JP7677997B2 - キナーゼターゲットエンゲージメントの増強 - Google Patents

キナーゼターゲットエンゲージメントの増強 Download PDF

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JP7677997B2
JP7677997B2 JP2022571786A JP2022571786A JP7677997B2 JP 7677997 B2 JP7677997 B2 JP 7677997B2 JP 2022571786 A JP2022571786 A JP 2022571786A JP 2022571786 A JP2022571786 A JP 2022571786A JP 7677997 B2 JP7677997 B2 JP 7677997B2
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mouse
human
kinase
variant
active
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JP2023526677A (ja
JPWO2021237118A5 (https=
JP2023526677A5 (https=
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ジェームス ヴァスタ
マシュー ロバース
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Promega Corp
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Promega Corp
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/48—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving transferase
    • C12Q1/485—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving transferase involving kinase
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N24/00—Investigating or analyzing materials by the use of nuclear magnetic resonance, electron paramagnetic resonance or other spin effects
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/6428—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes"
    • G01N2021/6439—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes" with indicators, stains, dyes, tags, labels, marks
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90—Enzymes; Proenzymes
    • G01N2333/914—Hydrolases (3)

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  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • High Energy & Nuclear Physics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Peptides Or Proteins (AREA)
  • Enzymes And Modification Thereof (AREA)
JP2022571786A 2020-05-22 2021-05-21 キナーゼターゲットエンゲージメントの増強 Active JP7677997B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US202063028729P 2020-05-22 2020-05-22
US63/028,729 2020-05-22
US202063109103P 2020-11-03 2020-11-03
US63/109,103 2020-11-03
PCT/US2021/033703 WO2021237118A2 (en) 2020-05-22 2021-05-21 Enhancement of kinase target engagement

Publications (4)

Publication Number Publication Date
JP2023526677A JP2023526677A (ja) 2023-06-22
JPWO2021237118A5 JPWO2021237118A5 (https=) 2024-05-28
JP2023526677A5 JP2023526677A5 (https=) 2024-05-28
JP7677997B2 true JP7677997B2 (ja) 2025-05-15

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JP2022571786A Active JP7677997B2 (ja) 2020-05-22 2021-05-21 キナーゼターゲットエンゲージメントの増強

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US (2) US20210363565A1 (https=)
EP (1) EP4153770A2 (https=)
JP (1) JP7677997B2 (https=)
WO (1) WO2021237118A2 (https=)

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2019232225A1 (en) 2018-05-30 2019-12-05 Promega Corporation Broad-spectrum kinase binding agents

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US103A (en) 1836-12-10 Process
US8669A (en) 1852-01-20 John waters
US4812409A (en) 1986-01-31 1989-03-14 Eastman Kodak Company Hydrolyzable fluorescent substrates and analytical determinations using same
US4810636A (en) 1986-12-09 1989-03-07 Miles Inc. Chromogenic acridinone enzyme substrates
US5368484A (en) 1992-05-22 1994-11-29 Atari Games Corp. Vehicle simulator with realistic operating feedback
US6162931A (en) 1996-04-12 2000-12-19 Molecular Probes, Inc. Fluorinated xanthene derivatives
US7393656B2 (en) 2001-07-10 2008-07-01 The Board Of Trustees Of The Leland Stanford Junior University Methods and compositions for risk stratification
US7268229B2 (en) 2001-11-02 2007-09-11 Promega Corporation Compounds to co-localize luminophores with luminescent proteins
US7429472B2 (en) 2003-01-31 2008-09-30 Promega Corporation Method of immobilizing a protein or molecule via a mutant dehalogenase that is bound to an immobilized dehalogenase substrate and linked directly or indirectly to the protein or molecule
EP1594962B1 (en) 2003-01-31 2014-08-27 Promega Corporation Covalent tethering of functional groups to proteins
US7425436B2 (en) 2004-07-30 2008-09-16 Promega Corporation Covalent tethering of functional groups to proteins and substrates therefor
WO2007016975A1 (en) * 2005-07-29 2007-02-15 F. Hoffmann-La Roche Ag Kinase and phosphatase assays based on fret
AR065015A1 (es) * 2007-01-26 2009-05-13 Smithkline Beecham Corp Derivados de antranilamida, composiciones farmaceuticas que los contienen, y usos para el tratamiento del cancer
ES2795287T3 (es) 2009-05-01 2020-11-23 Promega Corp Luciferasas de Oplophorus sintéticas con mayor emisión de luz
SG10202103336SA (en) 2010-11-02 2021-04-29 Promega Corp Novel coelenterazine substrates and methods of use
US20140099654A1 (en) 2012-09-26 2014-04-10 Promega Corporation Real-time monitoring
ES2926463T3 (es) 2013-03-15 2022-10-26 Promega Corp Activación de la bioluminiscencia mediante complementación estructural
WO2014176700A1 (en) * 2013-05-01 2014-11-06 Université de Montréal Biosensors for ras-dependent signaling pathways and use thereof
JP7092677B2 (ja) 2016-02-15 2022-06-28 プロメガ コーポレイション セレンテラジン類似体
JP7212612B2 (ja) 2016-07-28 2023-01-25 プロメガ コーポレイション セレンテラジン類縁体
US9943505B2 (en) 2016-09-09 2018-04-17 Corcept Therapeutics, Inc. Glucocorticoid receptor modulators to treat pancreatic cancer

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2019232225A1 (en) 2018-05-30 2019-12-05 Promega Corporation Broad-spectrum kinase binding agents

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Luke W. Koblan et al.，Assessment of Bromodomain Target Engagement by a Series of BI2536 Analogues with Miniaturized BET-BRET，ChemMedChem，Vol.11，2016年，p.2575-2581

Also Published As

Publication number Publication date
US20210363565A1 (en) 2021-11-25
WO2021237118A2 (en) 2021-11-25
WO2021237118A3 (en) 2022-02-10
US20250188510A1 (en) 2025-06-12
JP2023526677A (ja) 2023-06-22
EP4153770A2 (en) 2023-03-29

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