JPH0440347B2 - - Google Patents

Info

Publication number
JPH0440347B2
JPH0440347B2 JP56086555A JP8655581A JPH0440347B2 JP H0440347 B2 JPH0440347 B2 JP H0440347B2 JP 56086555 A JP56086555 A JP 56086555A JP 8655581 A JP8655581 A JP 8655581A JP H0440347 B2 JPH0440347 B2 JP H0440347B2
Authority
JP
Japan
Prior art keywords
group
dimethylpyrimidine
crystals
cyclopenta
dihydro
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
JP56086555A
Other languages
English (en)
Japanese (ja)
Other versions
JPS57203072A (en
Inventor
Toshiharu Kamioka
Isao Nakayama
Takeo Pponda
Takashi Furubayashi
Tokio Obata
Katsutoshi Fujii
Mikio Kojima
Juji Akyoshi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sankyo Co Ltd
Ube Corp
Original Assignee
Sankyo Co Ltd
Ube Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sankyo Co Ltd, Ube Industries Ltd filed Critical Sankyo Co Ltd
Priority to JP56086555A priority Critical patent/JPS57203072A/ja
Priority to PH27381A priority patent/PH20130A/en
Priority to US06/384,416 priority patent/US4450162A/en
Priority to EP82302870A priority patent/EP0067630B1/en
Priority to DE8282302870T priority patent/DE3263653D1/de
Priority to ES512880A priority patent/ES8307760A1/es
Priority to KR8202513A priority patent/KR880002234B1/ko
Priority to FI821990A priority patent/FI77454C/fi
Priority to CA000404529A priority patent/CA1169861A/en
Priority to ZA823917A priority patent/ZA823917B/xx
Publication of JPS57203072A publication Critical patent/JPS57203072A/ja
Publication of JPH0440347B2 publication Critical patent/JPH0440347B2/ja
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/42—One nitrogen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Psychiatry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
JP56086555A 1981-06-05 1981-06-05 4-anilinopyrimidine derivative, its preparation, antidepressant comprising it as active ingredient Granted JPS57203072A (en)

Priority Applications (10)

Application Number Priority Date Filing Date Title
JP56086555A JPS57203072A (en) 1981-06-05 1981-06-05 4-anilinopyrimidine derivative, its preparation, antidepressant comprising it as active ingredient
PH27381A PH20130A (en) 1981-06-05 1982-05-31 Pyrimidine derivatives,a process for preparing them and pharmaceutical composition containing them
US06/384,416 US4450162A (en) 1981-06-05 1982-06-02 Pyrimidine derivatives and a pharmaceutical composition containing them
EP82302870A EP0067630B1 (en) 1981-06-05 1982-06-03 Pyrimidine derivatives, a process for preparing them and a pharmaceutical composition containing them
DE8282302870T DE3263653D1 (en) 1981-06-05 1982-06-03 Pyrimidine derivatives, a process for preparing them and a pharmaceutical composition containing them
ES512880A ES8307760A1 (es) 1981-06-05 1982-06-04 Un procedimiento para la preparacion de derivados de 4-anilino-pirimidina.
KR8202513A KR880002234B1 (ko) 1981-06-05 1982-06-04 4-아닐리노피리미딘 유도체의 제조방법
FI821990A FI77454C (fi) 1981-06-05 1982-06-04 Foerfarande foer framstaellning av som laekemedel anvaendbara 4-anilino-pyrimidinderivat.
CA000404529A CA1169861A (en) 1981-06-05 1982-06-04 Pyrimidine derivatives, a process for preparing them and a pharmaceutical composition containing them
ZA823917A ZA823917B (en) 1981-06-05 1982-06-04 Pyrimidine derivatives, a process for preparing them and a pharmaceutical composition containing them

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP56086555A JPS57203072A (en) 1981-06-05 1981-06-05 4-anilinopyrimidine derivative, its preparation, antidepressant comprising it as active ingredient

Publications (2)

Publication Number Publication Date
JPS57203072A JPS57203072A (en) 1982-12-13
JPH0440347B2 true JPH0440347B2 (forum.php) 1992-07-02

Family

ID=13890246

Family Applications (1)

Application Number Title Priority Date Filing Date
JP56086555A Granted JPS57203072A (en) 1981-06-05 1981-06-05 4-anilinopyrimidine derivative, its preparation, antidepressant comprising it as active ingredient

Country Status (10)

Country Link
US (1) US4450162A (forum.php)
EP (1) EP0067630B1 (forum.php)
JP (1) JPS57203072A (forum.php)
KR (1) KR880002234B1 (forum.php)
CA (1) CA1169861A (forum.php)
DE (1) DE3263653D1 (forum.php)
ES (1) ES8307760A1 (forum.php)
FI (1) FI77454C (forum.php)
PH (1) PH20130A (forum.php)
ZA (1) ZA823917B (forum.php)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK130584A (da) * 1983-04-08 1984-10-09 Ciba Geigy Ag N-(2-nitrophenyl)-4-amino-pyrimidin-derivater samt deres fremstilling og anvendelse som mikrobicider
PH21918A (en) * 1983-07-25 1988-04-08 Ciba Geigy Ag N-(2-nitrophenyl)-5-aminopyrimidine derivatives,the preparation and use thereof
EP0139613A1 (de) * 1983-08-29 1985-05-02 Ciba-Geigy Ag N-(2-Nitrophenyl)-4-aminopyrimidin-Derivate, deren Herstellung und Verwendung
US4725600A (en) * 1984-07-13 1988-02-16 Fujisawa Pharmaceutical Co., Ltd. Pyrimidine compounds having activity as a cardiotonic anti-hypertensive cerebrovascular vasodilator and anti-platelet aggregation agent
JPS6270A (ja) * 1985-03-07 1987-01-06 Sankyo Co Ltd シクロペンタ〔ｄ〕ピリミジン誘導体
DE3618353A1 (de) * 1986-05-31 1987-12-03 Hoechst Ag Schaedlingsbekaempfungsmittel auf der basis von aminopyrimidin-derivaten sowie neue aminopyrimidin-verbindungen
US5037980A (en) * 1988-04-18 1991-08-06 American Cyanamid Company Phenyl imidazo[1,2-a]pyrimidines
GR900100380A (el) * 1989-05-20 1991-10-10 Fisons Plc Μέ?οδος παρασκευής αντι-φλεγμονωδών παραγώγων αμινοφενόλης.
US5234936A (en) * 1991-10-24 1993-08-10 American Home Products Corporation Pyrimidocycloalkanes as a ii antagonists
WO1994007890A1 (en) * 1992-10-05 1994-04-14 Ube Industries, Ltd. Pyrimidine compound
KR100643419B1 (ko) * 1998-03-27 2006-11-10 얀센 파마슈티카 엔.브이. Ｈｉｖ를 억제하는 피리미딘 유도체
CZ299380B6 (cs) * 1998-03-27 2008-07-09 Janssen Pharmaceutica N. V. Pyrimidinová sloucenina, použití této slouceniny pro prípravu léciva, farmaceutický prostredek tutoslouceninu obsahující, zpusob prípravy tohoto prostredku a uvedené slouceniny a kombinace a produktuvedenou slouceninu obsahující
EA005423B1 (ru) 1999-09-24 2005-02-24 Янссен Фармацевтика Н.В. Противовирусные композиции
CN100398524C (zh) * 2003-08-12 2008-07-02 弗·哈夫曼-拉罗切有限公司 作为crf拮抗剂的四氢喹唑啉衍生物
CN101084214A (zh) 2004-11-17 2007-12-05 迈卡纳治疗股份有限公司 激酶抑制剂
NZ567241A (en) * 2005-09-30 2010-08-27 Miikana Therapeutics Inc Substituted pyrazole compounds
EP2166849A4 (en) * 2007-06-11 2010-09-15 Miikana Therapeutics Inc SUBSTITUTED PYRAZOL COMPOUNDS
US8946239B2 (en) 2008-07-10 2015-02-03 Duquesne University Of The Holy Spirit Substituted pyrrolo, -furano, and cyclopentylpyrimidines having antimitotic and/or antitumor activity and methods of use thereof
WO2015160489A2 (en) 2014-04-03 2015-10-22 Duquesne University Of The Holy Spirit Substituted cyclopenta pyrimidine bicyclic compounds having antimitotic and/or antitumor activity and methods of use thereof
GB2578974B (en) * 2015-04-17 2020-08-19 Univ Holy Ghost Duquesne Cyclopenta[d]pyrimidines as antitubulin and antitumor agents

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2719846A (en) * 1954-05-06 1955-10-04 Searle & Co 4[n-(beta-diethylaminoethyl) anilino]-pyrimidine and acid addition salts thereof
US3321478A (en) * 1963-09-20 1967-05-23 American Cyanamid Co Aminoethoxyphenyl amine, ether, and sulfide derivatives of pyrimidine
FR2190818B1 (forum.php) * 1972-06-28 1975-03-07 Roussel Uclaf
CH593266A5 (forum.php) * 1973-09-20 1977-11-30 Delalande Sa
DE2626495A1 (de) * 1976-06-12 1977-12-29 Bayer Ag Quartaere reaktivverbindungen

Also Published As

Publication number Publication date
ZA823917B (en) 1983-04-27
FI77454B (fi) 1988-11-30
US4450162A (en) 1984-05-22
KR880002234B1 (ko) 1988-10-20
ES512880A0 (es) 1983-08-01
DE3263653D1 (en) 1985-06-13
EP0067630B1 (en) 1985-05-08
ES8307760A1 (es) 1983-08-01
CA1169861A (en) 1984-06-26
KR840000508A (ko) 1984-02-22
FI821990A0 (fi) 1982-06-04
JPS57203072A (en) 1982-12-13
FI77454C (fi) 1989-03-10
PH20130A (en) 1986-10-02
EP0067630A1 (en) 1982-12-22

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