JP7424001B2 - 医療用ゴム組成物および医療用ゴム部品 - Google Patents
医療用ゴム組成物および医療用ゴム部品 Download PDFInfo
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- JP7424001B2 JP7424001B2 JP2019209030A JP2019209030A JP7424001B2 JP 7424001 B2 JP7424001 B2 JP 7424001B2 JP 2019209030 A JP2019209030 A JP 2019209030A JP 2019209030 A JP2019209030 A JP 2019209030A JP 7424001 B2 JP7424001 B2 JP 7424001B2
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- rubber
- medical
- medical rubber
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- 239000005060 rubber Substances 0.000 title claims description 133
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- 229920005555 halobutyl Polymers 0.000 claims description 25
- 239000003431 cross linking reagent Substances 0.000 claims description 23
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- 229920005601 base polymer Polymers 0.000 claims description 17
- 238000004132 cross linking Methods 0.000 claims description 11
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- GDVKFRBCXAPAQJ-UHFFFAOYSA-A dialuminum;hexamagnesium;carbonate;hexadecahydroxide Chemical compound [OH-].[OH-].[OH-].[OH-].[OH-].[OH-].[OH-].[OH-].[OH-].[OH-].[OH-].[OH-].[OH-].[OH-].[OH-].[OH-].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Al+3].[Al+3].[O-]C([O-])=O GDVKFRBCXAPAQJ-UHFFFAOYSA-A 0.000 description 11
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- YXIWHUQXZSMYRE-UHFFFAOYSA-N 1,3-benzothiazole-2-thiol Chemical compound C1=CC=C2SC(S)=NC2=C1 YXIWHUQXZSMYRE-UHFFFAOYSA-N 0.000 description 2
- IXDGHAZCSMVIFX-UHFFFAOYSA-N 6-(dibutylamino)-1h-1,3,5-triazine-2,4-dithione Chemical compound CCCCN(CCCC)C1=NC(=S)NC(=S)N1 IXDGHAZCSMVIFX-UHFFFAOYSA-N 0.000 description 2
- MLZQBMZXBHDWJM-UHFFFAOYSA-N 6-anilino-1h-1,3,5-triazine-2,4-dithione Chemical compound N1C(=S)NC(=S)N=C1NC1=CC=CC=C1 MLZQBMZXBHDWJM-UHFFFAOYSA-N 0.000 description 2
- 239000005995 Aluminium silicate Substances 0.000 description 2
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- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Chemical group BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 description 2
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- NLYAJNPCOHFWQQ-UHFFFAOYSA-N kaolin Chemical compound O.O.O=[Al]O[Si](=O)O[Si](=O)O[Al]=O NLYAJNPCOHFWQQ-UHFFFAOYSA-N 0.000 description 2
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- 229940071643 prefilled syringe Drugs 0.000 description 2
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- 239000003381 stabilizer Substances 0.000 description 2
- 125000000383 tetramethylene group Chemical group [H]C([H])([*:1])C([H])([H])C([H])([H])C([H])([H])[*:2] 0.000 description 2
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- KUAZQDVKQLNFPE-UHFFFAOYSA-N thiram Chemical compound CN(C)C(=S)SSC(=S)N(C)C KUAZQDVKQLNFPE-UHFFFAOYSA-N 0.000 description 2
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- RIPYNJLMMFGZSX-UHFFFAOYSA-N (5-benzoylperoxy-2,5-dimethylhexan-2-yl) benzenecarboperoxoate Chemical compound C=1C=CC=CC=1C(=O)OOC(C)(C)CCC(C)(C)OOC(=O)C1=CC=CC=C1 RIPYNJLMMFGZSX-UHFFFAOYSA-N 0.000 description 1
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- FYRCDEARNUVZRG-UHFFFAOYSA-N 1,1,5-trimethyl-3,3-bis(2-methylpentan-2-ylperoxy)cyclohexane Chemical compound CCCC(C)(C)OOC1(OOC(C)(C)CCC)CC(C)CC(C)(C)C1 FYRCDEARNUVZRG-UHFFFAOYSA-N 0.000 description 1
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- IISBACLAFKSPIT-UHFFFAOYSA-N bisphenol A Chemical compound C=1C=C(O)C=CC=1C(C)(C)C1=CC=C(O)C=C1 IISBACLAFKSPIT-UHFFFAOYSA-N 0.000 description 1
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- 125000000484 butyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 239000011575 calcium Substances 0.000 description 1
- BRPQOXSCLDDYGP-UHFFFAOYSA-N calcium oxide Chemical compound [O-2].[Ca+2] BRPQOXSCLDDYGP-UHFFFAOYSA-N 0.000 description 1
- 239000000292 calcium oxide Substances 0.000 description 1
- ODINCKMPIJJUCX-UHFFFAOYSA-N calcium oxide Inorganic materials [Ca]=O ODINCKMPIJJUCX-UHFFFAOYSA-N 0.000 description 1
- DKVNPHBNOWQYFE-UHFFFAOYSA-N carbamodithioic acid Chemical compound NC(S)=S DKVNPHBNOWQYFE-UHFFFAOYSA-N 0.000 description 1
- 150000001721 carbon Chemical group 0.000 description 1
- 229910052799 carbon Inorganic materials 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 239000000460 chlorine Substances 0.000 description 1
- 229910052801 chlorine Inorganic materials 0.000 description 1
- 125000001309 chloro group Chemical group Cl* 0.000 description 1
- 230000003749 cleanliness Effects 0.000 description 1
- 239000003086 colorant Substances 0.000 description 1
- 238000013329 compounding Methods 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 238000007906 compression Methods 0.000 description 1
- 230000006835 compression Effects 0.000 description 1
- 229910000431 copper oxide Inorganic materials 0.000 description 1
- SPTHWAJJMLCAQF-UHFFFAOYSA-M ctk4f8481 Chemical compound [O-]O.CC(C)C1=CC=CC=C1C(C)C SPTHWAJJMLCAQF-UHFFFAOYSA-M 0.000 description 1
- 125000001995 cyclobutyl group Chemical group [H]C1([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 description 1
- 125000000582 cycloheptyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 description 1
- 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 description 1
- 125000006547 cyclononyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C([H])([H])C1([H])[H] 0.000 description 1
- 125000000640 cyclooctyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C([H])([H])C1([H])[H] 0.000 description 1
- 125000001511 cyclopentyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 description 1
- 125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 description 1
- 125000002704 decyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 description 1
- LSXWFXONGKSEMY-UHFFFAOYSA-N di-tert-butyl peroxide Chemical group CC(C)(C)OOC(C)(C)C LSXWFXONGKSEMY-UHFFFAOYSA-N 0.000 description 1
- AFZSMODLJJCVPP-UHFFFAOYSA-N dibenzothiazol-2-yl disulfide Chemical compound C1=CC=C2SC(SSC=3SC4=CC=CC=C4N=3)=NC2=C1 AFZSMODLJJCVPP-UHFFFAOYSA-N 0.000 description 1
- 125000000118 dimethyl group Chemical group [H]C([H])([H])* 0.000 description 1
- SWSQBOPZIKWTGO-UHFFFAOYSA-N dimethylaminoamidine Natural products CN(C)C(N)=N SWSQBOPZIKWTGO-UHFFFAOYSA-N 0.000 description 1
- 125000005982 diphenylmethyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])(*)C1=C([H])C([H])=C([H])C([H])=C1[H] 0.000 description 1
- PXJJSXABGXMUSU-UHFFFAOYSA-N disulfur dichloride Chemical compound ClSSCl PXJJSXABGXMUSU-UHFFFAOYSA-N 0.000 description 1
- 239000012990 dithiocarbamate Substances 0.000 description 1
- 125000003438 dodecyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 description 1
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- 238000010828 elution Methods 0.000 description 1
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- 238000001704 evaporation Methods 0.000 description 1
- 230000008020 evaporation Effects 0.000 description 1
- 239000012632 extractable Substances 0.000 description 1
- 238000011011 extractables test Methods 0.000 description 1
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- 229920001903 high density polyethylene Polymers 0.000 description 1
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- 229910052739 hydrogen Inorganic materials 0.000 description 1
- 229920002681 hypalon Polymers 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 239000003112 inhibitor Substances 0.000 description 1
- 230000005764 inhibitory process Effects 0.000 description 1
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- 229910003475 inorganic filler Inorganic materials 0.000 description 1
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- JEIPFZHSYJVQDO-UHFFFAOYSA-N iron(III) oxide Inorganic materials O=[Fe]O[Fe]=O JEIPFZHSYJVQDO-UHFFFAOYSA-N 0.000 description 1
- 125000000959 isobutyl group Chemical group [H]C([H])([H])C([H])(C([H])([H])[H])C([H])([H])* 0.000 description 1
- 125000001972 isopentyl group Chemical group [H]C([H])([H])C([H])(C([H])([H])[H])C([H])([H])C([H])([H])* 0.000 description 1
- 229920003049 isoprene rubber Polymers 0.000 description 1
- 125000000555 isopropenyl group Chemical group [H]\C([H])=C(\*)C([H])([H])[H] 0.000 description 1
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- 229910052744 lithium Inorganic materials 0.000 description 1
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- 239000002075 main ingredient Substances 0.000 description 1
- 238000000691 measurement method Methods 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 229910052751 metal Inorganic materials 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 1
- 239000011707 mineral Substances 0.000 description 1
- 125000002950 monocyclic group Chemical group 0.000 description 1
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- DEQZTKGFXNUBJL-UHFFFAOYSA-N n-(1,3-benzothiazol-2-ylsulfanyl)cyclohexanamine Chemical compound C1CCCCC1NSC1=NC2=CC=CC=C2S1 DEQZTKGFXNUBJL-UHFFFAOYSA-N 0.000 description 1
- 125000004108 n-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 description 1
- 125000001280 n-hexyl group Chemical group C(CCCCC)* 0.000 description 1
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- 125000004123 n-propyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])* 0.000 description 1
- 125000001624 naphthyl group Chemical group 0.000 description 1
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- 229910052757 nitrogen Inorganic materials 0.000 description 1
- JFNLZVQOOSMTJK-KNVOCYPGSA-N norbornene Chemical compound C1[C@@H]2CC[C@H]1C=C2 JFNLZVQOOSMTJK-KNVOCYPGSA-N 0.000 description 1
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 1
- OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 description 1
- 125000002347 octyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 125000001147 pentyl group Chemical group C(CCCC)* 0.000 description 1
- 239000000825 pharmaceutical preparation Substances 0.000 description 1
- 125000005561 phenanthryl group Chemical group 0.000 description 1
- 150000002989 phenols Chemical class 0.000 description 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 description 1
- 125000004346 phenylpentyl group Chemical group C1(=CC=CC=C1)CCCCC* 0.000 description 1
- 150000004714 phosphonium salts Chemical class 0.000 description 1
- 229920001084 poly(chloroprene) Polymers 0.000 description 1
- 229920002589 poly(vinylethylene) polymer Polymers 0.000 description 1
- 229920000058 polyacrylate Polymers 0.000 description 1
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- 229920001748 polybutylene Polymers 0.000 description 1
- 125000005575 polycyclic aromatic hydrocarbon group Chemical group 0.000 description 1
- 229920001223 polyethylene glycol Polymers 0.000 description 1
- 229920001195 polyisoprene Polymers 0.000 description 1
- 230000000379 polymerizing effect Effects 0.000 description 1
- 229920005672 polyolefin resin Polymers 0.000 description 1
- 229920002223 polystyrene Polymers 0.000 description 1
- 239000005077 polysulfide Substances 0.000 description 1
- 229920001021 polysulfide Polymers 0.000 description 1
- 150000008117 polysulfides Polymers 0.000 description 1
- 229910052700 potassium Inorganic materials 0.000 description 1
- 238000003825 pressing Methods 0.000 description 1
- QQONPFPTGQHPMA-UHFFFAOYSA-N propylene Natural products CC=C QQONPFPTGQHPMA-UHFFFAOYSA-N 0.000 description 1
- 150000003242 quaternary ammonium salts Chemical class 0.000 description 1
- 239000012488 sample solution Substances 0.000 description 1
- 150000003335 secondary amines Chemical class 0.000 description 1
- 229920002379 silicone rubber Polymers 0.000 description 1
- 239000004945 silicone rubber Substances 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 239000012086 standard solution Substances 0.000 description 1
- 239000008117 stearic acid Substances 0.000 description 1
- 229920003048 styrene butadiene rubber Polymers 0.000 description 1
- QAZLUNIWYYOJPC-UHFFFAOYSA-M sulfenamide Chemical compound [Cl-].COC1=C(C)C=[N+]2C3=NC4=CC=C(OC)C=C4N3SCC2=C1C QAZLUNIWYYOJPC-UHFFFAOYSA-M 0.000 description 1
- 229940052367 sulfur,colloidal Drugs 0.000 description 1
- SWAXTRYEYUTSAP-UHFFFAOYSA-N tert-butyl ethaneperoxoate Chemical compound CC(=O)OOC(C)(C)C SWAXTRYEYUTSAP-UHFFFAOYSA-N 0.000 description 1
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
- 125000001973 tert-pentyl group Chemical group [H]C([H])([H])C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
- 150000003512 tertiary amines Chemical class 0.000 description 1
- 238000010998 test method Methods 0.000 description 1
- 239000012085 test solution Substances 0.000 description 1
- YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 description 1
- 229920001169 thermoplastic Polymers 0.000 description 1
- 239000004416 thermosoftening plastic Substances 0.000 description 1
- 125000003944 tolyl group Chemical group 0.000 description 1
- KNXVOGGZOFOROK-UHFFFAOYSA-N trimagnesium;dioxido(oxo)silane;hydroxy-oxido-oxosilane Chemical compound [Mg+2].[Mg+2].[Mg+2].O[Si]([O-])=O.O[Si]([O-])=O.[O-][Si]([O-])=O.[O-][Si]([O-])=O KNXVOGGZOFOROK-UHFFFAOYSA-N 0.000 description 1
- 229940070710 valerate Drugs 0.000 description 1
- NQPDZGIKBAWPEJ-UHFFFAOYSA-N valeric acid Chemical compound CCCCC(O)=O NQPDZGIKBAWPEJ-UHFFFAOYSA-N 0.000 description 1
- 125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 description 1
- 239000004636 vulcanized rubber Substances 0.000 description 1
- 239000011701 zinc Substances 0.000 description 1
- 229910052725 zinc Inorganic materials 0.000 description 1
- 150000003752 zinc compounds Chemical class 0.000 description 1
- 239000011787 zinc oxide Substances 0.000 description 1
- MBBWTVUFIXOUBE-UHFFFAOYSA-L zinc;dicarbamodithioate Chemical compound [Zn+2].NC([S-])=S.NC([S-])=S MBBWTVUFIXOUBE-UHFFFAOYSA-L 0.000 description 1
- 239000004711 α-olefin Substances 0.000 description 1
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- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L29/00—Materials for catheters, medical tubing, cannulae, or endoscopes or for coating catheters
- A61L29/04—Macromolecular materials
- A61L29/041—Macromolecular materials obtained by reactions only involving carbon-to-carbon unsaturated bonds
- A61L29/042—Rubbers
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- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L23/00—Compositions of homopolymers or copolymers of unsaturated aliphatic hydrocarbons having only one carbon-to-carbon double bond; Compositions of derivatives of such polymers
- C08L23/26—Compositions of homopolymers or copolymers of unsaturated aliphatic hydrocarbons having only one carbon-to-carbon double bond; Compositions of derivatives of such polymers modified by chemical after-treatment
- C08L23/28—Compositions of homopolymers or copolymers of unsaturated aliphatic hydrocarbons having only one carbon-to-carbon double bond; Compositions of derivatives of such polymers modified by chemical after-treatment by reaction with halogens or compounds containing halogen
- C08L23/283—Halogenated homo- or copolymers of iso-olefins
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- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
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- A61B5/15—Devices for taking samples of blood
- A61B5/150007—Details
- A61B5/150351—Caps, stoppers or lids for sealing or closing a blood collection vessel or container, e.g. a test-tube or syringe barrel
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- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
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Description
次に、本発明で使用する(b)液状ポリマーについて説明する。前記(b)液状ポリマーは、常温(23℃)で液状のポリマーである。前記(b)液状ポリマーとしては、液状ポリブテン、液状ポリイソプレン、液状ポリブタジエン、液状ポリα-オレフィン、液状エチレンα-オレフィン共重合体、液状エチレンプロピレン共重合体、液状エチレンブチレン共重合体等が挙げられる。これらのなかでも、液状ポリブテンまたは液状ポリブタジエンが好ましく、液状ポリブテンがより好ましい。
本発明の医療用ゴム組成物は、(a)基材ポリマーと(b)液状ポリマーと、その他、必要に応じて加える配合材料とを混練することにより得られる。混練は、例えば、オープンロール、密閉式ニーダーなどを用いて行うことができる。混練物は、リボン状、シート状、ペレット状などに成形することが好ましく、シート状に成形することがより好ましい。
表1に示した材料を混練して医療用ゴム組成物を調製した。混練は、オープンロールを用いて、20℃で約10分間行った。
塩素化ブチルゴム:エクソンモービル社製HT-1066
臭素化ブチルゴム:ランクセス社製 X_Butyl BB 2030
液状ポリブテン1:JXTGエネルギー社製ポリブテンHV35(100℃動粘度:85mm2/s)
液状ポリブテン2:JXTGエネルギー社製ポリブテンHV50(100℃動粘度:110mm2/s)
液状ポリブテン3:JXTGエネルギー社製ポリブテンHV100(100℃動粘度:220mm2/s)
液状ポリブテン4:JXTGエネルギー社製ポリブテンHV300(100℃動粘度:590mm2/s)
液状ポリブテン5:Ineos社製ポリブテンIndopol H-100(100℃動粘度:170mm2/s)
液状ポリブタジエン:クレイバレー社製Ricon 131(ブルックフィールド型粘度:2750mPa・s(25℃))
酸化マグネシウム:協和化学工業社製マグサラット150s
酸化チタン:チタン工業社製KR-380
タルク:イメリススペシャリティーズ社製ミストロンベーパー
カーボンブラック:三菱ケミカル社製ダイアブラックG
オイル:出光興産社製PW380
トリアジン誘導体:三協化成社製ジスネットDB
硫黄:鶴見化学社製 5%油入り硫黄
(1)ガス透過係数(cc・cm/cm2・sec・cmHg)
得られた医療用ゴム組成物から、ガス透過係数測定用の試験片を作製し、ガス透過係数を測定した。測定は、JIS-K6275-1に準じて、GTR社製GTR-30XASRを用いて、差圧法により行った。
試験ガス:N2、O2、空気(75%N2+25%O2)
測定サンプル:ゴム組成物を180℃×6分間プレス成型して、厚みが0.5mm~1.0mmのスラブを作製した。
<相対評価>
ゴム組成物No.1を基準配合としその空気透過係数を100として、空気透過係数を指数化した。
◎:80以下
○:80超、90以下
×:90超
測定サンプル:前記のように配合したゴム組成物を180℃×6分間プレス成型して2mmのスラブを作製した。それをφ17mmのポンチで打ち抜いて試験サンプルとした。
製造したサンプルについて、第17改正日本薬局法「7.03輸液用ゴム栓試験法」所載の「溶出物試験」を実施した。適合条件は、以下の通りとした。
試験液の性状:無色澄明
UV透過率:層長10mmで、波長430nmおよび波長650nmの透過率が99.0%以上
紫外吸収スペクトル:波長220nm~350nmにおける吸光度が0.20以下
pH:試験液および空試験液の差が1.0以下
亜鉛:試料溶液の吸光度が、標準溶液の吸光度以下
過マンガン酸カリウム還元物質:2.0mL/100mL以下(薬局方の規格)
蒸発残留物:2.0mg以下
表中、過マンガン酸カリウム還元物質濃度が、0.5mL/100mL以下の場合には、「○」を、過マンガン酸カリウム還元物質濃度が、0.5mL/100mL超の場合には、「△」を記載している。
〇:液状ポリマーの粘度が低く、取扱いが容易である。
×:液状ポリマーの粘度が高く、取扱いが難しい。
20:医療用ゴム栓、21:天板、22:栓脚、23:穿刺部、24:医療容器、26:ナイロンフィルム層、25:キャップ、41:ノズルキャップ、42:注射筒、43:ノズル、44:針、45:針付きシリンジ
Claims (9)
- (a)ハロゲン化ブチルゴムを含有する基材ポリマーと
(b)液状ポリマーと、
(c)架橋剤とを含有し、
前記(a)ハロゲン化ブチルゴムは、塩素化ブチルゴムまたは臭素化ブチルゴムであることを特徴とする医療用ゴム組成物の架橋物(ただし、動的架橋型熱可塑性エラストマーを除く)。 - 前記(b)液状ポリマーは、液状ポリブテンまたは液状ポリブタジエンを含有する請求項1に記載の医療用ゴム組成物の架橋物。
- 前記(b)液状ポリマーの動粘度(100℃)は、50mm2/s~4000mm2/sである請求項1または2に記載の医療用ゴム組成物の架橋物。
- (a)基材ポリマー100質量部に対して、(b)液状ポリマーを1質量部~20質量部含有する請求項1~3のいずれか一項に記載の医療用ゴム組成物の架橋物。
- (a)ハロゲン化ブチルゴムとして塩素化ブチルゴムを含み、(c)架橋剤としてトリアジン誘導体を含有する請求項1~4のいずれか一項に記載の医療用ゴム組成物の架橋物。
- (a)ハロゲン化ブチルゴムとして臭素化ブチルゴムを含み、(c)架橋剤として、金属酸化物を含有する請求項1~4のいずれか一項に記載の医療用ゴム組成物の架橋物。
- さらに(d)充填剤を含有する請求項1~6のいずれか一項に記載の医療用ゴム組成物の架橋物。
- 請求項1~7のいずれか一項に記載の医療用ゴム組成物の架橋物からなる医療用ゴム部品。
- シリンジ用のキャップ、プランジャストッパー、または、真空採血管用ゴム栓である請求項8に記載の医療用ゴム部品。
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CN202010371665.9A CN112898693A (zh) | 2019-11-19 | 2020-05-06 | 医疗用橡胶组合物和医疗用橡胶部件 |
EP20203926.9A EP3824914A1 (en) | 2019-11-19 | 2020-10-26 | Medical rubber composition and medical rubber component |
US16/951,305 US20210147657A1 (en) | 2019-11-19 | 2020-11-18 | Medical rubber composition and medical rubber component |
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JP2013112703A (ja) | 2011-11-25 | 2013-06-10 | Sumitomo Rubber Ind Ltd | 熱可塑性エラストマー組成物および医療用ゴム用品 |
JP2018079235A (ja) | 2016-11-18 | 2018-05-24 | 住友ゴム工業株式会社 | ノズルキャップおよびそのノズルキャップを使ったプレフィルドシリンジ |
JP2018110610A (ja) | 2017-01-06 | 2018-07-19 | 住友ゴム工業株式会社 | ノズルキャップ及び医療用プレフィルドシリンジ |
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JP2000044730A (ja) * | 1998-07-31 | 2000-02-15 | Yokohama Rubber Co Ltd:The | ゴム組成物 |
JP4601127B2 (ja) | 2000-06-06 | 2010-12-22 | 住友ゴム工業株式会社 | 医療用ゴム栓 |
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DK1227126T3 (da) * | 2001-01-30 | 2006-12-04 | Daikyo Seiko Ltd | Gummisammensætning anvendt til en gummiprop til et medikament eller til en medicinsk behandling eller dets tævrbundne produkt |
JP4732720B2 (ja) * | 2004-07-15 | 2011-07-27 | 東海ゴム工業株式会社 | 冷媒輸送用ホース |
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KR102602677B1 (ko) * | 2015-07-28 | 2023-11-14 | 에누오케 가부시키가이샤 | 할로겐화 부틸 고무 조성물과 방진 그로밋 |
JP2019209030A (ja) | 2018-06-08 | 2019-12-12 | 株式会社三共 | 遊技機 |
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JP2013112703A (ja) | 2011-11-25 | 2013-06-10 | Sumitomo Rubber Ind Ltd | 熱可塑性エラストマー組成物および医療用ゴム用品 |
JP2018079235A (ja) | 2016-11-18 | 2018-05-24 | 住友ゴム工業株式会社 | ノズルキャップおよびそのノズルキャップを使ったプレフィルドシリンジ |
JP2018110610A (ja) | 2017-01-06 | 2018-07-19 | 住友ゴム工業株式会社 | ノズルキャップ及び医療用プレフィルドシリンジ |
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