JPH0441423A - Percutaneous absorbable pharmaceutical and method for percutaneous administration - Google Patents

Percutaneous absorbable pharmaceutical and method for percutaneous administration

Info

Publication number
JPH0441423A
JPH0441423A JP14927590A JP14927590A JPH0441423A JP H0441423 A JPH0441423 A JP H0441423A JP 14927590 A JP14927590 A JP 14927590A JP 14927590 A JP14927590 A JP 14927590A JP H0441423 A JPH0441423 A JP H0441423A
Authority
JP
Grant status
Application
Patent type
Prior art keywords
percutaneous
temperature
membrane
ch
phase transition
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP14927590A
Inventor
Koichi Ikeda
Mitsuo Okano
Yasuhisa Sakurai
Original Assignee
Nippon Kayaku Co Ltd
Tokyo Jiyoshi Ika Univ
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date

Links

Abstract

PURPOSE: To obtain a percutaneous absorbable pharmaceutical, responsive to a change in external temperatures and capable of on-off control over percutaneous administration of a drug with hardly any individual difference by using a temperature-responsive hydrogel membrane in a release control membrane.
CONSTITUTION: A temperature-responsive hydrogel membrane capable of absorbing water and swelling below the phase transition temperature, releasing water and contracting above the phase transition temperature is used in a release control membrane of a percutaneous pharmaceutical containing 4 layers of a coating layer, a drug storing layer, the aforementioned release control layer and a tacky layer. A water-insoluble polymer prepared by using ≥50 mol%, especially ≥75 mol% compound (e.g. N-n-propylacrylamide) expressed by formula I (R1 is H or methyl; R2 and R3 are H or lower alkyl) and/or a compound (e.g. N-acryloylpyrrolidine) expressed by formula II [A is (CH2)n (n is 4-6) or (CH2)2-O-(CH2)2] is used as the temperature-responsive hydrogel membrane and the phase transition temperature thereof is preferably within the range of 0-50°C, especially 20-32°C.
COPYRIGHT: (C)1992,JPO&Japio
JP14927590A 1990-06-07 1990-06-07 Percutaneous absorbable pharmaceutical and method for percutaneous administration Pending JPH0441423A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP14927590A JPH0441423A (en) 1990-06-07 1990-06-07 Percutaneous absorbable pharmaceutical and method for percutaneous administration

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP14927590A JPH0441423A (en) 1990-06-07 1990-06-07 Percutaneous absorbable pharmaceutical and method for percutaneous administration

Publications (1)

Publication Number Publication Date
JPH0441423A true true JPH0441423A (en) 1992-02-12

Family

ID=15471655

Family Applications (1)

Application Number Title Priority Date Filing Date
JP14927590A Pending JPH0441423A (en) 1990-06-07 1990-06-07 Percutaneous absorbable pharmaceutical and method for percutaneous administration

Country Status (1)

Country Link
JP (1) JPH0441423A (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7223826B2 (en) * 2003-01-30 2007-05-29 3M Innovative Properties Company Amide-functional polymers, compositions, and methods
US8900556B2 (en) 2003-01-30 2014-12-02 3M Innovative Properties Company Hardenable thermally responsive compositions

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7223826B2 (en) * 2003-01-30 2007-05-29 3M Innovative Properties Company Amide-functional polymers, compositions, and methods
US8900556B2 (en) 2003-01-30 2014-12-02 3M Innovative Properties Company Hardenable thermally responsive compositions

Similar Documents

Publication Publication Date Title
US4376118A (en) Stable nonaqueous solution of tetracycline salt
Ishihara et al. Controlled release of organic substances using polymer membrane with responsive function for amino compounds
JPH0467986A (en) Coating solution
JPS62286961A (en) Novel oxime ester compound and production thereof
JPH02202813A (en) Percutaneous absorbing preparation
JPS59210083A (en) 1,3,4-thiadiazol-5-one derivative, its preparation, and herbicide containing said derivative as active component
JPH02242858A (en) Water-absorbing agent and production thereof
JPH03179323A (en) Composition for liquid crystal oriented film
JPH04364123A (en) Coating material and enteric granule produced by using the same
JPH04218528A (en) In vivo degradable type high-molecular polymer
JPS535180A (en) Preparation of 3,4-dihydro-2 (1h) quinazoline derivatives
JPS55110111A (en) Preparation of highly water-absorbing hydrogel
JPH02214731A (en) Polymeric oriented film substrate
JPH04326932A (en) Polyester porous film
JPH01287019A (en) Slowly releasing drug preparation
JPS63186722A (en) Selfcrosslinking resin composition
JPH0352903A (en) Production of water-absorptive resin with little water-solubles
JPS63308087A (en) Temperature-dependent photochromic composition
JPS6393718A (en) Injection
JPS5813624A (en) Preparation of polyglycolic acid
JPH02183231A (en) Material for organic nonlinear optical element and organic nonlinear optical thin-film formed by using this material
JPS6123656A (en) Anti-icing organic coating composition
JPH04360826A (en) Controlled release pharmaceutical preparation
JPS5594955A (en) Film-forming coating solution
JPH03264589A (en) Triazolo-1,4-diazepine compound