JP7568648B2 - 二次元ｌｃ－ｍｓ／ｍｓシステム - Google Patents

二次元ｌｃ－ｍｓ／ｍｓシステム Download PDF

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JP7568648B2
JP7568648B2 JP2021567966A JP2021567966A JP7568648B2 JP 7568648 B2 JP7568648 B2 JP 7568648B2 JP 2021567966 A JP2021567966 A JP 2021567966A JP 2021567966 A JP2021567966 A JP 2021567966A JP 7568648 B2 JP7568648 B2 JP 7568648B2
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acetonitrile
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JP2022534363A5 (https=
JP2022534363A (ja
JPWO2020243502A5 (https=
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ウェイ－リエン・チュアン
フェリペ・ガソス・ロペス
ホシュア・パチェコ
ジェラード・サンデリンク
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Genzyme Corp
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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/26—Conditioning of the fluid carrier; Flow patterns
    • G01N30/38—Flow patterns
    • G01N30/46—Flow patterns using more than one column
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/10—Selective adsorption, e.g. chromatography characterised by constructional or operational features
    • B01D15/18—Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to flow patterns
    • B01D15/1864—Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to flow patterns using two or more columns
    • B01D15/1871—Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to flow patterns using two or more columns placed in series
    • B01D15/1878—Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to flow patterns using two or more columns placed in series for multi-dimensional chromatography
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/32—Bonded phase chromatography
    • B01D15/322—Normal bonded phase
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/32—Bonded phase chromatography
    • B01D15/325—Reversed phase
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/04—Preparation or injection of sample to be analysed
    • G01N30/06—Preparation
    • G01N30/14—Preparation by elimination of some components
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/26—Conditioning of the fluid carrier; Flow patterns
    • G01N30/38—Flow patterns
    • G01N30/46—Flow patterns using more than one column
    • G01N30/461—Flow patterns using more than one column with serial coupling of separation columns
    • G01N30/463—Flow patterns using more than one column with serial coupling of separation columns for multidimensional chromatography
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/26—Conditioning of the fluid carrier; Flow patterns
    • G01N30/38—Flow patterns
    • G01N30/46—Flow patterns using more than one column
    • G01N30/468—Flow patterns using more than one column involving switching between different column configurations
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/62—Detectors specially adapted therefor
    • G01N30/72—Mass spectrometers
    • G01N30/7233—Mass spectrometers interfaced to liquid or supercritical fluid chromatograph
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/89—Inverse chromatography
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6848—Methods of protein analysis involving mass spectrometry
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/92—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving lipids, e.g. cholesterol, lipoproteins, or their receptors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N2030/022—Column chromatography characterised by the kind of separation mechanism
    • G01N2030/027—Liquid chromatography
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2405/00—Assays, e.g. immunoassays or enzyme assays, involving lipids
    • G01N2405/08—Sphingolipids
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/04—Endocrine or metabolic disorders
    • G01N2800/044—Hyperlipemia or hypolipemia, e.g. dyslipidaemia, obesity

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  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Endocrinology (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
  • Electron Tubes For Measurement (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
JP2021567966A 2019-05-31 2020-05-29 二次元ｌｃ－ｍｓ／ｍｓシステム Active JP7568648B2 (ja)

Priority Applications (2)

Application Number Priority Date Filing Date Title
JP2024172920A JP7804023B2 (ja) 2019-05-31 2024-10-02 二次元ｌｃ－ｍｓ／ｍｓシステム
JP2026001177A JP2026062952A (ja) 2019-05-31 2026-01-07 二次元ｌｃ－ｍｓ／ｍｓシステム

Applications Claiming Priority (3)

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US201962855636P 2019-05-31 2019-05-31
US62/855,636 2019-05-31
PCT/US2020/035231 WO2020243502A1 (en) 2019-05-31 2020-05-29 Two-dimensional lc-ms/ms systems

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JP2022534363A JP2022534363A (ja) 2022-07-29
JP2022534363A5 JP2022534363A5 (https=) 2023-06-01
JPWO2020243502A5 JPWO2020243502A5 (https=) 2023-06-01
JP7568648B2 true JP7568648B2 (ja) 2024-10-16

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JP2024172920A Active JP7804023B2 (ja) 2019-05-31 2024-10-02 二次元ｌｃ－ｍｓ／ｍｓシステム
JP2026001177A Pending JP2026062952A (ja) 2019-05-31 2026-01-07 二次元ｌｃ－ｍｓ／ｍｓシステム

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US (2) US12292424B2 (https=)
EP (2) EP3976218B1 (https=)
JP (3) JP7568648B2 (https=)
KR (2) KR20260040656A (https=)
CN (2) CN119861166A (https=)
AU (1) AU2020282831B2 (https=)
CA (1) CA3140183A1 (https=)
DK (1) DK3976218T3 (https=)
ES (1) ES3026686T3 (https=)
HU (1) HUE071194T2 (https=)
IL (2) IL288497B1 (https=)
PL (1) PL3976218T3 (https=)
TW (1) TWI862597B (https=)
WO (1) WO2020243502A1 (https=)

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CN120254137B (zh) * 2025-06-05 2026-04-14 科诺美(北京)科技有限公司 辅酶q10的检测方法及其应用
CN120820662B (zh) * 2025-09-17 2025-11-18 岛津企业管理（中国）有限公司 一种同步分析检测水产品中代谢物和脂质的方法

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JP2003028849A (ja) 2001-07-10 2003-01-29 Hiromasa Tojo 自動化脂質組成一斉分析装置
JP2007205954A (ja) 2006-02-03 2007-08-16 Hitachi High-Technologies Corp ３次元液体クロマトグラフィ
JP2014514541A (ja) 2011-03-23 2014-06-19 アイデックス ヘルス アンド サイエンス エルエルシー 多次元液体分析用バルブ及び分割システム
JP2016522406A (ja) 2013-05-14 2016-07-28 セントジーン アーゲー ニーマン・ピック病の診断のための方法
JP2016526050A (ja) 2013-06-07 2016-09-01 ジェンザイム・コーポレーション 酸性スフィンゴミエリナーゼ障害のマーカーおよびその使用
JP2017173281A (ja) 2016-03-25 2017-09-28 公立大学法人大阪府立大学 分析方法及び分析装置
US10018603B2 (en) 2014-08-20 2018-07-10 Korea Research Institute Of Standards And Science Two-dimensional liquid chromatography system for heart-cut method
US20180306797A1 (en) 2017-04-24 2018-10-25 Washington University Methods of detecting ceramide

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KR100614099B1 (ko) 2005-11-25 2006-08-22 한국과학기술연구원 뇨 또는 플라즈마 시료 중의 디에이치이에이 설페이트의검출방법
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Publication number Priority date Publication date Assignee Title
JP2003028849A (ja) 2001-07-10 2003-01-29 Hiromasa Tojo 自動化脂質組成一斉分析装置
JP2007205954A (ja) 2006-02-03 2007-08-16 Hitachi High-Technologies Corp ３次元液体クロマトグラフィ
JP2014514541A (ja) 2011-03-23 2014-06-19 アイデックス ヘルス アンド サイエンス エルエルシー 多次元液体分析用バルブ及び分割システム
JP2016522406A (ja) 2013-05-14 2016-07-28 セントジーン アーゲー ニーマン・ピック病の診断のための方法
JP2016526050A (ja) 2013-06-07 2016-09-01 ジェンザイム・コーポレーション 酸性スフィンゴミエリナーゼ障害のマーカーおよびその使用
US10018603B2 (en) 2014-08-20 2018-07-10 Korea Research Institute Of Standards And Science Two-dimensional liquid chromatography system for heart-cut method
JP2017173281A (ja) 2016-03-25 2017-09-28 公立大学法人大阪府立大学 分析方法及び分析装置
US20180306797A1 (en) 2017-04-24 2018-10-25 Washington University Methods of detecting ceramide

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JP7804023B2 (ja) 2026-01-21
PL3976218T3 (pl) 2025-06-09
CA3140183A1 (en) 2020-12-03
AU2020282831B2 (en) 2026-03-05
JP2026062952A (ja) 2026-04-10
ES3026686T3 (en) 2025-06-11
EP3976218B1 (en) 2025-02-19
AU2020282831A1 (en) 2021-12-16
IL288497B1 (en) 2026-04-01
KR20260040656A (ko) 2026-03-25
EP4560320A3 (en) 2025-08-13
IL326850A (en) 2026-04-01
IL288497A (en) 2022-01-01
JP2025000908A (ja) 2025-01-07
EP4560320A2 (en) 2025-05-28
CN119861166A (zh) 2025-04-22
KR20220016103A (ko) 2022-02-08
US20220252559A1 (en) 2022-08-11
DK3976218T3 (da) 2025-05-05
JP2022534363A (ja) 2022-07-29
CN114364980B (zh) 2024-12-27
KR102936574B1 (ko) 2026-03-09
WO2020243502A1 (en) 2020-12-03
CN114364980A (zh) 2022-04-15
TW202111322A (zh) 2021-03-16
TWI862597B (zh) 2024-11-21
US12292424B2 (en) 2025-05-06
US20250327780A1 (en) 2025-10-23
HUE071194T2 (hu) 2025-08-28
EP3976218A1 (en) 2022-04-06

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