JPH02174784A - Isothiazoloquinoline derivative - Google Patents

Isothiazoloquinoline derivative

Info

Publication number
JPH02174784A
JPH02174784A JP32776188A JP32776188A JPH02174784A JP H02174784 A JPH02174784 A JP H02174784A JP 32776188 A JP32776188 A JP 32776188A JP 32776188 A JP32776188 A JP 32776188A JP H02174784 A JPH02174784 A JP H02174784A
Authority
JP
Japan
Prior art keywords
derivative
formula
gram
alkyl
lower
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP32776188A
Inventor
Eiichi Ecchu
Yasuo Ito
Hideo Kato
Nobuo Ogawa
Noriyuki Yagi
Toshihiko Yoshida
Original Assignee
Hokuriku Seiyaku Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hokuriku Seiyaku Co Ltd filed Critical Hokuriku Seiyaku Co Ltd
Priority to JP32776188A priority Critical patent/JPH02174784A/en
Publication of JPH02174784A publication Critical patent/JPH02174784A/en
Application status is Pending legal-status Critical

Links

Abstract

NEW MATERIAL:The compound of formula I [R1 is lower (hydroxy)alkyl; R2 and R3 are H or lower alkyl; n is 2 or 3; R2 and R3 are not H at the same time when R1 is methyl].
EXAMPLE: 9-Cyclopropyl-6-fluoro-7-(3-hydroxymethyl-1-piperazinyl)-isothiazolo[5,4- b]quinoline-3,4(2H,9H)-dione.
USE: Antibacterial agent against gram-positive bacteria and gram-negative bacteria.
PREPARATION: A 7-halogenoisothiazoloquinoline derivative of formula II (x is halogen) is made to react with a cyclic amine compound of formula III in a solvent optionally in the presence of a base.
COPYRIGHT: (C)1990,JPO&Japio
JP32776188A 1988-12-27 1988-12-27 Isothiazoloquinoline derivative Pending JPH02174784A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP32776188A JPH02174784A (en) 1988-12-27 1988-12-27 Isothiazoloquinoline derivative

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP32776188A JPH02174784A (en) 1988-12-27 1988-12-27 Isothiazoloquinoline derivative

Publications (1)

Publication Number Publication Date
JPH02174784A true JPH02174784A (en) 1990-07-06

Family

ID=18202694

Family Applications (1)

Application Number Title Priority Date Filing Date
JP32776188A Pending JPH02174784A (en) 1988-12-27 1988-12-27 Isothiazoloquinoline derivative

Country Status (1)

Country Link
JP (1) JPH02174784A (en)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7199128B2 (en) 2005-02-02 2007-04-03 Achillion Pharmaceuticals, Inc. 8-N-substituted-2H-isothiazolo[5,4-b]quinolizine-3,4-diones and related compounds as antiinfective agents
US7659399B2 (en) 2005-01-05 2010-02-09 Achillion Pharmaceuticals, Inc. 1-thia-2,4a-diaza-cyclopenta[b]napththalene-3,4-diones and related compounds as anti-infective agents
US8044204B2 (en) 2005-07-27 2011-10-25 Achillion Pharmaceuticals, Inc. 8-methoxy-9H-isothiazolo[5,4-b]quinoline-3,4-diones and related compounds as anti-infective agents
US8114888B2 (en) 2005-02-16 2012-02-14 Achillion Pharmaceuticals, Inc. Isothiazoloquinolones and related compounds as anti-infective agents
US8173636B2 (en) 2009-04-03 2012-05-08 Achillion Pharmaceuticals, Inc. Hydroxylthienoquinolones and related compounds as anti-infective agents

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7659399B2 (en) 2005-01-05 2010-02-09 Achillion Pharmaceuticals, Inc. 1-thia-2,4a-diaza-cyclopenta[b]napththalene-3,4-diones and related compounds as anti-infective agents
US7199128B2 (en) 2005-02-02 2007-04-03 Achillion Pharmaceuticals, Inc. 8-N-substituted-2H-isothiazolo[5,4-b]quinolizine-3,4-diones and related compounds as antiinfective agents
US8114888B2 (en) 2005-02-16 2012-02-14 Achillion Pharmaceuticals, Inc. Isothiazoloquinolones and related compounds as anti-infective agents
US8044204B2 (en) 2005-07-27 2011-10-25 Achillion Pharmaceuticals, Inc. 8-methoxy-9H-isothiazolo[5,4-b]quinoline-3,4-diones and related compounds as anti-infective agents
US8946422B2 (en) 2005-07-27 2015-02-03 Achillion Pharmaceuticals, Inc. 8-methoxy-9H-isothiazolo[5,4-B]quinoline-3,4-diones and related compounds as anti-infective agents
US8173636B2 (en) 2009-04-03 2012-05-08 Achillion Pharmaceuticals, Inc. Hydroxylthienoquinolones and related compounds as anti-infective agents

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