JPH037169A - 血管内薬物供給膨張カテーテル - Google Patents

血管内薬物供給膨張カテーテル

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Publication number
JPH037169A
JPH037169A JP2132444A JP13244490A JPH037169A JP H037169 A JPH037169 A JP H037169A JP 2132444 A JP2132444 A JP 2132444A JP 13244490 A JP13244490 A JP 13244490A JP H037169 A JPH037169 A JP H037169A
Authority
JP
Japan
Prior art keywords
tubular member
distal end
sleeve
expander
liquid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2132444A
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English (en)
Other versions
JPH0464709B2 (ja
Inventor
Rick L Shockey
リック・エル・ショッキー
Tassel Robert A Van
ロバート・エイ・ヴァン・タッセル
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Schneider USA Inc
Original Assignee
Schneider USA Inc
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Filing date
Publication date
Application filed by Schneider USA Inc filed Critical Schneider USA Inc
Publication of JPH037169A publication Critical patent/JPH037169A/ja
Publication of JPH0464709B2 publication Critical patent/JPH0464709B2/ja
Granted legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M25/00—Catheters; Hollow probes
    • A61M25/10—Balloon catheters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/82—Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M16/00—Devices for influencing the respiratory system of patients by gas treatment, e.g. ventilators; Tracheal tubes
    • A61M16/04—Tracheal tubes
    • A61M16/0434—Cuffs
    • A61M16/0454—Redundant cuffs
    • A61M16/0456—Redundant cuffs one cuff within another
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M16/00—Devices for influencing the respiratory system of patients by gas treatment, e.g. ventilators; Tracheal tubes
    • A61M16/04—Tracheal tubes
    • A61M16/0475—Tracheal tubes having openings in the tube
    • A61M16/0477—Tracheal tubes having openings in the tube with incorporated means for delivering or removing fluids
    • A61M16/0481—Tracheal tubes having openings in the tube with incorporated means for delivering or removing fluids through the cuff wall
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M25/00—Catheters; Hollow probes
    • A61M25/10—Balloon catheters
    • A61M25/1011—Multiple balloon catheters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M25/00—Catheters; Hollow probes
    • A61M25/10—Balloon catheters
    • A61M25/104—Balloon catheters used for angioplasty
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods
    • A61B17/22—Implements for squeezing-off ulcers or the like on inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; for invasive removal or destruction of calculus using mechanical vibrations; for removing obstructions in blood vessels, not otherwise provided for
    • A61B2017/22082—Implements for squeezing-off ulcers or the like on inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; for invasive removal or destruction of calculus using mechanical vibrations; for removing obstructions in blood vessels, not otherwise provided for after introduction of a substance
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M25/00—Catheters; Hollow probes
    • A61M25/10—Balloon catheters
    • A61M25/1011—Multiple balloon catheters
    • A61M2025/1013—Multiple balloon catheters with concentrically mounted balloons, e.g. being independently inflatable
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M25/00—Catheters; Hollow probes
    • A61M25/10—Balloon catheters
    • A61M2025/1043—Balloon catheters with special features or adapted for special applications
    • A61M2025/105—Balloon catheters with special features or adapted for special applications having a balloon suitable for drug delivery, e.g. by using holes for delivery, drug coating or membranes

Landscapes

  • Health & Medical Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pulmonology (AREA)
  • Biomedical Technology (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Anesthesiology (AREA)
  • Hematology (AREA)
  • Biophysics (AREA)
  • Child & Adolescent Psychology (AREA)
  • Vascular Medicine (AREA)
  • Emergency Medicine (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Cardiology (AREA)
  • Transplantation (AREA)
  • Media Introduction/Drainage Providing Device (AREA)
  • Materials For Medical Uses (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Surgical Instruments (AREA)
  • Prostheses (AREA)
  • Tires In General (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicinal Preparation (AREA)

Abstract

(57)【要約】本公報は電子出願前の出願データであるた
め要約のデータは記録されません。

Description

【発明の詳細な説明】 直呈上立五亙１里 本発明は、経皮経膣血管成形外科手術を実行する装置及
び方法、詳細には、処置されるべ籾組織障害の場所の膨
張と、適当な薬物その他の液体を処置する場所に同時に
送ることを可能とする装置及び方法に関する。
又１０五遣 １９７０年代半年代前は、動脈硬化又はその他の血管の
狭窄障害のＩＡ置の主たる方法は、該ブロックを外科的
に摘出するか、冠状動脈の場合は、患者の足から切り取
った血管を移植して閉塞した動脈バイパスを通す、ドク
ター・Ａ・グロインツィヒによる最初の進歩した方法以
後、今日では適切な場所にバルーン薬物供給膨張カテー
テルを導き、処置されるべぎ場所へ血管組織を通す通路
を形成する。バルーンが閉塞した場所に並列に配置され
、薬物供給膨張カテーテルの内腔を通して膨張液が導か
れ、バルーンを膨張させ、ブロックに抗して拡張して、
閉塞した血管を広げ、あるいは開く、このような方法は
従来の外科的手術よりも外傷を少なくする。
が　′　しようとする課 本発明は、膨張薬物供給膨張カテーテルの構造に関する
評価すべ幹多数の改良を含んでいる。
射的に０指していることは、使用される素材の改良、ト
ルク特性、そしてもちろん、寸法の縮小であり、それに
より比較的小さな血管を処置できる。経皮経腔冠状動脈
血管形成外科（ＰＴＣＡ）手術になお残っている問題は
、処置された血管がはっきりと残らないことが時々ある
ことである。実際に、おそらく事例の３３％が１２か月
以内に再手術の必要が生ずる。一定の薬物が、一定のタ
イプの狭窄障害の再発を減少させるのに効果があること
が知られている０例えば、順調な筋肉細胞の成長を阻止
する傾向を示す評価のある薬物がある。この性買のせい
で、その薬物の注射による投与は好ましくなく、障害の
ある場所に血液の流れにより運ぶことだけが許されてい
る。この理由は、必要とされる投与薬物の中には、望ま
しくない副作用があり得ることである。しかしながら、
そして本発明によれば、該薬物が直接障害場所へ向けら
れるならば、かなり少量の投与で充分であり、副作用は
最少化される。
成形外科又はアテレクトミイ（切除）手術に続いて、機
械的ステントが挿入されて、処置場所に再狭窄が生じな
いようにすることも示唆されている。しかしながら、直
接の外科的方法以外に効果的方法がないために、ステン
トを位置決めする装置が使用されてきた。冠状動脈の場
合には外傷を生ずる外科的！Ａ置よりも修復（ｒｅｐａ
ｌｒ）が要求されるため、バルーンを使用する成形外科
の利点が無駄となっている。
１　を　゛するための 従って本発明の主たる目的は改良された薬物供給膨張カ
テーテルを提供することである。
本発明のその他の目的は、再狭窄を防ぐために、液薬そ
の他の物質を直接処置される障害の場所に投与すること
を可能とする薬物供給膨張カテーテルを提供することで
ある。
本発明のその他の目的は、処置されるべき閉塞障害の場
所において拡張し膨張する薬物供給膨張カテーテルを提
供し、同時にこれがその場所にあるステントを形成して
、量を少なくした薬物をプラークに噴霧する薬物供給膨
張カテーテルを提供することである。
更にその他の本発明の目的は、その末端部に一対の同心
的エキスパンダを有し、外側のものが注入されるべき薬
物を供給し、内側のものが膨張と薬物管理を行うために
膨張液を注入する多数内腔薬物供給膨張カテーテルを提
供することである。
本発明の血管的薬物供給膨張カテーテルは３本の細長い
、可撓性の、プラスチックチューブを備え、これらが相
互に同心的に配置されている。前記同心的チューブの末
端部に配置されているのは、外側及び内側の中空のエキ
スパンダスリーブである。内側エキスパンダスリーブは
それの基部端で中間チューブの末端部に接着され、それ
に対して前記内側スリーブの末端部は内側チューブの末
端部に接着されている。いくらか類似の方式で、前記外
側中空エキスパンダスリーブはそれの基部端で最も外側
のチューブに、それの末端部で最も内側の末端部に接着
されている。この方式で、前記最も内側のスリーブの内
部は中間チューブの内腔に液体連絡し、これに対して前
記最も外側のスリーブの内部が前記最も外側のチューブ
の内腔に連絡している。前記最も外側のスリーブには、
精密に制御されたレーザービームにより形成された微細
小孔のパターンが設けられている。適当なマニフォルド
が前記３木の同心的に配置された薬物供給膨張カテーテ
ルの基部端に連結され、膨張液及びその他の液状の物質
が前記外側のチューブ部材の内腔へ入ることを可能とし
ている。この方式で、前記最も内側のスリーブの内圧が
増加すると、それが膨張し、薬物が同時に微細小孔を通
して強制され、処置されるべき場所に薬物その他の物質
が噴霧され、そこを浸潤する。
東−凰一週 図面を参照すると、本発明の好ましい実施例からなる、
番号ｌＯにより表示された血管的薬物供給膨張カテーテ
ルが表示されている。そこには、それぞれ番号１２．１
４．１６により同定された、第１、第２及び第３の同心
的又は同軸的に配置された細長い可撓性プラスチックチ
ューブ状部材が含まれているのが見える。前記３本のチ
ューブは通常は長さ１３５　ｃａｒで、最も外側のチュ
ーブ１２は処置場所の付近の血管組織の部分を容易に通
過する寸法である。この構成は、細長いガイドワイヤ１
８をおおって通過するように、ワイヤをおおって通過す
るシステムとして描かれ、前記ガイドワイヤは案内薬物
供給膨張カテーテル（図示されていない）を通フて通過
し、ガイドワイヤの末端部が障害のある場所を通ってそ
のむこうまで通過するようになされている。
それの末端部２０において最も外側のチューブ１２の外
側表面に適当に接着されているのは、薄い膜スリーブの
形態の第１エキスパンダ部材２２である。スリーブ２２
の末端部２４はそれの末端部２６において最も内側のチ
ューブ１６の外面に接着されている。ｒａ小細孔のパタ
ーン２８はエキスパンダ部材２２の壁全体に形成されて
いる。エキスパンダ部材２２がポリエチレン・テトラタ
レード、又はポリビニル・クロライドのような２軸方向
の熱可塑プラスチック材料からなるところでは、微小細
孔２８は精密レーザーを使用して形成可能である。
外側エキスパンダ部材又はスリーブ２２の内部に配置さ
れているのは内側エキスパンダスリーブ３Ｇである。こ
れはそれの基部端で中間チューブ１４の外面に接着され
ている。それの他（末端）の端は最も内側のチューブ１
６の外面に接着されている。
図面の部分的断面図から容易に明白となるように、最も
外側のチューブ１２の内腔３２は外側エキスパンダ部材
２２の内部と液体連絡し、それに対し中間チューブの内
１１２３４は最も内側のエキスパンダ部材３０の内部と
液体連絡している。最も内側の内腔３６は描かれている
ようにガイドワイヤのために留保されている。
薬物供給膨張カテーテル組立体の基部端に適切に取り付
けられているのは、それぞれ内腔３２及び３４に連絡し
ている一対のポート４０及び４２を有する成形プラスチ
ックハブ３８である。ポート４０．４２はルアー（Ｌｕ
ｅｒ）連結の形状で、米国特許第４．７２３９３８号明
細書に示されているタイプの、シリンジのような膨張道
具の取付けを容易にしている。
ハブ３８の基部端に配置されているのは、ガイドワイヤ
１８を調節するために最も内側のチューブの内腔３６に
連結されているボア４４である。ガイドワイヤ１８が除
去されると、最も内側のチューブの内１１２３１ｉは処
置場所の末端に血液を充満させるために使用され、下流
側の阻血を防ぎ、又は対照的な方法（ｃｏｎｔｒａｓｔ
　ｍｅｄｉａ）を導入する。別な方法では、最も内側の
チューブ１６の内腔は処置場所の圧力を測定する通路と
して、又は処置プロセスの間に緩むかもしれない組織の
破片を吸収するために使用可能である。薬物供給膨張カ
テーテルボディ１２．１４．１６は現在では通常は血管
成形及び血管画像薬物供給膨張カテーテルを製造するの
に使用されている様々な材料から製造可能である０通常
の材料はＰＶＣ，ナイロン、及びポリウレタンである。
ガイドワイヤ１８は特許文献において公知の技術により
、ステンレスから製造可能である。
使用する場合、ガイドワイヤ１８は従来はガイド薬物供
給膨張カテーテル（図示されていない）を通して通過し
、処置されるべき場所を横断する。
それに続いて、最も内側のチューブ１Ｂが前記ガイドワ
イヤの基部端をおおって嵌合し、次にエキスパンダ部材
２２と３０とが処置されるべき場所に並ぶまで、ガイド
ワイヤに沿って前進する。図面においては、エキスパン
ダ２２．３０はそれの膨張した形状で示されているが、
それの前進作動の間、これらエキスパンダはチューブ状
部材１６の外部に密着して従っていることを理解すべき
である。
放射線で見えるマーカーバンド４６の助けを借りて、−
旦前記薬物供給膨張カチーチルの末端部が適切に位置決
めされると、選択された薬物その他の物質が基部ポート
４０を経て導入され、内腔３２を紅て、外側エキスパン
ダ部材２２の領域へ入る。薬物の注入により、外側エキ
スパンダ部材２２がいくらか膨張するが５通常は薬物物
質が注入される圧力は微小細孔２８を通って外へ薬物が
大部分排出される圧力よりも低い、物質の供給と膨張と
を同時に実行するために、次にポート４２、それから内
腔３４を経てエキスパンダスリーブ３０内部に膨張液が
注入される。圧力が増加するにつれて、通常はフないし
ｌθ負気圧接近し、前記エキスパンダ部材がそれの所定
の最大直径まで膨張し、そうすることにより、液体物質
に強制力を加えて、特定の薬物その他の物質をポート２
８を経て効率的に処置されるべぎ場所にａｊｌＨする。
内側スリーブ３０の膨張によっても、障害に対する圧力
が発生し、薬物その他の物質が供給される時に血管の壁
に力を加える。膨張圧力と薬物の放出の組み合せにより
、処置される血管に対し長期の開放性を提供する。
同様に当業者に明白なことは、図面に示されている３本
の同心的チューブを使用する代りに、３本の平行な内腔
な有する１本の突出したチューブも膨張と薬物とを）２
供するために使用可能である。
純粋に例示的であるが、薬物はアスピリン又はバーサン
チンを含み、処置場所での血小板の凝集を防ぎ、ヘブリ
ン又はプロスタグランジンが凝結を防ぎ、又はその他の
薬物が順調な筋肉細胞の成長を効率的に妨げる。光硬化
性の生体になじむ、ゼネラル・エレクトリック社、ドウ
・コーニング社及びその他により提供されるシリコンも
考慮の対象となり、これが本発明の薬物供給膨張カテー
テルを通して注入され、次に直ちに光ファイバーにより
供給される４８０ナノメータの可視光線により硬化され
、その場所に固形のチューブ状ステントを形成する。
本発明は特定の異る装置などにより実行可能であり、そ
のような装置及び作業手順の両方についての様々な改良
は、本発明の範囲を逸脱することなく可能であることを
理解すべきである。
【図面の簡単な説明】
図は本発明による血管内薬物供給膨張カテーテルの断面
図を示す。 ｌＯ・・・血管内薬物供給膨張カテーテル、１２．１４
．１６・・・チューブ状部材、１８・・・ガイドワイヤ
、２０・・・最も外側のチューブの末端部、２２・・・
スリーブ、２４・・・スリーブの末端部、２６・・・最
も内側のチューブの末端部、２８・・・微小細孔、３０
・・・エキスパンダスリーブ、３２．３４．３６・・・
内腔、４０．４２・・・ボート、４６・・・マーカーバ
ンド。

Claims (1)

  1. 【特許請求の範囲】 １、血管内に物質を供給する膨張カテーテルであって、 （ａ）相互に同心的に配電された第１、第２、第３の細
    長い可撓性のプラスチックチューブ状部材を備え、それ
    ぞれが基部端と、末端部と、前記基部端及び前記末端部
    の間に延びる内腔と、を有し、 （ｂ）一端を前記第２のチューブ状部材の前記末端部に
    接着し、他端を前記第３のチューブ状部材の前記末端部
    に接着する、第１の中空の膨張可能なスリーブ手段を備
    え、該第１の中空の膨張可能なスリーブ手段が前記第２
    のチューブ状部材と液体連絡し、 （ｃ）一端を前記第１のチューブ状部材の前記末端部に
    接着し、他端を前記第３のチューブ状部材の前記末端部
    に接着する、第１の中空の膨張可能なスリーブ手段を備
    え、前記第２の中空の膨張可能なスリーブ手段が前記第
    １のチューブ状部材と液体連絡し、前記第２の中空のス
    リーブ手段が前記第２のスリーブ手段を通って半径方向
    に延びる微細小孔のパターンを含み、 （ｄ）マニフォルド手段が前記第１、第２、第３のチュ
    ーブ状部材の前記基部端に連結されて、前記第２のチュ
    ーブ腸部材の前記内腔へ膨張液を導入し、かつ液体を前
    記第１のチューブ状部材の前記内腔へ噴霧し、それによ
    り、前記膨張液により膨張した前記第１の中空のスリー
    ブ手段が膨張する時に、噴霧液が前記第２のスリーブ手
    段にある前記微小細孔を通して散布される、血管内に物
    質を供給する膨張カテーテル。 ２、請求項１に記載の薬物供給膨張カテーテルにおいて
    、前記第３のチューブ状部材の前記内腔を通して挿入可
    能なガイドワイヤを更に含む薬物供給膨張カテーテル。 ３、請求項１に記載の薬物供給膨張カテーテルにおいて
    、前記第１及び第２スリーブ手段が２軸の方向性を有す
    る熱可塑フィルムから製造されている薬物供給膨張カテ
    ーテル。 ４、請求項３に記載の薬物供給膨張カテーテルにおいて
    、前記フィルムがポリエチレンテレフタレート（ＰＥＴ
    ）からなる薬物供給膨張カテーテル。 ５、血管の内壁に生じた動脈硬化障害を処置する方法で
    あつて、 （ａ）膨張可能なエキスパンダ部材を有する膨張カテー
    テルを患者の血管組織を通して、前記エキスパンダ部材
    が前記障害場所に対し相対的に並ぶまで通過させる段階
    と、 （ｂ）前記障害場所に圧力をかけるために前記エキスパ
    ンダ部材を膨張させる段階と、 （ｃ）同時に前記エキスパンダ部材を通して前記障害場
    所へ噴霧液を散布する段階とを備えた、血管の内壁に生
    じた動脈硬化障害を処置する方法。 ６、請求項５に記載の方法において、前記噴霧液が薬物
    を含む液体である方法。 ７、請求項６に記載の方法において、前記噴霧液が固化
    可能な液体プラスチックである方法。 ８、請求項５に記載の方法において、前記膨張カテーテ
    ルが、 （ａ）相互に同心的に配置された第１、第２、第３の細
    長い可撓性のプラスチックチューブ状部材を備え、それ
    ぞれが基部端と、末端部と、前記基部端及び前記末端部
    の間に延びる内腔と、を有し、 （ｂ）一端を前記第２のチューブ状部材の前記末端部に
    接着し、他端を前記第３のチューブ状部材の前記末端部
    に接着する、第１の中空のエキスパンダスリーブを備え
    、該第１の中空のエキスパンダスリーブが前記第２のチ
    ューブ状部材と液体連絡し、 （ｃ）一端を前記第１のチューブ状部材の前記末端部に
    接着し、他端を前記第３のチューブ状部材の前記末端部
    に接着する第１の中空のエキスパンダスリーブを備え、
    前記第２の中空のエキスパンダスリーブが前記第１のチ
    ューブ状部材と液体連絡し、前記第２の中空のエキスパ
    ンダスリーブが前記第２のエキスパンダスリーブを通っ
    て半径方向に延びる微細小孔のパターンを含み、 （ｄ）マニフォルド手段が前記第１、第２、第３のチュ
    ーブ状部材の前記基部端に連結されて、前記第２のチュ
    ーブ腸部材の前記内腔へ膨張液を導入し、かつ液体を前
    記第１のチューブ状部材の前記内腔へ液状薬物を噴霧し
    、それにより、前記膨張液により膨張した前記第１の中
    空のエキスパンダスリーブが膨張する時に、液状薬物が
    前記第２のエキスパンダスリーブにある前記微小細孔を
    通して散布される、装置を備えてなる方法。
JP2132444A 1989-05-25 1990-05-22 血管内薬物供給膨張カテーテル Granted JPH037169A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/356,520 US4994033A (en) 1989-05-25 1989-05-25 Intravascular drug delivery dilatation catheter
US356520 1989-05-25

Publications (2)

Publication Number Publication Date
JPH037169A true JPH037169A (ja) 1991-01-14
JPH0464709B2 JPH0464709B2 (ja) 1992-10-15

Family

ID=23401779

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2132444A Granted JPH037169A (ja) 1989-05-25 1990-05-22 血管内薬物供給膨張カテーテル

Country Status (15)

Country Link
US (1) US4994033A (ja)
EP (1) EP0399712B1 (ja)
JP (1) JPH037169A (ja)
KR (1) KR930002271B1 (ja)
AT (1) ATE103499T1 (ja)
AU (1) AU611077B2 (ja)
CA (1) CA2017319C (ja)
DE (2) DE69007674T2 (ja)
DK (1) DK0399712T3 (ja)
ES (1) ES2050370T3 (ja)
FI (1) FI902583A0 (ja)
IE (1) IE63848B1 (ja)
IL (1) IL94439A (ja)
NO (1) NO902292L (ja)
PT (1) PT94150B (ja)

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AU611077B2 (en) 1991-05-30
AU5595690A (en) 1990-12-06
PT94150B (pt) 1997-01-31
DE69007674T2 (de) 1994-07-14
KR930002271B1 (ko) 1993-03-27
EP0399712B1 (en) 1994-03-30
IE901880L (en) 1990-11-25
PT94150A (pt) 1991-01-08
IE63848B1 (en) 1995-06-14
US4994033A (en) 1991-02-19
CA2017319C (en) 1995-05-09
DK0399712T3 (da) 1994-05-16
FI902583A0 (fi) 1990-05-24
IL94439A0 (en) 1991-03-10
EP0399712A1 (en) 1990-11-28
NO902292D0 (no) 1990-05-23
DE9005882U1 (de) 1990-11-08
IL94439A (en) 1995-03-15
ATE103499T1 (de) 1994-04-15
NO902292L (no) 1990-11-26
CA2017319A1 (en) 1990-11-25
DE69007674D1 (de) 1994-05-05
KR900017623A (ko) 1990-12-19
JPH0464709B2 (ja) 1992-10-15
ES2050370T3 (es) 1994-05-16

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