JPH02503890A - Polymer surface coating method and products coated using the method - Google Patents

Abstract

(57) [Summary] This bulletin contains application data before electronic filing, so abstract data is not recorded.

Description

[Detailed description of the invention] This application is a continuation in part of serial number 157856 filed on February 19, 1988. This is an application.

field of invention The present invention is directed to the field of coating polymer surfaces, in particular to treating polymer surfaces with Withstands harsh sterilization processes and long-term contact with human blood and other body fluids, with virtually no Smooth, durable, smooth coating that never loses its smoothness. The present invention relates to a method for producing tinging. More specifically, the present invention Surgical devices made from various polymeric materials are coated with How to create a smooth, durable, slippery coating It is something that

Background of the invention Various polymer materials such as silicone rubber and polyvinyl chloride (PVC) etc. The use of devices made from materials occupies an important place in the performance of numerous surgical procedures. It's starting to happen. Among these devices, one important category is surgical tubes, surgical inserts, and surgical tubes, all of which are It is important in removing blood and other fluids from surgical or wound sites.

Generally, for such treatments, an inert, usually polymeric material is used. A tubular device is inserted into body tissue, and blood flows through the device over a period of several days. It has to be allowed to flow freely. equipment currently used, In particular, silicone products are undesirable because they have a high resistance when passed through tissue. stomach. The biggest problem is that there is a problem, especially on the inside of the drain pipe made of silicone or PvC. There is an undesirably high level of clot formation. In particular, serious problems , the clot that forms may be difficult to remove, especially in the case of silicone. It is. These unfavorable properties are caused by the fact that the surface of the silicone rubber tube is extremely This is due to the fact that it is highly hydrophobic and only slightly wetted by aqueous media. .

Devices made of PVC are better than silicone, but they also do not allow the surface to get wet. <<, I can't say it's smooth either. For this reason, for example, silicone Coating the surface of devices made of various polymeric materials such as The wettability and slipperiness of these devices, especially for uneven drainage pipes, have been investigated. It is desirable to develop methods that allow improvements to be made under the situations encountered when It was considered a good thing.

Among the prior art, applicants have coated various polymeric materials that come into contact with human body fluids. The following are known to address the issue of

U.S. Patent No. 4,100,309 discloses a multi-step method for applying a hydrophilic coating onto a substrate. Discloses the law. US Patent No. 4119094 is US Patent No. 410 0309 and according to the methods described therein. The patent is claimed for the article that was developed by the patentee.

U.S. Patent No. 3,925,178 treats plastic contact lenses. , discloses a method to make the lens surface hydrophilic without changing the optical properties of the lens. .

U.S. Patent No. 4,312,575 also discloses an ultra-thin transparent resin film formed using a glow discharge method. A transparent hydrophilic barrier coating is disclosed.

U.S. Patent No. 4,589,873 discloses that vinyl pipes are made using FDP in a DMF solution. There is a teaching of coating.

None of the above-mentioned references describes the process which is the subject of the present invention or the method produced therewith. It is not intended to teach products that may be used.

Summary of the invention The present invention can be used to treat polymeric surfaces to form eccentric drainage tubes or other surgical devices. A smooth, durable and slippery coating especially suitable for use as It is oriented towards a method of making.

Description of the invention silicone, pvc, latex, polyester, polyurethane or thermoplastic The surface of the lastomer has a hydrogel surface, that is, it is wettable in water and is smooth. By creating a curved surface, the performance of uneven drainage devices made of silicone rubber or PvC can be substantially improved. It was found that this would lead to significant improvement. For example, The frictional forces generated on the surface when inserted into or removed from the This will result in a significant reduction. Most importantly, these surfaces prevent blood from coagulating. The fact that the tendency to remove blood clots is reduced and the ease of removing blood clots is greatly improved has been presented. Ru. It is also generally recognized that fluorinated surfaces (i.e. (Teflon or Teflon-like materials) compared to silicone rubber or PvC surfaces. , which has a much lower tendency to clot formation (i.e., is less likely to form blood clots) is probably due to its low surface energy and low coefficient of friction. . Therefore, a low energy fluorinated surface has a low tendency to clot formation. Furthermore, even if a blood clot is formed, it is expected that it will be a surface to which there is less adhesion. .

It is an object of the present invention to use various polymeric materials such as silicone and PvC. Improved surface properties for localized or surgical site drainage devices made from materials This is a method or process that can be applied. What improvements in surface properties should be achieved? , resulting in a more wet and slippery surface, or a drop in energy that can lead to blood clots. Either it becomes a hard surface. Each of these properties Is it applied by a coating of chemically fixed hydrogel polymers? , or fluorinated the surface of silicone rubber and PvC, or It will be applied by coating it with a bong. thus denatured For a polymer surface to be useful, it must meet four conditions: Must meet the standards.

This is a standard that can be said to be a well-treated (coated) uneven drainage device. The specifications are as follows.

1. Even if the modified surface is in contact with local secretions, it will not last for at least 100 hours. characteristics must be maintained.

2. The method and/or conditions for creating such surfaces are limited to round tubes and irregular cross-sectional shapes. It must be applicable to the inner and outer diameters (surfaces) of pipes with These circles Combinations of narrow tubes and/or irregularly shaped tubes are usually combined with suction devices. used in combination It is known as a closed type partial drainage device. For example, trademark (Snyder Hemo vac) or trademark (Surgivac).

3. The modified surface can withstand sterilization treatment with ethylene oxide, preventing deterioration and cracking. , reduced shelf life or physical properties of the layer or surface of the polymeric substrate. It must be something that will not damage the environment.

4. The methods and/or conditions for creating such surfaces must be safe (e.g., FDA-approved). Pass the USP XIX alasvI) Scale-up is possible using continuous, semi-continuous or batch manufacturing methods. It has to be something.

Needless to say, for example silicone rubber (crosslinked polydimethylsiloxane) There are significant differences between polyvinyl chloride (CPVC) and soft PVC (PVC). The basic polymer structure is However, the silicones actually used are cross-linked (silica) filler-containing silicones. rubber (i.e., a three-dimensional insoluble network), whereas PVc is a soluble It is a thermoplastic resin and does not contain plasticizers that are potentially leached by solvents. However, it does not contain fillers.

Silicone is relatively stable and has low surface energy (extremely difficult to get wet with water) material, whereas PVC has moderate surface energy and water wettability, and salt Reactions based on the presence of elementary-carbon bonds (thermal or strong bases, possible quaternization of amines, desorption of HCI).

However, silicones contain chemically active silanes (SiH) and/or vinyl. Some ru (S i CH=CH2) groups remain. These groups form the surface of the tube. chemical linkage (grafting) if present in sufficient concentration on or near There is a possibility of using it for The silica filler in silicone is also reactive on the surface. It has a silanol (SiOH) group, which is also used on the rubber surface or its If it is present in sufficient concentration directly below it, it will graft and produce useful binding. Dioctyl phthalate can be used to make people feel the same!・) Presence of plasticizer. plasticity Agents sometimes migrate to the surface (bloom), interfere with surface reactions, and/or or may be leached during treatment with solvents, so that the surface It will become harder, more brittle and more prone to cracking.

However, it is important to remember that vinyl pipes are not cross-linked. Since no organic liquid can be used as a solvent for PVC, This means that it will become eroded or eroded. This is a silicone tube In contrast, silicone tubing is cross-linked and non-cross-linked silicone. Even if it is in a liquid that is a solvent for it, it will only swell and will not dissolve.

Therefore, silicones can be easily and conveniently treated using a wide range of solvents and immersion conditions. It can be impregnated with various bonding or grafting agents. On the other hand, vinyl Solvent solutions used for processing must be selected and used with care.

Therefore, depending on the coating method or treatment method, silicone, PvC, etc. There are polymeric materials that can be used with either, but the requirements for the characteristics of the substrate surface must be taken into account. You have to keep that in mind and adapt your methods to that surface if necessary. . Some treatment methods can only be used on specific surfaces. That would be the case.

When conducting experiments necessary to evaluate the method of the present invention, silicone rubber is , methylene chloride or l.

1. Swell with a suitable swelling solvent such as 1-trichloroethane to form a rubber. Impregnated with a binder or hardening agent, the pot is selected from a suitable breeding solvent or aqueous solution. Coated with rimmer. To obtain an adherent coating, various drying/ A heat curing method was used. To prevent coating dissolution or premature erosion. For this purpose, selectively coated samples may be coated with the same or sometimes different crosslinkers. and then post-treated with a hardening agent so that the coating is swollen in water but insoluble in water. There may be times when it is necessary to do so.

The treatment of PVC was approached more carefully from the standpoint of substrate solubility. to PVC The best solvent treatment medium is determined by comparing the curing of a range of solvents against It was.

Alcohols have been found to be the best treatment medium.

Wet chemical (acid, base, oxidation) treatment of the polymer surface to be coated. The surface may be pretreated by either physical or gas phase (halogenation) or chemical activation may be beneficial. These treatments Allows the container to be wetted by a chemical bonding or polymer coating solution. Ru. This process also introduces groups that actually react with the material, thereby adding heat to the surface. Drogel polymers can be chemically bonded or encouraged to bond. I can do it.

Choline (trademark: Rohaand) I from Rohm and Haas For the first time, strong organic bases such as AAS (manufactured by AAS) have shown promise as a pretreatment method for silicone surfaces. It is known that there is. Strong acids (e.g. sulfuric acid) or oxidizing agents (e.g. Calcium hypochlorite) had no effect on the base.

A series of coating techniques with and without choline base pretreatment were then applied. The initial wetting or coating properties of the silicone rubber are However, subsequent base treatment results in a satisfactory hydrogel coating. It was not necessarily necessary to make silicone tubes.

The need for solvent swelling pretreatment or brimer coating on silicone surfaces is eliminated. It is proven. Petrarch PS07B (trimethoxypropylsilyl Brimers (substituted polyethyleneimine) are extremely A smooth PvP adhesion top coat is obtained that is easily converted and remains stable in water. It becomes a slippery wet coating. Furthermore, the prior art (Becton in 1988) U.S. Patent No. 4,589,873) issued to Dlekinson, If the dimethylformamide solution of pvp is a solvent (toluene or xylene) It is claimed to be effective when used on pre-swollen silicone tubes. this When I tried it, it turned out that it didn't work. In this method, on the silicone However, the PVP coating could not be completely heated.

For example, silicone tubing swollen with xylene was prepared using a 4% DMF solution of PVPK-90. Even when I immersed it in liquid, it didn't get wet. DVP/DMF solution, remove the tube from the solution Then, it completely fell out of the tube. No liquid film remained on the surface of the tube. It is. (See Table 21 Example ■) The equilibrium swelling amount and leachable content are as shown in Table 1. Two batches of silicone tubes were measured. Based on this knowledge, evaluate The brimer solution to be used is PVC solvent methylene chloride or 1.1.1 -trichloroethane. However, methylene Chloride is not a suitable coating medium for PvC Brimer solutions. It was confirmed that something was wrong. The media for the brimer are isopropanol and It was determined that alcohols such as methanol were far superior. this medium If so, it won't dissolve the vinyl and therefore has much better flexibility and shape retention. become.

Soak a vinyl tube in a 2-4% PVP/methanol solution, and replace the wet tube with 80-1 Dry in a circulating air oven at 50°C for 20 minutes at 80°C and 5 minutes at 150°C. This creates a smooth surface that gets wet with water. 2-4% PVP isopropyl A similar quantitatively smoother coat can be obtained by drying the coat solution in a similar manner. ting is obtained. However, these wet and slippery coats Ting can be easily removed by lightly rubbing it with your fingers while it is wet. Vine Even after the hanging coating is gone, the vinyl surface is still wet. Water spreads over the surface and forms a film. However, the smooth lubricity It is no longer acceptable. On the other hand, the coating solution contained 0.2% PS07B. The initial water wettability and smoothness are similar; The degree of roughness is quantitatively much more durable, and this effect also The improvement will be improved if the solution is based on isopropanol rather than methanol. It's good.

Table 1 Equilibrium swelling amount and leaching potential of silicone tube in methylene chloride sex% Swelling,% Batch #1 (a) 14L11152.9154.9 - - - Batch #2 (b) 165.2 1774 - 11 11.5 190.7 187.4 188.0 Weight reduction, % Batch #1 1.0 1.78 1.70 − − − − -Batch #2 2.05-2.50-2JO- 2,700 dimensional change% outer diameter Batch #I N, A, N, A, 211.9 - - Batch #2 14J N, A, 211.9 - 211.9 Dimensional change, % length Batch $1 - - 26.0 - - - (b) Second batch of silicone tubes, without post-curing Such results, untreated controls The following properties can be used to obtain a smoother surface in water or in an aqueous medium: A processing method consisting of steps has been developed.

-N-trimethoxypropylsilylpolyethyleneimine (PetrarchPS O7B) Application of brimer coat. In the case of silicone, methylene chloride or If trichloroetha > sol e, heel (P ¥ C), isopropanol /methanol or isopropanol solution.

- Pharmacopoetical grade polyacrylic acid, Carbopol 94.0 (B, F, Goodr (manufactured by ich) or poly(methyl vinyl ether/maleic anhydride) , Gantrez AN 169 (manufactured by GAP Carp) dimethylform Amide (DMF) solution or 1:1 methanol/isopropanol solution as above Application of a tie coat.

- Borihynylpyrrolidone (PVP), K-90 (GAP C.

rp) or n-propyl or isopropyl alcohol as described above. Application of a slippery coating consisting of an alcoholic solution such as

Alternatively, when processing silicone polymer devices, the series of treatments already described above may be used. To increase the sensitivity of silicone to e.g. Pretreatment step using quaternary organic bases such as (Rohm & HaaS trademark) can be carried out first.

Although the present invention has been outlined above, the details of the present invention will be better understood with reference to the following examples. Let's deepen.

Example Throughout the illustrative description of the process of the present invention, silicone and A VCO tube was used as a sample.

1. Cut each sample tube to a length of 15 inches, cut a slit in one end, and Each reference number is labeled. Drill two holes in the same end for hanging during the drying process. The sample was immersed vertically for 2 minutes into a 16 inch long glass tube containing a dropper. unintentionally The tube was placed in a circulating air oven at 80° C. for 15 minutes.

3. Remove the tube from the furnace, cool it to room temperature for a few minutes, and then add it to the NH and treatment solution. Soaked for 10 seconds. Place the tube back into the oven at 80''C for a drying time of 30 minutes.

4. Remove from the furnace and cool to room temperature, then add GantreZAN-169 solution to the tube. immerse it in the water for 10 seconds. When the soaking is finished, the tube is placed again in the oven at 80℃ for 15 minutes. there was.

5. In the final step, gently place the tube into the polyvinylpyrrolidone solution for 15 seconds.

The drying procedure described above was carried out with an extended drying time of 30 minutes.

(N-trimethoxypropylsilyl polyethyleneimine; Petrarch PS 076) Prepare a 0.2% solution of the above items. For silicone tubes , methylene chloride or 1,1,1-trichloroethane solution, PVC tube In this case, use a solution of either methanol and/or isopropanol. P SO7B must be refrigerated when not in use to prevent moisture absorption.

n, NH, treatment solution The composition of this solution is as follows. Distilled water 1.05ml1. 6 ml methanol , ammonium hydroxide (29.7% NH3) 0.9ml m, Gantrez AN-189GAP Corporation Gantrez An-1,69 is made into a 0.25-2.0% DMF solution. Like or 0.25-. in a 1:1 ratio of methanol and isopropanol. It is set to 0%. More preferably, a 0.25-1.0% solution is used.

■, Polyvinylpyrrolidone solution Preferably another product from GAF Corporation, PVP K-90. A 0.25-5-0% solution in distilled water. It is better to use 0.25-2゜0% solution. I like it. Concentration levels will vary depending on experimental requirements.

Example 1-13 A treatment procedure that produces a smoother surface than the untreated control silicone. This was clarified through a series of processing examples.

The processing steps are as follows.

Silicone using a quaternary organic base (Choline: manufactured by Rohm & Haas) pretreatment - Brimer treatment, N-)rimethoxybrobysilyl polyethyleneimine (Petrarch PS 07G) methylene chloride solution.

- Tie coat, local grade polyacrylic acid, Carbopo! 940 (B, F, G (manufactured by Oodrich) or poly(methyl vinyl ether/maleic anhydride) ), Gantrez AN-169 (GAF Corp.

ration) DMF solution.

Smooth coating on one surface, polyvinylpyrrolidone (PVP), K -90CGAP Corporation) aqueous solution.

Porcine 5k1n Te5t Table 2 shows the average force measured using the .

(Margin below) Table 2 Silicone tube; Examples of processing variation factors 18% PSO76 acid/salt Base 0.25% 1.5% PVP Pork Skin Test K Chollne Kai? -Carbapol K-90 average force 2 10 minutes (a) x -x 2.35 0.723 -x -x x2.750.284 60 minutes X -X 2.88 0.245 8 0 minutes X' - GantrazAN169 X 3. 20 0.35XD! IF solution (4, 15, 2, 25) 6 30 minutes x Po1yox VSR3 012.4g 0JO0.3g% aqueous solution 7 30 minutes X Po1yox VSR 2,180,94COAG 0.18″A aqueous solution 8 30 minutes X −X 3.220. 749 30 minutes × Acid (c) × −3,6 30,52in so minutes x base (d) x 3JD 1.7B11 (control) no treatment 3.03 0J112 0J112 Flame treatment (sl sulated plasma),) toluene solution Kratoo, 3JOO , 911 selar solution 13 Swelling in xylene for 30 minutes, PVP (X-90) 4% DMF solution 1.33 0.78 Soak for 5 seconds, dry (a) Heating with hot air gun during processing (b) N4 rimethoxysilylbropyl polyethyleneimine (Petrarch 5% methylene chloride solution of PSD7B) (c) Methanol 105ml, distilled water 6ml, water 111　0.9ml (d) Meth Nol 105ml, distilled water 6ml, 2L 7% NH1 water (S ammonium hydroxide) 0.9ml Example 14-H Perform a procedure similar to that used in Example 1-13 in a series of treatments for PVC. Clarified with an example.

The processing steps used were as follows.

- Brimer coat, trimexypropylsilyl polyethyleneimine (Pet rarch PSO7B) isopropanol/methanol or isopropanazine le solution.

-Tie coat, poly(methyl vinyl ether/maleic anhydride) s Gan Isopropaz of trez AN-169 (manufactured by GAP Corporation) alcohol/methanol 1:1 mixture solution.

-Smooth coating on the surface, polyvinylpyrrolidone (PVP), K -90 (manufactured by GAP Corporation) aqueous solution.

The measurement results of the average force determined by the pigskin test are shown in Table 3.

Bect advocates coating vinyl pipes with a PvP DMF solution. As taught in U.S. Patent No. 4,589,873 issued to Dickinson on Certain prior art was also repeated.

It has been found that the solvent DMF rapidly attacks and dissolves the surface of vinyl tubing. Cor The coated product will therefore easily warp and the resulting coating will The results quickly become extremely uneven and of poor quality.

Also, the wet coating is then dried using a hot air gun and placed in water. The transparent surface becomes wet and smooth, but soon turns white and opaque. this From an aesthetic point of view, it can be said that this is an uninteresting appearance. Leave the coating at room temperature. or dried in an oven at a relatively low temperature (e.g. 80°C for 15 to 30 minutes) If you rub it in between your fingers, the wet coating will come off easily and the surface will become cloudy. That's what happens. Coat PVC using a 4% methanol solution of PVP Even if the tube was immersed for 100 seconds and dried at 80°C for 30 minutes, the coating remained. It dissolves quickly in water and can be removed by gently rubbing it with your fingers, leaving it slippery. You end up with an empty tube.

(Margin below) Jio, Chollna Ca rboppl Average power iIb,＞ 1.5 - - PVP (K-9's) 　　　　1.5　2.41g　　　　　　　　　　1.5%FVP(TMP＞/5 alar　　　　OJj　　[31G　　---1,5%Elvuld@ 1.73　　　　　5go61/Pi Medium (Hunting 1) 20 - 14 Surprising Polyethyleneimine - -1.5% El vulde 1.3B 0.76 (PEI) (C ) 80817P1'P (WD21 - - 1.5[1vulda] IJ9 1.01g081/P)'P (rib 1) 22 − − 1.5% EIvm lde　　　　　　　1.5g　1.03goal/PvP(M 2g ----1,,5%EIvulde 1. , $1 0JBgoalha(Iueel　1701so14haph>24　-　　　 - - - 1. S%EIvulds 1.80 1.408061/Klueel IF (14ecIl/IP υ25 − DJ4% pl:l −−L, 5℃Iv ulde 1. BS 0.108%l/PvP (Aya0υIP A) 26 - OJ4$PEI - 1,6% Elvul ds　　　　　　　1.25　DJSgoalノPEx-60QQILl OH/IP7. )no,u%Ill:l　　　　　　　　　　　--1,5%E lvulds8flU/1ueel LF(llsO)1/IPA) ! , 15 0.132g-OJj%PEI--1.5! Go: Ivuldaεo ai/Nikaiol LFO4eOH/IPA) 1.26 0.61ω (N-trimethoxysilylpropyl)polyethylimine (Petrucb 1l S07B) 5% methylene chloride solution (b) NHy treatment/1+29.7%N H, water o, h+, water lO fine 1, methanol 6yo 1 (e) 16% aqueous solution (ωn 01) 0.84% prepared by diluting m1 mouth 1, FEI 600) with methanol Polyethyleneimine solution tested silicone and PYC coatings Various coating components were evaluated. The results are shown in Table 4-6. look The best ingredients produced are:

-For brimers and silicones, dissolve PSO7B in trichloroethane. For PVC, use Improper Tool/Methanol or Isoproper Tool PS07B is dissolved in water.

-Tie coat, Gantrez AN 169 with methanol/isopropate Dissolved from a 1:1 mixture.

-Smooth surface coating, made by dissolving PVP K-90 in water.

(Margin below) Table 4: Evaluated brimers Silicone Silane coupling agent Polymer cup in a series Ring agent PS 07B is the best Ganew-V-220 treatment appeared promising.

Olefin / Same pendant group as in pyp.

Vinylpyrrolidone copolymer Cantrez AN-169 MeOH/processing seems promising It seemed to me.

IPA solution, maleic anhydride half ester suspension Kraton Effective on flame treated silicon.

Styrene/Inbrene 5IILIIIlted pljis++a treatment/styrene block copolymer 1’i’c Silane Cobbing Agent PSO7B works well .

Polyethyleneimine It is less smooth than the control world.

Table 5 Evaluated tie/coat neck Cantrez AN-169, maleic anhydride suspension (2) smooth cantr Methyl half ester of ez^N-1,69 Best) 1eO) 1/IPA dissolved in Gantrez ES, maleic anhydride in advance with ethyl half ester A certain cantrez half ester ES 22 5 is the best of the series, but Gantrez 169 methyl half ester is The slip properties are significantly inferior to those dissolved in A/MeOH (50:50).

) Iiches Prime 49113 PV P　The top coat is elastic and wettable. Ethylene acrylic acid is dispersed in NH3 water. (a) Addition of water when applying PVP top coat Decomposes into maleic acid.

! ! 6. Polymers evaluated PVP, polyvinylpyrrolidone, best 5elar s ethylene/ When combined with vinyl alcohol PvP, the strength of the copolymer increases. The slipperiness decreases.

Gintrez AN-169, maleic anhydride suspension pvp no 5elar Test in combination with EIvam1da 8061, nylon H A smooth coating was obtained in combination with ucel. 1υeel, hydroxypropylcellulose Elvaslde 8061 A smooth coating was obtained in combination with PE0X, poly(ethyloxazoline) Elvamlde 8061 A smooth coating with poor strength can be obtained in combination with It was.

Po+yoxs polyethylene oxide K No improvement observed ynar 461s polyvinylidene fluoride coated without brimer almost same as control (silicone) Using the materials shown in Table 7-9 and following the procedure used in Example 1-28, further A series of evaluations of the ingredients were performed. The results of the evaluation conducted are also shown in Table 7-9.

Example 29-60 Using the materials shown in Table 7-9, prepare two different ingredients according to the procedure performed in Example 9, 1-18. A series of further evaluations were conducted.

Although the present invention has been described with reference to various specific examples and embodiments, the present invention is not limited to these. It is not determined.

It should be understood that a wide variety of implementations are possible within the scope of the claims.

(Margin below) international search report 1 car + Rj1. Senatmuel"("6IIN@T5M/+lEQ Q/nn Ef1.1

Claims (1)

[Claims] 1. Treat articles or equipment with polymeric surfaces to make them smooth and durable. , a treatment method consisting of the following steps to create a coating with good slipperiness (1) Application of a primer coat to the polymeric surface of the above article or equipment (2) Poly(acrylic acid aqueous solution, poly(methyl vinyl ether)/ dimethylformamide solution of maleic anhydride, poly(methyl vinyl ether/ maleic anhydride) in a 1:1 mixture of methanol/isopropanol, and (methyl vinyl ether/maleic anhydride) from methanol to pentanol. alcohols selected from lower alcohols or their mixtures with water application of a tie coat consisting of a solution selected from the solutions of products; (3) A coating with good slipperiness made of polyvinylpyrrolidone solution on the above surface. Application of ting. 2. Patent claim 1. , the article is made of silicone, polyvinyl chloride, latex. Polyesters, polyesters, polyurethanes, and thermoplastic elastomers. A method in which the material has a limer surface. 3. In patent claim 2, the polymer surface is silicone, latex, polyester. Methods that are Stell, polyurethanes and thermoplastic elastomers. 4. In claim 3, the surface of the article or device is A method in which the method is pretreated with a quaternary organic base. 5. In patent claim 3, the applied primer coat is N-trimethoxy- A method consisting of a methylene chloride solution of propylsilyl polyethyleneimine. 6. In claim 3, the tie coat to be applied is a polyacrylic acid aqueous solution, Dimethylformamide solution of poly(methyl bier ether/maleic anhydride), and poly(methyl vinyl ether/maleic anhydride) methanol/isopropylene A method consisting of a solution selected from a solution of a 1:1 mixture of Panol. 7. The method of claim 2, wherein the polymeric surface is polyvinyl chloride. 8. In claim 7, the applied primer coat is N-trimethoxy. Isopropanol or isopropanol of propylsilyl polyethyleneimine/ A method consisting of a solution of a methanol mixture. 9. In claim 7, the applied tie coat is made of poly(methyl vinyl ether). from a solution of 1:1 methanol/isopropanol mixture of How to become. 10. In patent claim 1, the polymer surface is silicone, latex, polyester. stell, polyurethane and thermoplastic elastomers, and the plastic to be applied. The immer coat is a trichloride of N-trimethoxypropylsilyl polyethyleneimine. Loethane solution and the tie coat to be applied is poly(methyl vinyl ether) / maleic anhydride) in a 1:1 methanol/isopropanol mixture. , also a slippery coating to be applied is polyvinylpyrrolidone water. How to be a solution. 11. In patent claim 1, the polymer surface is polyvinyl chloride, and the coated surface is polyvinyl chloride. The primer coat to be applied is N-trimethoxypropylsilyl polyethyleneimide. of isopropanol/methanol mixture or isopropanol alone. Yes, the tie coat to be applied is poly(methyl vinyl ether/anhydrous maleic) solution of methanol/isopropanol 1:1 mixture of A method in which the slippery coating to be applied is an aqueous solution of polyvinylpyrrolidone. 12. Processed to create a smooth, durable and slippery coating. an article or device having a textured polymeric surface, the article or device having a Polyacrylic acid aqueous solution, poly(methyl vinyl ether/anhydrous male) (indic acid) in dimethylformamide, and poly(methyl vinyl ether/free water (maleic acid) in a 1:1 methanol/isopropanol mixture. A primer coat consisting of a solution of polyvinylpyrrolidone is applied to the surface. By applying a liquid coating with good slipperiness, the coating , an article or device formed by 13. Silicone, latex treated according to the method of claims 5 and 6 , polyester, polyurethane and thermoplastic elastomer surfaces or equipment. 14. having a polyvinyl chloride surface treated according to the method of patent claims 8 and 9. Articles or equipment that 15. having a polymeric surface treated according to the method of claim 10 or 11. article or equipment that 16. A tubular shape with a polymeric surface treated according to the method of claim 1. article or equipment. 17. A flat shape with a polymeric surface treated according to the method of claim 1. article or equipment. 18. A surgical procedure having a polymeric surface treated according to the method of claim 1. article or equipment suitable for a purpose 19. For drain pipes having a polymeric surface treated according to the method of claim 1 article or equipment suitable for 20. having a polymeric surface treated according to the method of claim 1; article or equipment whose surfaces can withstand the harsh conditions of steam sterilization without disadvantage.