JPH02131569A - Microchamber plate, particle discrimination, particle treating device and cell treating device - Google Patents

Microchamber plate, particle discrimination, particle treating device and cell treating device

Info

Publication number
JPH02131569A
JPH02131569A JP63283601A JP28360188A JPH02131569A JP H02131569 A JPH02131569 A JP H02131569A JP 63283601 A JP63283601 A JP 63283601A JP 28360188 A JP28360188 A JP 28360188A JP H02131569 A JPH02131569 A JP H02131569A
Authority
JP
Japan
Prior art keywords
electrodes
treating device
particle
pair
change
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP63283601A
Other versions
JP2829005B2 (en
Inventor
Yoshio Kawamura
Hiroyuki Kohita
Kazuo Sato
Shinji Tanaka
Original Assignee
Hitachi Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hitachi Ltd filed Critical Hitachi Ltd
Priority to JP63283601A priority Critical patent/JP2829005B2/en
Priority claimed from US07/425,028 external-priority patent/US5183744A/en
Publication of JPH02131569A publication Critical patent/JPH02131569A/en
Application granted granted Critical
Publication of JP2829005B2 publication Critical patent/JP2829005B2/en
Anticipated expiration legal-status Critical
Application status is Expired - Fee Related legal-status Critical

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M35/00Means for application of stress for stimulating the growth of microorganisms or the generation of fermentation or metabolic products; Means for electroporation or cell fusion
    • C12M35/02Electrical or electromagnetic means, e.g. for electroporation or for cell fusion
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277Apparatus
    • B01J2219/00279Features relating to reactor vessels
    • B01J2219/00306Reactor vessels in a multiple arrangement
    • B01J2219/00313Reactor vessels in a multiple arrangement the reactor vessels being formed by arrays of wells in blocks
    • B01J2219/00315Microtiter plates
    • B01J2219/00317Microwell devices, i.e. having large numbers of wells
    • CCHEMISTRY; METALLURGY
    • C40COMBINATORIAL TECHNOLOGY
    • C40BCOMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES, IN SILICO LIBRARIES
    • C40B60/00Apparatus specially adapted for use in combinatorial chemistry or with libraries
    • C40B60/14Apparatus specially adapted for use in combinatorial chemistry or with libraries for creating libraries

Abstract

PURPOSE: To automatically carry out a large amount of cell fusion by equipping plural partition chambers having a pair of electrode in the interior and a means of impressing electric voltage between the electrodes independently in each chamber.
CONSTITUTION: A silicon wafer, etc., is subjected to anisotropic etching treatment and provided with lattice partition chambers 101-103 and 201-203 and each partition chamber is provided with a pair of electrodes 802 and 803 to give a microchamber plate 901. Electrical voltage is impressed between the electrodes and a pair of cells existing between the electrodes are mutually contacted and fused. Change in shape of fused cell is known from change in potential between the electrodes and pulse voltage of fusion is strengthened or weakened and controlled. Since an electric fusion condition depending upon change in individual of cells existing in each partition chamber can be finely controlled, a great number of cells can be efficiently fused.
COPYRIGHT: (C)1990,JPO&Japio
JP63283601A 1988-11-11 1988-11-11 Micro-chamber plate, cell detection method using the same, processing method and apparatus and cell Expired - Fee Related JP2829005B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP63283601A JP2829005B2 (en) 1988-11-11 1988-11-11 Micro-chamber plate, cell detection method using the same, processing method and apparatus and cell

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP63283601A JP2829005B2 (en) 1988-11-11 1988-11-11 Micro-chamber plate, cell detection method using the same, processing method and apparatus and cell
US07/425,028 US5183744A (en) 1988-10-26 1989-10-23 Cell handling method for cell fusion processor

Publications (2)

Publication Number Publication Date
JPH02131569A true JPH02131569A (en) 1990-05-21
JP2829005B2 JP2829005B2 (en) 1998-11-25

Family

ID=17667618

Family Applications (1)

Application Number Title Priority Date Filing Date
JP63283601A Expired - Fee Related JP2829005B2 (en) 1988-11-11 1988-11-11 Micro-chamber plate, cell detection method using the same, processing method and apparatus and cell

Country Status (1)

Country Link
JP (1) JP2829005B2 (en)

Cited By (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003096002A1 (en) * 2002-05-13 2003-11-20 Matsushita Electric Industrial Co., Ltd. Instrument and method for measuring action signal of biological sample
WO2003104788A1 (en) * 2002-06-05 2003-12-18 松下電器産業株式会社 Extracellular potential measuring device and method for fabricating the same
JP2004504022A (en) * 2000-07-14 2004-02-12 ユニバーシティ オブ サウス フロリダ Electric fusion chamber
WO2004050866A1 (en) * 2002-12-03 2004-06-17 Genetronics, Inc. Large-scale electroporation plates, systems, and methods of use
JP2005156234A (en) * 2003-11-21 2005-06-16 Matsushita Electric Ind Co Ltd Extracellular potential measuring device and extracellular potential measuring method using it
JP2007529215A (en) * 2004-03-15 2007-10-25 アマクサ ゲゼルシャフト ミット ベシュレンクテル ハフツング Container and a device for generating an electric field in different chambers
US7736477B2 (en) 2004-08-25 2010-06-15 Panasonic Corporation Probe for measuring electric potential of cell
US7776193B2 (en) 2005-12-20 2010-08-17 Panasonic Corporation Cell electrophysiological sensor
KR101015978B1 (en) * 2008-04-18 2011-02-25 대한민국 Cell fusion dish for micromanipulated cell-oocyte complex
US8071363B2 (en) 2006-05-25 2011-12-06 Panasonic Corporation Chip for cell electrophysiological sensor, cell electrophysiological sensor using the same, and manufacturing method of chip for cell electrophysiological sensor
JP2012098036A (en) * 2010-10-29 2012-05-24 Sony Corp Sample flow-in apparatus, sample flow-in chip and sample flow-in method
US8202439B2 (en) 2002-06-05 2012-06-19 Panasonic Corporation Diaphragm and device for measuring cellular potential using the same, manufacturing method of the diaphragm
US8318477B2 (en) 2005-06-07 2012-11-27 Panasonic Corporation Cellular electrophysiological measurement device and method for manufacturing the same
US8445263B2 (en) 2006-07-06 2013-05-21 Panasonic Corporation Device for cellular electrophysiology sensor, cellular electrophysiology sensor using the device, and method for manufacturing the cellular electrophysiology sensor device
US9377388B2 (en) 1997-03-14 2016-06-28 Trustees Of Tufts College Methods for detecting target analytes and enzymatic reactions
US10107804B2 (en) 2001-03-23 2018-10-23 Trustees Of Tufts College Methods for detecting target analytes and enzymatic reactions

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6363372A (en) * 1986-09-05 1988-03-19 Hitachi Ltd Cell fusion device
JPS6363397U (en) * 1986-10-14 1988-04-26
JPS63160575A (en) * 1986-12-24 1988-07-04 Norin Suisan Gijutsu Joho Kyokai Cell fusion apparatus
JPS63269977A (en) * 1987-04-30 1988-11-08 Hitachi Ltd Cell fusion apparatus

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6363372A (en) * 1986-09-05 1988-03-19 Hitachi Ltd Cell fusion device
JPS6363397U (en) * 1986-10-14 1988-04-26
JPS63160575A (en) * 1986-12-24 1988-07-04 Norin Suisan Gijutsu Joho Kyokai Cell fusion apparatus
JPS63269977A (en) * 1987-04-30 1988-11-08 Hitachi Ltd Cell fusion apparatus

Cited By (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10241026B2 (en) 1997-03-14 2019-03-26 Trustees Of Tufts College Target analyte sensors utilizing microspheres
US9377388B2 (en) 1997-03-14 2016-06-28 Trustees Of Tufts College Methods for detecting target analytes and enzymatic reactions
JP2004504022A (en) * 2000-07-14 2004-02-12 ユニバーシティ オブ サウス フロリダ Electric fusion chamber
US10107804B2 (en) 2001-03-23 2018-10-23 Trustees Of Tufts College Methods for detecting target analytes and enzymatic reactions
WO2003096002A1 (en) * 2002-05-13 2003-11-20 Matsushita Electric Industrial Co., Ltd. Instrument and method for measuring action signal of biological sample
US7501278B2 (en) 2002-06-05 2009-03-10 Panasonic Corporation Extracellular potential measuring device and method for fabricating the same
US8202439B2 (en) 2002-06-05 2012-06-19 Panasonic Corporation Diaphragm and device for measuring cellular potential using the same, manufacturing method of the diaphragm
WO2003104788A1 (en) * 2002-06-05 2003-12-18 松下電器産業株式会社 Extracellular potential measuring device and method for fabricating the same
US8232084B2 (en) 2002-06-05 2012-07-31 Panasonic Corporation Device for measuring extracellular potential and method of manufacturing device
EA009405B1 (en) * 2002-12-03 2007-12-28 Дженетроникс, Инк. The plates and systems for large-scale electroporation and methods for their use
WO2004050866A1 (en) * 2002-12-03 2004-06-17 Genetronics, Inc. Large-scale electroporation plates, systems, and methods of use
US8247218B2 (en) 2003-11-21 2012-08-21 Panasonic Corporation Extracellular potential sensing element, device for measuring extracellular potential, apparatus for measuring extracellular potential and method of measuring extracellular potential by using the same
JP2005156234A (en) * 2003-11-21 2005-06-16 Matsushita Electric Ind Co Ltd Extracellular potential measuring device and extracellular potential measuring method using it
US8030059B2 (en) 2003-11-21 2011-10-04 Panasonic Corporation Apparatus for measuring extracellular potential
JP2007529215A (en) * 2004-03-15 2007-10-25 アマクサ ゲゼルシャフト ミット ベシュレンクテル ハフツング Container and a device for generating an electric field in different chambers
US7736477B2 (en) 2004-08-25 2010-06-15 Panasonic Corporation Probe for measuring electric potential of cell
US8318477B2 (en) 2005-06-07 2012-11-27 Panasonic Corporation Cellular electrophysiological measurement device and method for manufacturing the same
US7927474B2 (en) 2005-12-20 2011-04-19 Panasonic Corporation Cell electrophysiological sensor
US7776193B2 (en) 2005-12-20 2010-08-17 Panasonic Corporation Cell electrophysiological sensor
US8071363B2 (en) 2006-05-25 2011-12-06 Panasonic Corporation Chip for cell electrophysiological sensor, cell electrophysiological sensor using the same, and manufacturing method of chip for cell electrophysiological sensor
US8445263B2 (en) 2006-07-06 2013-05-21 Panasonic Corporation Device for cellular electrophysiology sensor, cellular electrophysiology sensor using the device, and method for manufacturing the cellular electrophysiology sensor device
KR101015978B1 (en) * 2008-04-18 2011-02-25 대한민국 Cell fusion dish for micromanipulated cell-oocyte complex
JP2012098036A (en) * 2010-10-29 2012-05-24 Sony Corp Sample flow-in apparatus, sample flow-in chip and sample flow-in method

Also Published As

Publication number Publication date
JP2829005B2 (en) 1998-11-25

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Legal Events

Date Code Title Description
LAPS Cancellation because of no payment of annual fees