JP6936217B2 - ヒト化型親和性成熟抗ＦｃＲｎ抗体 - Google Patents

ヒト化型親和性成熟抗ＦｃＲｎ抗体 Download PDF

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JP6936217B2
JP6936217B2 JP2018511346A JP2018511346A JP6936217B2 JP 6936217 B2 JP6936217 B2 JP 6936217B2 JP 2018511346 A JP2018511346 A JP 2018511346A JP 2018511346 A JP2018511346 A JP 2018511346A JP 6936217 B2 JP6936217 B2 JP 6936217B2
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antibody
fcrn
seq
antigen
binding
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JP2018522578A (ja
JP2018522578A5 (https=
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ジェイ．ブランバーグ ローレンス
ジェイ．ブランバーグ ローレンス
エス．ブランバーグ リチャード
エス．ブランバーグ リチャード
ダーナ ジョーンズ スーザン
ダーナ ジョーンズ スーザン
ルーペニアン デリー
ルーペニアン デリー
ジョージ エドワード ホールゲイト ロバート
ジョージ エドワード ホールゲイト ロバート
デイビッド ジョーンズ ティモシー
デイビッド ジョーンズ ティモシー
ロバート ハーン アーロン
ロバート ハーン アーロン
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シンティミューン，インコーポレイティド
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    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/283—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against Fc-receptors, e.g. CD16, CD32, CD64
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    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
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    • G01—MEASURING; TESTING
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    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6863—Cytokines, i.e. immune system proteins modifying a biological response such as cell growth proliferation or differentiation, e.g. TNF, CNF, GM-CSF, lymphotoxin, MIF or their receptors
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/54—F(ab')2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
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    • C07—ORGANIC CHEMISTRY
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    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

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JP2018511346A 2015-05-12 2016-05-12 ヒト化型親和性成熟抗ＦｃＲｎ抗体 Expired - Fee Related JP6936217B2 (ja)

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US201562160423P 2015-05-12 2015-05-12
US62/160,423 2015-05-12
US201562217490P 2015-09-11 2015-09-11
US62/217,490 2015-09-11
PCT/US2016/032168 WO2016183352A1 (en) 2015-05-12 2016-05-12 Humanized affinity matured anti-fcrn antibodies

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JP2018522578A (ja) 2018-08-16
CN108025066A (zh) 2018-05-11
IL255601A (en) 2018-01-31
EP3294335B1 (en) 2023-07-05
HK1251483A1 (zh) 2019-02-01
AU2016262100A1 (en) 2017-12-21
CA3022547A1 (en) 2016-11-17
US20180291101A1 (en) 2018-10-11
US20200207854A1 (en) 2020-07-02
AU2022200024A1 (en) 2022-02-03
EP3294335A1 (en) 2018-03-21
CN108025066B (zh) 2022-04-12
ES2956662T3 (es) 2023-12-26
KR20180023900A (ko) 2018-03-07
AU2016262100B2 (en) 2021-10-14
EP3294335C0 (en) 2023-07-05
WO2016183352A1 (en) 2016-11-17
US10626175B2 (en) 2020-04-21
JP2022008301A (ja) 2022-01-13
US20200181262A1 (en) 2020-06-11
CN114716550A (zh) 2022-07-08
EP3294335A4 (en) 2019-02-20

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