JP7605214B2 - アルデヒドによるニトリルヒドラターゼの反応性向上 - Google Patents

アルデヒドによるニトリルヒドラターゼの反応性向上 Download PDF

Info

Publication number
JP7605214B2
JP7605214B2 JP2022550734A JP2022550734A JP7605214B2 JP 7605214 B2 JP7605214 B2 JP 7605214B2 JP 2022550734 A JP2022550734 A JP 2022550734A JP 2022550734 A JP2022550734 A JP 2022550734A JP 7605214 B2 JP7605214 B2 JP 7605214B2
Authority
JP
Japan
Prior art keywords
compound
nitrile
aldehyde
reaction
biocatalyst
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
JP2022550734A
Other languages
English (en)
Japanese (ja)
Other versions
JPWO2022172880A5 (https=
JPWO2022172880A1 (https=
Inventor
隆文 山口
典史 萩谷
誠 加納
一哉 高梨
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Mitsubishi Chemical Corp
Original Assignee
Mitsubishi Chemical Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mitsubishi Chemical Corp filed Critical Mitsubishi Chemical Corp
Publication of JPWO2022172880A1 publication Critical patent/JPWO2022172880A1/ja
Publication of JPWO2022172880A5 publication Critical patent/JPWO2022172880A5/ja
Priority to JP2024165284A priority Critical patent/JP2024178359A/ja
Application granted granted Critical
Publication of JP7605214B2 publication Critical patent/JP7605214B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/88—Lyases (4.)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/02—Amides, e.g. chloramphenicol or polyamides; Imides or polyimides; Urethanes, i.e. compounds comprising N-C=O structural element or polyurethanes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y402/00—Carbon-oxygen lyases (4.2)
    • C12Y402/01—Hydro-lyases (4.2.1)
    • C12Y402/01084—Nitrile hydratase (4.2.1.84)

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
  • Enzymes And Modification Thereof (AREA)
JP2022550734A 2021-02-10 2022-02-07 アルデヒドによるニトリルヒドラターゼの反応性向上 Active JP7605214B2 (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2024165284A JP2024178359A (ja) 2021-02-10 2024-09-24 アルデヒドによるニトリルヒドラターゼの反応性向上

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2021019409 2021-02-10
JP2021019409 2021-02-10
PCT/JP2022/004577 WO2022172880A1 (ja) 2021-02-10 2022-02-07 アルデヒドによるニトリルヒドラターゼの反応性向上

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2024165284A Division JP2024178359A (ja) 2021-02-10 2024-09-24 アルデヒドによるニトリルヒドラターゼの反応性向上

Publications (3)

Publication Number Publication Date
JPWO2022172880A1 JPWO2022172880A1 (https=) 2022-08-18
JPWO2022172880A5 JPWO2022172880A5 (https=) 2023-07-05
JP7605214B2 true JP7605214B2 (ja) 2024-12-24

Family

ID=82837863

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2022550734A Active JP7605214B2 (ja) 2021-02-10 2022-02-07 アルデヒドによるニトリルヒドラターゼの反応性向上
JP2024165284A Pending JP2024178359A (ja) 2021-02-10 2024-09-24 アルデヒドによるニトリルヒドラターゼの反応性向上

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2024165284A Pending JP2024178359A (ja) 2021-02-10 2024-09-24 アルデヒドによるニトリルヒドラターゼの反応性向上

Country Status (7)

Country Link
US (1) US20240093251A1 (https=)
EP (1) EP4279600A4 (https=)
JP (2) JP7605214B2 (https=)
KR (1) KR20230128527A (https=)
CN (1) CN116888269A (https=)
AU (1) AU2022219778A1 (https=)
WO (1) WO2022172880A1 (https=)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2024178359A (ja) * 2021-02-10 2024-12-24 三菱ケミカル株式会社 アルデヒドによるニトリルヒドラターゼの反応性向上

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2002369697A (ja) 2001-06-15 2002-12-24 Daicel Chem Ind Ltd アミド化合物の製造方法
JP2010022334A (ja) 2008-07-24 2010-02-04 Mitsubishi Rayon Co Ltd 立体選択性を有するニトリルヒドラターゼ遺伝子
JP6020741B1 (ja) 2014-12-17 2016-11-02 三菱レイヨン株式会社 アクリルアミド水溶液及びアクリルアミド系重合体の製造方法
JP2017184686A (ja) 2016-04-08 2017-10-12 三菱ケミカル株式会社 グルタルアルデヒド含有酵素組成物

Family Cites Families (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5617918A (en) 1979-07-23 1981-02-20 Chisso Corp Manufacture of dichlorosilane
AU627648B2 (en) 1990-02-28 1992-08-27 Teruhiko Beppu Dna fragment encoding a polypeptide having nitrile hydratase activity, a transformant containing the gene and a process for the production of amides using the transformant
JP3076631B2 (ja) 1991-07-12 2000-08-14 ダイセル化学工業株式会社 アミド化合物の製造方法および新規な微生物
JPH0530982A (ja) 1991-08-05 1993-02-09 Mitsubishi Kasei Corp アミド類の製造法
JPH05161495A (ja) 1991-12-17 1993-06-29 Mitsubishi Kasei Corp アミド類の製造法
JPH05103681A (ja) 1991-10-14 1993-04-27 Mitsubishi Kasei Corp アミド類の製造法
JPH0530983A (ja) 1991-08-05 1993-02-09 Mitsubishi Kasei Corp アミド類の製造法
JPH05236975A (ja) 1992-02-28 1993-09-17 Mitsubishi Kasei Corp アミド類の製造法
JPH05236976A (ja) 1992-02-28 1993-09-17 Mitsubishi Kasei Corp アミド類の製造法
JPH0530984A (ja) 1991-08-05 1993-02-09 Mitsubishi Kasei Corp アミド類の製造法
JPH05236977A (ja) 1991-09-12 1993-09-17 Mitsubishi Kasei Corp アミド類の製造法
JP3409353B2 (ja) 1992-04-30 2003-05-26 住友化学工業株式会社 アミド化合物の製造方法および使用される微生物
JPH0655148A (ja) 1992-08-06 1994-03-01 Hitachi Ltd ガラス基板洗浄装置
JPH0725494A (ja) 1993-07-06 1995-01-27 Tec Corp 給紙ローラ機構
JPH0856684A (ja) 1994-08-16 1996-03-05 Mitsui Toatsu Chem Inc 微生物によるアミド化合物の製造法
JP3531997B2 (ja) 1995-03-29 2004-05-31 三井化学株式会社 形質転換体を用いたアミド化合物の製造法
JP3380133B2 (ja) 1996-02-14 2003-02-24 三井化学株式会社 新規なニトリルヒドラターゼ
US5863750A (en) * 1996-12-18 1999-01-26 Cytec Tech Corp Methods for the detoxification of nitrile and/or amide compounds
JP3428404B2 (ja) 1997-10-23 2003-07-22 三菱レイヨン株式会社 アミド化合物の製造方法
JP4459375B2 (ja) 2000-04-04 2010-04-28 三菱レイヨン株式会社 ニトリル化合物の精製方法
EP1689861B1 (en) 2003-12-02 2011-11-09 Ciba Specialty Chemicals Water Treatments Limited Strain of rhodococcus rhodochrous ncimb 41164 and its use as producer of nitrile hydratase
JP2005295815A (ja) 2004-04-07 2005-10-27 Mitsui Chemicals Inc ニトリルヒドラターゼの安定化または活性化方法
CN103146670B (zh) 2004-05-26 2014-11-26 Dia-Nitrix株式会社 改良型腈水合酶
GB0416101D0 (en) * 2004-07-19 2004-08-18 Ciba Spec Chem Water Treat Ltd Process for preparing monomers and polymers thereof
JP4916685B2 (ja) 2005-08-05 2012-04-18 三菱レイヨン株式会社 改良型ニトリルヒドラターゼ
KR101197843B1 (ko) 2005-10-21 2012-11-05 엘지전자 주식회사 엠피쓰리 플레이어를 지원하는 휴대용 컴퓨터의 제어장치및 방법
JP4916709B2 (ja) 2005-11-24 2012-04-18 三菱レイヨン株式会社 改良型ニトリルヒドラターゼ
JP5030579B2 (ja) 2006-12-26 2012-09-19 三菱レイヨン株式会社 ロドコッカス属細菌用発現ベクター
JP5069032B2 (ja) 2007-04-04 2012-11-07 ダイヤニトリックス株式会社 改良型ニトリルヒドラターゼ
JP5532618B2 (ja) 2009-01-30 2014-06-25 三菱レイヨン株式会社 改良型ニトリルヒドラターゼ及びその製造方法
KR101835160B1 (ko) 2010-02-22 2018-03-07 미쯔비시 케미컬 주식회사 안정된 아크릴아마이드 수용액
CN103649312B (zh) 2011-05-31 2017-03-22 三菱丽阳株式会社 改良型腈水合酶
EP2811021B1 (en) 2011-06-07 2016-11-02 Mitsubishi Rayon Co., Ltd. Improved nitrile hydratase
RU2689606C2 (ru) 2014-06-06 2019-05-28 Мицубиси Кемикал Корпорейшн Улучшенная нитрилгидратаза
JP7243506B2 (ja) 2019-07-18 2023-03-22 株式会社デンソー モータ
EP4279600A4 (en) * 2021-02-10 2025-06-11 Mitsubishi Chemical Corporation Improved nitrile hydratase reactivity using aldehyde

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2002369697A (ja) 2001-06-15 2002-12-24 Daicel Chem Ind Ltd アミド化合物の製造方法
JP2010022334A (ja) 2008-07-24 2010-02-04 Mitsubishi Rayon Co Ltd 立体選択性を有するニトリルヒドラターゼ遺伝子
JP6020741B1 (ja) 2014-12-17 2016-11-02 三菱レイヨン株式会社 アクリルアミド水溶液及びアクリルアミド系重合体の製造方法
JP2017184686A (ja) 2016-04-08 2017-10-12 三菱ケミカル株式会社 グルタルアルデヒド含有酵素組成物

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2024178359A (ja) * 2021-02-10 2024-12-24 三菱ケミカル株式会社 アルデヒドによるニトリルヒドラターゼの反応性向上

Also Published As

Publication number Publication date
JP2024178359A (ja) 2024-12-24
US20240093251A1 (en) 2024-03-21
EP4279600A1 (en) 2023-11-22
EP4279600A4 (en) 2025-06-11
CN116888269A (zh) 2023-10-13
AU2022219778A9 (en) 2024-09-12
AU2022219778A1 (en) 2023-06-22
WO2022172880A1 (ja) 2022-08-18
KR20230128527A (ko) 2023-09-05
JPWO2022172880A1 (https=) 2022-08-18

Similar Documents

Publication Publication Date Title
CN105899664B (zh) 用于精细化学品的改进生产的重组微生物
RU2385932C2 (ru) НИТРИЛГИДРАТАЗА ИЗ Rhodococcus
RU2385876C2 (ru) Устойчивые к цианидам нитрилгидратазы
KR20160057478A (ko) 정제 화학약품의 개선된 생산을 위한 재조합 미생물
JP4708677B2 (ja) 微生物触媒を用いたアミド化合物の製造方法
CN109797164B (zh) 一种新型腈水合酶高效催化脂肪二腈水合反应的体系
JP2024178359A (ja) アルデヒドによるニトリルヒドラターゼの反応性向上
CN105755023A (zh) 一种玉米赤霉烯酮降解酶基因及高产菌株
WO2001073101A1 (en) Process for producing amide compounds
CN104450657B (zh) 腈水合酶及其编码基因和应用
JP4672161B2 (ja) アミド化合物の製造方法
US9382560B2 (en) Method for producing amide compound
WO2001053253A1 (en) Method of purifying amide compound
RU2827406C2 (ru) Повышение реакционной способности нитрилгидратазы с помощью альдегида
WO2014080687A1 (ja) １，４－ブタンジオールの製造方法及び微生物
WO2011148867A1 (ja) アミド化合物の製造方法
CN103975071B (zh) 丙烯酰胺水溶液的制造方法
JP2001270857A (ja) アミド化合物の精製方法
CN120917145A (zh) 酰胺化合物的制造方法
KR101894617B1 (ko) 아크릴아미드 수용액의 제조 방법
JP2012062268A (ja) アミド化合物の精製方法
JP4709186B2 (ja) 微生物触媒を用いたアミド化合物の製造方法
CN120677247A (zh) 酰胺化合物的制造方法
CN121592686A (zh) 产丝氨醇大肠杆菌基因工程菌株及其应用
WO2014080683A1 (ja) １，４－ブタンジオールの製造方法及び微生物

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20230421

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20230421

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20240319

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20240502

A02 Decision of refusal

Free format text: JAPANESE INTERMEDIATE CODE: A02

Effective date: 20240709

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20240924

A911 Transfer to examiner for re-examination before appeal (zenchi)

Free format text: JAPANESE INTERMEDIATE CODE: A911

Effective date: 20241002

TRDD Decision of grant or rejection written
A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

Effective date: 20241112

A61 First payment of annual fees (during grant procedure)

Free format text: JAPANESE INTERMEDIATE CODE: A61

Effective date: 20241125

R150 Certificate of patent or registration of utility model

Ref document number: 7605214

Country of ref document: JP

Free format text: JAPANESE INTERMEDIATE CODE: R150