JPH01110368A - Autologous blood transfusion set - Google Patents

Abstract

PURPOSE:To safely and efficiently collect and transfuse blood, by uniting an infusion member, a blood transfusion member, a blood-collecting member, a washing agent tank and a connecting member via joint tubes. CONSTITUTION:An infusion member 2 includes a liquid-guiding needle 7a, connection tubes 8 and 9 made of flexible poly(vinyl chloride), etc., and an instillation cylinder 11. A blood transfusion member 3a includes an instillation cylinder 12a made of poly(vinyl chloride), etc., and a connection tube 13a made of flexible poly(vinyl chloride), etc. A blood-collecting member 4 includes a blood-collecting needle 20a and connection tubes 21 and 22 made of flexible poly(vinyl chloride), etc. A washing agent tank 6 includes a waste bag made of flexible poly(vinyl chloride), etc., and connection tubes 27 and 28. A connecting member 51a includes a male connector 52a and a connection tube 55a. The members 2, 3a, 3b, 4, 6, 51a, 51b and 51c are connected together with joint tubes 41, 42 and 43 made of hard poly(vinyl chloride), etc., respectively via the connection tubes 9, 13a, 13b, 21, 22, 27, 28 and 40.

Description

DETAILED DESCRIPTION OF THE INVENTION [Field of Industrial Application] The present invention relates to an autologous blood transfusion set that allows transfusion of stored blood and collection of fresh blood at the same time.

[Prior Art and Problems] Currently, blood collected in a plastic bag is used for transfusion within 21 days, but blood that is actually collected is used within about 7 days. If the storage period is prolonged, hemolysis and microaggregate formation in the blood will progress, so it is not desirable to use this blood for blood transfusions, and it is desirable to use the collected blood for transfusions as soon as possible. Yes.

Furthermore, currently, the amount of blood that can be collected from a donor at one time is 4.
The limit is 00 to 500 mJL. This is because collecting a large amount of blood from a donor at one time has a large effect on the living body (anemia, decrease in blood components, etc.) considering the balance of body fluids. Also, the fresh side of others,
Due to the risk of infection with syphilis and hepatitis, efforts are being made to secure autologous blood transfusions.

[Means for Solving the Problems] Therefore, the present invention solves the above problems and performs blood transfusion and blood collection safely and efficiently.Basically, (1) liquid introduction needle 7a connecting tube 8 .9 and drip tube 11 (2) Connecting pipe 13a and filters 14a and 15 inside
Blood transfusion member 3a consisting of a drip tube 12a loaded with blood transfusion tubes 12a and 16a and attached with a blood introduction needle 17a.
3a, 24a (4) Cleaning liquid storage member 6 consisting of connecting tubes 27, 28 and waste liquid bag 26 (5) Connector member 52a and connecting tube 55a, the connector member 51a is the protector 54a, and these components 2.3a, 4.6.51a are connected to the connecting pipe 41.4.
The present invention provides an autotransfusion set which is integrally connected via 2.43.

[Function] With the above configuration, ■ Filling the blood transfusion member 3a with physiological saline from the infusion member 2. ■ Fresh blood from the donor is collected through the transfusion blood collection member 4, and the blood prepared in advance is transferred through the connecting member 51a. Introducing into the storage member 5a ■Dropping physiological saline from the infusion member 2 into the transfusion blood collection member 4■Transfusing the stored blood of the donor to the donor via the transfusion member 3a and the transfusion blood collection member 4. , ② are repeated, and the blood collection and infusion are alternately carried out in a well-balanced manner without too much or too little so as not to burden the donor.Finally, the electrolyte solution is poured into the donor blood from the mixed injection part provided in the middle of the blood transfusion and blood collection member 4. By replenishing fluids to the donor, autotransfusion can be performed without sacrificing the donor's physical strength.

[Example] Fig. 1 is a schematic diagram showing an example of the autologous blood transfusion system of the present invention. The autotransfusion cell) 1 basically includes an infusion member 2, blood transfusion members 3a and 3b, a blood transfusion member 4, and a connecting member 51.
It is composed of a cleaning liquid storage member 6, 51b and 51C1.

The infusion member 2 is loaded with a liquid introduction needle 7a in which a needle 70 made of stainless steel or the like is implanted in a needle base 7b, a connecting tube 8.9 made of flexible polyvinyl chloride or the like, and a filter 10 made of polyamide such as nylon. The drip tube 11 is made of polyvinyl chloride or the like.

The blood transfusion member 3a consists of a drip tube i2a made of polyvinyl chloride or the like and a connecting tube 13a made of flexible polyvinyl chloride or the like.
15a and 16a are loaded, and a connecting tube 18a made of polyvinyl chloride or the like is attached to the end of the blood introduction needle 17a made of polycarbonate acid or the like and the connecting tube 13a.

The transfusion blood collection member 4 includes a needle 20b made of stainless steel or the like, attached to the needle base 20.
A blood transfusion needle 20a is implanted in the needle base 20c and has a rotation 120d attached to the needle base 20c, and a connecting tube 21.22 made of flexible polyvinyl chloride or the like, and a silicone tube is placed between the two connecting tubes 21.22. Mixed injection parts 23a and 24a made of polycarbonate acid or the like are provided with puncture buttons 23b and 24b made of rubber or the like embedded therein.

The cleaning liquid storage member 6 includes a waste liquid bag 26 made of flexible polyvinyl chloride or the like and a connecting pipe 27, 28 made of flexible polyvinyl chloride or the like, and a male luer is attached to the end of the connecting pipe 27, 28. 29 and 30 are installed, and connected via a connecting tube 31 made of silicone rubber or the like.

A check valve 33 made of flexible polyvinyl chloride or silicone rubber M is attached to the waste liquid inlet 32 of the waste liquid bag 26 .

The connecting member 51a consists of a connector member, that is, a male connector 52a, and a connecting pipe 55a, and a lock nut 53a of the male connector 52a is inserted in the middle of the connecting pipe 55a.
is loosely fitted into the male connector 52a and the lock nut 53.
A is covered with a protector 54a and is formed so as not to come into contact with the outside air. The connecting member 51a is made of a material such as polyvinyl chloride, polypropylene, or polycarbonate.

These components 2, 3a, 3b, 4.6.51a, 5
1b and 51c are connected by connecting pipes 41.42.43 made of hard polyvinyl chloride or the like via connecting pipes 9.13a, 13b, and 21.22.27.28.40, respectively.

Roll clamps A, B, and C made of polypropylene acid or the like are attached to the connecting pipes 9.13a and 13b.

Duraclamps D, E, and F made of polypropylene acid or the like are attached to the connecting pipes 22, 27, and 40.

The liquid introduction needle 7a, the blood introduction needle 17a1, and the blood transfusion needle 20a are respectively covered with needle caps 101, 102, 103 made of polypropylene acid or the like to prevent them from coming into contact with the outside air.

FIG. 2 shows a blood storage member 5a in which a parent bag 56a and a child bag 57a, each made of flexible polyvinyl chloride, are connected via a connecting pipe 58a, and the parent bag 56a
At the upper end, there is polyvinyl chloride at the tip as a connecting member.
A connecting pipe 59 equipped with a female connector 81a made of a material such as polypropylene or polycarbonate, and having a communicating piece 70a made of polycarbonate acid or the like arranged in the middle.
A and a connecting pipe 60a to which a slide clamp G made of polypropylene acid or the like is attached are connected.

The female connector 81a is covered with a protector 82a to prevent it from coming into contact with the outside air.

Next, a method of using the present invention will be explained with reference to FIG.

(1) Priming operation Roll clamps A, B, C and Jura D, E, F are closed and the liquid introduction needle 7a is connected to a container (not shown) filled with physiological saline. Roll clamp A
While opening the drip tube 11 and pumping the drip tube 11,
Physiological saline is introduced to the predetermined level within the chamber.

When the liquid level reaches a predetermined level, the roll clamp B is opened and the physiological saline is further introduced into the drip tube 12a through the connecting pipe 13a.

When the specified liquid level is reached, further roll clamp C is applied.
Open it and similarly introduce physiological saline into the drip tube 12b to a predetermined liquid level.

Next, open Jura Clamps D, E, and F, and while adjusting the degree of opening of Roll Clamp A, drop the physiological saline and introduce the air from the connecting pipes 40, 27, and 28 into the waste liquid bag 2B together with the physiological saline. Drive out, clamp D, E, F
Close to finish priming. .

(2) Break the protectors 54a and 82a that cover the male connector 52a of the first blood collection connection member 51a and the female connector 81a of the blood storage member 5a, and fit the male connector 52a and female connector 81a together. In order to securely fit and fix, these fitting parts are further fixed with lock nuts 53a. ), the communication piece 70a placed in the middle of the connecting tube 59a is cut, the blood passages of the connecting tubes 55a and 59a are opened, the blood transfusion needle 20a is inserted into the blood donor, and the clamp E is inserted.
, release clamp G.

Blood is collected through a blood transfusion needle 20a, a connecting tube 21.22.55a,
It enters the parent bag 56a via 60a and 59a.

When a predetermined amount of blood has been collected, the slide clamp G placed in the middle of the connecting tube 60a is closed, the roll clamp A and the Jura clamp D are opened, and the saline is poured from the annular fluid member 2 through the connecting tube 40. Then, the blood is dripped into the blood transfusion member 4. This can prevent blood from stagnating and solidifying within the blood transfusion/collection member 4 before proceeding to the next operation.

At this time, the blood transfusion/collection needle 20a remains inserted into the blood donor in order to maintain a closed system until the blood transfusion and blood collection are completed.

(3) Blood transfusion operation A blood bag (not shown) in which blood has been stored and stored in advance from the previous blood collection is inserted into the blood introduction needle 1 of the blood transfusion member 13a.
Connect to 7a.

Close roll clamp A, open roll clamp B,
For blood, connect tube 13a, 40° 22.21, blood transfusion needle 20
Blood is transfused to the donor via a. The speed of blood transfusion at this time is preferably approximately 6011/1n (so that the blood does not fall down the drip core into a continuous thread).

When the blood transfusion in the blood bag (not shown) is completed, roll clamp B is closed.

The roll clamp A is opened again, and physiological saline is introduced into the blood sampling member 4 in order to prevent the blood remaining in the ring blood collecting member 4 from coagulating.

(4) Second blood collection A new blood storage member 5b (not shown, the configuration of each part is as follows:
This is the same as 5a above, and will be explained below by replacing a in FIG. 2 with b. ) to prepare.

In the same manner as the one-time blood collection, the male connector 52b and the female connector 81b are fitted, the communication piece 70b is cut, and the Jura clamp E and the slide clamp 60b are opened. The blood is passed through the blood transfusion needle 20a and the connecting tubes 21, 22, .
55b, Bob, and 59b, it enters the parent bag 56b.

After a predetermined amount of blood has been collected, clamp E is closed, clamp A is opened, and physiological saline is dripped from the infusion member 2 into the blood transfusion member 4.

(5) Closing the end clamp E and replenishing the electrolyte solution prepared in advance to the blood donor via the mixed column part 23a, the connecting tube 21, and the blood transfusion needle 20a.

Finally, the connecting tubes 80a and 60b are hermetically welded using a welder, and the blood storage members 5a and 5b are separated and stored at 4° C. for the next blood transfusion.

In the autotransfusion set of the present invention, as shown in FIG. 3, by newly adding connecting tubes 44 and 45, blood transfusion member 3C1 connection members 51d and 51e (other than the shape and structure shown in FIG. 1, which are normally used) It is also possible to use the blood transfusion port and brochure of the existing blood bag.) can be added.

In this way, more than ten types of embodiments can be implemented by combining blood storage members with various blood capacities,
As shown in Table 1, blood collection patterns are combined according to the donor's health condition and physical strength to determine the amount of blood to be prepared before blood collection.

(Margins below) Table 1 [Notes] (1) Examples 1 to 3 are examples of methods in which the blood collected at the start is transfused the next time, and an additional 20 G-hair to 400 si of blood is collected ( 2) In Examples 4 and 5, 200 x 2 blood samples were taken at the beginning, and blood was collected twice.

Example (3) of Note: In addition, the examples of Example 1 to Example 3 were divided into two systems. Due to the switch bag method every other week, large;
You can also convert your blood into FA blood.

Furthermore, the increase sensitivity can be varied by about 100 sR'It depending on the hemoglobin status of the donor before blood collection.

(4) Examples 1 to 5 are basic examples, but this method can be used to increase the number of times, or by combining Examples 1 to 5.

You can secure more noisy blood.

Next, specific examples of each part of the autotransfusion set of the present invention will be described.

As another example of the connecting member 51a, for example, as shown in FIG. 4, a female connector 91 (for example, a blood transfusion port used in a normal blood bag) having a thin wall WI94 formed therein is connected, and the other A needle member 93 capable of breaking the thin membrane 94 (for example, a normal blood transfusion,
In addition to the protector, the needle member 93 can be covered with a needle cap (such as a Roketon needle used in an infusion set).
You can also wear a crown.

When there are two or more pairs of blood transfusion members, one drip tube 81 has a blood introduction needle 62a as shown in FIG. 5(a).

Alternatively, as shown in FIG. 5(b), the connecting tube 84 of the infusion member may be connected to the aforementioned connecting tubes 63a, 82b.
3b may be attached to the drip barrel 1111.

As a result, the number of parts can be reduced by the amount of the removed drip tube.

A specific embodiment of the check valve 33 formed in the cleaning liquid storage member 6 is shown in FIGS. 6 and 7, where (a) is a plan view, (b) is a cross-sectional view taken along line A-A in (a), and shown in FIG. It is a sectional view of B.

The check valve B4 shown in FIG. 6 is formed by overlapping two flexible polyvinyl chloride sheets 65 and heat-sealing the ends 66. The check valve 87 in FIG.
It is called a "duck beak valve" and is integrally molded from flexible polyvinyl chloride or silicone rubber. 68 is a beak portion formed thin.

By attaching these check valves B4.87 to the waste liquid inlet 32 of the waste liquid bag 2B, when pressure is applied from the outside of the waste liquid bag 2B after introducing the cleaning liquid into the waste liquid bag 2B, the external pressure will be reversed. Seat 115 of stop valve 84. f15, the beak part 68 of the reverse valve 67 works in the direction of crushing B8, so that the used washing liquid does not enter the inside of the autotransfusion set again, and hygiene is maintained.

The male luer 28.30 attached to the end of the connecting pipe 27.28 of the cleaning liquid storage member 6 is used as follows.

When blood is collected by puncturing a blood donor with the transfusion blood collection needle 20a, if trouble occurs due to clogging of blood cells or the like inside the needle 20b of the transfusion blood collection needle 20a, the male luer 30 is exposed by removing the connecting tube 31. For example, as shown in FIG. 9, the blood sampling needle 71 is connected to the female luer 72 of the blood sampling needle 71 prepared as a spare, and the blood sampling needle 71 is inserted into the blood donor.

The blood is transferred to the blood storage member 5a via the connecting pipe 27.37a.
On the other hand, the blood transfusion needle 20a introduced into the main bag 35a is connected to the other male luer 29 and used for waste liquid treatment.

Various filters 14a loaded inside the drip tube 12a,
The bore size of 15a and lea is 210 l, respectively.
1130 IL, 35 end, and is formed small from the blood inlet to the outlet direction. This makes it possible to completely prevent microaggregates in the blood from entering the autotransfusion set.

Filters 14a, 15a, lea are ■ 14a and 1
5a are stacked and welded inside the drip tube, and the lea is welded and attached to the lower end of the drip tube.

■ 14a, 15a, and IEta are laminated all at once and welded and attached to the inner surface of the drip tube.

It can be loaded into the drip tube 12a as follows.

Child bag 5 (attached to parent bag 58a via connecting tube 58a) in blood storage member 5a? a is parent bug 58a
It is used when sampling the blood collected during the test for blood tests, etc. This is particularly useful for blood tests that require a large amount of sample.

As described above, blood transfusions and blood collections are repeated until the amount of blood collected is relatively large, and fluid replacement is given to the donor in an amount equivalent to the amount of blood collected from the donor.
The burden on blood donors is small.

Moreover, the liquid introduction needle 7 attached to the autotransfusion set of the present invention
a. Number of blood introduction needles 17a, blood transfusion needles 20a and connecting tubes 4
1.42.43 shape and each component 2.3a, 4.6
．． The material of 51a etc. can be arbitrarily set depending on the purpose of use.

[Effects of the Invention] As explained above, the autologous blood transfusion set of the present invention: ■ transfuses blood collected from a donor without losing its freshness, and at the same time transfuses more than all the blood transfused from the donor into body fluids; Since blood can be collected without disturbing the equilibrium balance and can be used in a recycling system, it is especially suitable for the preservation of donor's own blood and for autologous transfusion.

■Constituent members (1) to (5) are connected together, and by appropriately selecting the number of connecting members and the capacity of the parent bag in the blood storage member connected to the connecting members, it can accommodate various patients. autologous blood transfusion can be performed.

This is an excellent invention that has the following effects.

[Brief explanation of the drawing]

FIG. 1 is a schematic diagram showing the basic configuration of the autotransfusion set of the present invention, FIG. 2 is a schematic diagram of a blood storage member used in connection with the autotransfusion set of the present invention, and FIG. 3 is a schematic diagram of the autotransfusion set of the present invention. FIG. 4 is a schematic diagram showing another embodiment of the autotransfusion set of the present invention, and FIG. 5(b) is a schematic diagram showing other embodiments of the infusion member constituting the autotransfusion set, FIG. 5(b) is a schematic diagram showing other embodiments of the infusion member and blood transfusion member, and FIGS. 6 and 7 are An example of a check valve attached to a cleaning liquid storage member, (L) is a plan view, (b)
) is a sectional view of (a), FIG. 8 is an enlarged view of the vicinity of the connecting tube of the cleaning fluid storage member, and FIG. 9 is a schematic diagram showing an example of how to use the male lure of the cleaning fluid storage member. set, 2 is an infusion member, 3 is a blood transfusion member, 4 is a blood transfusion member, 5
a, 5b are blood storage members, 6 is a cleaning liquid storage member, 11.
12a and 12b are drip tubes, 7a is a liquid introduction needle, 17a is a blood introduction needle, 20a is a loop extraction needle, 23a and 24a are mixed injection parts, and 26 is a waste liquid bag. 29.30 is a male luer, 31 is a connecting pipe, 33 is a check valve, 35a, 35b are parent bags, 36a, 36b are child bags, 41.42.43.44.45 is a connecting pipe, 8.9.
13a, 13b, 21.22.27.28.55a, 5
5b, 55C559a, 60a are connecting pipes, 51a, 51
b, 51c, 51d, 51e are connection members, 52a is a male connector, 53a is a lock nut, 54a, 82a are protectors, 70a is a communication piece, 81a, 91 are female connectors, 93 is a needle member, 94 is a thin membrane, 'A , B
, C is roll clamp, D, E, F are Jura clamp,
G and H indicate slide clamps. Patent applicant: Kawasumi Chemical Industry Co., Ltd. Cross
Takeo Figure 5 (a) (b) (a)

Claims (1)

[Scope of Claims] An autologous blood transfusion set used to transfuse a predetermined amount of blood that has been previously collected and stored from a blood donor into the donor, as well as to collect a new predetermined amount of blood from the donor. (1) An infusion member consisting of a liquid introduction needle, a connecting tube, and an infusion tube; (2) a blood transfusion member consisting of a connecting tube and an infusion tube with a filter inside and a blood infusion needle attached; (3) an infusion member; A transfusion blood collection member consisting of a blood collection needle, a connecting tube, and a mixed injection part (4) A washing liquid storage member consisting of a connecting tube and a waste liquid bag (5) A cleaning liquid storage member consisting of a connector member and a connecting tube, and the connector member is covered with a protector. An autotransfusion set characterized in that the connecting members (1) to (5) described above are connected together via a connecting tube.