JP7664020B2 - カリウムチャネルアゴニストによる腫瘍浸潤リンパ球の増殖及びその治療的使用 - Google Patents

カリウムチャネルアゴニストによる腫瘍浸潤リンパ球の増殖及びその治療的使用 Download PDF

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JP7664020B2
JP7664020B2 JP2019536179A JP2019536179A JP7664020B2 JP 7664020 B2 JP7664020 B2 JP 7664020B2 JP 2019536179 A JP2019536179 A JP 2019536179A JP 2019536179 A JP2019536179 A JP 2019536179A JP 7664020 B2 JP7664020 B2 JP 7664020B2
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ティー． ロッツェ，マイケル
リッチピチャイ，クリット
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アイオバンス バイオセラピューティクス，インコーポレイテッド
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/10—Cellular immunotherapy characterised by the cell type used
    • A61K40/11—T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
    • A61K40/41—Vertebrate antigens
    • A61K40/42—Cancer antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K40/00—Cellular immunotherapy
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    • A61K40/4202—Receptors, cell surface antigens or cell surface determinants
    • A61K40/4203—Receptors for growth factors
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0636—T lymphocytes
    • C12N5/0638—Cytotoxic T lymphocytes [CTL] or lymphokine activated killer cells [LAK]
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    • C12N2500/00—Specific components of cell culture medium
    • C12N2500/05—Inorganic components
    • C12N2500/10—Metals; Metal chelators
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/20—Cytokines; Chemokines
    • C12N2501/23—Interleukins [IL]
    • C12N2501/2302—Interleukin-2 (IL-2)
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/50—Cell markers; Cell surface determinants
    • C12N2501/515—CD3, T-cell receptor complex
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    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/999—Small molecules not provided for elsewhere

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JP2019536179A 2017-01-06 2018-01-05 カリウムチャネルアゴニストによる腫瘍浸潤リンパ球の増殖及びその治療的使用 Active JP7664020B2 (ja)

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JP2022180592A JP7682840B2 (ja) 2017-01-06 2022-11-10 カリウムチャネルアゴニストによる腫瘍浸潤リンパ球の増殖及びその治療的使用

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US201762443519P 2017-01-06 2017-01-06
US62/443,519 2017-01-06
US201762466921P 2017-03-03 2017-03-03
US62/466,921 2017-03-03
US201762504385P 2017-05-10 2017-05-10
US62/504,385 2017-05-10
PCT/US2018/012610 WO2018129336A1 (en) 2017-01-06 2018-01-05 Expansion of tumor infiltrating lymphocytes with potassium channel agonists and therapeutic uses thereof

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JP2020503351A5 JP2020503351A5 (https=) 2021-02-18
JP7664020B2 true JP7664020B2 (ja) 2025-04-17

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JP2022180592A Active JP7682840B2 (ja) 2017-01-06 2022-11-10 カリウムチャネルアゴニストによる腫瘍浸潤リンパ球の増殖及びその治療的使用

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US (2) US11357841B2 (https=)
EP (1) EP3565586B1 (https=)
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CA (1) CA3049165A1 (https=)
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WO (1) WO2018129336A1 (https=)

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