JP7752686B2 - 生体分子プローブを使用した組織のマルチプレックス質量分析イメージングのための新規な光切断可能な質量タグ - Google Patents

生体分子プローブを使用した組織のマルチプレックス質量分析イメージングのための新規な光切断可能な質量タグ

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JP7752686B2
JP7752686B2 JP2023526248A JP2023526248A JP7752686B2 JP 7752686 B2 JP7752686 B2 JP 7752686B2 JP 2023526248 A JP2023526248 A JP 2023526248A JP 2023526248 A JP2023526248 A JP 2023526248A JP 7752686 B2 JP7752686 B2 JP 7752686B2
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mass
msi
maldi
tissue
antibody
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マール ジェイ． リム，
ガーゲイ ヤグニック，
ケネス ジェイ． ロスチャイルド，
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アンバージェン， インコーポレイテッド
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C271/20—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by nitrogen atoms not being part of nitro or nitroso groups
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    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
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    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
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    • G01N33/531—Production of immunochemical test materials
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    • G01N33/575—Immunoassay; Biospecific binding assay; Materials therefor for cancer
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    • G01N33/6842—Proteomic analysis of subsets of protein mixtures with reduced complexity, e.g. membrane proteins, phosphoproteins, organelle proteins
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    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6848—Methods of protein analysis involving mass spectrometry
    • G01N33/6851—Methods of protein analysis involving laser desorption ionisation mass spectrometry
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    • G01N2333/4724—Lectins
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    • G01N2570/00—Omics, e.g. proteomics, glycomics or lipidomics; Methods of analysis focusing on the entire complement of classes of biological molecules or subsets thereof, i.e. focusing on proteomes, glycomes or lipidomes
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  • Investigating Or Analysing Biological Materials (AREA)
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  • Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
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JP2023526248A 2020-10-29 2021-08-11 生体分子プローブを使用した組織のマルチプレックス質量分析イメージングのための新規な光切断可能な質量タグ Active JP7752686B2 (ja)

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US202063106990P 2020-10-29 2020-10-29
US63/106,990 2020-10-29
PCT/US2021/045520 WO2022093357A1 (en) 2020-10-29 2021-08-11 Novel photocleavable mass-tags for multiplexed mass spectrometric imaging of tissues using biomolecular probes

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EP (1) EP4237839A4 (https=)
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KR (2) KR20240125080A (https=)
CN (1) CN116457664B (https=)
AU (2) AU2021372349B2 (https=)
CA (1) CA3195979A1 (https=)
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