JPH04144561A - Nutrient transfusion-containing bag - Google Patents

Abstract

PURPOSE:To form the nutrient transfusion-contg. bag for aseptic mixing and dosing of an amino acid transfusion and a fat transfusion by housing both transfusions to the respective chambers of the two-chamber bag in such a manner that the total fat weight in the fat transfusion to the total amino acid weight in the amino acid transfusion attains a specific ratio. CONSTITUTION:The nutrient transfusion-contg. bag which is housed with the amino acid transfusion and the fat transfusion in the respective chambers of the two-chamber bag so as to attain 0.5 to 1 ratio of the total fat weight in the fat transfusion to the total amino acid weight in the amino acid transfusion is formed. The two-chamber bag is a soft bag-shaped container made of plastics and the central part thereof is thermally welded separably to a band shape. A transfusion injection port or discharge port is provided to each of the two chambers which are liquidtightly isolated. The amino acid transfusion and the fat transfusion are packed and hermetically sealed respectively in gaseous nitrogen flow in the respective chambers of the two-chamber bag and are then subjected to high-pressure steam sterilization.

Description

DETAILED DESCRIPTION OF THE INVENTION [Field of Industrial Application] The present invention relates to a bag containing a nutritional infusion for intravenously administering an amino acid infusion and a fat infusion that are mixed aseptically before use.

[Conventional technology]

Various infusion solutions have been developed for intravenously supplying nutrients to patients who are unable to take nutritional sources orally.

However, a two-chamber bag containing amino acid infusions and fat infusions in nutritionally favorable ratios has not yet been developed.

[Problem to be solved by the invention]

Amino acids administered to patients are used for protein synthesis, and some are consumed as a heat source. Therefore, it is said that when amino acids are administered together with fat or carbohydrates, the proportion of amino acids utilized for protein synthesis increases.

Fat has about twice the calorific value per unit weight as carbohydrates,
Although it is excellent as a heat source, there are problems such as excessive administration leading to accumulation in organs and an increase in the concentration of neutral fats (triglycerides) in the blood.

Therefore, an object of the present invention is to provide a bag containing a nutritional infusion solution for aseptically mixing and administering both amino acids and fats in a ratio that allows the living body to efficiently utilize both of the infusions.

[Means to solve the problem]

In order to solve the above problems, the present inventors intravenously administered amino acids and fat to rats, and investigated nitrogen balance, DNA vs.
As a result of intensive research using NA ratio, plasma triglyceride concentration, triglyceride content in organs, etc. as indicators, we discovered that good results can be obtained when the dose of amino acids is greater than the dose of fat, and we have completed the present invention. In other words, the present invention is such that the amino acid infusion and the fat infusion are placed in each chamber of the two-chamber bag so that the ratio of the total fat weight in the fat infusion to the total amino acid weight in the amino acid infusion is 0.5 to 1. The invention relates to bags containing nutritional infusions, each housed in a bag containing a nutritional infusion solution.

The amino acid infusion used in the present invention contains a well-balanced combination of essential amino acids and non-essential amino acids, and is widely applicable to various diseases and prostitution, as well as for postoperative patients, liver disease patients, kidney disease patients, etc. Any drug developed for patients with a specific disease may be used. Among them, those with emphasis on nutritional effects are preferred, and for example, those with the following amino acid and no acid compositions can be shown.

Composition of amino acids L-isoleucine, L-leucine L, and lysine (g/10 hours of severe punishment for all amino acids) 4.0-13.0 10.0-20.0 3.5-・13.0 I7-methionine 1.5-・10.0■, -
Futa Nylalanine 3.0-10.0L-) 1/Onine 3゜0-...11.0L-h Rib [Fan 0.5-5.0I7-valine 38
0-16.0L-arginine 5.0 = 2
1.0L--histidine 2.0-8.5 aminoacetic acid 2.0-12゜OL-alanine
3.0-1560L--aspartic acid
0-・4.0L-cystine 0-1
．． 0L-cystine O-0,3 L--glutamic acid 〇-・7゜OL-proline 165-・6.01, ---u phosphorus
0.5-3.0L--Tyrosine
The concentration of 0.1-5.0 amino acid infusion is preferably 5 to 15 (ti/v)%.

In addition, for fat infusion, for example, soybean oil, coconut oil, sesame oil, perilla oil, linseed oil, cottonseed oil, safflower oil, fish oil, etc. can be emulsified in a C-in-water type according to a conventional method, and usually 5
=20h/υ)% concentration is preferred17.

There is no particular difficulty in manufacturing the bag containing the nutritional infusion of the present invention. Fill the chamber with 0.5 of its amino acid
- The remaining chamber may be filled with an amount of fat liquid containing 1 times the weight of fat and sterilized.

〔Example〕

The two-chamber bag is a flexible bag-like container made of plastic, and the central part is heat-welded to two T' knee chambers that can be peeled off in the form of a strip, and each of the two T' knee chambers is separated in a liquid-tight manner. A device with an inlet or outlet was used.

Each chamber of this two-chamber bag was filled with the following amino acid infusion and fat infusion in a nitrogen stream, sealed in a sealed bag, and sterilized with high-pressure steam.

Example 1 (1) Ingredients (C) L in amino acid infusion 500 doors (filled)
-Isoleucine 4.55 L-Leucine 6645 L-Lysine Acetate 5.00 L-Methionine 2.20 L-phy, Nylalanine 3,50 1,-1-Leonine 3,751, -Tryptophan L--Valine 7.0O L-Arginine, 50 ■5-Histidine 2.50 Aminoacetic acid 3,50 ■, ~Alanine 3655 1,-Aspartic acid 0.50 1,-Cystine 0.181, -Glutamic acid 0.25Summer, -Proline
2.50I, -Serine 0685 L-Tyrosine 0.20 (Total weight of free amino acids 50.18g) 11 Ingredients in fat infusion 500d (filling) (g) Soybean oil
50.0 Purified soybean lecithin 6.0 Concentrated glycerin 12.5 Example 2 (1) Components (g) of amino acid infusion 5001d (filling)
) L-isoleucine 2.80 L-leucine 6.25 L-lysine acetate 6.20 L-methionine 1.75 L-phenylalanine 4.675 L-) leonine 3.25 L-) ribtophan 0.65 L-valine 2 .25 L-Arginine 3395 L-Histidine 3.00 Amineacetic acid 5.35 L-Alanine 3.10 L-Aspartic acid 1.90 0.50 3.25 L-Cystine L-Glutamic acid L-Proline 1.65 L- Serine 1.1O L-Tyrosine 0.175 (Total weight of free amino acids 50.00g) (2) Ingredients in 250m of fat infusion (filled) (g) Perilla oil
So, o.

Egg yolk lecithin 6.00 Concentrated glycerin 12.50 Example 3 (1) Components (g) in amino acid infusion 500m (filled)
L-isoleucine 4.60 L-leucine 4.725 L-lysine hydrochloride 1.975 L-methionine 0.22 L-phenylalanine 0.15 L-) leonine 1.07 L-) ribtophan 0.35 L-valine 4. 45 Shi-arginine 7, 685 L-histidine 1.55 L-alanine aminoacetate 2.70 4.20 0.10 2.65 1.30 0.20 37.53g) Ingredients (g) 25.00 3. 00 6.25 L-aspartic acid L-proline L-serine L-tyrosine (total weight of free amino acids (2) Flil [250 m (filling) Coconut oil refined soybean lecithin concentrated glycerin Example 4 (1) Amino acid infusion 500 d (filling) ) Ingredients (g)
L-isoleucine 3.75 L-leucine 5.00 L-lysine 2.50 L-methionine 2.50 L-phenylalanine 2.50 L-luonine 1.25 L-)liptophan 1.25 L-valine 3.75 L-Arginine 1.50 L-Histidine 1.25 Aminoacetic acid 0.75 L-Alanine 1.50 L-Aspartic acid 0.125 L-Glutamic acid 0.125 L-Proline 1.00 L-Serine 0.50 L- Tyrosine 0.25 (Total weight of free amino acids 29.50 g) (2) Components in 250 m (filling) of fat infusion (g) Coconut oil
25.00 Egg yolk lecithin 3.00 Concentrated glycerin 6.25 (Test example) The test solutions were an infusion containing only amino acids, an infusion containing only soybean oil as an oil-in-water emulsion, and an infusion containing amino acids and soybean oil in varying ratios. An infusion solution was prepared and used.

However, the types of amino acids, the blending ratios of each amino acid, and the blending ratios of soybean oil, purified soybean lecithin, and concentrated glycerin were the same as in Example 1.

Test Example 1 Using 7-week-old SD rats (7 rats per group), central static catheterization was performed under anesthesia.

Subsequently, physiological saline was administered at lif/hr for 1 day under fasting conditions, and then the test solution was added to 245 ml of 6. The dose was 1°/hr for 1 day. After administration, urine, blood and various organs were collected, and nitrogen balance, liver and muscle [?] were collected. NA/I) NA ratio, plasma]・
Liglyceride concentration and triglyceride content in the liver and thighs were measured, and the following results were obtained.

(1) Nitrogen balance As shown in the table below, positive nitrogen balance was shown when the amino acid content was equal to the fat content.

(2) IINA/DNA ratio in the liver and muscle The amino acid content is equal to or higher than the fat content, and the RN in the liver and muscle
A high A/Dh ratio was observed, and protein synthesis was observed to be accelerated.

(3) Blood-related triglyceride concentration When the amino acid content was equal to or greater than the fat content, the vascular triglyceride concentration was clearly lowered, and it was observed that the clearance of blood triglycerides was enhanced.

(4) Triglyceride content in organs When the amino acid content was equal to or more than the fat content, the triglyceride content in the liver and lungs became a low value, and a decrease in fat V in the tissues was observed.

Test Example 2 The test solution was administered in the same manner as in Test Example 1 using 8-week-old SD male rats (5 rats per group). After the administration, the organs were collected and the weight of epididymal fat, the triglyceride content in the liver and the tile were measured, and the following results were obtained.

(1) Epididymal fat weight When the fat content exceeds the amino acid content, the epididymal fat weight increases markedly, and it is assumed that L1i1 rib accumulation of adipose tissue occurs.

(2) Triglyceride content in organs When the fat content exceeded the amino acid content, the triglyceride content in the liver and lungs increased significantly, and fat accumulation in the tissues was observed.

From the above results, it was estimated that the amount of fat administered in the nutritional infusion is preferably 0.5 to 1 times the amount of amino acid administered.

〔Effect of the invention〕

According to the present invention, the amino acid infusion and the fat infusion can be mixed aseptically by opening the isolation means of the two-chamber bag, and the nitrogen source and heat source can be safely administered at a ratio favorable to the living body.

Patent applicant: Morishita Pharmaceutical Co., Ltd.

Claims (1)

[Claims] (1) A nutritional infusion in which an amino acid infusion and a fat infusion are stored in each chamber of a two-chamber bag so that the ratio of the total fat weight in the fat infusion to the total amino acid weight in the amino acid infusion is 0.5 to 1. bag.