JPH03291258A - Fluorocyclopropylamine - Google Patents
FluorocyclopropylamineInfo
- Publication number
- JPH03291258A JPH03291258A JP9191090A JP9191090A JPH03291258A JP H03291258 A JPH03291258 A JP H03291258A JP 9191090 A JP9191090 A JP 9191090A JP 9191090 A JP9191090 A JP 9191090A JP H03291258 A JPH03291258 A JP H03291258A
- Authority
- JP
- Japan
- Prior art keywords
- compound
- acid
- formula
- salt
- fluorocyclopropylamine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000001875 compounds Chemical class 0.000 abstract 5
- VEXZGXHMUGYJMC-UHFFFAOYSA-N HCl Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 abstract 4
- 150000003839 salts Chemical class 0.000 abstract 3
- 239000011780 sodium chloride Substances 0.000 abstract 3
- 239000002253 acid Substances 0.000 abstract 2
- DTQVDTLACAAQTR-UHFFFAOYSA-N trifluoroacetic acid Chemical compound OC(=O)C(F)(F)F DTQVDTLACAAQTR-UHFFFAOYSA-N 0.000 abstract 2
- DYTNTYHQHKPQEX-LJUKVTEVSA-N (1R,2S)-2-fluorocyclopropan-1-amine;hydrochloride Chemical compound Cl.N[C@@H]1C[C@@H]1F DYTNTYHQHKPQEX-LJUKVTEVSA-N 0.000 abstract 1
- TUKJTSUSKQOYCD-UHFFFAOYSA-N 2-fluorocyclopropan-1-amine Chemical compound NC1CC1F TUKJTSUSKQOYCD-UHFFFAOYSA-N 0.000 abstract 1
- PZAGQUOSOTUKEC-UHFFFAOYSA-N acetic acid;sulfuric acid Chemical compound CC(O)=O.OS(O)(=O)=O PZAGQUOSOTUKEC-UHFFFAOYSA-N 0.000 abstract 1
- 239000004599 antimicrobial Substances 0.000 abstract 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 abstract 1
- 229910052799 carbon Inorganic materials 0.000 abstract 1
- 238000001816 cooling Methods 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 239000005457 ice water Substances 0.000 abstract 1
- 229910052500 inorganic mineral Inorganic materials 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 239000000463 material Substances 0.000 abstract 1
- 239000011707 mineral Substances 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
- 238000003756 stirring Methods 0.000 abstract 1
Abstract
NEW MATERIAL:An optically active 2-fluorocyclopropylamine expressed by the formula (* is asymmetric carbon) and salt thereof.
EXAMPLE: (1R, 2S)-2-Fluorocyclopropylamine-hydrochloride.
USE: A medicine and production intermediate for antimicrobial compound.
PREPARATION: Cis-1-(tert. butoxycarbonylamino)-2-fluorocyclopropane is reacted with a mineral acid such as hydrochloric acid (e.g. concentrated hydrochloric acid) or sulfuric acid or trifluoroacetic acid while stirring the former compound under cooling by ice water and gradually adding the latter compound to the former compound to provide the compound expressed by the formula. When the compound expressed by the formula is an acid salt, it can be converted into free form by treating it by an ordinary method, but it may be used for next reaction directly in the form of the salt.
COPYRIGHT: (C)1991,JPO&Japio
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP9191090A JP2938925B2 (en) | 1990-04-06 | 1990-04-06 | Fluorocyclopropylamine |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP9191090A JP2938925B2 (en) | 1990-04-06 | 1990-04-06 | Fluorocyclopropylamine |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPH03291258A true JPH03291258A (en) | 1991-12-20 |
| JP2938925B2 JP2938925B2 (en) | 1999-08-25 |
Family
ID=14039738
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP9191090A Expired - Lifetime JP2938925B2 (en) | 1990-04-06 | 1990-04-06 | Fluorocyclopropylamine |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JP2938925B2 (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0743299A1 (en) * | 1995-05-15 | 1996-11-20 | Bayer Ag | Process for the preparation of 2-fluorocyclopropylamine sulfonic acid salts and the chemical compound 2-fluorocyclopropylisocyanate |
-
1990
- 1990-04-06 JP JP9191090A patent/JP2938925B2/en not_active Expired - Lifetime
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0743299A1 (en) * | 1995-05-15 | 1996-11-20 | Bayer Ag | Process for the preparation of 2-fluorocyclopropylamine sulfonic acid salts and the chemical compound 2-fluorocyclopropylisocyanate |
Also Published As
| Publication number | Publication date |
|---|---|
| JP2938925B2 (en) | 1999-08-25 |
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