JPH04187667A - Production of 2-substituted hydroxyiminopropanedinitrile - Google Patents

Production of 2-substituted hydroxyiminopropanedinitrile

Info

Publication number
JPH04187667A
JPH04187667A JP31638090A JP31638090A JPH04187667A JP H04187667 A JPH04187667 A JP H04187667A JP 31638090 A JP31638090 A JP 31638090A JP 31638090 A JP31638090 A JP 31638090A JP H04187667 A JPH04187667 A JP H04187667A
Authority
JP
Japan
Prior art keywords
compound
formula
compound expressed
substituted
hydroxyiminopropanedinitrile
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP31638090A
Other languages
Japanese (ja)
Inventor
Takatsugu Shiyundou
Hiroshi Nakatani
Yoshitaka Fujiwara
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Takeda Pharmaceutical Co Ltd
Original Assignee
Takeda Chemical Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Takeda Chemical Industries Ltd filed Critical Takeda Chemical Industries Ltd
Priority to JP31638090A priority Critical patent/JPH04187667A/en
Publication of JPH04187667A publication Critical patent/JPH04187667A/en
Pending legal-status Critical Current

Links

Abstract

PURPOSE: To obtain the subject high-purity compound in high yield using simple operation by alkylating K or Li salt of 2-hydroxyiminopropanedinitrile.
CONSTITUTION: A compound expressed by formula I (M is K or Li) is reacted with an alkylating agent in a molar amount of 0.5-3 times, preferably 0.5-2 times based on the aforementioned compound expressed by formula I to provide a compound expressed by formula II (R1 is straight-chain, branched or cyclic alkyl which may be substituted). The compound expressed by formula I is obtained by reacting malonitrile with nitrous acid or its salt under acidic conditions and then reacting the resultant compound with a K or an Li compound. The compound expressed by formula II is useful as an intermediate raw material compound for 2-substituted hydroxyimino-2(5-amino-1,2,4- thiadiazol-3-yl)acetic acids or their salts useful as an acylating agent for producing cephalosporin-based compounds having antimicrobial action.
COPYRIGHT: (C)1992,JPO&Japio
JP31638090A 1990-11-20 1990-11-20 Production of 2-substituted hydroxyiminopropanedinitrile Pending JPH04187667A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP31638090A JPH04187667A (en) 1990-11-20 1990-11-20 Production of 2-substituted hydroxyiminopropanedinitrile

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP31638090A JPH04187667A (en) 1990-11-20 1990-11-20 Production of 2-substituted hydroxyiminopropanedinitrile

Publications (1)

Publication Number Publication Date
JPH04187667A true JPH04187667A (en) 1992-07-06

Family

ID=18076443

Family Applications (1)

Application Number Title Priority Date Filing Date
JP31638090A Pending JPH04187667A (en) 1990-11-20 1990-11-20 Production of 2-substituted hydroxyiminopropanedinitrile

Country Status (1)

Country Link
JP (1) JPH04187667A (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2014203855A2 (en) 2013-06-21 2014-12-24 イハラケミカル工業株式会社 Manufacturing method for 2-amino-2-hydroxyimino-n-alkoxy acetoimidoyl cyanide, and manufacturing intermediate thereof
US10544092B2 (en) 2015-12-25 2020-01-28 Shenyang Sinochem Agrochemicals R&D Co., Ltd. Malononitrile oxime ether compound and use thereof

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2014203855A2 (en) 2013-06-21 2014-12-24 イハラケミカル工業株式会社 Manufacturing method for 2-amino-2-hydroxyimino-n-alkoxy acetoimidoyl cyanide, and manufacturing intermediate thereof
WO2014203855A3 (en) * 2013-06-21 2015-01-29 イハラケミカル工業株式会社 Manufacturing method for 2-amino-2-hydroxyimino-n-alkoxy acetoimidoyl cyanide, and manufacturing intermediate thereof
CN105377812A (en) * 2013-06-21 2016-03-02 庵原化学工业株式会社 Manufacturing method for 2-amino-2-hydroxyimino-n-alkoxy acetoimidoyl cyanide, and manufacturing intermediate thereof
JPWO2014203855A1 (en) * 2013-06-21 2017-02-23 イハラケミカル工業株式会社 Process for producing 2-amino-2-hydroxyimino-N-alkoxyacetimidoylcyanide and its intermediate
CN105377812B (en) * 2013-06-21 2018-09-18 组合化学工业株式会社 The preparation method of 2- amino -2- oximido-N- alkoxy acetimidoyl cyanides and its prepare intermediate
US10544092B2 (en) 2015-12-25 2020-01-28 Shenyang Sinochem Agrochemicals R&D Co., Ltd. Malononitrile oxime ether compound and use thereof

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