JPH04334357A - Acyl derivative having enzyme-inhibiting action - Google Patents

Acyl derivative having enzyme-inhibiting action

Info

Publication number
JPH04334357A
JPH04334357A JP12825691A JP12825691A JPH04334357A JP H04334357 A JPH04334357 A JP H04334357A JP 12825691 A JP12825691 A JP 12825691A JP 12825691 A JP12825691 A JP 12825691A JP H04334357 A JPH04334357 A JP H04334357A
Authority
JP
Japan
Prior art keywords
compound
formula
etc
agent
inhibiting action
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP12825691A
Inventor
Akihiko Hosoda
Jiro Inaba
Takahide Nakayama
Yasuo Sekine
Masahiro Shibata
Kazuhiko Takasaki
Naoko Tanabe
Original Assignee
Fujirebio Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fujirebio Inc filed Critical Fujirebio Inc
Priority to JP12825691A priority Critical patent/JPH04334357A/en
Publication of JPH04334357A publication Critical patent/JPH04334357A/en
Application status is Pending legal-status Critical

Links

Abstract

PURPOSE: To provide a novel compound having a prolyl endopeptibase activity- inhibiting action and useful as an anti-dement agent, especially an anti-amnestic agent.
CONSTITUTION: A compound of formula I [X is COR1, CO2R2, SO2R3, etc., (R1-R3 are H, 1-15C hydrocarbon, etc.,); Y, Z are methine, N; A is single bond, methylene, 2-3C polymethylene; B is methylene, 2-3C polymethylene; W is amino acid residue,-D-CO-(D is 1-4C alkylene, etc.,); n is 0,1; C is -OR9, -N(R10)(R11) (R9 is 1-10C hydrocarbon; R10, R11 can be combined with each other into a substitutable cyclic ring group)], e.g. N-(D,L-1-benzyloxycarbonylpiperidine-2- carbonyl)(L)-methionine ethyl ester. The compound of formula I is produced by reacting a compound of formula II with a compound of formula: E2-(W)n-C(E2 is the same as E1) in the presence of a condensing agent (e.g. carbonyldiimidazole) in a solvent such as THF at -20 to 30°C.
COPYRIGHT: (C)1992,JPO&Japio
JP12825691A 1991-05-02 1991-05-02 Acyl derivative having enzyme-inhibiting action Pending JPH04334357A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP12825691A JPH04334357A (en) 1991-05-02 1991-05-02 Acyl derivative having enzyme-inhibiting action

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP12825691A JPH04334357A (en) 1991-05-02 1991-05-02 Acyl derivative having enzyme-inhibiting action

Publications (1)

Publication Number Publication Date
JPH04334357A true JPH04334357A (en) 1992-11-20

Family

ID=14980359

Family Applications (1)

Application Number Title Priority Date Filing Date
JP12825691A Pending JPH04334357A (en) 1991-05-02 1991-05-02 Acyl derivative having enzyme-inhibiting action

Country Status (1)

Country Link
JP (1) JPH04334357A (en)

Cited By (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0706999A1 (en) * 1993-06-30 1996-04-17 Sumitomo Pharmaceuticals Company, Limited Novel dipiperidine derivative
WO1999003832A1 (en) * 1997-07-14 1999-01-28 Phytera Symbion Aps Piperidine oligomers and combinatorial libraries thereof
WO1999061431A1 (en) * 1998-05-28 1999-12-02 Probiodrug Gesellschaft für Arzneimittelforschung mbH New dipeptidyl peptidase iv effectors
WO2001023376A1 (en) * 1999-09-29 2001-04-05 Ortho-Mcneil Pharmaceutical, Inc. Isonipecotamides for the treatment of integrin-mediated disorders
WO2001047887A1 (en) * 1999-12-24 2001-07-05 Bayer Aktiengesellschaft β-AMINO ACID COMPOUNDS AS INTEGRIN ANTAGONISTS
US6303661B1 (en) 1996-04-25 2001-10-16 Probiodrug Use of dipeptidyl peptidase IV effectors for lowering the blood glucose level in mammals
US6319893B1 (en) 1998-07-31 2001-11-20 Probiodrug Raising blood sugar level in hypoglycemic mammals by administering inhibitors of dipeptidyl peptidase IV
US6500804B2 (en) 2000-03-31 2002-12-31 Probiodrug Ag Method for the improvement of islet signaling in diabetes mellitus and for its prevention
US6559314B2 (en) 1999-06-10 2003-05-06 Probiodrug Ag Method for the production of thiazolidin
US6844316B2 (en) 2001-09-06 2005-01-18 Probiodrug Ag Inhibitors of dipeptidyl peptidase I
WO2005016883A3 (en) * 2003-08-14 2005-04-14 Steven A Boyd Acrylamide derivatives as vla-1 integrin antagonists and uses thereof
US6890905B2 (en) 2001-04-02 2005-05-10 Prosidion Limited Methods for improving islet signaling in diabetes mellitus and for its prevention
EP1533310A1 (en) * 1999-09-29 2005-05-25 Ortho-McNeil Pharmaceutical, Inc. Isonipecotamides for the treatment of integrin-mediated disorders
US6946480B2 (en) 2002-02-28 2005-09-20 Hans-Ulrich Demuth Glutaminyl based DPIV inhibitors
US6949515B2 (en) 1999-08-24 2005-09-27 Probiodrug Ag Effectors of dipeptidyl peptidase IV for topical use
US7053055B2 (en) 1998-06-24 2006-05-30 Prosidion Ltd. Compounds of unstable DP IV-inhibitors
US7081460B2 (en) 2001-04-09 2006-07-25 Ortho-Mcneil Pharmaceutical, Inc. Quinazoline and quinazoline-like compounds for the treatment of integrin-mediated disorders
WO2006012226A3 (en) * 2004-06-24 2006-07-27 Incyte Corp N-substituted piperidines and their use as pharmaceuticals
US7084120B2 (en) 1998-06-24 2006-08-01 Probiodrug Ag Prodrugs of DP IV-inhibitors
US7109347B2 (en) 2001-06-27 2006-09-19 Probiodrug Ag Dipeptidyl peptidase IV inhibitors and their uses as anti-cancer agents
US7132104B1 (en) 2000-10-27 2006-11-07 Probiodrug Ag Modulation of central nervous system (CNS) dipeptidyl peptidase IV (DPIV) -like activity for the treatment of neurological and neuropsychological disorders
US7304081B2 (en) 2004-05-07 2007-12-04 Incyte Corporation Amido compounds and their use as pharmaceuticals
US7368421B2 (en) 2001-06-27 2008-05-06 Probiodrug Ag Use of dipeptidyl peptidase IV inhibitors in the treatment of multiple sclerosis
US7371871B2 (en) 2003-05-05 2008-05-13 Probiodrug Ag Inhibitors of glutaminyl cyclase
US7381537B2 (en) 2003-05-05 2008-06-03 Probiodrug Ag Use of inhibitors of glutaminyl cyclases for treatment and prevention of disease
JP2008535892A (en) * 2005-04-11 2008-09-04 プロビオドルグ エージー Prolyl endopeptidase inhibitors
US7608577B2 (en) 2001-10-12 2009-10-27 Osi Pharmaceuticals, Inc. Peptidyl ketones as inhibitors of DPIV
US7687665B2 (en) 2004-06-24 2010-03-30 Incyte Corporation 2-methylprop anamides and their use as pharmaceuticals
US7838544B2 (en) 2006-05-17 2010-11-23 Incyte Corporation Heterocyclic inhibitors of 11-β hydroxyl steroid dehydrogenase type 1 and methods of using the same
US7897633B2 (en) 2004-02-05 2011-03-01 Probiodrug Ag Inhibitors of glutaminyl cyclase
US7998959B2 (en) 2006-01-12 2011-08-16 Incyte Corporation Modulators of 11-β hydroxyl steroid dehydrogenase type 1, pharmaceutical compositions thereof, and methods of using the same
US8193207B2 (en) 2005-12-05 2012-06-05 Incyte Corporation Lactam compounds and methods of using the same
US9434692B2 (en) 2006-10-03 2016-09-06 Arena Pharmaceuticals, Inc. Pyrazole derivatives as modulators of the 5-HT2A serotonin receptor useful for the treatment of disorders related thereto
US9745270B2 (en) 2008-10-28 2017-08-29 Arena Pharmaceuticals, Inc. Processes useful for the preparation of 1-[3-(4-bromo-2-methyl-2H-pyrazol-3-yl)-4-methoxy-phenyl]-3-(2,4-difluoro-phenyl)-urea and crystalline forms related thereto
US9775829B2 (en) 2003-07-22 2017-10-03 Arena Pharmaceuticals, Inc. Diaryl and arylheteroaryl urea derivatives as modulators of the 5-HT2A serotonin receptor useful for the prophylaxis and treatment of disorders related thereto
US9801856B2 (en) 2008-10-28 2017-10-31 Arena Pharmaceuticals, Inc. Composition of a 5-HT2A serotonin receptor modulator useful for the treatment of disorders related thereto
US10022355B2 (en) 2015-06-12 2018-07-17 Axovant Sciences Gmbh Diaryl and arylheteroaryl urea derivatives as modulators of the 5-HT2A serotonin receptor useful for the prophylaxis and treatment of REM sleep behavior disorder
US10034859B2 (en) 2015-07-15 2018-07-31 Axovant Sciences Gmbh Diaryl and arylheteroaryl urea derivatives as modulators of the 5-HT2A serotonin receptor useful for the prophylaxis and treatment of hallucinations associated with a neurodegenerative disease
US10058549B2 (en) 2007-08-15 2018-08-28 Arena Pharmaceuticals, Inc. Imidazo[1,2-α]pyridine derivatives as modulators of the 5-HT2A serotonin receptor useful for the treatment of disorders related thereto
US10059691B2 (en) 2008-04-02 2018-08-28 Arena Pharmaceuticals, Inc. Processes for the preparation of pyrazole derivatives useful as modulators of the 5-HT2A serotonin receptor

Cited By (59)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0706999A4 (en) * 1993-06-30 1996-05-22
US5607948A (en) * 1993-06-30 1997-03-04 Sumitomo Pharmaceuticals Co., Ltd. Dipiperidine derivatives
EP0706999A1 (en) * 1993-06-30 1996-04-17 Sumitomo Pharmaceuticals Company, Limited Novel dipiperidine derivative
US6303661B1 (en) 1996-04-25 2001-10-16 Probiodrug Use of dipeptidyl peptidase IV effectors for lowering the blood glucose level in mammals
WO1999003832A1 (en) * 1997-07-14 1999-01-28 Phytera Symbion Aps Piperidine oligomers and combinatorial libraries thereof
WO1999061431A1 (en) * 1998-05-28 1999-12-02 Probiodrug Gesellschaft für Arzneimittelforschung mbH New dipeptidyl peptidase iv effectors
US6548481B1 (en) 1998-05-28 2003-04-15 Probiodrug Ag Effectors of dipeptidyl peptidase IV
US7053055B2 (en) 1998-06-24 2006-05-30 Prosidion Ltd. Compounds of unstable DP IV-inhibitors
US7084120B2 (en) 1998-06-24 2006-08-01 Probiodrug Ag Prodrugs of DP IV-inhibitors
US7166579B2 (en) 1998-06-24 2007-01-23 Prosidion Limited Prodrugs of DP IV-inhibitors
US6319893B1 (en) 1998-07-31 2001-11-20 Probiodrug Raising blood sugar level in hypoglycemic mammals by administering inhibitors of dipeptidyl peptidase IV
US6559314B2 (en) 1999-06-10 2003-05-06 Probiodrug Ag Method for the production of thiazolidin
US6949515B2 (en) 1999-08-24 2005-09-27 Probiodrug Ag Effectors of dipeptidyl peptidase IV for topical use
WO2001023376A1 (en) * 1999-09-29 2001-04-05 Ortho-Mcneil Pharmaceutical, Inc. Isonipecotamides for the treatment of integrin-mediated disorders
EP1533310A1 (en) * 1999-09-29 2005-05-25 Ortho-McNeil Pharmaceutical, Inc. Isonipecotamides for the treatment of integrin-mediated disorders
US7718673B2 (en) 1999-09-29 2010-05-18 Ortho-Mcneil Pharmaceutical, Inc. Isonipecotamides for the treatment of integrin-mediated disorders
US6794386B2 (en) 1999-12-24 2004-09-21 Bayer Aktiengesellschaft β-amino acid compounds as integrin antagonists
WO2001047887A1 (en) * 1999-12-24 2001-07-05 Bayer Aktiengesellschaft β-AMINO ACID COMPOUNDS AS INTEGRIN ANTAGONISTS
US6500804B2 (en) 2000-03-31 2002-12-31 Probiodrug Ag Method for the improvement of islet signaling in diabetes mellitus and for its prevention
US7435420B2 (en) 2000-10-27 2008-10-14 Probiodrug Ag Dipeptidyl peptidase IV inhibitors for the treatment of anxiety
US7132104B1 (en) 2000-10-27 2006-11-07 Probiodrug Ag Modulation of central nervous system (CNS) dipeptidyl peptidase IV (DPIV) -like activity for the treatment of neurological and neuropsychological disorders
US6890905B2 (en) 2001-04-02 2005-05-10 Prosidion Limited Methods for improving islet signaling in diabetes mellitus and for its prevention
US7081460B2 (en) 2001-04-09 2006-07-25 Ortho-Mcneil Pharmaceutical, Inc. Quinazoline and quinazoline-like compounds for the treatment of integrin-mediated disorders
US7368576B2 (en) 2001-06-27 2008-05-06 Probiodrug Ag Dipeptidyl peptidase IV inhibitors and their uses as anti-cancer agents
US7368421B2 (en) 2001-06-27 2008-05-06 Probiodrug Ag Use of dipeptidyl peptidase IV inhibitors in the treatment of multiple sclerosis
US7109347B2 (en) 2001-06-27 2006-09-19 Probiodrug Ag Dipeptidyl peptidase IV inhibitors and their uses as anti-cancer agents
US6844316B2 (en) 2001-09-06 2005-01-18 Probiodrug Ag Inhibitors of dipeptidyl peptidase I
US7144856B2 (en) 2001-09-06 2006-12-05 Probiodrug Ag Inhibitors of dipeptidyl peptidase I
US7608577B2 (en) 2001-10-12 2009-10-27 Osi Pharmaceuticals, Inc. Peptidyl ketones as inhibitors of DPIV
US6946480B2 (en) 2002-02-28 2005-09-20 Hans-Ulrich Demuth Glutaminyl based DPIV inhibitors
US7371871B2 (en) 2003-05-05 2008-05-13 Probiodrug Ag Inhibitors of glutaminyl cyclase
US7381537B2 (en) 2003-05-05 2008-06-03 Probiodrug Ag Use of inhibitors of glutaminyl cyclases for treatment and prevention of disease
US9775829B2 (en) 2003-07-22 2017-10-03 Arena Pharmaceuticals, Inc. Diaryl and arylheteroaryl urea derivatives as modulators of the 5-HT2A serotonin receptor useful for the prophylaxis and treatment of disorders related thereto
WO2005016883A3 (en) * 2003-08-14 2005-04-14 Steven A Boyd Acrylamide derivatives as vla-1 integrin antagonists and uses thereof
US7897633B2 (en) 2004-02-05 2011-03-01 Probiodrug Ag Inhibitors of glutaminyl cyclase
US9126927B2 (en) 2004-05-07 2015-09-08 Incyte Holdings Corporation Amido compounds and their use as pharmaceuticals
US8058288B2 (en) 2004-05-07 2011-11-15 Incyte Corporation Amido compounds and their use as pharmaceuticals
US7776874B2 (en) 2004-05-07 2010-08-17 Incyte Corporation Amido compounds and their use as pharmaceuticals
US9957229B2 (en) 2004-05-07 2018-05-01 Incyte Holdings Corporation Amido compounds and their use as pharmaceuticals
US7304081B2 (en) 2004-05-07 2007-12-04 Incyte Corporation Amido compounds and their use as pharmaceuticals
US9670154B2 (en) 2004-05-07 2017-06-06 Incyte Holdings Corporation Amido compounds and their use as pharmaceuticals
US8288417B2 (en) 2004-06-24 2012-10-16 Incyte Corporation N-substituted piperidines and their use as pharmaceuticals
US7687665B2 (en) 2004-06-24 2010-03-30 Incyte Corporation 2-methylprop anamides and their use as pharmaceuticals
WO2006012226A3 (en) * 2004-06-24 2006-07-27 Incyte Corp N-substituted piperidines and their use as pharmaceuticals
US8071624B2 (en) 2004-06-24 2011-12-06 Incyte Corporation N-substituted piperidines and their use as pharmaceuticals
JP2008535892A (en) * 2005-04-11 2008-09-04 プロビオドルグ エージー Prolyl endopeptidase inhibitors
US8193207B2 (en) 2005-12-05 2012-06-05 Incyte Corporation Lactam compounds and methods of using the same
US7998959B2 (en) 2006-01-12 2011-08-16 Incyte Corporation Modulators of 11-β hydroxyl steroid dehydrogenase type 1, pharmaceutical compositions thereof, and methods of using the same
US7838544B2 (en) 2006-05-17 2010-11-23 Incyte Corporation Heterocyclic inhibitors of 11-β hydroxyl steroid dehydrogenase type 1 and methods of using the same
US9732039B2 (en) 2006-10-03 2017-08-15 Arena Pharmeceuticals, Inc. Pyrazole derivatives as modulators of the 5-HT2A serotonin receptor useful for the treatment of disorders related thereto
US9434692B2 (en) 2006-10-03 2016-09-06 Arena Pharmaceuticals, Inc. Pyrazole derivatives as modulators of the 5-HT2A serotonin receptor useful for the treatment of disorders related thereto
US10058549B2 (en) 2007-08-15 2018-08-28 Arena Pharmaceuticals, Inc. Imidazo[1,2-α]pyridine derivatives as modulators of the 5-HT2A serotonin receptor useful for the treatment of disorders related thereto
US10059691B2 (en) 2008-04-02 2018-08-28 Arena Pharmaceuticals, Inc. Processes for the preparation of pyrazole derivatives useful as modulators of the 5-HT2A serotonin receptor
US10117851B2 (en) 2008-10-28 2018-11-06 Arena Pharmaceuticals, Inc. Composition of a 5-HT2A serotonin receptor modulator useful for the treatment of disorders related thereto
US9745270B2 (en) 2008-10-28 2017-08-29 Arena Pharmaceuticals, Inc. Processes useful for the preparation of 1-[3-(4-bromo-2-methyl-2H-pyrazol-3-yl)-4-methoxy-phenyl]-3-(2,4-difluoro-phenyl)-urea and crystalline forms related thereto
US10071075B2 (en) 2008-10-28 2018-09-11 Arena Pharmaceuticals, Inc. Processes useful for the preparation of 1-[3-(4-bromo-2-methyl-2H-pyrazol-3-yl)-4-methoxy-phenyl]-3-(2,4-difluoro-phenyl)-urea and crystalline forms related thereto
US9801856B2 (en) 2008-10-28 2017-10-31 Arena Pharmaceuticals, Inc. Composition of a 5-HT2A serotonin receptor modulator useful for the treatment of disorders related thereto
US10022355B2 (en) 2015-06-12 2018-07-17 Axovant Sciences Gmbh Diaryl and arylheteroaryl urea derivatives as modulators of the 5-HT2A serotonin receptor useful for the prophylaxis and treatment of REM sleep behavior disorder
US10034859B2 (en) 2015-07-15 2018-07-31 Axovant Sciences Gmbh Diaryl and arylheteroaryl urea derivatives as modulators of the 5-HT2A serotonin receptor useful for the prophylaxis and treatment of hallucinations associated with a neurodegenerative disease

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