JP7436151B2 - ビタミンb12類の光安定化方法 - Google Patents
ビタミンb12類の光安定化方法 Download PDFInfo
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- JP7436151B2 JP7436151B2 JP2019102030A JP2019102030A JP7436151B2 JP 7436151 B2 JP7436151 B2 JP 7436151B2 JP 2019102030 A JP2019102030 A JP 2019102030A JP 2019102030 A JP2019102030 A JP 2019102030A JP 7436151 B2 JP7436151 B2 JP 7436151B2
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- 238000000034 method Methods 0.000 title claims description 33
- FEZWOUWWJOYMLT-DSRCUDDDSA-M cobalt;[(2r,3s,4r,5s)-5-(5,6-dimethylbenzimidazol-1-yl)-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl] [(2r)-1-[3-[(1r,2r,3r,4z,7s,9z,12s,13s,14z,17s,18s,19r)-2,13,18-tris(2-amino-2-oxoethyl)-7,12,17-tris(3-amino-3-oxopropyl)-3,5,8,8,13,15,18,19-octamethyl-2,7,1 Chemical compound [Co].[N-]([C@@H]1[C@H](CC(N)=O)[C@@]2(C)CCC(=O)NC[C@@H](C)OP(O)(=O)O[C@H]3[C@H]([C@H](O[C@@H]3CO)N3C4=CC(C)=C(C)C=C4N=C3)O)\C2=C(C)/C([C@H](C\2(C)C)CCC(N)=O)=N/C/2=C\C([C@H]([C@@]/2(CC(N)=O)C)CCC(N)=O)=N\C\2=C(C)/C2=N[C@]1(C)[C@@](C)(CC(N)=O)[C@@H]2CCC(N)=O FEZWOUWWJOYMLT-DSRCUDDDSA-M 0.000 title claims description 25
- 239000000203 mixture Substances 0.000 claims description 62
- FDJOLVPMNUYSCM-UVKKECPRSA-L cobalt(3+);[(2r,3s,4r,5s)-5-(5,6-dimethylbenzimidazol-1-yl)-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl] [(2r)-1-[3-[(2r,3r,4z,7s,9z,12s,13s,14z,17s,18s,19r)-2,13,18-tris(2-amino-2-oxoethyl)-7,12,17-tris(3-amino-3-oxopropyl)-3,5,8,8,13,15,18,19-octamethyl-2,7, Chemical compound [Co+3].N#[C-].C1([C@H](CC(N)=O)[C@@]2(C)CCC(=O)NC[C@@H](C)OP([O-])(=O)O[C@H]3[C@H]([C@H](O[C@@H]3CO)N3C4=CC(C)=C(C)C=C4N=C3)O)[N-]\C2=C(C)/C([C@H](C\2(C)C)CCC(N)=O)=N/C/2=C\C([C@H]([C@@]/2(CC(N)=O)C)CCC(N)=O)=N\C\2=C(C)/C2=N[C@]1(C)[C@@](C)(CC(N)=O)[C@@H]2CCC(N)=O FDJOLVPMNUYSCM-UVKKECPRSA-L 0.000 claims description 40
- 239000004094 surface-active agent Substances 0.000 claims description 12
- ZAKOWWREFLAJOT-CEFNRUSXSA-N D-alpha-tocopherylacetate Chemical compound CC(=O)OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C ZAKOWWREFLAJOT-CEFNRUSXSA-N 0.000 claims description 6
- 229940042585 tocopherol acetate Drugs 0.000 claims description 6
- -1 Carboxylate salts Chemical class 0.000 description 59
- GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 description 38
- 235000014113 dietary fatty acids Nutrition 0.000 description 36
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- 229930195729 fatty acid Natural products 0.000 description 36
- RMRCNWBMXRMIRW-BYFNXCQMSA-M cyanocobalamin Chemical compound N#C[Co+]N([C@]1([H])[C@H](CC(N)=O)[C@]\2(CCC(=O)NC[C@H](C)OP(O)(=O)OC3[C@H]([C@H](O[C@@H]3CO)N3C4=CC(C)=C(C)C=C4N=C3)O)C)C/2=C(C)\C([C@H](C/2(C)C)CCC(N)=O)=N\C\2=C\C([C@H]([C@@]/2(CC(N)=O)C)CCC(N)=O)=N\C\2=C(C)/C2=N[C@]1(C)[C@@](C)(CC(N)=O)[C@@H]2CCC(N)=O RMRCNWBMXRMIRW-BYFNXCQMSA-M 0.000 description 22
- 239000000047 product Substances 0.000 description 22
- 230000000176 photostabilization Effects 0.000 description 20
- 229930003427 Vitamin E Natural products 0.000 description 16
- 239000004359 castor oil Substances 0.000 description 16
- 235000019438 castor oil Nutrition 0.000 description 16
- WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 description 16
- ZEMPKEQAKRGZGQ-XOQCFJPHSA-N glycerol triricinoleate Natural products CCCCCC[C@@H](O)CC=CCCCCCCCC(=O)OC[C@@H](COC(=O)CCCCCCCC=CC[C@@H](O)CCCCCC)OC(=O)CCCCCCCC=CC[C@H](O)CCCCCC ZEMPKEQAKRGZGQ-XOQCFJPHSA-N 0.000 description 16
- 239000011709 vitamin E Substances 0.000 description 16
- 229940046009 vitamin E Drugs 0.000 description 16
- 235000019165 vitamin E Nutrition 0.000 description 16
- 229920003171 Poly (ethylene oxide) Polymers 0.000 description 14
- AGVAZMGAQJOSFJ-WZHZPDAFSA-M cobalt(2+);[(2r,3s,4r,5s)-5-(5,6-dimethylbenzimidazol-1-yl)-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl] [(2r)-1-[3-[(1r,2r,3r,4z,7s,9z,12s,13s,14z,17s,18s,19r)-2,13,18-tris(2-amino-2-oxoethyl)-7,12,17-tris(3-amino-3-oxopropyl)-3,5,8,8,13,15,18,19-octamethyl-2 Chemical compound [Co+2].N#[C-].[N-]([C@@H]1[C@H](CC(N)=O)[C@@]2(C)CCC(=O)NC[C@@H](C)OP(O)(=O)O[C@H]3[C@H]([C@H](O[C@@H]3CO)N3C4=CC(C)=C(C)C=C4N=C3)O)\C2=C(C)/C([C@H](C\2(C)C)CCC(N)=O)=N/C/2=C\C([C@H]([C@@]/2(CC(N)=O)C)CCC(N)=O)=N\C\2=C(C)/C2=N[C@]1(C)[C@@](C)(CC(N)=O)[C@@H]2CCC(N)=O AGVAZMGAQJOSFJ-WZHZPDAFSA-M 0.000 description 14
- 239000011666 cyanocobalamin Substances 0.000 description 13
- 235000000639 cyanocobalamin Nutrition 0.000 description 13
- 229960002104 cyanocobalamin Drugs 0.000 description 13
- 239000011715 vitamin B12 Substances 0.000 description 13
- 238000000354 decomposition reaction Methods 0.000 description 12
- DSSYKIVIOFKYAU-XCBNKYQSSA-N (R)-camphor Chemical compound C1C[C@@]2(C)C(=O)C[C@@H]1C2(C)C DSSYKIVIOFKYAU-XCBNKYQSSA-N 0.000 description 10
- 241000723346 Cinnamomum camphora Species 0.000 description 10
- 229960000846 camphor Drugs 0.000 description 10
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- 239000003814 drug Substances 0.000 description 10
- 150000004665 fatty acids Chemical class 0.000 description 10
- 239000002537 cosmetic Substances 0.000 description 9
- 229920001214 Polysorbate 60 Polymers 0.000 description 8
- 235000013305 food Nutrition 0.000 description 8
- KWIUHFFTVRNATP-UHFFFAOYSA-N glycine betaine Chemical compound C[N+](C)(C)CC([O-])=O KWIUHFFTVRNATP-UHFFFAOYSA-N 0.000 description 8
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerol Natural products OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 7
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 7
- 239000002738 chelating agent Substances 0.000 description 7
- 229910052708 sodium Inorganic materials 0.000 description 7
- 239000011734 sodium Substances 0.000 description 7
- 150000005846 sugar alcohols Polymers 0.000 description 7
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 6
- 229930006000 Sucrose Natural products 0.000 description 6
- 150000005215 alkyl ethers Chemical class 0.000 description 6
- 239000005720 sucrose Substances 0.000 description 6
- 229930003799 tocopherol Natural products 0.000 description 6
- 235000010384 tocopherol Nutrition 0.000 description 6
- 239000011732 tocopherol Substances 0.000 description 6
- 229960001295 tocopherol Drugs 0.000 description 6
- 150000001875 compounds Chemical class 0.000 description 5
- LYCAIKOWRPUZTN-UHFFFAOYSA-N ethylene glycol Natural products OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 5
- 235000011187 glycerol Nutrition 0.000 description 5
- 239000002674 ointment Substances 0.000 description 5
- 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 description 5
- 229920000053 polysorbate 80 Polymers 0.000 description 5
- 239000000843 powder Substances 0.000 description 5
- 150000003839 salts Chemical class 0.000 description 5
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 5
- GVJHHUAWPYXKBD-IEOSBIPESA-N α-tocopherol Chemical compound OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-IEOSBIPESA-N 0.000 description 5
- IIZPXYDJLKNOIY-JXPKJXOSSA-N 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine Chemical class CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCC\C=C/C\C=C/C\C=C/C\C=C/CCCCC IIZPXYDJLKNOIY-JXPKJXOSSA-N 0.000 description 4
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 description 4
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 4
- 229960003237 betaine Drugs 0.000 description 4
- 125000002235 cyanocobalamin group Chemical group 0.000 description 4
- 238000002845 discoloration Methods 0.000 description 4
- 150000002148 esters Chemical group 0.000 description 4
- 239000000499 gel Substances 0.000 description 4
- 239000007788 liquid Substances 0.000 description 4
- 239000006210 lotion Substances 0.000 description 4
- 239000000244 polyoxyethylene sorbitan monooleate Substances 0.000 description 4
- 229920002503 polyoxyethylene-polyoxypropylene Polymers 0.000 description 4
- 229940068968 polysorbate 80 Drugs 0.000 description 4
- 239000000600 sorbitol Substances 0.000 description 4
- 238000003860 storage Methods 0.000 description 4
- 229940088594 vitamin Drugs 0.000 description 4
- 229930003231 vitamin Natural products 0.000 description 4
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- 239000011782 vitamin Substances 0.000 description 4
- 150000003722 vitamin derivatives Chemical class 0.000 description 4
- JNYAEWCLZODPBN-JGWLITMVSA-N (2r,3r,4s)-2-[(1r)-1,2-dihydroxyethyl]oxolane-3,4-diol Chemical compound OC[C@@H](O)[C@H]1OC[C@H](O)[C@H]1O JNYAEWCLZODPBN-JGWLITMVSA-N 0.000 description 3
- IAYPIBMASNFSPL-UHFFFAOYSA-N Ethylene oxide Chemical compound C1CO1 IAYPIBMASNFSPL-UHFFFAOYSA-N 0.000 description 3
- OYHQOLUKZRVURQ-HZJYTTRNSA-N Linoleic acid Chemical compound CCCCC\C=C/C\C=C/CCCCCCCC(O)=O OYHQOLUKZRVURQ-HZJYTTRNSA-N 0.000 description 3
- PMZURENOXWZQFD-UHFFFAOYSA-L Sodium Sulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=O PMZURENOXWZQFD-UHFFFAOYSA-L 0.000 description 3
- ZMANZCXQSJIPKH-UHFFFAOYSA-N Triethylamine Chemical compound CCN(CC)CC ZMANZCXQSJIPKH-UHFFFAOYSA-N 0.000 description 3
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 3
- 239000006071 cream Substances 0.000 description 3
- 239000000551 dentifrice Substances 0.000 description 3
- 150000005690 diesters Chemical class 0.000 description 3
- MTHSVFCYNBDYFN-UHFFFAOYSA-N diethylene glycol Chemical compound OCCOCCO MTHSVFCYNBDYFN-UHFFFAOYSA-N 0.000 description 3
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- GTABBGRXERZUAH-UHFFFAOYSA-N hexadecan-1-ol;2-methyloxirane;oxirane Chemical compound C1CO1.CC1CO1.CCCCCCCCCCCCCCCCO GTABBGRXERZUAH-UHFFFAOYSA-N 0.000 description 3
- 239000004615 ingredient Substances 0.000 description 3
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- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 3
- ZQPPMHVWECSIRJ-KTKRTIGZSA-N oleic acid Chemical compound CCCCCCCC\C=C/CCCCCCCC(O)=O ZQPPMHVWECSIRJ-KTKRTIGZSA-N 0.000 description 3
- 239000003826 tablet Substances 0.000 description 3
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- PUPZLCDOIYMWBV-UHFFFAOYSA-N (+/-)-1,3-Butanediol Chemical compound CC(O)CCO PUPZLCDOIYMWBV-UHFFFAOYSA-N 0.000 description 2
- VBICKXHEKHSIBG-UHFFFAOYSA-N 1-monostearoylglycerol Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCC(O)CO VBICKXHEKHSIBG-UHFFFAOYSA-N 0.000 description 2
- ASKIVFGGGGIGKH-UHFFFAOYSA-N 2,3-dihydroxypropyl 16-methylheptadecanoate Chemical compound CC(C)CCCCCCCCCCCCCCC(=O)OCC(O)CO ASKIVFGGGGIGKH-UHFFFAOYSA-N 0.000 description 2
- IZHVBANLECCAGF-UHFFFAOYSA-N 2-hydroxy-3-(octadecanoyloxy)propyl octadecanoate Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCC(O)COC(=O)CCCCCCCCCCCCCCCCC IZHVBANLECCAGF-UHFFFAOYSA-N 0.000 description 2
- RFVNOJDQRGSOEL-UHFFFAOYSA-N 2-hydroxyethyl octadecanoate Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCCO RFVNOJDQRGSOEL-UHFFFAOYSA-N 0.000 description 2
- GJJVAFUKOBZPCB-UHFFFAOYSA-N 2-methyl-2-(4,8,12-trimethyltrideca-3,7,11-trienyl)-3,4-dihydrochromen-6-ol Chemical compound OC1=CC=C2OC(CCC=C(C)CCC=C(C)CCC=C(C)C)(C)CCC2=C1 GJJVAFUKOBZPCB-UHFFFAOYSA-N 0.000 description 2
- KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 description 2
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- XDOFQFKRPWOURC-UHFFFAOYSA-N 16-methylheptadecanoic acid Chemical compound CC(C)CCCCCCCCCCCCCCC(O)=O XDOFQFKRPWOURC-UHFFFAOYSA-N 0.000 description 1
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- Coloring Foods And Improving Nutritive Qualities (AREA)
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Description
項1. ビタミンB12類を含む組成物にビタミンE類を含有させる、ビタミンB12類の光安定化方法。
項2. ビタミンB12類1重量部当たり、含有させるビタミンE類が0.00125~1000重量部である、項1に記載のビタミンB12類の光安定化方法。
項3. ビタミンB12類を含む組成物に、ビタミンB12類1重量部当たり10重量部以下となる比率で界面活性剤を含有させる、項1又は2に記載のビタミンB12類の光安定化方法。
項4. ビタミンB12類を含む組成物が水性組成物である、項1~3のいずれかに記載のビタミンB12類の光安定化方法。
ビタミンB12類とは、ビタミンB12(シアノコバラミン)、その誘導体、及びそれらの塩を指す。本発明で使用されるビタミンB12類の種類については、飲食品、口腔ケア製品、医薬品、化粧料等の製品に配合可能であることを限度として特に制限されない。例えば、ビタミンB12の誘導体としては、メチルコバラミン、ヒドロキソコバラミン、アデノシルコバラミン、アクアコバラミン等が挙げられる。また、ビタミンB12及びその誘導体の塩としては、例えば、酢酸塩、トリフルオロ酢酸塩、酪酸塩、パルミチン酸塩、ステアリン酸塩、フマル酸塩、マレイン酸塩、コハク酸塩、マロン酸塩、乳酸塩、酒石酸塩、クエン酸塩等のカルボン酸塩;メタンスルホン酸塩、トルエンスルホン酸塩、トシル酸塩等の有機スルホン酸塩;塩酸塩、硫酸塩、硝酸塩、リン酸塩等の無機酸塩;メチルアミン、トリエチルアミン、トリエタノールアミン等の有機アミン塩;ナトリウム塩、カリウム塩等のアルカリ金属塩;カルシウム、マグネシウム等のアルカリ土類金属塩;アンモニウム塩等が挙げられる。これらのビタミンB12類は、1種単独で使用してもよく、また2種以上を組み合わせて使用してもよい。
本発明の光安定化方法では、ビタミンB12類の光安定化を図るために、ビタミンB12類を含む組成物にビタミンE類を配合する。
本発明の光安定化方法において、ビタミンB12類を含む組成物には、ビタミンE類に加えて界面活性剤を含有させてもよい。特に、ビタミンB12類を含む組成物が水性組成物である場合には、ビタミンE類を水性組成物中で可溶化させるために、界面活性剤が含有されていることが望ましい。
本発明の光安定化方法において、ビタミンB12類を含む組成物には、更にカンフルを含有させてもよい。カンフルを含有させることによって、より一層効果的にビタミンB12類の光安定化を図ることが可能になる。
本発明の光安定化方法において、ビタミンB12類を含む組成物には、更にキレート剤を含有させてもよい。本発明で使用されるキレート剤の種類については、飲食品、口腔ケア製品、医薬品、化粧料等の製品に配合可能であることを限度として特に制限されないが、例えば、エデト酸、クエン酸、コハク酸、及びこれら塩等が挙げられる。塩の形態としては、例えば、ナトリウム塩、カリウム塩等のアルカリ金属塩等が挙げられる。これらのキレート剤は、1種単独で使用してもよく、また2種以上を組み合わせて使用してもよい。
本発明の光安定化方法において、ビタミンB12類を含む組成物に、更に多価アルコールを含有させてもよい。本発明で使用される多価アルコールの種類としては、例えば、エチレングリコール、1,3-ブチレングリコール、プロピレングリコール、イソプレングリコール、ジエチレングリコール、ジプロピレングリコール、ポリプロピレングリコール、グリセリン等が挙げられる。これらの多価アルコールは、1種単独で使用してもよく、また2種以上を組み合わせて使用してもよい。
本発明の光安定化方法において、ビタミンB12類を含む組成物には、前記成分の他に、当該組成物の形状や製品形態に応じて、各種の薬理成分、食品素材、添加剤等の成分を含有させてもよい。このような成分の種類については、ビタミンB12類を含む組成物の形状や製品形態に応じて使用可能なものを適宜選定すればよいが、例えば、水、薬理成分、油脂類、ロウ類、炭化水素類、脂肪酸類、高級アルコール類、エステル類、水溶性高分子、金属石鹸、1価低級アルコール類、pH調整剤、緩衝剤、酸化防止剤、紫外線防止剤、防腐剤、香料、粉体、増粘剤、色素等が挙げられる。これらの成分は、1種単独で使用してもよく、また2種以上を組み合わせて使用してもよい。これらの成分の濃度については、使用する成分の種類や組成物の形状及び製品形態等に応じて適宜設定される。
本発明の光安定化方法において、ビタミンB12類を含む組成物は、水性組成物又は非水性組成物のいずれであってもよい。一般的にビタミンB12類は水性組成物中で光暴露により分解され易くなる傾向があるが、本発明によれば、水性組成物中でも光暴露によるビタミンB12類の分解を効果的に抑制できる。このような本発明の効果を鑑みると、本発明の光安定化方法において、ビタミンB12類を含む組成物の好適な例として水性組成物が挙げられる。
表1に示す組成の水性組成物を調製した。500ml容の透明容器(ポリエチレンテレフタレート製)に得られた水性組成物500mlを充填し、昼間に直射日光が当たる室内(南側の窓から10cm離れた場所)に23日間静置した。23日間の静置後に、水性組成物の外観を目視にて観察し、以下の判定基準に従って、シアノコバラミンの保存安定性を判定した。なお、シアノコバラミンはピンク色の色調を呈し、分解されると退色するため、本試験において、退色が多い程、シアノコバラミンの分解が進んでいることを示している。
<シアノコバラミンの保存安定性>
◎ :製造直後に比べて、色調が同等である。
○ :製造直後に比べて、僅かに退色が認められるが許容範囲内である。
× :製造直後に比べて、明らかに退色が認められ許容できない。
××:退色が著しく、ほぼ無色になっている。
表2に示す組成の水性組成物を調製した。得られた水性組成物を、前記試験例1と同様の方法でシアノコバラミンの保存安定性を評価したところ、いずれも、光暴露によるシアノコバラミンの分解を効果的に抑制できていた。
Claims (4)
- ビタミンB12類を含む組成物にトコフェロール酢酸エステルを含有させる、ビタミンB12類の光安定化方法。
- ビタミンB12類1重量部当たり、含有させるトコフェロール酢酸エステルが0.00125~1000重量部である、請求項1に記載のビタミンB12類の光安定化方法。
- ビタミンB12類を含む組成物に、ビタミンB12類1重量部当たり10重量部以下となる比率で界面活性剤を含有させる、請求項1又は2に記載のビタミンB12類の光安定化方法。
- ビタミンB12類を含む組成物が水性組成物である、請求項1~3のいずれかに記載のビタミンB12類の光安定化方法。
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WO2004098614A1 (ja) | 2003-05-07 | 2004-11-18 | Eisai Co., Ltd. | メチルコバラミン含有凍結乾燥製剤及びその製造方法 |
JP2005247799A (ja) | 2004-03-08 | 2005-09-15 | Zeria Pharmaceut Co Ltd | 点眼剤 |
JP2020196672A (ja) | 2019-05-31 | 2020-12-10 | 小林製薬株式会社 | ビタミンb12類含有組成物 |
JP2020196670A (ja) | 2019-05-31 | 2020-12-10 | 小林製薬株式会社 | 水性組成物 |
JP2020196671A (ja) | 2019-05-31 | 2020-12-10 | 小林製薬株式会社 | ビタミンb12類の光安定化方法 |
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JPS539312A (en) * | 1976-07-09 | 1978-01-27 | Sankyo Co Ltd | Preparation of light-stable mecobalamin or cobamamide parenteral injections |
DK0416773T3 (da) * | 1989-08-31 | 1993-03-29 | Takeda Chemical Industries Ltd | Vitamin B12 præparat |
JP3061062B2 (ja) * | 1990-06-18 | 2000-07-10 | エーザイ株式会社 | ビタミンb▲下1▼▲下2▼の光安定化方法及びビタミンb▲下1▼▲下2▼を含有する医薬組成物 |
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WO2004098614A1 (ja) | 2003-05-07 | 2004-11-18 | Eisai Co., Ltd. | メチルコバラミン含有凍結乾燥製剤及びその製造方法 |
JP2005247799A (ja) | 2004-03-08 | 2005-09-15 | Zeria Pharmaceut Co Ltd | 点眼剤 |
JP2020196672A (ja) | 2019-05-31 | 2020-12-10 | 小林製薬株式会社 | ビタミンb12類含有組成物 |
JP2020196670A (ja) | 2019-05-31 | 2020-12-10 | 小林製薬株式会社 | 水性組成物 |
JP2020196671A (ja) | 2019-05-31 | 2020-12-10 | 小林製薬株式会社 | ビタミンb12類の光安定化方法 |
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