substituted
- ligand
- product
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/0474—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group
- A61K51/0478—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group complexes from non-cyclic ligands, e.g. EDTA, MAG3
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/0474—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group
- A61K51/0476—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group complexes from monodendate ligands, e.g. sestamibi
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2123/00—Preparations for testing in vivo
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Optics & Photonics (AREA)
- Physics & Mathematics (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Abstract
Description
Claims (10)
- 1.Tc=NR、Tc−N=NYまたはTc(−N=NY)2(ここにおいて、 Rはアリール、置換または無置換のアルキルまたは=NR1R2であり; Yはアリールまたは置換または無置換のアルキルであり;R1およびR2は水素 、アリールまたは置換または無置換の脂肪族または環状アルキルであり、これら は同一でも異なっていてもよいが、ともに水素である場合は除く)、および 錯体に生物学的標的探索能を与えるリガンドからなるテクネチウム(99Tcま たは99mTc)錯体。
- 2.LnTc=NR (ここにおいて、Lは1価または多価のリガンドであり;nは1、2、3または 4であり; Rは上記定義のとおりである)の構造を有する請求項1の錯体。
- 3.LnTc−N=NY (ここにおいて、Lは1価または多価のリガンドであり;nは1、2、3または 4であり; Yは上記定義のとおりである)の構造を有する請求項1の錯体。
- 4.LnTc(−N=NY)2 (ここにおいて、Lは1価または多価のリガンドであり;nは1、2、3または 4であり; Yは上記定義のとおりである)の構造を有する請求項1の錯体。
- 5.アルキルが酸素、窒素、硫黄および/またはリンで置換されている請求項1 〜4のいずれかに記載の錯体。
- 6.リガンドが:Q2B(CD2)nBQ2(ここにおいて、Qは水素、アリー ルまたは置換または無置換のアルキルであり、BはPまたはAsであり、; (CD2)は置換または無置換のメチレンでありnは1、2、3または4である )で表されるホスフィンまたはアルシンである請求項1〜5のいずれかに記載の 錯体。
- 7.錯体の生物学的標的探索能が存在するリガンドの性質および/または置換基 RおよびYの性質によって決定される放射性薬剤として有用な請求項1〜6のい ずれかに記載の錯体。
- 8.テクネチウムオキソ含有化合物をヒドラジン、アミン、イソシアネート、ス ルフィニルアミンまたはホスフィンイミンと縮合させることによって誘導体とす る工程からなる、 Tc=NR、Tc−N=NYまたはTc(−N=NY)2(ここにおいて、Rお よび上記請求項1の定義のとおりである)を有するテクネチウム(99Tcまた は99mTc)錯体の合成法。
- 9.テクネチウムとハロゲンの結合を有する錯体とヒドラジンまたはアミンとを 反応させることからなる、 Tc=NR、Tc−N=NYまたはTc(−N=NY)2(ここにおいて、Rお よびYは上記請求項1の定義のとおりである)を有するテクネチウム(99Tc または99mTc)錯体の合成法。
- 10.請求項1〜7のいずれかに記載のテクネチウム錯体からなる放射性薬剤。
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB898919488A GB8919488D0 (en) | 1989-08-29 | 1989-08-29 | New cores for technetium radiopharmaceuticals |
GB8919488.0 | 1989-08-29 |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2001197466A Division JP3341001B2 (ja) | 1989-08-29 | 2001-05-25 | テクネチウム放射性薬剤の新しいコア |
Publications (2)
Publication Number | Publication Date |
---|---|
JPH04506810A true JPH04506810A (ja) | 1992-11-26 |
JP3221875B2 JP3221875B2 (ja) | 2001-10-22 |
Family
ID=10662202
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP51331090A Expired - Lifetime JP3221875B2 (ja) | 1989-08-29 | 1990-08-28 | テクネチウム放射性薬剤の新しいコア |
JP2001197466A Expired - Lifetime JP3341001B2 (ja) | 1989-08-29 | 2001-05-25 | テクネチウム放射性薬剤の新しいコア |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2001197466A Expired - Lifetime JP3341001B2 (ja) | 1989-08-29 | 2001-05-25 | テクネチウム放射性薬剤の新しいコア |
Country Status (7)
Country | Link |
---|---|
EP (1) | EP0441953B1 (ja) |
JP (2) | JP3221875B2 (ja) |
AT (1) | ATE131072T1 (ja) |
CA (1) | CA2039732A1 (ja) |
DE (1) | DE69024038T2 (ja) |
GB (1) | GB8919488D0 (ja) |
WO (1) | WO1991003262A1 (ja) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2005507950A (ja) * | 2001-11-09 | 2005-03-24 | シエル・インターナシヨナル・リサーチ・マートスハツペイ・ベー・ヴエー | ジエンのテロメリゼーションのための二座配位子 |
Families Citing this family (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU3133593A (en) * | 1991-11-08 | 1993-06-07 | Curators Of The University Of Missouri, The | Multifunctional ligands for potential use in the design of therapeutic or diagnostic radiopharmaceutical imaging agents |
US5744120A (en) * | 1993-03-30 | 1998-04-28 | The Dupont Merick Pharmaceutical Company | Ternary radiopharmaceutical complexes |
US5879657A (en) * | 1993-03-30 | 1999-03-09 | The Dupont Merck Pharmaceutical Company | Radiolabeled platelet GPIIb/IIIa receptor antagonists as imaging agents for the diagnosis of thromboembolic disorders |
US5750088A (en) * | 1993-03-30 | 1998-05-12 | The Dupont Merck Pharmaceutical Company | Stable hydrazones linked to a peptide moiety as reagents for the preparation of radiopharmaceuticals |
US5541289A (en) * | 1994-03-30 | 1996-07-30 | Washington University | Phosphine containing amino acids and peptides and methods of preparing and using same |
IT1286879B1 (it) * | 1996-11-21 | 1998-07-17 | Consiglio Nazionale Ricerche | Leganti 1,3-difosfinopropanici e complessi da essi formati con metalli di transizione,loro preparazione e uso |
US6403054B1 (en) * | 1997-05-28 | 2002-06-11 | Bristol-Myers Squibb Pharma Company | Ternary ligand complexes useful as radiopharmaceuticals |
US6251364B1 (en) | 1999-03-29 | 2001-06-26 | Dupont Pharmaceuticals Company | Ternary ligand complexes useful as radiopharmaceuticals |
US6534038B2 (en) | 2000-04-07 | 2003-03-18 | Bristol-Myers Squibb Pharma Company | Ternary ligand complexes useful as radiopharmaceuticals |
US6517814B2 (en) | 2001-01-09 | 2003-02-11 | Bristol-Myers Squibb Pharma Company | Macrocyclic chelants useful for metallopharmaceuticals |
US6776977B2 (en) | 2001-01-09 | 2004-08-17 | Bristol-Myers Squibb Pharma Company | Polypodal chelants for metallopharmaceuticals |
EP1417977A1 (en) * | 2002-11-07 | 2004-05-12 | BRACCO IMAGING S.p.A. | Radioactive transition metal-imido hetero-diphosphine complexes, their preparation and radiopharmaceutical compositions thereof |
-
1989
- 1989-08-29 GB GB898919488A patent/GB8919488D0/en active Pending
-
1990
- 1990-08-28 AT AT90914225T patent/ATE131072T1/de active
- 1990-08-28 EP EP90914225A patent/EP0441953B1/en not_active Revoked
- 1990-08-28 CA CA002039732A patent/CA2039732A1/en not_active Abandoned
- 1990-08-28 JP JP51331090A patent/JP3221875B2/ja not_active Expired - Lifetime
- 1990-08-28 WO PCT/GB1990/001330 patent/WO1991003262A1/en not_active Application Discontinuation
- 1990-08-28 DE DE69024038T patent/DE69024038T2/de not_active Revoked
-
2001
- 2001-05-25 JP JP2001197466A patent/JP3341001B2/ja not_active Expired - Lifetime
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2005507950A (ja) * | 2001-11-09 | 2005-03-24 | シエル・インターナシヨナル・リサーチ・マートスハツペイ・ベー・ヴエー | ジエンのテロメリゼーションのための二座配位子 |
Also Published As
Publication number | Publication date |
---|---|
GB8919488D0 (en) | 1989-10-11 |
EP0441953A1 (en) | 1991-08-21 |
WO1991003262A1 (en) | 1991-03-21 |
EP0441953B1 (en) | 1995-12-06 |
DE69024038T2 (de) | 1996-04-25 |
JP3221875B2 (ja) | 2001-10-22 |
ATE131072T1 (de) | 1995-12-15 |
DE69024038D1 (de) | 1996-01-18 |
JP3341001B2 (ja) | 2002-11-05 |
JP2002060397A (ja) | 2002-02-26 |
CA2039732A1 (en) | 1991-03-01 |
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