JPH03157373A - Production of 2-aminomethylpyrazines and/or 2-aminomethylpiperazine - Google Patents

Production of 2-aminomethylpyrazines and/or 2-aminomethylpiperazine

Info

Publication number
JPH03157373A
JPH03157373A JP29549989A JP29549989A JPH03157373A JP H03157373 A JPH03157373 A JP H03157373A JP 29549989 A JP29549989 A JP 29549989A JP 29549989 A JP29549989 A JP 29549989A JP H03157373 A JPH03157373 A JP H03157373A
Authority
JP
Japan
Prior art keywords
cyanopyrazine
reaction system
aminomethylpiperazine
aminomethylpyrazine
production
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP29549989A
Other languages
Japanese (ja)
Other versions
JP2815636B2 (en
Inventor
Yoshio Iguchi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Koei Chemical Co Ltd
Original Assignee
Koei Chemical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Koei Chemical Co Ltd filed Critical Koei Chemical Co Ltd
Priority to JP29549989A priority Critical patent/JP2815636B2/en
Publication of JPH03157373A publication Critical patent/JPH03157373A/en
Application granted granted Critical
Publication of JP2815636B2 publication Critical patent/JP2815636B2/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Abstract

PURPOSE: To obtain the title compound useful as an intermediate for drugs and agricultural chemicals readily and in high yield by catalytically hydrogenating a 2-cyanopyrazine in the presence of a hydrogenating catalyst and a solvent while feeding the 2-cyanopyrazine to the reaction system.
CONSTITUTION: A hydrogenating catalyst (e.g. Raney nickel) and a solvent (e.g. dioxane) are added to the a reaction system, a 2-cyanopyrazine is catalytically hydrogenated while feeding the 2-cyanopyrazine to the reaction system to give a 2-aminomethylpyrazine and/or a 2-aminomethylpiperazine. The reaction temperature is 100-142°C, when the 2-aminomethylpyrazine is produced and 148-200°C when 2-aminomethylpiperazine is produced and the reaction pressure is 5-50kg/cm2. In production of the 2-aminomethylpyrazine, addition of ammonia to the reaction system preferably suppress side reactions.
COPYRIGHT: (C)1991,JPO&Japio
JP29549989A 1989-11-14 1989-11-14 Process for producing 2-aminomethylpyrazines and / or 2-aminomethylpiperazines Expired - Fee Related JP2815636B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP29549989A JP2815636B2 (en) 1989-11-14 1989-11-14 Process for producing 2-aminomethylpyrazines and / or 2-aminomethylpiperazines

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP29549989A JP2815636B2 (en) 1989-11-14 1989-11-14 Process for producing 2-aminomethylpyrazines and / or 2-aminomethylpiperazines

Publications (2)

Publication Number Publication Date
JPH03157373A true JPH03157373A (en) 1991-07-05
JP2815636B2 JP2815636B2 (en) 1998-10-27

Family

ID=17821405

Family Applications (1)

Application Number Title Priority Date Filing Date
JP29549989A Expired - Fee Related JP2815636B2 (en) 1989-11-14 1989-11-14 Process for producing 2-aminomethylpyrazines and / or 2-aminomethylpiperazines

Country Status (1)

Country Link
JP (1) JP2815636B2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2018048930A1 (en) * 2016-09-07 2018-03-15 Pharmakea, Inc. Lysyl oxidase-like 2 inhibitors and uses thereof

Also Published As

Publication number Publication date
JP2815636B2 (en) 1998-10-27

Similar Documents

Publication Publication Date Title
JPS559020A (en) Preparation of tertiary amine having long-chain alkyl group
JPH03157373A (en) Production of 2-aminomethylpyrazines and/or 2-aminomethylpiperazine
JPS62129257A (en) Production of benzylamine
JPH04247069A (en) Production of aminomethylpyridines having chlorine atom on alpha-site
JPH0193549A (en) Production of 1,1,1,2-tetrafluoroethane
JPS60146885A (en) Production of furfurylamine and/or tetrahydrofurfurylamine
JPH04117348A (en) Production of aliphatic primary amine
JPH03109361A (en) Preparation of bis(aminomethyl)norcamphanes
JPS6339832A (en) Production of pentafluorobenzaldehyde dialkyl acetal
JPS61251663A (en) Production of aminomethylpyridine
JPS6322036A (en) Selective preparation of perhydroacenaphthene trans isomer
JPS61176556A (en) Production of cyclopentylamine
JPS63280035A (en) Production of trifluoromethyltoluene
JPS60174776A (en) Preparation of piperidine
JPS62108827A (en) Production of 3-methylbutene-1
JPS6048953A (en) Preparation of dimethylhexamethylenediamine
JPS60178877A (en) Preparation of tetrahydrofurfurylamine
JPS6219541A (en) Production of fluorobenzene
JPS62277338A (en) Method for purifying o-methylacetophenone
JPS6483056A (en) Production of aminomethylcyclohexanecarboxylic acid amide
JPH02108642A (en) Production of 2-cyclohexylpropanol
JPS6185334A (en) Production of cycloolefin
JPH04154742A (en) Production of aromatic amino compound
JPS57117526A (en) Preparation of polycondensate from omega-oxypentadecanoic acid
JPS59148772A (en) Preparation of hexamethyleneimine

Legal Events

Date Code Title Description
R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

LAPS Cancellation because of no payment of annual fees