JPH0324009A - Therapeutic agent for liver disease - Google Patents

Therapeutic agent for liver disease

Info

Publication number
JPH0324009A
JPH0324009A JP16056289A JP16056289A JPH0324009A JP H0324009 A JPH0324009 A JP H0324009A JP 16056289 A JP16056289 A JP 16056289A JP 16056289 A JP16056289 A JP 16056289A JP H0324009 A JPH0324009 A JP H0324009A
Authority
JP
Grant status
Application
Patent type
Prior art keywords
etc
active ingredient
therapeutic agent
lower alkyl
formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP16056289A
Inventor
Iwao Arai
Ien Yon Chan
Katsuo Hatayama
Shohei Higuchi
Ryan Hoan
Chii Chon Jou
Gun Tao Riu
Tatsuhiko Sano
Bin Fua Yan
Yoshinari Yoshikawa
Original Assignee
Chunguo Iishue Kuushueyuan Yaou Ienjusuuo
Taisho Pharmaceut Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date

Links

Abstract

PURPOSE: To prepare a therapeutic agent for liver diseases, comprising a specific N-substituted amide derivative containing a new compound as an active ingredient, capable of manifesting inhibiting actions on liver damages and useful for preventing and treating the liver diseases.
CONSTITUTION: This therapeutic agent for liver diseases comprises an N- substituted amide derivative represented by formula I [A is phenyl, naphthyl, thienyl, pyridyl, etc., which may be substituted with a lower alkyl, a lower alkoxy, a halogen, OH, etc.; B is represented by formula II, III, IV (R is a lower alkyl) or formula V, VI or VII; R1 to R3 are each H or a lower alkyl; R1 is H, a 1-18C alkyl, a 2-17C alkenyl, phenyl, etc.] including a new compound in which B is formula II and R4 is other than H, etc., e.g. N-(4-fluorophenacyl)- N-methylformamide as an active ingredient. A carrier and an adjuvant are added to the active ingredient and the resultant mixture is then formulated as a powder, a granule, a capsule, a tablet, etc., which are administered. The daily dose thereof is 0.5-10mg/kg, expressed in terms of the amount of the active ingredient and administered in one to several divided portions.
COPYRIGHT: (C)1991,JPO
JP16056289A 1989-06-22 1989-06-22 Therapeutic agent for liver disease Pending JPH0324009A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP16056289A JPH0324009A (en) 1989-06-22 1989-06-22 Therapeutic agent for liver disease

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP16056289A JPH0324009A (en) 1989-06-22 1989-06-22 Therapeutic agent for liver disease

Publications (1)

Publication Number Publication Date
JPH0324009A true true JPH0324009A (en) 1991-02-01

Family

ID=15717670

Family Applications (1)

Application Number Title Priority Date Filing Date
JP16056289A Pending JPH0324009A (en) 1989-06-22 1989-06-22 Therapeutic agent for liver disease

Country Status (1)

Country Link
JP (1) JPH0324009A (en)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998057926A1 (en) * 1997-06-16 1998-12-23 American Home Products Corporation Elevation of hdl cholesterol by n-[2-[ (aminothioxomethyl)hydrazono] -2-arylethyl]amides
US6034272A (en) * 1997-06-16 2000-03-07 American Home Products Corporation Elevation of HDL cholesterol by N-[4-[(aminothioxomethyl) hydrazono]-4-arylbutyl]amides
US6049006A (en) * 1997-06-16 2000-04-11 American Home Products Corp. Elevation of HDL cholesterol by N-[2-[(aminothioxomethyl) hydrazono]-2-arylethyl]amides
JP2002520325A (en) * 1998-07-09 2002-07-09 アベンティス ファルマ ソシエテ アノニム 4- (3-pyridinyl)-1h-manufacturing processes and intermediates used imidazole

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998057926A1 (en) * 1997-06-16 1998-12-23 American Home Products Corporation Elevation of hdl cholesterol by n-[2-[ (aminothioxomethyl)hydrazono] -2-arylethyl]amides
US6034272A (en) * 1997-06-16 2000-03-07 American Home Products Corporation Elevation of HDL cholesterol by N-[4-[(aminothioxomethyl) hydrazono]-4-arylbutyl]amides
US6049006A (en) * 1997-06-16 2000-04-11 American Home Products Corp. Elevation of HDL cholesterol by N-[2-[(aminothioxomethyl) hydrazono]-2-arylethyl]amides
JP2002520325A (en) * 1998-07-09 2002-07-09 アベンティス ファルマ ソシエテ アノニム 4- (3-pyridinyl)-1h-manufacturing processes and intermediates used imidazole

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