JPH0352443B2 - - Google Patents
Info
- Publication number
- JPH0352443B2 JPH0352443B2 JP57150399A JP15039982A JPH0352443B2 JP H0352443 B2 JPH0352443 B2 JP H0352443B2 JP 57150399 A JP57150399 A JP 57150399A JP 15039982 A JP15039982 A JP 15039982A JP H0352443 B2 JPH0352443 B2 JP H0352443B2
- Authority
- JP
- Japan
- Prior art keywords
- chitosan
- rifampicin
- alone
- inhibitory concentration
- minimum inhibitory
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 229920001661 Chitosan Polymers 0.000 claims description 32
- JQXXHWHPUNPDRT-WLSIYKJHSA-N rifampicin Chemical compound O([C@](C1=O)(C)O/C=C/[C@@H]([C@H]([C@@H](OC(C)=O)[C@H](C)[C@H](O)[C@H](C)[C@@H](O)[C@@H](C)\C=C\C=C(C)/C(=O)NC=2C(O)=C3C([O-])=C4C)C)OC)C4=C1C3=C(O)C=2\C=N\N1CC[NH+](C)CC1 JQXXHWHPUNPDRT-WLSIYKJHSA-N 0.000 claims description 29
- 229960001225 rifampicin Drugs 0.000 claims description 29
- 239000000203 mixture Substances 0.000 claims description 10
- 230000000844 anti-bacterial effect Effects 0.000 claims description 8
- 150000003839 salts Chemical class 0.000 claims description 6
- 230000002401 inhibitory effect Effects 0.000 description 14
- 229920002101 Chitin Polymers 0.000 description 6
- 241000238557 Decapoda Species 0.000 description 6
- 230000000694 effects Effects 0.000 description 5
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 4
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 4
- BDAGIHXWWSANSR-UHFFFAOYSA-N methanoic acid Natural products OC=O BDAGIHXWWSANSR-UHFFFAOYSA-N 0.000 description 4
- 241000894006 Bacteria Species 0.000 description 3
- KWYUFKZDYYNOTN-UHFFFAOYSA-M Potassium hydroxide Chemical compound [OH-].[K+] KWYUFKZDYYNOTN-UHFFFAOYSA-M 0.000 description 3
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 3
- 239000007864 aqueous solution Substances 0.000 description 3
- 230000001580 bacterial effect Effects 0.000 description 3
- 239000000843 powder Substances 0.000 description 3
- 230000004083 survival effect Effects 0.000 description 3
- OSWFIVFLDKOXQC-UHFFFAOYSA-N 4-(3-methoxyphenyl)aniline Chemical compound COC1=CC=CC(C=2C=CC(N)=CC=2)=C1 OSWFIVFLDKOXQC-UHFFFAOYSA-N 0.000 description 2
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 description 2
- 241001465754 Metazoa Species 0.000 description 2
- OVRNDRQMDRJTHS-UHFFFAOYSA-N N-acelyl-D-glucosamine Natural products CC(=O)NC1C(O)OC(CO)C(O)C1O OVRNDRQMDRJTHS-UHFFFAOYSA-N 0.000 description 2
- 241000589517 Pseudomonas aeruginosa Species 0.000 description 2
- 230000003115 biocidal effect Effects 0.000 description 2
- 230000002301 combined effect Effects 0.000 description 2
- 230000000850 deacetylating effect Effects 0.000 description 2
- 239000002552 dosage form Substances 0.000 description 2
- 229940079593 drug Drugs 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- 235000019253 formic acid Nutrition 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 238000002156 mixing Methods 0.000 description 2
- 229950006780 n-acetylglucosamine Drugs 0.000 description 2
- 238000011160 research Methods 0.000 description 2
- 239000000243 solution Substances 0.000 description 2
- IEDVJHCEMCRBQM-UHFFFAOYSA-N trimethoprim Chemical compound COC1=C(OC)C(OC)=CC(CC=2C(=NC(N)=NC=2)N)=C1 IEDVJHCEMCRBQM-UHFFFAOYSA-N 0.000 description 2
- 229960001082 trimethoprim Drugs 0.000 description 2
- ZCYVEMRRCGMTRW-UHFFFAOYSA-N 7553-56-2 Chemical compound [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 description 1
- 235000001674 Agaricus brunnescens Nutrition 0.000 description 1
- 241000193830 Bacillus <bacterium> Species 0.000 description 1
- 241000238424 Crustacea Species 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 241000239366 Euphausiacea Species 0.000 description 1
- 241000192125 Firmicutes Species 0.000 description 1
- 241000238631 Hexapoda Species 0.000 description 1
- 241000699670 Mus sp. Species 0.000 description 1
- -1 N-acetyl-D-glucosamine polysaccharide Chemical class 0.000 description 1
- OVRNDRQMDRJTHS-FMDGEEDCSA-N N-acetyl-beta-D-glucosamine Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O OVRNDRQMDRJTHS-FMDGEEDCSA-N 0.000 description 1
- 206010034133 Pathogen resistance Diseases 0.000 description 1
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 1
- 241000191967 Staphylococcus aureus Species 0.000 description 1
- 241000700605 Viruses Species 0.000 description 1
- 230000021736 acetylation Effects 0.000 description 1
- 238000006640 acetylation reaction Methods 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 239000003513 alkali Substances 0.000 description 1
- 239000012670 alkaline solution Substances 0.000 description 1
- 229940124350 antibacterial drug Drugs 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 229910000019 calcium carbonate Inorganic materials 0.000 description 1
- 210000004027 cell Anatomy 0.000 description 1
- 210000002421 cell wall Anatomy 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 238000002512 chemotherapy Methods 0.000 description 1
- 239000013065 commercial product Substances 0.000 description 1
- 239000013078 crystal Substances 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 229940072185 drug for treatment of tuberculosis Drugs 0.000 description 1
- 230000002708 enhancing effect Effects 0.000 description 1
- 230000000855 fungicidal effect Effects 0.000 description 1
- 239000000417 fungicide Substances 0.000 description 1
- 238000000338 in vitro Methods 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 229910052740 iodine Inorganic materials 0.000 description 1
- 239000011630 iodine Substances 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 230000000813 microbial effect Effects 0.000 description 1
- 229920005615 natural polymer Polymers 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 229920001282 polysaccharide Polymers 0.000 description 1
- 239000005017 polysaccharide Substances 0.000 description 1
- 230000002250 progressing effect Effects 0.000 description 1
- 238000012827 research and development Methods 0.000 description 1
- 238000007873 sieving Methods 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 238000005507 spraying Methods 0.000 description 1
- 229960005404 sulfamethoxazole Drugs 0.000 description 1
- IIACRCGMVDHOTQ-UHFFFAOYSA-N sulfamic acid Chemical compound NS(O)(=O)=O IIACRCGMVDHOTQ-UHFFFAOYSA-N 0.000 description 1
- JLKIGFTWXXRPMT-UHFFFAOYSA-N sulphamethoxazole Chemical compound O1C(C)=CC(NS(=O)(=O)C=2C=CC(N)=CC=2)=N1 JLKIGFTWXXRPMT-UHFFFAOYSA-N 0.000 description 1
- 230000002195 synergetic effect Effects 0.000 description 1
- 239000000814 tuberculostatic agent Substances 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Landscapes
- Agricultural Chemicals And Associated Chemicals (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP57150399A JPS5946208A (ja) | 1982-08-30 | 1982-08-30 | 抗菌性組成物 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP57150399A JPS5946208A (ja) | 1982-08-30 | 1982-08-30 | 抗菌性組成物 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS5946208A JPS5946208A (ja) | 1984-03-15 |
| JPH0352443B2 true JPH0352443B2 (fr) | 1991-08-12 |
Family
ID=15496122
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP57150399A Granted JPS5946208A (ja) | 1982-08-30 | 1982-08-30 | 抗菌性組成物 |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS5946208A (fr) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FI73121C (fi) * | 1985-08-08 | 1987-09-10 | Valio Meijerien | Vaextbefraemjande foder och tillsatsaemne foer anvaendning daeri. |
| JPS6440409A (en) * | 1987-08-06 | 1989-02-10 | Fuji Spinning Co Ltd | Molded chitosan product containing immobilized bacteriophage |
| CA2323419C (fr) | 1998-03-12 | 2009-05-05 | Oji Paper Co., Ltd. | Bactericides |
| KR100371091B1 (ko) * | 1999-12-09 | 2003-02-07 | 주식회사대성미생물연구소 | 동물용 복합항생제 조성물 |
| AU2004323928B2 (en) | 2004-10-13 | 2011-03-17 | Kabushiki Kaisha Yakult Honsha | Additive for feeds and feed containing the same |
| RU2423977C1 (ru) | 2010-04-20 | 2011-07-20 | Открытое Акционерное Общество "Фармасинтез" | Противотуберкулезное лекарственное средство на основе 4-тиоуреидоиминометилпиридиния перхлората, способ его получения и способ лечения |
-
1982
- 1982-08-30 JP JP57150399A patent/JPS5946208A/ja active Granted
Also Published As
| Publication number | Publication date |
|---|---|
| JPS5946208A (ja) | 1984-03-15 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN103732232B (zh) | 包含抗生素和分散剂或者抗粘结剂的组合物 | |
| WO2011028967A1 (fr) | Procédés et compositions pour détruire un biofilm au moyen de composés dérivés de chitosane | |
| WO2019135136A1 (fr) | Complexes de coordination ayant une activité microbienne et pouvant être incorporés dans des compositions d'acide hyaluronique | |
| JPH0352443B2 (fr) | ||
| BG64027B1 (bg) | Средство за потапяне на бозки | |
| Siddiqui et al. | Sea cucumber as a therapeutic aquatic resource for human health | |
| JPH0372043B2 (fr) | ||
| JP2019189543A (ja) | 抗ヒト免疫不全ウイルス剤組成物 | |
| ES2290195T3 (es) | Uso de hidratos de carbono para eliminar infecciones intestinales en animales. | |
| Barillo | Topical antimicrobials in burn wound care: a recent history | |
| JP5098015B2 (ja) | 菌体膜傷害性・抗菌性物質とその利用方法 | |
| RU2130312C1 (ru) | Лечебный препарат, обладающий бактерицидным и вирулицидным действием - йодомидол | |
| Davtyan et al. | Design of iodine-lithium-α-dextrin liquid crystal with potent antimicrobial and anti-inflammatory properties | |
| Fouad | Chitosan as an antimicrobial compound: modes of action and resistance mechanisms | |
| EP3733176B1 (fr) | Composition comprenant de la pipéracilline, sa préparation pharmaceutique et son utilisation | |
| KR101787247B1 (ko) | 키토산-카페인산 유도체를 유효성분으로 하는 항균성 조성물 | |
| CN110179967A (zh) | 多粘菌素母核和一种抗生素的组合物及其应用 | |
| CN102961331A (zh) | 一种壳聚糖碘溶液配方及其制备方法 | |
| US20140072598A1 (en) | Medicinal preparation "renessans" having an antibacterial, anti-ulcerous and immuno-modulating action | |
| US3681493A (en) | Antibacterial compositions | |
| JPH06107551A (ja) | 関節症治療剤 | |
| US3148113A (en) | Concurrent oral administration of glucosamine with a tetracycline antibiotic for enhanced antibiotic blood levels | |
| CN108484793B (zh) | 一种菊粉-壳聚糖偶联物、药物组合物、其应用和其制备方法 | |
| Fu et al. | Synergistic activity of apalcillin and gentamicin in a combination therapy in experimental Pseudomonas bacteraemia of neutropenic mice | |
| KR101842041B1 (ko) | 하제 조성물 |